@article{DietzschBraesigkSeideletal.2022, author = {Dietzsch, Stefan and Braesigk, Annett and Seidel, Clemens and Remmele, Julia and Kitzing, Ralf and Schlender, Tina and Mynarek, Martin and Geismar, Dirk and Jablonska, Karolina and Schwarz, Rudolf and Pazos, Montserrat and Weber, Damien C. and Frick, Silke and Gurtner, Kristin and Matuschek, Christiane and Harrabi, Semi Ben and Gl{\"u}ck, Albrecht and Lewitzki, Victor and Dieckmann, Karin and Benesch, Martin and Gerber, Nicolas U. and Obrecht, Denise and Rutkowski, Stefan and Timmermann, Beate and Kortmann, Rolf-Dieter}, title = {Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma—an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial}, series = {Strahlentherapie und Onkologie}, volume = {198}, journal = {Strahlentherapie und Onkologie}, number = {3}, issn = {0179-7158}, doi = {10.1007/s00066-021-01822-0}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-307812}, pages = {282-290}, year = {2022}, abstract = {Purpose In Germany, Austria, and Switzerland, pretreatment radiotherapy quality control (RT-QC) for tumor bed boost (TB) in non-metastatic medulloblastoma (MB) was not mandatory but was recommended for patients enrolled in the SIOP PNET5 MB trial between 2014 and 2018. This individual case review (ICR) analysis aimed to evaluate types of deviations in the initial plan proposals and develop uniform review criteria for TB boost. Patients and methods A total of 78 patients were registered in this trial, of whom a subgroup of 65 patients were available for evaluation of the TB treatment plans. Dose uniformity was evaluated according to the definitions of the protocol. Additional RT-QC criteria for standardized review of target contours were elaborated and data evaluated accordingly. Results Of 65 initial TB plan proposals, 27 (41.5\%) revealed deviations of target volume delineation. Deviations according to the dose uniformity criteria were present in 14 (21.5\%) TB plans. In 25 (38.5\%) cases a modification of the RT plan was recommended. Rejection of the TB plans was rather related to unacceptable target volume delineation than to insufficient dose uniformity. Conclusion In this analysis of pretreatment RT-QC, protocol deviations were present in a high proportion of initial TB plan proposals. These findings emphasize the importance of pretreatment RT-QC in clinical trials for MB. Based on these data, a proposal for RT-QC criteria for tumor bed boost in non-metastatic MB was developed.}, language = {en} } @article{DuerrnagelBeyerThomaleetal.2022, author = {D{\"u}rrnagel, Matteo and Beyer, Jacob and Thomale, Ronny and Schwemmer, Tilman}, title = {Unconventional superconductivity from weak coupling}, series = {The European Physical Journal B}, volume = {95}, journal = {The European Physical Journal B}, number = {7}, issn = {1434-6028}, doi = {10.1140/epjb/s10051-022-00371-4}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-325153}, year = {2022}, abstract = {We develop a joint formalism and numerical framework for analyzing the superconducting instability of metals from a weak coupling perspective. This encompasses the Kohn-Luttinger formulation of weak coupling renormalization group for superconductivity as well as the random phase approximation imposed on the diagrammatic expansion of the two-particle Green's function. The central quantity to resolve is the effective interaction in the Cooper channel, for which we develop an optimized numerical framework. Our code is capable of treating generic multi-orbital models in two as well as three spatial dimensions and, in particular, arbitrary avenues of spin-orbit coupling.}, language = {en} } @article{KourouZarvalis2022, author = {Kourou, Maria and Zarvalis, Konstantinos}, title = {Compact sets in petals and their backward orbits under semigroups of holomorphic functions}, series = {Potential Analysis}, volume = {59}, journal = {Potential Analysis}, number = {4}, issn = {0926-2601}, doi = {10.1007/s11118-022-10036-7}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-324368}, pages = {1913-1939}, year = {2022}, abstract = {Let (ϕ\(_t\))\(_{t≥0}\) be a semigroup of holomorphic functions in the unit disk \(\mathbb {D}\) and K a compact subset of \(\mathbb {D}\). We investigate the conditions under which the backward orbit of K under the semigroup exists. Subsequently, the geometric characteristics, as well as, potential theoretic quantities for the backward orbit of K are examined. More specifically, results are obtained concerning the asymptotic behavior of its hyperbolic area and diameter, the harmonic measure and the capacity of the condenser that K forms with the unit disk.}, language = {en} } @article{Franz2022, author = {Franz, David J.}, title = {Moral responsibility for self-deluding beings}, series = {Philosophia}, volume = {50}, journal = {Philosophia}, number = {4}, issn = {0048-3893}, doi = {10.1007/s11406-022-00469-0}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-324871}, pages = {1791-1807}, year = {2022}, abstract = {In this article, I argue for four theses. First, libertarian and compatibilist accounts of moral responsibility agree that the capability of practical reason is the central feature of moral responsibility. Second, this viewpoint leads to a reasons-focused account of human behavior. Examples of human action discussed in debates about moral responsibility suggest that typical human actions are driven primarily by the agent's subjective reasons and are sufficiently transparent for the agent. Third, this conception of self-transparent action is a questionable idealization. As shown by psychological research on self-assessment, motivated reasoning, and terror management theory, humans oftentimes have only a limited understanding of their conduct. Self-deception is rather the rule than the exception. Fourth, taking the limited self-transparency of practical reason seriously leads to a socially contextualized conception of moral responsibility.}, language = {en} } @article{BeyerGothMueller2022, author = {Beyer, Jacob and Goth, Florian and M{\"u}ller, Tobias}, title = {Better integrators for functional renormalization group calculations}, series = {The European Physical Journal B}, volume = {95}, journal = {The European Physical Journal B}, number = {7}, issn = {1434-6028}, doi = {10.1140/epjb/s10051-022-00378-x}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-325131}, year = {2022}, abstract = {We analyze a variety of integration schemes for the momentum space functional renormalization group calculation with the goal of finding an optimized scheme. Using the square lattice t-t' Hubbard model as a testbed we define and benchmark the quality. Most notably we define an error estimate of the solution for the ordinary differential equation circumventing the issues introduced by the divergences at the end of the FRG flow. Using this measure to control for accuracy we find a threefold reduction in number of required integration steps achievable by choice of integrator. We herewith publish a set of recommended choices for the functional renormalization group, shown to decrease the computational cost for FRG calculations and representing a valuable basis for further investigations.}, language = {en} } @misc{Spano2022, author = {Spano, Nicola}, title = {Book Review: The Routledge Handbook of Phenomenology of Agency}, series = {Husserl Studies}, volume = {38}, journal = {Husserl Studies}, number = {2}, issn = {0167-9848}, doi = {10.1007/s10743-022-09303-7}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-324731}, pages = {221-226}, year = {2022}, abstract = {No abstract available.}, language = {en} } @article{Spano2022, author = {Spano, Nicola}, title = {Husserl's taxonomy of action}, series = {Husserl Studies}, volume = {38}, journal = {Husserl Studies}, number = {3}, issn = {0167-9848}, doi = {10.1007/s10743-022-09306-4}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-324744}, pages = {251-271}, year = {2022}, abstract = {In the present article I discuss, in confrontation with the most recent studies on Husserl's phenomenology of acting and willing, the taxonomy of action that is collected in the volume 'Wille und Handlung' of the Husserliana edition Studien zur Struktur des Bewussteins. In so doing, I first present Husserl's universal characterization of action (Handlung) as a volitional process (willentlicher Vorgang). Then, after clarifying what it means for a process to have a character of volitionality (Willentlichkeit), I illustrate the various types of actions, which Husserl distinguishes as 'straightforward' (schlicht) or 'deciding' (entscheidend), 'primary' (prim{\"a}r) or 'secondary' (sekund{\"a}r), 'inner' (innere) or 'outer' ({\"a}ußere), 'immediate' (unmittelbar) or mediate (mittelbar), 'simple' (einfach) or 'compound' (zusammengesetzt). Finally, I consider Husserl's discussion of the direction and foundation of action.}, language = {en} } @article{DedukhDaCruzKneitzetal.2022, author = {Dedukh, Dmitrij and Da Cruz, Irene and Kneitz, Susanne and Marta, Anatolie and Ormanns, Jenny and Tichop{\´a}d, Tom{\´a}š and Lu, Yuan and Alsheimer, Manfred and Janko, Karel and Schartl, Manfred}, title = {Achiasmatic meiosis in the unisexual Amazon molly, Poecilia formosa}, series = {Chromosome Research}, volume = {30}, journal = {Chromosome Research}, number = {4}, doi = {10.1007/s10577-022-09708-2}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-325128}, pages = {443-457}, year = {2022}, abstract = {Unisexual reproduction, which generates clonal offspring, is an alternative strategy to sexual breeding and occurs even in vertebrates. A wide range of non-sexual reproductive modes have been described, and one of the least understood questions is how such pathways emerged and how they mechanistically proceed. The Amazon molly, Poecilia formosa, needs sperm from males of related species to trigger the parthenogenetic development of diploid eggs. However, the mechanism, of how the unreduced female gametes are produced, remains unclear. Cytological analyses revealed that the chromosomes of primary oocytes initiate pachytene but do not proceed to bivalent formation and meiotic crossovers. Comparing ovary transcriptomes of P. formosa and its sexual parental species revealed expression levels of meiosis-specific genes deviating from P. mexicana but not from P. latipinna. Furthermore, several meiosis genes show biased expression towards one of the two alleles from the parental genomes. We infer from our data that in the Amazon molly diploid oocytes are generated by apomixis due to a failure in the synapsis of homologous chromosomes. The fact that this failure is not reflected in the differential expression of known meiosis genes suggests the underlying molecular mechanism may be dysregulation on the protein level or misexpression of a so far unknown meiosis gene, and/or hybrid dysgenesis because of compromised interaction of proteins from diverged genomes.}, language = {en} } @article{FrickeRedlichZhangetal.2022, author = {Fricke, Ute and Redlich, Sarah and Zhang, Jie and Tobisch, Cynthia and Rojas-Botero, Sandra and Benjamin, Caryl S. and Englmeier, Jana and Ganuza, Cristina and Riebl, Rebekka and Uhler, Johannes and Uphus, Lars and Ewald, J{\"o}rg and Kollmann, Johannes and Steffan-Dewenter, Ingolf}, title = {Plant richness, land use and temperature differently shape invertebrate leaf-chewing herbivory on plant functional groups}, series = {Oecologia}, volume = {199}, journal = {Oecologia}, number = {2}, doi = {10.1007/s00442-022-05199-4}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-325079}, pages = {407-417}, year = {2022}, abstract = {Higher temperatures can increase metabolic rates and carbon demands of invertebrate herbivores, which may shift leaf-chewing herbivory among plant functional groups differing in C:N (carbon:nitrogen) ratios. Biotic factors influencing herbivore species richness may modulate these temperature effects. Yet, systematic studies comparing leaf-chewing herbivory among plant functional groups in different habitats and landscapes along temperature gradients are lacking. This study was conducted on 80 plots covering large gradients of temperature, plant richness and land use in Bavaria, Germany. We investigated proportional leaf area loss by chewing invertebrates ('herbivory') in three plant functional groups on open herbaceous vegetation. As potential drivers, we considered local mean temperature (range 8.4-18.8 °C), multi-annual mean temperature (range 6.5-10.0 °C), local plant richness (species and family level, ranges 10-51 species, 5-25 families), adjacent habitat type (forest, grassland, arable field, settlement), proportion of grassland and landscape diversity (0.2-3 km scale). We observed differential responses of leaf-chewing herbivory among plant functional groups in response to plant richness (family level only) and habitat type, but not to grassland proportion, landscape diversity and temperature—except for multi-annual mean temperature influencing herbivory on grassland plots. Three-way interactions of plant functional group, temperature and predictors of plant richness or land use did not substantially impact herbivory. We conclude that abiotic and biotic factors can assert different effects on leaf-chewing herbivory among plant functional groups. At present, effects of plant richness and habitat type outweigh effects of temperature and landscape-scale land use on herbivory among legumes, forbs and grasses.}, language = {en} } @article{ZupancRoessler2022, author = {Zupanc, G{\"u}nther K. H. and R{\"o}ssler, Wolfgang}, title = {Government funding of research beyond biomedicine: challenges and opportunities for neuroethology}, series = {Journal of Comparative Physiology A}, volume = {208}, journal = {Journal of Comparative Physiology A}, number = {3}, doi = {10.1007/s00359-022-01552-3}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-325113}, pages = {443-456}, year = {2022}, abstract = {Curiosity-driven research is fundamental for neuroethology and depends crucially on governmental funding. Here, we highlight similarities and differences in funding of curiosity-driven research across countries by comparing two major funding agencies—the National Science Foundation (NSF) in the United States and the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG). We interviewed representatives from each of the two agencies, focusing on general funding trends, levels of young investigator support, career-life balance, and international collaborations. While our analysis revealed a negative trend in NSF funding of biological research, including curiosity-driven research, German researchers in these areas have benefited from a robust positive trend in DFG funding. The main reason for the decrease in curiosity-driven research in the US is that the NSF has only partially been able to compensate for the funding gap resulting from the National Institutes of Health restricting their support to biomedical research using select model organisms. Notwithstanding some differences in funding programs, particularly those relevant for scientists in the postdoctoral phase, both the NSF and DFG clearly support curiosity-driven research.}, language = {en} }