@phdthesis{Hager2011,
  author    = {Hager, Benjamin Dietrich},
  title     = {Einfluss eines antibiotikagetr{\"a}nkten Schwammes auf sternale Wundkomplikationen - eine prospektiv randomisierte Doppelblindstudie},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-74955},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2011},
  abstract  = {Die prophylaktische retrosternale Einlage eines Gentamicin-Kollagen Schwammes wurde in letzter Zeit in mehreren Studien untersucht und ist wird kontrovers diskutiert. Die vorliegende Studie ist die erste prospektiv randomisierte, Einzelzentrums-Doppelblind-Studie zur Untersuchung der Effektivit{\"a}t, im Hinblick auf die Reduktion sternaler Wundkomplikationen nach herzchirurgischen Eingriffen, eines retrosternal eingelegten Gentamicin-Kollagen-Schwammes.},
  subject      = {Wundinfektion},
  language  = {de}
}
@article{BaumbachHoertererOppeltetal.2022,
  author    = {Baumbach, Sebastian Felix and H{\"o}rterer, Hubert and Oppelt, Sonja and Szeimies, Ulrike and Polzer, Hans and Walther, Markus},
  title     = {Do pre-operative radiologic assessment predict postoperative outcomes in patients with insertional Achilles tendinopathy?: a retrospective database study},
  series = {Archives of Orthopaedic and Trauma Surgery},
  volume    = {142},
  journal   = {Archives of Orthopaedic and Trauma Surgery},
  number    = {11},
  issn      = {1434-3916},
  doi       = {10.1007/s00402-021-03897-x},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-307963},
  pages     = {3045-3052},
  year      = {2022},
  abstract  = {Introduction Diagnosis and treatment of insertional tendinopathy of the Achilles tendon (IAT) remains a challenge. The aim of this study was to assess the influence of pre-operative radiological pathologies on the patient-reported outcomes following open debridement of all pathologies for IAT. Materials and methods In this IRB-approved retrospective correlation and comparative study, patients with pre-operative imaging were identified from the authors' retrospective IAT database comprising of 118 patients. All were treated by a standardized surgical treatment strategy utilizing a midline, transachillary approach and debridement of all pathologies. A total of fifteen radiologic parameters were measured on radiographs (RX) and MRI. The patient-reported outcomes were assessed using the Victorian Institute of Sport Assessment-Achilles questionnaire (VISA-A-G) and the general health questionnaire SF-12 at a minimum follow-up of 12 months. The data are presented as mean ± SD (95\% CI). Results 88 patients (74.6\%) with an average age of 50 ± 12 (47-52) years were included. Radiographs were available in 68 patients and MRI in 53. The mean follow-up was 3.8 ± 1.9 (3.4-4.3) years. The overall VISA-A-G was 81 ± 22 (77-86), the SF-12 PCS 54 ± 7 (52-55), and the SF-12 MCS 52 ± 9 (50-54) points. None of the assessed radiological parameters had a significant influence on the patient-reported outcome following surgical treatment for IAT. Conclusion In this retrospective correlation study, no significant association was found between preoperative radiographic and MRI radiologic parameters for IAT and postoperative patient-reported outcomes (VISA-A-G and SF-12).},
  language  = {en}
}
@article{DiersBaumLehmannetal.2022,
  author    = {Diers, Johannes and Baum, Philip and Lehmann, Kai and Uttinger, Konstatin and Baumann, Nikolas and Pietryga, Sebastian and Hankir, Mohammed and Matthes, Niels and Lock, Johann F. and Germer, Christoph-Thomas and Wiegering, Armin},
  title     = {Disproportionately high failure to rescue rates after resection for colorectal cancer in the geriatric patient population - A nationwide study},
  series = {Cancer Medicine},
  volume    = {11},
  journal   = {Cancer Medicine},
  number    = {22},
  doi       = {10.1002/cam4.4784},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-312858},
  pages     = {4256-4264},
  year      = {2022},
  abstract  = {Background Colorectal cancer incidence increases with patient age. The aim of this study was to assess, at the nationwide level, in-hospital mortality, and failure to rescue in geriatric patients (≥ 80 years old) with colorectal cancer arising from postoperative complications. Methods All patients receiving surgery for colorectal cancer in Germany between 2012 and 2018 were identified in a nationwide database. Association between age and in-hospital mortality following surgery and failure to rescue, defined as death after complication, were determined in univariate and multivariate analyses. Results Three lakh twenty-eight thousands two hundred and ninety patients with colorectal cancer were included of whom 77,287 were 80 years or older. With increasing age, a significant relative increase in right hemicolectomy was observed. In general, these patients had more comorbid conditions and higher frailty. In-hospital mortality following colorectal cancer surgery was 4.9\% but geriatric patients displayed a significantly higher postoperative in-hospital mortality of 10.6\%. The overall postoperative complication rate as well as failure to rescue increased with age. In contrast, surgical site infection (SSI) and anastomotic leakage (AL) did not increase in geriatric patients, whereas the associated mortality increased disproportionately (13.3\% for SSI and 29.9\% mortality for patients with AI, both p < 0.001). Logistic regression analysis adjusting for confounders showed that geriatric patients had almost five-times higher odds for death after surgery than the baseline age group below 60 (OR 4.86; 95\%CI [4.45-5.53], p < 0.001). Conclusion Geriatric patients have higher mortality after colorectal cancer surgery. This may be partly due to higher frailty and disproportionately higher rates of failure to rescue arising from postoperative complications.},
  language  = {en}
}
@phdthesis{Kegel2006,
  author    = {Kegel, Christian},
  title     = {Der Verschluss nach alloplastischer infragenualer Gef{\"a}ßrekonstruktion - Ursachen und Konsequenzen - Eine retrospektive Analyse 1993 - 2001},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-21228},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2006},
  abstract  = {Einleitung: In der Behandlung der peripheren arteriellen Verschlusskrankheit (pAVK) hat die Implantation von Kunststoffprothesen einen festen Stellenwert. Allerdings weisen diese, eine h{\"o}here Thrombogenit{\"a}t, Infekt- und damit auch Verschlussrate als die Eigenvene auf. Im Falle eines Bypassverschlusses ist die Extremit{\"a}t h{\"a}ufig gef{\"a}hrdet und es ergibt sich ein unmittelbarer Handlungsbedarf. Ziel der hier dargestellten Untersuchung war es, {\"u}ber einen bestimmten Zeitraum alle F{\"a}lle mit Bypassverschluss zu erfassen, um prognostische Kriterien und ein optimiertes Management dieser Patienten herauszuarbeiten. Material und Methoden: Anhand der MS-Access-Gef{\"a}ßdatenbank der Abteilung f{\"u}r vaskul{\"a}re und endovaskul{\"a}re Chirurgie der Universit{\"a}tsklinik W{\"u}rzburg wurden alle Patienten, die im Zeitraum vom 01.01.1993 bis zum 31.12.2001 wegen eines Bypass-Verschlusses nach kniegelenks-{\"u}berschreitender Rekonstruktion vorstellig wurden, erfasst und anhand der Aktenlage analysiert. Dabei wurden folgende Daten in die Untersuchung miteinbezogen: demographische Aspekte, kardiovaskul{\"a}re Risikofaktoren, Voroperationen, Medikation, Symptomatik und Indikation zur Erstoperation sowie zum Verschlusszeitpunkt, Umst{\"a}nde der Operation/Behandlung (Notfall, Operateur, Dauer, angewandtes Verfahren) und Verlaufsdaten (Komplikationen, Letalit{\"a}t, Offenheits- und Amputationsrate). Diese Daten wurden zun{\"a}chst in eine MS-Excel-Tabelle eingelesen und dann mit Hilfe der SPSS-Software ausgewertet. Hierzu wurde verwendet: Chi-Quadrat-Test (Fisher und Yates bzw. Mehta und Patel), U-Test nach Mann und Whitney (Rangsummentest), Rangvarianzanalyse nach Kruskal und Wallis, Rangkorrelation nach Kendall, {\"U}berlebensstatistik nach Kaplan und Meier sowie die daraus resultierende multivariate {\"U}berlebensstatistik nach dem „Proportional Hazards"-Modell von Cox verwendet. Ergebnisse: Im genannten Zeitraum wurden 202 Patienten an einem solchen Bypassverschluss behandelt. Aus statistischen Gr{\"u}nden wurde in den F{\"a}llen, in denen im Verlauf beide Beine betroffen waren, das zweite ausgeschlossen. Bei 78\% (n=157) dieser Patienten lag bei Erstimplantation eine chronisch-kritische Isch{\"a}mie vor (21\% AVK Stadium III, 51\% Stadium VI), was auch mit dem Vorliegen kardiovaskul{\"a}rer Risikofaktoren und Herzinsuffizienz korrelierte. Insgesamt waren bei 76 Patienten ein- bzw. durchflussverbessernde Maßnahmen der Arteria femoralis superficialis vor der Erstimplantation durchgef{\"u}hrt worden. Bei 75\% (n = 154) der Byp{\"a}sse waren die distalen Anastomosen im Bereich der A. poplitea III, A. tibialis anterior und des Truncus tibiofibularis erfolgt, wobei auch der Stenosierungsgrad der distalen Anschlussgef{\"a}ße mit dem AVK-Stadium korrelierte. Es zeigte sich, dass mehr als 79\% (n = 161) der Byp{\"a}sse innerhalb eines Jahres wieder verschlossen waren, 27,7 \% sofort (0-3 Tage), 52,0\% im Sinne eines Fr{\"u}h- (4-365 Tage) und 20,3\% im Sinne eines Sp{\"a}tverschlusses (> 1 Jahr). 30,2\% (n = 61) der Patienten mussten beim ersten Verschluss bereits major-amputiert werden, bei allen anderen wurden {\"u}berwiegend operative Revaskularisierungsmaßnahmen durchgef{\"u}hrt, davon erhielten 34 einen neuen Bypass. Dies wurde um so h{\"a}ufiger ausgef{\"u}hrt, je sp{\"a}ter der Verschluss auftrat. Die Offenheitsrate lag nach 1 Jahr bei 18,9\% und nach 3 Jahren bei 13,1\%, die Beinerhaltungsrate bei 58,4\% bzw. 55,9\%. Die multivariaten Analyse zeigte, dass eine Antikoagulation mit Marcumar, die Verwendung von Polyester (Dacron®) und die Erfahrung des Operateurs einen positiven Einfluss hatten. Dagegen verschlechterte sich die Prognose hinsichtlich Letalit{\"a}t, Offenheit und Beinerhalt bei Vorliegen einer Herz- und/oder Niereninsuffizienz signifikant. Aus den erhobenen Daten konnte ein Prognoseindex ermittelt werden: In Verbindung mit der Auspr{\"a}gung der Begleiterkrankungen und des Allgemeinzustandes des Patienten kann abgesch{\"a}tzt werden, ob eine weitere Bein-erhaltende Operation sinnvoll ist oder eine großz{\"u}gige Indikation zur Amputation gestellt werden sollte. Diskussion: Der Verschluss eines Kunststoffbypasses mit distaler Anastomose unterhalb des Kniegelenks geht mit einer sehr ung{\"u}nstigen Prognose einher. Anhand des hier vorgestellten Prognoseindex soll es dem Behandelnden erleichtert werden, eine Entscheidung zu treffen, inwiefern weiterf{\"u}hrende Maßnahmen indiziert sind, oder ob der Patient eher von einer Beinamputation profitiert. Eine Marcumarisierung nach erfolgreicher Behandlung eines solchen Verschlusses sollte generell empfohlen werden. Weiterhin ist zu diskutieren, ob nicht eine Optimierung der Ergebnisse (in geeigneten F{\"a}llen) mit der Durchf{\"u}hrung einer intra-arteriellen Lyse zur Demaskierung der zugrunde liegenden Ursache und anschließender gezielter Beseitigung dieser L{\"a}sion zu erreichen w{\"a}re. Um die Resultate generell zu verbessern, w{\"a}re sicher auch eine regelm{\"a}ßige Ultraschallkontrolle der Prothesen sinnvoll, um einen drohenden Verschluss („failing graft") durch eine rechtzeitige Intervention zu verhindern.},
  language  = {de}
}
@article{KunathKrauseWullichetal.2013,
  author    = {Kunath, Frank and Krause, Steffen F. and Wullich, Bernd and Goebell, Peter J. and Engehausen, Dirk G. and Burger, Maximilian and Meerpohl, Joerg J. and Keck, Bastian},
  title     = {Bladder cancer - the neglected tumor: a descriptive analysis of publications referenced in MEDLINE and data from the register clinicaltrials.gov},
  series = {BMC Urology},
  volume    = {13},
  journal   = {BMC Urology},
  number    = {56},
  doi       = {10.1186/1471-2490-13-56},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-122133},
  year      = {2013},
  abstract  = {Background: Uro-oncological neoplasms have both a high incidence and mortality rate and are therefore a major public health problem. The aim of this study was to evaluate research activity in uro-oncology over the last decade. Methods: We searched MEDLINE and ClinicalTrials.gov systematically for studies on prostatic, urinary bladder, kidney, and testicular neoplasms. The increase in newly published reports per year was analyzed using linear regression. The results are presented with 95\% confidence intervals, and a p value <0.05 was considered statistically significant. Results: The number of new publications per year increased significantly for prostatic, kidney and urinary bladder neoplasms (all <0.0001). We identified 1,885 randomized controlled trials (RCTs); also for RCTs, the number of newly published reports increased significantly for prostatic (p = 0.001) and kidney cancer (p = 0.005), but not for bladder (p = 0.09) or testicular (p = 0.44) neoplasms. We identified 3,114 registered uro-oncological studies in ClinicalTrials.gov. However, 85\% of these studies are focusing on prostatic (45\%) and kidney neoplasms (40\%), whereas only 11\% were registered for bladder cancers. Conclusions: While the number of publications on uro-oncologic research rises yearly for prostatic and kidney neoplasms, urothelial carcinomas of the bladder seem to be neglected despite their important clinical role. Clinical research on neoplasms of the urothelial bladder must be explicitly addressed and supported.},
  language  = {en}
}
@article{KaemmererTribiusCohrsetal.2023,
  author    = {K{\"a}mmerer, Peer W. and Tribius, Silke and Cohrs, Lena and Engler, Gabriel and Ettl, Tobias and Freier, Kolja and Frerich, Bernhard and Ghanaati, Shahram and Gosau, Martin and Haim, Dominik and Hartmann, Stefan and Heiland, Max and Herbst, Manuel and Hoefert, Sebastian and Hoffmann, J{\"u}rgen and H{\"o}lzle, Frank and Howaldt, Hans-Peter and Kreutzer, Kilian and Leonhardt, Henry and Lutz, Rainer and Moergel, Maximilian and Modabber, Ali and Neff, Andreas and Pietzka, Sebastian and Rau, Andrea and Reichert, Torsten E. and Smeets, Ralf and Sproll, Christoph and Steller, Daniel and Wiltfang, J{\"o}rg and Wolff, Klaus-Dietrich and Kronfeld, Kai and Al-Nawas, Bilal},
  title     = {Adjuvant radiotherapy in patients with squamous cell carcinoma of the oral cavity or oropharynx and solitary ipsilateral lymph node metastasis (pN1) — a prospective multicentric cohort study},
  series = {Cancers},
  volume    = {15},
  journal   = {Cancers},
  number    = {6},
  issn      = {2072-6694},
  doi       = {10.3390/cancers15061833},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-311024},
  year      = {2023},
  abstract  = {(1) Background: Evaluation of impact of adjuvant radiation therapy (RT) in patients with oral squamous cell carcinoma of the oral cavity/oropharynx (OSCC) of up to 4 cm (pT1/pT2) and solitary ipsilateral lymph node metastasis (pN1). A non-irradiated group with clinical follow-up was chosen for control, and survival and quality of life (QL) were compared; (2) Methods: This prospective multicentric comprehensive cohort study included patients with resected OSCC (pT1/pT2, pN1, and cM0) who were allocated into adjuvant radiation therapy (RT) or observation. The primary endpoint was overall survival. Secondary endpoints were progression-free survival and QL after surgery; (3) Results: Out of 27 centers, 209 patients were enrolled with a median follow-up of 3.4 years. An amount of 137 patients were in the observation arm, and 72 received adjuvant irradiation. Overall survival did not differ between groups (hazard ratio (HR) 0.98 [0.55-1.73], p = 0.94). There were fewer neck metastases (HR 0.34 [0.15-0.77]; p = 0.01), as well as fewer local recurrences (HR 0.41 [0.19-0.89]; p = 0.02) under adjuvant RT. For QL, irradiated patients showed higher values for the symptom scale pain after 0.5, two, and three years (all p < 0.05). After six months and three years, irradiated patients reported higher symptom burdens (impaired swallowing, speech, as well as teeth-related problems (all p < 0.05)). Patients in the RT group had significantly more problems with mouth opening after six months, one, and two years (p < 0.05); (4) Conclusions: Adjuvant RT in patients with early SCC of the oral cavity and oropharynx does not seem to influence overall survival, but it positively affects progression-free survival. However, irradiated patients report a significantly decreased QL up to three years after therapy compared to the observation group.},
  language  = {en}
}
@article{JakubietzMeffertSchmidtetal.2017,
  author    = {Jakubietz, Michael G. and Meffert, Rainer H. and Schmidt, Karsten and Gruenert, Joerg G. and Jakubietz, Rafael G.},
  title     = {Acute A4 Pulley Reconstruction with a First Extensor Compartment Onlay Graft},
  series = {Plastic and Reconstructive Surgery Global Open},
  volume    = {5},
  journal   = {Plastic and Reconstructive Surgery Global Open},
  number    = {6},
  doi       = {10.1097/GOX.0000000000001361},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-158057},
  pages     = {e1361},
  year      = {2017},
  abstract  = {Background: The integrity of the flexor tendon pulley apparatus is crucial for unimpaired function of the digits. Although secondary reconstruction is an established procedure in multi-pulley injuries, acute reconstruction of isolated, closed pulley ruptures is a rare occurrence. There are 3 factors influencing the functional outcome of a reconstruction: gapping distance between tendon and bone (E-space), bulkiness of the reconstruction, and stability. As direct repair is rarely done, grafts are used to reinforce the pulley. An advantage of the first extensor retinaculum graft is the synovial coating providing the possibility to be used both as a direct graft with synovial coating or as an onlay graft after removal of the synovia when the native synovial layer is present. Methods: A graft from the first dorsal extensor compartment is used as an onlay graft to reinforce the sutured A4 pulley. This technique allows reconstruction of the original dimensions of the pulley system while stability is ensured by anchoring the onlay graft to the bony insertions of the pulley. Results: Anatomical reconstruction can be achieved with this method. The measured E-space remained 0 mm throughout the recovery, while the graft incorporated as a slim reinforcement of the pulley, displaying no bulkiness. Conclusions: The ideal reconstruction should provide synovial coating and sufficient strength with minimal bulk. Early reconstruction using an onlay graft offers these options. The native synovial lining is preserved and the graft is used to reinforce the pulley.},
  language  = {en}
}
@article{JunGholamiSongetal.2014,
  author    = {Jun, Kyong-Hwa and Gholami, Spedideh and Song, Tae-Jin and Au, Joyce and Haddad, Dana and Carson, Joshua and Chen, Chun-Hao and Mojica, Kelly and Zanzonico, Pat and Chen, Nanhai G. and Zhang, Qian and Szalay, Aladar and Fong, Yuman},
  title     = {A novel oncolytic viral therapy and imaging technique for gastric cancer using a genetically engineered vaccinia virus carrying the human sodium iodide symporter},
  series = {Journal of Experimental \& Clinical Cancer Research},
  volume    = {33},
  journal   = {Journal of Experimental \& Clinical Cancer Research},
  number    = {2},
  issn      = {1756-9966},
  doi       = {10.1186/1756-9966-33-2},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-117716},
  year      = {2014},
  abstract  = {Background: Gastric cancers have poor overall survival despite recent advancements in early detection methods, endoscopic resection techniques, and chemotherapy treatments. Vaccinia viral therapy has had promising therapeutic potential for various cancers and has a great safety profile. We investigated the therapeutic efficacy of a novel genetically-engineered vaccinia virus carrying the human sodium iodide symporter (hNIS) gene, GLV-1 h153, on gastric cancers and its potential utility for imaging with Tc-99m pertechnetate scintigraphy and I-124 positron emission tomography (PET). Methods: GLV-1 h153 was tested against five human gastric cancer cell lines using cytotoxicity and standard viral plaque assays. In vivo, subcutaneous flank tumors were generated in nude mice with human gastric cancer cells, MKN-74. Tumors were subsequently injected with either GLV-1 h153 or PBS and followed for tumor growth. Tc-99m pertechnetate scintigraphy and I-124 microPET imaging were performed. Results: GFP expression, a surrogate for viral infectivity, confirmed viral infection by 24 hours. At a multiplicity of infection (MOI) of 1, GLV-1 h153 achieved > 90\% cytotoxicity in MNK-74, OCUM-2MD3, and AGS over 9 days, and >70\% cytotoxicity in MNK-45 and TMK-1. In vivo, GLV-1 h153 was effective in treating xenografts (p < 0.001) after 2 weeks of treatment. GLV-1 h153-infected tumors were readily imaged by Tc-99m pertechnetate scintigraphy and I-124 microPET imaging 2 days after treatment. Conclusions: GLV-1 h153 is an effective oncolytic virus expressing the hNIS protein that can efficiently regress gastric tumors and allow deep-tissue imaging. These data encourages its continued investigation in clinical settings.},
  language  = {en}
}