@article{StoerkBernhardtBoehmetal.2022,
  author    = {St{\"o}rk, Stefan and Bernhardt, Alexandra and B{\"o}hm, Michael and Brachmann, Johannes and Dagres, Nikolaos and Frantz, Stefan and Hindricks, Gerd and K{\"o}hler, Friedrich and Zeymer, Uwe and Rosenkranz, Stephan and Angermann, Christiane and Aßmus, Birgit},
  title     = {Pulmonary artery sensor system pressure monitoring to improve heart failure outcomes (PASSPORT-HF): rationale and design of the PASSPORT-HF multicenter randomized clinical trial},
  series = {Clinical Research in Cardiology},
  volume    = {111},
  journal   = {Clinical Research in Cardiology},
  number    = {11},
  doi       = {10.1007/s00392-022-01987-3},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-324026},
  pages     = {1245-1255},
  year      = {2022},
  abstract  = {Background Remote monitoring of patients with New York Heart Association (NYHA) functional class III heart failure (HF) using daily transmission of pulmonary artery (PA) pressure values has shown a reduction in HF-related hospitalizations and improved quality of life in patients. Objectives PASSPORT-HF is a prospective, randomized, open, multicenter trial evaluating the effects of a hemodynamic-guided, HF nurse-led care approach using the CardioMEMS™ HF-System on clinical end points. Methods and results The PASSPORT-HF trial has been commissioned by the German Federal Joint Committee (G-BA) to ascertain the efficacy of PA pressure-guided remote care in the German health-care system. PASSPORT-HF includes adult HF patients in NYHA functional class III, who experienced an HF-related hospitalization within the last 12 months. Patients with reduced ejection fraction must be on stable guideline-directed pharmacotherapy. Patients will be randomized centrally 1:1 to implantation of a CardioMEMS™ sensor or control. All patients will receive post-discharge support facilitated by trained HF nurses providing structured telephone-based care. The trial will enroll 554 patients at about 50 study sites. The primary end point is a composite of the number of unplanned HF-related rehospitalizations or all-cause death after 12 months of follow-up, and all events will be adjudicated centrally. Secondary end points include device/system-related complications, components of the primary end point, days alive and out of hospital, disease-specific and generic health-related quality of life including their sub-scales, and laboratory parameters of organ damage and disease progression. Conclusions PASSPORT-HF will define the efficacy of implementing hemodynamic monitoring as a novel disease management tool in routine outpatient care. Trial registration ClinicalTrials.gov; NCT04398654, 13-MAY-2020.},
  language  = {en}
}
@article{IbebuchiSchoenbeinPaeth2022,
  author    = {Ibebuchi, Chibuike Chiedozie and Sch{\"o}nbein, Daniel and Paeth, Heiko},
  title     = {On the added value of statistical post-processing of regional climate models to identify homogeneous patterns of summer rainfall anomalies in Germany},
  series = {Climate Dynamics},
  volume    = {59},
  journal   = {Climate Dynamics},
  number    = {9-10},
  issn      = {0930-7575},
  doi       = {10.1007/s00382-022-06258-5},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-324122},
  pages     = {2769-2783},
  year      = {2022},
  abstract  = {A fuzzy classification scheme that results in physically interpretable meteorological patterns associated with rainfall generation is applied to classify homogeneous regions of boreal summer rainfall anomalies in Germany. Four leading homogeneous regions are classified, representing the western, southeastern, eastern, and northern/northwestern parts of Germany with some overlap in the central parts of Germany. Variations of the sea level pressure gradient across Europe, e.g., between the continental and maritime regions, is the major phenomenon that triggers the time development of the rainfall regions by modulating wind patterns and moisture advection. Two regional climate models (REMO and CCLM4) were used to investigate the capability of climate models to reproduce the observed summer rainfall regions. Both regional climate models (RCMs) were once driven by the ERA-Interim reanalysis and once by the MPI-ESM general circulation model (GCM). Overall, the RCMs exhibit good performance in terms of the regionalization of summer rainfall in Germany; though the goodness-of-match with the rainfall regions/patterns from observational data is low in some cases and the REMO model driven by MPI-ESM fails to reproduce the western homogeneous rainfall region. Under future climate change, virtually the same leading modes of summer rainfall occur, suggesting that the basic synoptic processes associated with the regional patterns remain the same over Germany. We have also assessed the added value of bias-correcting the MPI-ESM driven RCMs using a simple linear scaling approach. The bias correction does not significantly alter the identification of homogeneous rainfall regions and, hence, does not improve their goodness-of-match compared to the observed patterns, except for the one case where the original RCM output completely fails to reproduce the observed pattern. While the linear scaling method improves the basic statistics of precipitation, it does not improve the simulated meteorological patterns represented by the precipitation regimes.},
  language  = {en}
}
@article{RaiZieglerAbeletal.2022,
  author    = {Rai, P. and Ziegler, K. and Abel, D. and Pollinger, F. and Paeth, H.},
  title     = {Performance of a regional climate model with interactive vegetation (REMO-iMOVE) over Central Asia},
  series = {Theoretical and Applied Climatology},
  volume    = {150},
  journal   = {Theoretical and Applied Climatology},
  number    = {3-4},
  issn      = {0177-798X},
  doi       = {10.1007/s00704-022-04233-y},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-324155},
  pages     = {1385-1405},
  year      = {2022},
  abstract  = {The current study evaluates the regional climate model REMO (v2015) and its new version REMO-iMOVE, including interactive vegetation and plant functional types (PFTs), over two Central Asian domains for the period of 2000-2015 at two different horizontal resolutions (0.44° and 0.11°). Various statistical metrices along with mean bias patterns for precipitation, temperature, and leaf area index have been used for the model evaluation. A better representation of the spatial pattern of precipitation is found at 0.11° resolution over most of Central Asia. Regarding the mean temperature, both model versions show a high level of agreement with the validation data, especially at the higher resolution. This also reduces the biases in maximum and minimum temperature. Generally, REMO-iMOVE shows an improvement regarding the temperature bias but produces a larger precipitation bias compared to the REMO conventional version with interannually static vegetation. Since the coupled version is capable to simulate the mean climate of Central Asia like its parent version, both can be used for impact studies and future projections. However, regarding the new vegetation scheme and its spatiotemporal representation exemplified by the leaf area index, REMO-iMOVE shows a clear advantage over REMO. This better simulation is caused by the implementation of more realistic and interactive vegetation and related atmospheric processes which consequently add value to the regional climate model.},
  language  = {en}
}
@article{HackenbergMeyerHaefneretal.2022,
  author    = {Hackenberg, Stephan and Meyer, Till Jasper and H{\"a}fner, Johannes and Scheich, Matthias and St{\"o}th, Manuel and Al-Tinawi, Fadi and Neun, Tilmann and Mlynski, Robert and Hagen, Rudolf and Scherzad, Agmal},
  title     = {Surgical management of tympanojugular paragangliomas using the flexible CO\(_2\) laser},
  series = {European Archives of Oto-Rhino-Laryngology},
  volume    = {279},
  journal   = {European Archives of Oto-Rhino-Laryngology},
  number    = {12},
  doi       = {10.1007/s00405-022-07416-5},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-324164},
  pages     = {5623-5630},
  year      = {2022},
  abstract  = {Purpose Surgery is a standard therapy for tympanojugular paragangliomas (TJP). Maintaining the quality of life (QoL) requires functional preservation. The flexible CO\(_2\) laser allows contact-free tumor removal. This retrospective study compares the postoperative functional outcomes of TJP surgery with and without the flexible CO\(_2\) laser. Methods Between 2005 and 2019, 51 patients with TJP were surgically treated at a tertiary hospital. Until 2012, 17 patients received conventional surgery. Thereafter, the flexible laser was used in 34 patients. Tumor extend, pre- and postoperative cranial nerve function, and complications were compared between the groups. Results The cohort consisted of 33 class A and B tumors and 18 class C and D tumors. Preoperative embolization was performed in 17 cases. Class C/D TJP were usually removed via an infratemporal fossa type A approach. Gross total tumor removal was achieved in 14/18 class C/D tumors. 3/51 patients suffered from long-term partial or complete facial palsy. No differences in post-therapeutic cranial nerve function or complications were noted between the conventional and laser group. One recurrence was observed after complete tumor resection. Conclusion The flexible CO\(_2\) laser was shown to be a safe and effective alternative to conventional bipolar cauterization, which is appreciated by the surgeon in these highly vascularized tumors. Both techniques allowed a high tumor control rate and good long-term results also from a functional point of view.},
  language  = {en}
}
@article{RiedmannSchaperLugrin2022,
  author    = {Riedmann, Anna and Schaper, Philipp and Lugrin, Birgit},
  title     = {Integration of a social robot and gamification in adult learning and effects on motivation, engagement and performance},
  series = {AI \& Society},
  journal   = {AI \& Society},
  issn      = {0951-5666},
  doi       = {10.1007/s00146-022-01514-y},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-324208},
  year      = {2022},
  abstract  = {Learning is a central component of human life and essential for personal development. Therefore, utilizing new technologies in the learning context and exploring their combined potential are considered essential to support self-directed learning in a digital age. A learning environment can be expanded by various technical and content-related aspects. Gamification in the form of elements from video games offers a potential concept to support the learning process. This can be supplemented by technology-supported learning. While the use of tablets is already widespread in the learning context, the integration of a social robot can provide new perspectives on the learning process. However, simply adding new technologies such as social robots or gamification to existing systems may not automatically result in a better learning environment. In the present study, game elements as well as a social robot were integrated separately and conjointly into a learning environment for basic Spanish skills, with a follow-up on retained knowledge. This allowed us to investigate the respective and combined effects of both expansions on motivation, engagement and learning effect. This approach should provide insights into the integration of both additions in an adult learning context. We found that the additions of game elements and the robot did not significantly improve learning, engagement or motivation. Based on these results and a literature review, we outline relevant factors for meaningful integration of gamification and social robots in learning environments in adult learning.},
  language  = {en}
}
@article{WeithmannLinkBanzragchetal.2022,
  author    = {Weithmann, Greta and Link, Roman M. and Banzragch, Bat-Enerel and W{\"u}rzberg, Laura and Leuschner, Christoph and Schuldt, Bernhard},
  title     = {Soil water availability and branch age explain variability in xylem safety of European beech in Central Europe},
  series = {Oecologia},
  volume    = {198},
  journal   = {Oecologia},
  number    = {3},
  doi       = {10.1007/s00442-022-05124-9},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-324228},
  pages     = {629-644},
  year      = {2022},
  abstract  = {Xylem embolism resistance has been identified as a key trait with a causal relation to drought-induced tree mortality, but not much is known about its intra-specific trait variability (ITV) in dependence on environmental variation. We measured xylem safety and efficiency in 300 European beech (Fagus sylvatica L.) trees across 30 sites in Central Europe, covering a precipitation reduction from 886 to 522 mm year-1. A broad range of variables that might affect embolism resistance in mature trees, including climatic and soil water availability, competition, and branch age, were examined. The average P50 value varied by up to 1 MPa between sites. Neither climatic aridity nor structural variables had a significant influence on P50. However, P50 was less negative for trees with a higher soil water storage capacity, and positively related to branch age, while specific conductivity (Ks) was not significantly associated with either of these variables. The greatest part of the ITV for xylem safety and efficiency was attributed to random variability within populations. We conclude that the influence of site water availability on P50 and Ks is low in European beech, and that the high degree of within-population variability for P50, partly due to variation in branch age, hampers the identification of a clear environmental signal.},
  subject      = {Bodenwasser},
  language  = {en}
}
@article{Yan2022,
  author    = {Yan, Zhe},
  title     = {"I tried to control my emotions": nursing home care workers' experiences of emotional labor in China},
  series = {Journal of Cross-Cultural Gerontology},
  volume    = {37},
  journal   = {Journal of Cross-Cultural Gerontology},
  number    = {1},
  doi       = {10.1007/s10823-022-09452-4},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-324295},
  pages     = {1-22},
  year      = {2022},
  abstract  = {Despite dramatic expansions in the Chinese nursing home sector in meeting the increasing care needs of a rapidly aging population, direct care work in China remains largely devalued and socially unrecognized. Consequently, scant attention has been given to the caregiving experiences of direct care workers (DCWs) in Chinese nursing homes. In particular, given the relational nature of care work, there is little knowledge as to how Chinese DCWs manage emotions and inner feelings through their emotional labor. This article examines the emotional labor of Chinese DCWs through ethnographic data collected with 20 DCWs in one nursing home located in an urban setting in central China. Data were analyzed using conventional content analysis and constant comparison. Participants' accounts of sustaining a caring self, preserving professional identity, and hoping for reciprocity revealed implicit meanings about the often-conflicting nature of emotional labor and the nonreciprocal elements of care work under constrained working conditions. Importantly, the moral-cultural notion of bao (报 norm of reciprocity) was found to be central among DCWs in navigating strained resources and suggested their agency in meaning-construction. However, their constructed moral buffers may be insufficient if emotional labor continues to be made invisible by care organizations.},
  subject      = {Gerontologie},
  language  = {en}
}
@article{KindermannPohlmannRother2022,
  author    = {Kindermann, Katharina and Pohlmann-Rother, Sanna},
  title     = {Unterricht mit digitalen Medien?! : Mit welchen {\"U}berzeugungen und motivationalen Orientierungen zum unterrichtlichen Einsatz von Tablets starten Studierende ins Lehramtsstudium?},
  series = {Zeitschrift f{\"u}r Grundschulforschung},
  volume    = {15},
  journal   = {Zeitschrift f{\"u}r Grundschulforschung},
  number    = {2},
  issn      = {1865-3553},
  doi       = {10.1007/s42278-022-00145-y},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-324679},
  pages     = {435-452},
  year      = {2022},
  abstract  = {Die medienp{\"a}dagogische Kompetenz angehender Lehrkr{\"a}fte f{\"u}r die Primarstufe ist bislang nur ansatzweise erforscht und erfordert spezifische Zug{\"a}nge. Die hier vorgestellte quantitative Studie gibt einen Einblick, mit welchen mediendidaktischen {\"U}berzeugungen und motivationalen Orientierungen als zentrale und handlungsrelevante Bereiche professioneller Kompetenz Studierende der Grundschuldidaktik (N = 344) ins Lehramtsstudium starten, wie diese Konstrukte miteinander in Verbindung stehen und welche Pr{\"a}diktoren daf{\"u}r identifiziert werden k{\"o}nnen. In der Befragung wird das Tablet als exemplarisches digitales Endger{\"a}t gew{\"a}hlt. Die Ergebnisse zeigen, dass sich die angehenden Lehrkr{\"a}fte als kompetent im Umgang mit dem Tablet einsch{\"a}tzen und dem Tableteinsatz in der Schule tendenziell positiv gegen{\"u}berstehen, wohingegen sie diesen im Kontext des Anfangsunterrichts kritisch sehen.},
  subject      = {Medienp{\"a}dagogik},
  language  = {de}
}
@article{Puppe2022,
  author    = {Puppe, Frank},
  title     = {Gesellschaftliche Perspektiven einer fachspezifischen KI f{\"u}r automatisierte Entscheidungen},
  series = {Informatik Spektrum},
  volume    = {45},
  journal   = {Informatik Spektrum},
  number    = {2},
  issn      = {0170-6012},
  doi       = {10.1007/s00287-022-01443-6},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-324197},
  pages     = {88-95},
  year      = {2022},
  abstract  = {Die k{\"u}nstliche Intelligenz (KI) entwickelt sich rasant und hat bereits eindrucksvolle Erfolge zu verzeichnen, darunter {\"u}bermenschliche Kompetenz in den meisten Spielen und vielen Quizshows, intelligente Suchmaschinen, individualisierte Werbung, Spracherkennung, -ausgabe und -{\"u}bersetzung auf sehr hohem Niveau und hervorragende Leistungen bei der Bildverarbeitung, u. a. in der Medizin, der optischen Zeichenerkennung, beim autonomen Fahren, aber auch beim Erkennen von Menschen auf Bildern und Videos oder bei Deep Fakes f{\"u}r Fotos und Videos. Es ist zu erwarten, dass die KI auch in der Entscheidungsfindung Menschen {\"u}bertreffen wird; ein alter Traum der Expertensysteme, der durch Lernverfahren, Big Data und Zugang zu dem gesammelten Wissen im Web in greifbare N{\"a}he r{\"u}ckt. Gegenstand dieses Beitrags sind aber weniger die technischen Entwicklungen, sondern m{\"o}gliche gesellschaftliche Auswirkungen einer spezialisierten, kompetenten KI f{\"u}r verschiedene Bereiche der autonomen, d. h. nicht nur unterst{\"u}tzenden Entscheidungsfindung: als Fußballschiedsrichter, in der Medizin, f{\"u}r richterliche Entscheidungen und sehr spekulativ auch im politischen Bereich. Dabei werden Vor- und Nachteile dieser Szenarien aus gesellschaftlicher Sicht diskutiert.},
  subject      = {K{\"u}nstliche Intelligenz},
  language  = {de}
}
@article{ReimerSeyfriedFlemmingetal.2022,
  author    = {Reimer, Stanislaus and Seyfried, Florian and Flemming, Sven and Brand, Markus and Weich, Alexander and Widder, Anna and Plaßmeier, Lars and Kraus, Peter and D{\"o}ring, Anna and Hering, Ilona and Hankir, Mohammed K. and Meining, Alexander and Germer, Christoph-Thomas and Lock, Johan F. and Groneberg, Kaja},
  title     = {Evolution of endoscopic vacuum therapy for upper gastrointestinal leakage over a 10-year period: a quality improvement study},
  series = {Surgical Endoscopy},
  volume    = {36},
  journal   = {Surgical Endoscopy},
  number    = {12},
  doi       = {10.1007/s00464-022-09400-w},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-323953},
  pages     = {9169-9178},
  year      = {2022},
  abstract  = {Background Endoscopic vacuum therapy (EVT) is an effective treatment option for leakage of the upper gastrointestinal (UGI) tract. The aim of this study was to evaluate the clinical impact of quality improvements in EVT management on patients' outcome. Methods All patients treated by EVT at our center during 2012-2021 were divided into two consecutive and equal-sized cohorts (period 1 vs. period 2). Over time several quality improvement strategies were implemented including the earlier diagnosis and EVT treatment and technical optimization of endoscopy. The primary endpoint was defined as the composite score MTL30 (mortality, transfer, length-of-stay > 30 days). Secondary endpoints included EVT efficacy, complications, in-hospital mortality, length-of-stay (LOS) and nutrition status at discharge. Results A total of 156 patients were analyzed. During the latter period the primary endpoint MTL30 decreased from 60.8 to 39.0\% (P = .006). EVT efficacy increased from 80 to 91\% (P = .049). Further, the need for additional procedures for leakage management decreased from 49.9 to 29.9\% (P = .013) and reoperations became less frequent (38.0\% vs.15.6\%; P = .001). The duration of leakage therapy and LOS were shortened from 25 to 14 days (P = .003) and 38 days to 25 days (P = .006), respectively. Morbidity (as determined by the comprehensive complication index) decreased from 54.6 to 46.5 (P = .034). More patients could be discharged on oral nutrition (70.9\% vs. 84.4\%, P = .043). Conclusions Our experience confirms the efficacy of EVT for the successful management of UGI leakage. Our quality improvement analysis demonstrates significant changes in EVT management resulting in accelerated recovery, fewer complications and improved functional outcome.},
  language  = {en}
}
@article{ReibetanzKelmUttingeretal.2022,
  author    = {Reibetanz, Joachim and Kelm, Matthias and Uttinger, Konstantin L. and Reuter, Miriam and Schlegel, Nicolas and Hankir, Mohamed and Wiegering, Verena and Germer, Christoph-Thomas and Fassnacht, Martin and Lock, Johan Friso and Wiegering, Armin},
  title     = {Differences in morbidity and mortality between unilateral adrenalectomy for adrenal Cushing's syndrome and bilateral adrenalectomy for therapy refractory extra-adrenal Cushing's syndrome},
  series = {Langenbeck's Archives of Surgery},
  volume    = {407},
  journal   = {Langenbeck's Archives of Surgery},
  number    = {6},
  doi       = {10.1007/s00423-022-02568-8},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-323947},
  pages     = {2481-2488},
  year      = {2022},
  abstract  = {Purpose In selected cases of severe Cushing's syndrome due to uncontrolled ACTH secretion, bilateral adrenalectomy appears unavoidable. Compared with unilateral adrenalectomy (for adrenal Cushing's syndrome), bilateral adrenalectomy has a perceived higher perioperative morbidity. The aim of the current study was to compare both interventions in endogenous Cushing's syndrome regarding postoperative outcomes. Methods We report a single-center, retrospective cohort study comparing patients with hypercortisolism undergoing bilateral vs. unilateral adrenalectomy during 2008-2021. Patients with adrenal Cushing's syndrome due to adenoma were compared with patients with ACTH-dependent Cushing's syndrome (Cushing's disease and ectopic ACTH production) focusing on postoperative morbidity and mortality as well as long-term survival. Results Of 83 patients with adrenalectomy for hypercortisolism (65.1\% female, median age 53 years), the indication for adrenalectomy was due to adrenal Cushing's syndrome in 60 patients (72.2\%; 59 unilateral and one bilateral), and due to hypercortisolism caused by Cushing's disease (n = 16) or non-pituitary uncontrolled ACTH secretion of unknown origin (n = 7) (27.7\% of all adrenalectomies). Compared with unilateral adrenalectomy (n = 59), patients with bilateral adrenalectomy (n = 24) had a higher rate of severe complications (0\% vs. 33\%; p < 0.001) and delayed recovery (median: 10.2\% vs. 79.2\%; p < 0.001). Using the MTL30 marker, patients with bilateral adrenalectomy fared worse than patients after unilateral surgery (MTL30 positive: 7.2\% vs. 25.0\% p < 0.001). Postoperative mortality was increased in patients with bilateral adrenalectomy (0\% vs. 8.3\%; p = 0.081). Conclusion While unilateral adrenalectomy for adrenal Cushing's syndrome represents a safe and definitive therapeutic option, bilateral adrenalectomy to control ACTH-dependent extra-adrenal Cushing's syndrome or Cushing's disease is a more complicated intervention with a mortality of nearly 10\%.},
  language  = {en}
}
@article{KoehlerReeseHendricksetal.2022,
  author    = {K{\"o}hler, Franziska and Reese, Lena and Hendricks, Anne and Kastner, Carolin and M{\"u}ller, Sophie and Lock, Johan F. and Germer, Christoph-Thomas and Wiegering, Armin},
  title     = {Low-grade mucinous neoplasms (LAMN) of the appendix in Germany between 2011 and 2018: a nationwide analysis based on data provided by the German Center for Cancer Registry Data (ZfKD) at the Robert Koch Institute (RKI)},
  series = {Langenbeck's Archives of Surgery},
  volume    = {407},
  journal   = {Langenbeck's Archives of Surgery},
  number    = {8},
  doi       = {10.1007/s00423-022-02639-w},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-323919},
  pages     = {3615-3622},
  year      = {2022},
  abstract  = {Introduction Low-grade appendiceal mucinous neoplasms (LAMN) are semi-malignant tumors of the appendix which are incidentally found in up to 1\% of appendectomy specimen. To this day, no valid descriptive analysis on LAMN is available for the German population. Methods Data of LAMN (ICD-10: D37.3) were collected from the population-based cancer registries in Germany, provided by the German Center for Cancer Registry Data (Zentrum f{\"u}r Krebsregisterdaten—ZfKD). Data was anonymized and included gender, age at diagnosis, tumor staging according to the TNM-classification, state of residence, information on the performed therapy, and survival data. Results A total of 612 cases were reported to the ZfKD between 2011 and 2018. A total of 63.07\% were female and 36.93\% were male. Great inhomogeneity in reporting cases was seen in the federal states of Germany including the fact that some federal states did not report any cases at all. Age distribution showed a mean age of 62.03 years (SD 16.15) at diagnosis. However, data on tumor stage was only available in 24.86\% of cases (n = 152). A total of 49.34\% of these patients presented with a T4-stage. Likewise, information regarding performed therapy was available in the minority of patients: 269 patients received surgery, 22 did not and for 312 cases no information was available. Twenty-four patients received chemotherapy, 188 did not, and for 400 cases, no information was available. Overall 5-year survival was estimated at 79.52\%. Patients below the age of 55 years at time of diagnosis had a significantly higher 5-year survival rate compared to patients above the age of 55 years (85.77\% vs. 73.27\%). Discussion In this study, we observed an incidence of LAMN in 0.13\% of all appendectomy specimen in 2018. It seems likely that not all cases were reported to the ZfKD; therefore, case numbers may be considered underestimated. Age and gender distribution goes in line with international studies with females being predominantly affected. Especially regarding tumor stage and therapy in depth information cannot be provided through the ZfKD-database. This data analysis emphasizes the need for further studies and the need for setting up a specialized registry for this unique tumor entity to develop guidelines for the appropriate treatment and follow-up.},
  language  = {en}
}
@article{DewulfDietzMontgomeryetal.2022,
  author    = {Dewulf, Maxime and Dietz, Ulrich A. and Montgomery, Agneta and Pauli, Eric M. and Marturano, Matthew N. and Ayuso, Sullivan A. and Augenstein, Vedra A. and Lambrecht, Jan R. and K{\"o}hler, Gernot and Keller, Nicola and Wiegering, Armin and Muysoms, Filip},
  title     = {Robotische Hernienchirurgie Teil IV : Roboterassistierte endoskopische parastomale Hernienversorgung. Videobericht und Ergebnisse},
  series = {Chirurgie},
  volume    = {93},
  journal   = {Chirurgie},
  number    = {11},
  doi       = {10.1007/s00104-022-01715-7},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-323882},
  pages     = {1051-1062},
  year      = {2022},
  abstract  = {Die chirurgische Behandlung parastomaler Hernien gilt als komplex und ist bekanntermaßen komplikationstr{\"a}chtig. In der Vergangenheit wurden diese Hernien durch die Relokation des Stomas oder Nahtverfahren der Austrittstelle versorgt. In den letzten Jahren wurden verschiedene netzbasierte Techniken vorgeschlagen, die heute in der minimal-invasiven Chirurgie eingesetzt werden. Mit der Verbreitung der roboterassistierten Hernienchirurgie wurden die Netzverfahren weiterentwickelt und die Ergebnisse f{\"u}r die Patienten erheblich verbessert. In diesem Beitrag wird ein {\"U}berblick {\"u}ber die verf{\"u}gbaren Techniken der roboterassistierten Versorgung parastomaler Hernien pr{\"a}sentiert. Es werden technische {\"U}berlegungen und erste Ergebnisse des roboterassistierten modifizierten Sugarbaker-Verfahrens, der roboterassistierten Pauli-Technik und der Verwendung des trichterf{\"o}rmigen Netzes IPST vorgestellt. Dar{\"u}ber hinaus werden die Herausforderungen bei der roboterassistierten Versorgung parastomaler Hernien am Ileum-Conduit diskutiert. Die Operationstechniken werden durch Foto- und Videomaterial veranschaulicht.},
  language  = {de}
}
@article{AngerLockKleinetal.2022,
  author    = {Anger, Friedrich and Lock, Johan Friso and Klein, Ingo and Hartlapp, Ingo and Wiegering, Armin and Germer, Christoph-Thomas and Kunzmann, Volker and L{\"o}b, Stefan},
  title     = {Does concurrent cholestasis alter the prognostic value of preoperatively elevated CA19-9 serum levels in patients with pancreatic head adenocarcinoma?},
  series = {Annals of Surgical Oncology},
  volume    = {29},
  journal   = {Annals of Surgical Oncology},
  number    = {13},
  doi       = {10.1245/s10434-022-12460-w},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-323854},
  pages     = {8523-8533},
  year      = {2022},
  abstract  = {Background Pancreatic adenocarcinoma (PDAC) patients with preoperative carbohydrate antigen 19-9 (CA19-9) serum levels higher than 500 U/ml are classified as biologically borderline resectable (BR-B). To date, the impact of cholestasis on preoperative CA19-9 serum levels in these patients has remained unquantified. Methods Data on 3079 oncologic pancreatic resections due to PDAC that were prospectively acquired by the German Study, Documentation and Quality (StuDoQ) registry were analyzed in relation to preoperative CA19-9 and bilirubin serum values. Preoperative CA19-9 values were adjusted according to the results of a multivariable linear regression analysis of pathologic parameters, bilirubin, and CA19-9 values. Results Of 1703 PDAC patients with tumor located in the pancreatic head, 420 (24.5 \%) presented with a preoperative CA19-9 level higher than 500 U/ml. Although receiver operating characteristics (ROC) analysis failed to determine exact CA19-9 cut-off values for prognostic indicators (R and N status), the T, N, and G status; the UICC stage; and the number of simultaneous vein resections increased with the level of preoperative CA19-9, independently of concurrent cholestasis. After adjustment of preoperative CA19-9 values, 18.5 \% of patients initially staged as BR-B showed CA19-9 values below 500 U/ml. However, the postoperative pathologic results for these patients did not change compared with the patients who had CA19-9 levels higher than 500 U/ml after bilirubin adjustment. Conclusions In this multicenter dataset of PDAC patients, elevation of preoperative CA19-9 correlated with well-defined prognostic pathologic parameters. Bilirubin adjustment of CA19-9 is feasible but does not affect the prognostic value of CA19-9 in jaundiced patients.},
  language  = {en}
}
@article{HermJanieschFuchs2022,
  author    = {Herm, Lukas-Valentin and Janiesch, Christian and Fuchs, Patrick},
  title     = {Der Einfluss von menschlichen Denkmustern auf k{\"u}nstliche Intelligenz - eine strukturierte Untersuchung von kognitiven Verzerrungen},
  series = {HMD Praxis der Wirtschaftsinformatik},
  volume    = {59},
  journal   = {HMD Praxis der Wirtschaftsinformatik},
  number    = {2},
  issn      = {1436-3011},
  doi       = {10.1365/s40702-022-00844-1},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-323787},
  pages     = {556-571},
  year      = {2022},
  abstract  = {K{\"u}nstliche Intelligenz (KI) dringt vermehrt in sensible Bereiche des allt{\"a}glichen menschlichen Lebens ein. Es werden nicht mehr nur noch einfache Entscheidungen durch intelligente Systeme getroffen, sondern zunehmend auch komplexe Entscheidungen. So entscheiden z. B. intelligente Systeme, ob Bewerber in ein Unternehmen eingestellt werden sollen oder nicht. Oftmals kann die zugrundeliegende Entscheidungsfindung nur schwer nachvollzogen werden und ungerechtfertigte Entscheidungen k{\"o}nnen dadurch unerkannt bleiben, weshalb die Implementierung einer solchen KI auch h{\"a}ufig als sogenannte Blackbox bezeichnet wird. Folglich steigt die Bedrohung, durch unfaire und diskriminierende Entscheidungen einer KI benachteiligt behandelt zu werden. Resultieren diese Verzerrungen aus menschlichen Handlungen und Denkmustern spricht man von einer kognitiven Verzerrung oder einem kognitiven Bias. Aufgrund der Neuigkeit dieser Thematik ist jedoch bisher nicht ersichtlich, welche verschiedenen kognitiven Bias innerhalb eines KI-Projektes auftreten k{\"o}nnen. Ziel dieses Beitrages ist es, anhand einer strukturierten Literaturanalyse, eine gesamtheitliche Darstellung zu erm{\"o}glichen. Die gewonnenen Erkenntnisse werden anhand des in der Praxis weit verbreiten Cross-Industry Standard Process for Data Mining (CRISP-DM) Modell aufgearbeitet und klassifiziert. Diese Betrachtung zeigt, dass der menschliche Einfluss auf eine KI in jeder Entwicklungsphase des Modells gegeben ist und es daher wichtig ist „mensch-{\"a}hnlichen" Bias in einer KI explizit zu untersuchen.},
  language  = {de}
}
@article{FreichelSteegmansWinkelmann2022,
  author    = {Freichel, Chiara and Steegmans, Timo-Christian and Winkelmann, Axel},
  title     = {Ziele und Gestaltung digitaler Plattformen f{\"u}r Produktionsnetzwerke},
  series = {HMD Praxis der Wirtschaftsinformatik},
  volume    = {59},
  journal   = {HMD Praxis der Wirtschaftsinformatik},
  number    = {5},
  issn      = {1436-3011},
  doi       = {10.1365/s40702-022-00908-2},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-323779},
  pages     = {1281-1311},
  year      = {2022},
  abstract  = {Die interorganisatorische Zusammenarbeit in Produktionsnetzwerken kann Herausforderungen durch eine hohe Marktdynamik, immer anspruchsvollere Kundenbed{\"u}rfnisse und steigenden Kostendruck entgegenwirken. Neben der klassischen vertikalen Verschiebung von Kapazit{\"a}ten in Richtung geeigneter Zulieferer, lassen sich Fertigungskapazit{\"a}ten auch durch eine horizontale Zusammenarbeit zwischen produzierenden Unternehmen handeln. Im Sinne der Sharing Economy bieten digitale Plattformen eine geeignete Infrastruktur zur Verkn{\"u}pfung und Koordination der Marktakteure eines Produktionsnetzwerks. So k{\"o}nnen Fertigungsunternehmen flexibel Produktionsausf{\"a}llen entgegenwirken und freie Maschinenkapazit{\"a}ten auslasten. Eine wesentliche Voraussetzung f{\"u}r den Erfolg solcher digitalen Plattformen f{\"u}r Produktionsnetzwerke ist die Definition von Zielen, welche bisher in der Literatur nur unzureichend und nicht bezogen auf diese spezifische Plattformart untersucht wurden. In dieser Arbeit wird ein umf{\"a}ngliches konzeptionelles Zielmodell f{\"u}r diese spezifische Plattformart erstellt. Zu spezifischen Zielen digitaler Plattformen f{\"u}r Produktionsnetzwerke z{\"a}hlen neben wirtschaftlichen oder technischen Zielen beispielsweise auch produktionsbezogene Marktleistungsziele wie die Gew{\"a}hrleistung von Produktionsflexibilit{\"a}t. Aufbauend darauf wird gezeigt, wie das Design der beschriebenen Plattformen einen Einfluss auf die Erreichung bestimmter Ziele hat und wie spezielle Mechanismen zur Zielerreichung beitragen.},
  language  = {de}
}
@article{KippnichKippnichErhardetal.2022,
  author    = {Kippnich, Maximilian and Kippnich, Uwe and Erhard, Harald and Meybohm, Patrick and Wurmb, Thomas},
  title     = {Weiterentwicklung im Katastrophenschutz: Ziel, Strategie und Taktik am Beispiel der Hochwasserkatastrophe 2021 im Ahrtal},
  series = {Notfall + Rettungsmedizin},
  journal   = {Notfall + Rettungsmedizin},
  issn      = {1434-6222},
  doi       = {10.1007/s10049-022-01089-7},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-346737},
  pages     = {1-10},
  year      = {2022},
  abstract  = {Hintergrund und Fragestellung Im Rahmen der {\"u}ber{\"o}rtlichen Katastrophenhilfe war die Medizinische Task Force 47 (Unterfranken) im Juli 2021 bei der Hochwasserkatastrophe in Rheinland-Pfalz (Ahrtal) im Einsatz. Mit dem Ziel, m{\"o}gliche Verbesserungen im Katastrophenschutz aus Sicht einer {\"u}berregionalen Einheit aus dem Einsatz ableiten zu k{\"o}nnen, wurde dieser wissenschaftlich evaluiert und die Erkenntnisse in einen {\"u}bergeordneten Kontext gesetzt. Material und Methoden Nach Definition eines konkreten Auswerteprozesses wurden durch ein interdisziplin{\"a}res Expertengremium Einsatzunterlagen und relevante Konzepte des Bayerischen Roten Kreuzes gesichtet. Auf dieser Basis wurden Strategien und Taktiken entwickelt, um die vordefinierten Ziele zu erreichen. Ergebnisse Die Leistungsf{\"a}higkeit der Einsatzeinheiten k{\"o}nnte durch moderne Einsatzmittel (E-Bike, Drohnen, hochgel{\"a}ndeg{\"a}ngige Fahrzeuge) gesteigert werden. Zur Erh{\"o}hung der Reaktionsf{\"a}higkeit k{\"o}nnten neue Schnell-Einsatz-Gruppen (SEG) erforderlich sein, die als Teil von BOS-{\"u}bergreifenden Erkundungseinheiten agieren und in unwegsamen Gel{\"a}nden autark Einsatzauftr{\"a}ge abarbeiten k{\"o}nnen (SEG Erkundung und SEG Gel{\"a}nde-Infrastruktur-Logistik-Transport). Die taktischen Einheiten k{\"o}nnten in die regionale und {\"u}berregionale Katastrophenhilfe eingebunden und synchronisiert werden. Diskussion F{\"u}r den weitestgehend ehrenamtlich organisierten Katastrophenschutz in Deutschland k{\"o}nnte es in Zukunft erschwert sein, die Vielzahl m{\"o}glicher modernster Einsatzmittel im hochkomplexen Umfeld einer Katastrophe sicher einsetzen zu k{\"o}nnen. Eine Teilprofessionalisierung durch hauptamtliche F{\"u}hrungs- und Einsatzkr{\"a}fte k{\"o}nnte eine L{\"o}sung hierf{\"u}r sein.},
  language  = {de}
}
@article{SchmittMeybohmNeefetal.2022,
  author    = {Schmitt, Elke and Meybohm, Patrick and Neef, Vanessa and Baumgarten, Peter and Bayer, Alexandra and Choorapoikayil, Suma and Friederich, Patrick and Friedrich, Jens and Geisen, Christof and G{\"u}resir, Erdem and Gr{\"u}newald, Matthias and Gutjahr, Martin and Helmer, Philipp and Herrmann, Eva and M{\"u}ller, Markus and Narita, Diana and Raadts, Ansgar and Schwendner, Klaus and Seifried, Erhard and Stark, Patrick and Steinbicker, Andrea U. and Thoma, Josef and Velten, Markus and Weigt, Henry and Wiesenack, Christoph and Wittmann, Maria and Zacharowski, Kai and Piekarski, Florian},
  title     = {Preoperative anaemia and red blood cell transfusion in patients with aneurysmal subarachnoid and intracerebral haemorrhage - a multicentre subanalysis of the German PBM Network Registry},
  series = {Acta Neurochirurgica},
  volume    = {164},
  journal   = {Acta Neurochirurgica},
  organization    = {German PBM Network Collaborators},
  doi       = {10.1007/s00701-022-05144-7},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-346754},
  pages     = {985-999},
  year      = {2022},
  abstract  = {Purpose Anaemia is common in patients presenting with aneurysmal subarachnoid (aSAH) and intracerebral haemorrhage (ICH). In surgical patients, anaemia was identified as an idenpendent risk factor for postoperative mortality, prolonged hospital length of stay (LOS) and increased risk of red blood cell (RBC) transfusion. This multicentre cohort observation study describes the incidence and effects of preoperative anaemia in this critical patient collective for a 10-year period. Methods This multicentre observational study included adult in-hospital surgical patients diagnosed with aSAH or ICH of 21 German hospitals (discharged from 1 January 2010 to 30 September 2020). Descriptive, univariate and multivariate analyses were performed to investigate the incidence and association of preoperative anaemia with RBC transfusion, in-hospital mortality and postoperative complications in patients with aSAH and ICH. Results A total of n = 9081 patients were analysed (aSAH n = 5008; ICH n = 4073). Preoperative anaemia was present at 28.3\% in aSAH and 40.9\% in ICH. RBC transfusion rates were 29.9\% in aSAH and 29.3\% in ICH. Multivariate analysis revealed that preoperative anaemia is associated with a higher risk for RBC transfusion (OR = 3.25 in aSAH, OR = 4.16 in ICH, p < 0.001), for in-hospital mortality (OR = 1.48 in aSAH, OR = 1.53 in ICH, p < 0.001) and for several postoperative complications. Conclusions Preoperative anaemia is associated with increased RBC transfusion rates, in-hospital mortality and postoperative complications in patients with aSAH and ICH.},
  language  = {en}
}
@article{KippnichSkazelKlingshirnetal.2022,
  author    = {Kippnich, Maximilian and Skazel, Tobias and Klingshirn, Hanna and Gerken, Laura and Heuschmann, Peter and Haas, Kirsten and Schutzmeier, Martha and Brandstetter, Lilly and Weismann, Dirk and Reuschenbach, Bernd and Meybohm, Patrick and Wurmb, Thomas},
  title     = {Analyse des Weaningprozesses bei Intensivpatienten im Hinblick auf Dokumentation und Verlegung in weiterbehandelnde Einheiten},
  series = {Medizinische Klinik, Intensivmedizin und Notfallmedizin},
  volume    = {118},
  journal   = {Medizinische Klinik, Intensivmedizin und Notfallmedizin},
  doi       = {10.1007/s00063-022-00941-5},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-346742},
  pages     = {269-276},
  year      = {2022},
  abstract  = {Hintergrund und Fragestellung Die Entw{\"o}hnung von Beatmungsger{\"a}ten wird nicht immer auf der prim{\"a}r behandelnden Intensivstation abgeschlossen. Die Weiterverlegung in andere Behandlungseinrichtungen stellt einen sensiblen Abschnitt in der Behandlung und Rehabilitation des Weaningpatienten dar. Ziel der vorliegenden Studie war die Untersuchung des {\"U}berleitungsmanagements und des Interhospitaltransfers von Weaningpatienten unter besonderer Ber{\"u}cksichtigung der Dokumentationsqualit{\"a}t. Methodik Es erfolge eine retrospektive Datenanalyse eines Jahrs (2018) auf 2 Intensivstationen eines Universit{\"a}tsklinikums. Eingeschlossen wurden alle beatmeten Patienten mit folgenden Tracerdiagnosen: COPD, Asthma, Polytrauma, Pneumonie, Sepsis, ARDS und Reanimation (Beatmung > 24 h). Ergebnisse Insgesamt konnten 750 Patienten in die Untersuchung eingeschlossen werden (Alter 64 [52, 8-76; Median, IQR]; 32 \% weiblich). Davon waren 48 (6,4 \%) Patienten zum Zeitpunkt der Verlegung nicht entw{\"o}hnt (v. a. Sepsis und ARDS). Die Routinedokumentation war bei den Abschnitten „Spontaneous Breathing Trial", „Bewertung der Entw{\"o}hungsbereitschaft" und „vermutete Entw{\"o}hnbarkeit" ausreichend, um die Erf{\"u}llung der Parameter der S2k-Leitlinie „Prolongiertes Weaning" ad{\"a}quat zu beurteilen. Vorwiegend wurden diese Patienten mit Tracheostoma (76 \%) in Rehabilitationskliniken (44 \%) mittels spezialisierten Rettungsmitteln des arztbegleiteten Patiententransports verlegt (75 \%). Diskussion Die Verlegung nicht entw{\"o}hnter Patienten nach initialem Intensivaufenthalt ist ein relevantes Thema f{\"u}r den Interhospitaltransfer. Die Routinedokumentation eines strukturierten Weaningprozesses ist in Kernelementen ausreichend, um den Weaningprozess l{\"u}ckenlos zu beschreiben. Dies ist f{\"u}r die Kontinuit{\"a}t in der Weiterbehandlung dieser Patienten von großer Bedeutung.},
  language  = {de}
}
@article{TeichmuellerBastRittneretal.2022,
  author    = {Teichm{\"u}ller, K. and Bast, L. and Rittner, H. L. and Kindl, G.},
  title     = {Chronische Schmerzen im Seniorenalter vor dem Hintergrund der COVID-19-Pandemie},
  series = {Der Schmerz},
  volume    = {36},
  journal   = {Der Schmerz},
  doi       = {10.1007/s00482-022-00663-9},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-346778},
  pages     = {429-436},
  year      = {2022},
  abstract  = {Hintergrund Internationale Studien belegen negative Auswirkungen der COVID-19-Pandemie auf Stimmung und Stresslevel befragter Personen. Auch konnten Zusammenh{\"a}nge zwischen der Pandemie und h{\"o}heren Schmerzst{\"a}rken sowie st{\"a}rkerer schmerzbedingter Beeintr{\"a}chtigung nachgewiesen werden. Die Studienlage dazu, ob {\"a}ltere Menschen besser oder schlechter mit der Pandemie und ihren Auswirkungen umgehen k{\"o}nnen als j{\"u}ngere Personen, ist aber uneindeutig. Methodik Seit einigen Jahren bietet das Universit{\"a}tsklinikum W{\"u}rzburg ein multimodales Schmerztherapieprogramm f{\"u}r SeniorInnen an. F{\"u}r die vorliegende Arbeit wurden retrospektiv klinische Routinedaten zum Zeitpunkt des interdisziplin{\"a}ren multimodalen Assessments von n = 75 TeilnehmerInnen in den Jahren 2018 und 2019 mit denen von n = 42 Patientinnen w{\"a}hrend der COVID-19-Pandemie 2020-2021 verglichen. Wir untersuchten Schmerz, psychische Belastung und k{\"o}rperliches Funktionsniveau mithilfe des Deutschen Schmerzfragebogens, klinischer Diagnostik und geriatrischer Funktionstests. Ergebnisse Die beiden Teilstichproben unterschieden sich nicht in demografischen Merkmalen. Bez{\"u}glich Schmerzintensit{\"a}t und Beeintr{\"a}chtigung sowie der psychischen Belastung fanden sich ebenfalls keine signifikanten Unterschiede. Lediglich die Anzahl der schmerzbedingt beeintr{\"a}chtigten Tage war vor Corona signifikant h{\"o}her. Die geriatrischen Funktionstests zeigten signifikant bessere Werte w{\"a}hrend der Pandemie an. Diskussion Die vorliegenden Daten zeigen keine Verschlechterung von Schmerz und k{\"o}rperlichem sowie psychischem Wohlbefinden bei SeniorInnen vor dem Hintergrund der Pandemie. Weitere Studien sollten die m{\"o}glichen Gr{\"u}nde daf{\"u}r untersuchen. Diese k{\"o}nnten in einer h{\"o}heren Resilienz der SeniorInnen basierend auf ihrer Lebenserfahrung, finanziellen Sicherheit oder einer geringeren Ver{\"a}nderung des Lebensalltags liegen.},
  language  = {de}
}
@article{SchorscherKippnichMeybohmetal.2022,
  author    = {Schorscher, Nora and Kippnich, Maximilian and Meybohm, Patrick and Wurmb, Thomas},
  title     = {Lessons learned from terror attacks: thematic priorities and development since 2001 - results from a systematic review},
  series = {European Journal of Trauma and Emergency Surgery},
  volume    = {48},
  journal   = {European Journal of Trauma and Emergency Surgery},
  issn      = {1863-9941},
  doi       = {10.1007/s00068-021-01858-y},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-264862},
  pages     = {2613-2638},
  year      = {2022},
  abstract  = {PURPOSE The threat of national and international terrorism remains high. Preparation is the key requirement for the resilience of hospitals and out-of-hospital rescue forces. The scientific evidence for defining medical and tactical strategies often feeds on the analysis of real incidents and the lessons learned derived from them. This systematic review of the literature aims to identify and systematically report lessons learned from terrorist attacks since 2001. METHODS PubMed was used as a database using predefined search strategies and eligibility criteria. All countries that are part of the Organization for Economic Cooperation and Development (OECD) were included. The time frame was set between 2001 and 2018. RESULTS Finally 68 articles were included in the review. From these, 616 lessons learned were extracted and summarized into 15 categories. The data shows that despite the difference in attacks, countries, and casualties involved, many of the lessons learned are similar. We also found that the pattern of lessons learned is repeated continuously over the time period studied. CONCLUSIONS The lessons from terrorist attacks since 2001 follow a certain pattern and remained constant over time. Therefore, it seems to be more accurate to talk about lessons identified rather than lessons learned. To save as many victims as possible, protect rescue forces from harm, and to prepare hospitals at the best possible level it is important to implement the lessons identified in training and preparation.},
  language  = {en}
}
@article{WienrichCarolusRothIsigkeitetal.2022,
  author    = {Wienrich, Carolin and Carolus, Astrid and Roth-Isigkeit, David and Hotho, Andreas},
  title     = {Inhibitors and enablers to explainable AI success: a systematic examination of explanation complexity and individual characteristics},
  series = {Multimodal Technologies and Interaction},
  volume    = {6},
  journal   = {Multimodal Technologies and Interaction},
  number    = {12},
  issn      = {2414-4088},
  doi       = {10.3390/mti6120106},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-297288},
  year      = {2022},
  abstract  = {With the increasing adaptability and complexity of advisory artificial intelligence (AI)-based agents, the topics of explainable AI and human-centered AI are moving close together. Variations in the explanation itself have been widely studied, with some contradictory results. These could be due to users' individual differences, which have rarely been systematically studied regarding their inhibiting or enabling effect on the fulfillment of explanation objectives (such as trust, understanding, or workload). This paper aims to shed light on the significance of human dimensions (gender, age, trust disposition, need for cognition, affinity for technology, self-efficacy, attitudes, and mind attribution) as well as their interplay with different explanation modes (no, simple, or complex explanation). Participants played the game Deal or No Deal while interacting with an AI-based agent. The agent gave advice to the participants on whether they should accept or reject the deals offered to them. As expected, giving an explanation had a positive influence on the explanation objectives. However, the users' individual characteristics particularly reinforced the fulfillment of the objectives. The strongest predictor of objective fulfillment was the degree of attribution of human characteristics. The more human characteristics were attributed, the more trust was placed in the agent, advice was more likely to be accepted and understood, and important needs were satisfied during the interaction. Thus, the current work contributes to a better understanding of the design of explanations of an AI-based agent system that takes into account individual characteristics and meets the demand for both explainable and human-centered agent systems.},
  language  = {en}
}
@article{KleinCoccoUereyenetal.2022,
  author    = {Klein, Igor and Cocco, Arturo and Uereyen, Soner and Mannu, Roberto and Floris, Ignazio and Oppelt, Natascha and Kuenzer, Claudia},
  title     = {Outbreak of Moroccan locust in Sardinia (Italy): a remote sensing perspective},
  series = {Remote Sensing},
  volume    = {14},
  journal   = {Remote Sensing},
  number    = {23},
  issn      = {2072-4292},
  doi       = {10.3390/rs14236050},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-297232},
  year      = {2022},
  abstract  = {The Moroccan locust has been considered one of the most dangerous agricultural pests in the Mediterranean region. The economic importance of its outbreaks diminished during the second half of the 20th century due to a high degree of agricultural industrialization and other human-caused transformations of its habitat. Nevertheless, in Sardinia (Italy) from 2019 on, a growing invasion of this locust species is ongoing, being the worst in over three decades. Locust swarms destroyed crops and pasture lands of approximately 60,000 ha in 2022. Drought, in combination with increasing uncultivated land, contributed to forming the perfect conditions for a Moroccan locust population upsurge. The specific aim of this paper is the quantification of land cover land use (LCLU) influence with regard to the recent locust outbreak in Sardinia using remote sensing data. In particular, the role of untilled, fallow, or abandoned land in the locust population upsurge is the focus of this case study. To address this objective, LCLU was derived from Sentinel-2A/B Multispectral Instrument (MSI) data between 2017 and 2021 using time-series composites and a random forest (RF) classification model. Coordinates of infested locations, altitude, and locust development stages were collected during field observation campaigns between March and July 2022 and used in this study to assess actual and previous land cover situation of these locations. Findings show that 43\% of detected locust locations were found on untilled, fallow, or uncultivated land and another 23\% within a radius of 100 m to such areas. Furthermore, oviposition and breeding sites are mostly found in sparse vegetation (97\%). This study demonstrates that up-to-date remote sensing data and target-oriented analyses can provide valuable information to contribute to early warning systems and decision support and thus to minimize the risk concerning this agricultural pest. This is of particular interest for all agricultural pests that are strictly related to changing human activities within transformed habitats.},
  language  = {en}
}
@article{GhasemiLatifiPourhashemi2022,
  author    = {Ghasemi, Marziye and Latifi, Hooman and Pourhashemi, Mehdi},
  title     = {A novel method for detecting and delineating coppice trees in UAV images to monitor tree decline},
  series = {Remote Sensing},
  volume    = {14},
  journal   = {Remote Sensing},
  number    = {23},
  issn      = {2072-4292},
  doi       = {10.3390/rs14235910},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-297258},
  year      = {2022},
  abstract  = {Monitoring tree decline in arid and semi-arid zones requires methods that can provide up-to-date and accurate information on the health status of the trees at single-tree and sample plot levels. Unmanned Aerial Vehicles (UAVs) are considered as cost-effective and efficient tools to study tree structure and health at small scale, on which detecting and delineating tree crowns is the first step to extracting varied subsequent information. However, one of the major challenges in broadleaved tree cover is still detecting and delineating tree crowns in images. The frequent dominance of coppice structure in degraded semi-arid vegetation exacerbates this problem. Here, we present a new method based on edge detection for delineating tree crowns based on the features of oak trees in semi-arid coppice structures. The decline severity in individual stands can be analyzed by extracting relevant information such as texture from the crown area. Although the method presented in this study is not fully automated, it returned high performances including an F-score = 0.91. Associating the texture indices calculated in the canopy area with the phenotypic decline index suggested higher correlations of the GLCM texture indices with tree decline at the tree level and hence a high potential to be used for subsequent remote-sensing-assisted tree decline studies.},
  language  = {en}
}
@article{AyalaCarrilloFarfanCardenasNielsenetal.2022,
  author    = {Ayala-Carrillo, Mariana and Farf{\´a}n, Michelle and C{\´a}rdenas-Nielsen, Anah{\´i} and Lemoine-Rodr{\´i}guez, Richard},
  title     = {Are wildfires in the wildland-urban interface increasing temperatures? A land surface temperature assessment in a semi-arid Mexican city},
  series = {Land},
  volume    = {11},
  journal   = {Land},
  number    = {12},
  issn      = {2073-445X},
  doi       = {10.3390/land11122105},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-297308},
  year      = {2022},
  abstract  = {High rates of land conversion due to urbanization are causing fragmented and dispersed spatial patterns in the wildland-urban interface (WUI) worldwide. The occurrence of anthropogenic fires in the WUI represents an important environmental and social issue, threatening not only vegetated areas but also periurban inhabitants, as is the case in many Latin American cities. However, research has not focused on the dynamics of the local climate in the WUI. This study analyzes whether wildfires contribute to the increase in land surface temperature (LST) in the WUI of the metropolitan area of the city of Guanajuato (MACG), a semi-arid Mexican city. We estimated the pre- and post-fire LST for 2018-2021. Spatial clusters of high LST were detected using hot spot analysis and examined using ANOVA and Tukey's post-hoc statistical tests to assess whether LST is related to the spatial distribution of wildfires during our study period. Our results indicate that the areas where the wildfires occurred, and their surroundings, show higher LST. This has negative implications for the local ecosystem and human population, which lacks adequate infrastructure and services to cope with the effects of rising temperatures. This is the first study assessing the increase in LST caused by wildfires in a WUI zone in Mexico.},
  language  = {en}
}
@article{LindhoffLastBirschmannBidenharnetal.2022,
  author    = {Lindhoff-Last, Edelgard and Birschmann, Ingvild and Bidenharn, Antonia J. and Kuhn, Joachim and Lindau, Simone and Konstantinides, Stavros and Grottke, Oliver and Nowak-G{\"o}ttl, Ulrike and Lucks, Jessica and Zydek, Barbara and Heymann, Christian von and S{\"u}mnig, Ariane and Beyer-Westendorf, Jan and Schellong, Sebastian and Meybohm, Patrick and Greinacher, Andreas and Herrmann, Eva},
  title     = {Pharmacokinetics of phenprocoumon in emergency situations - results of the prospective observational RADOA-registry (reversal agent use in patients treated with direct oral anticoagulants or vitamin K antagonists registry)},
  series = {Pharmaceuticals},
  volume    = {15},
  journal   = {Pharmaceuticals},
  number    = {11},
  issn      = {1424-8247},
  doi       = {10.3390/ph15111437},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-297226},
  year      = {2022},
  abstract  = {Background: Phenprocoumon has been used as an oral anticoagulant in patients with thromboembolic disease for more than 40 years. So far its pharmacokinetics have not been analyzed in emergency situations. Methods: Phenprocoumon-treated patients with major bleeding or urgent surgery were included in a prospective, observational registry. Phenprocoumon drug concentrations were analyzed in samples, collected as part of routine care using ultraperformance liquid chromatography tandem mass spectrometry. Moreover, anticoagulant intensity and drug half-life (t1/2) were calculated. Results: 115 patients were included. Phenprocoumon levels declined over time with a half-life of 5.27 and 5.29 days in patients with major bleedings (n = 82) and with urgent surgery (n = 33). Baseline phenprocoumon levels were 2.2 times higher in the bleeding group compared to the surgery group (1.92 vs. 0.87 ng/mL, p < 0.0001). International normalized ratio (INR) values decreased rapidly during the first 24 h. In 27.6\% of patients a rebound of INR (recurrent increase > 1.5) was observed which was associated with significantly increased bleeding rates (22\% vs. 4.2\% in patients with or without INR rebound, p = 0.012). Conclusions: In emergency situations, the long half-life of phenprocoumon may cause INR rebound and associated recurrent bleedings. Optimal management may need to include repeated vitamin K supplementation over days.},
  language  = {en}
}
@article{GernerAghaiTrommeschlaegerKrausetal.2022,
  author    = {Gerner, Bettina and Aghai-Trommeschlaeger, Fatemeh and Kraus, Sabrina and Grigoleit, G{\"o}tz Ulrich and Zimmermann, Sebastian and Kurlbaum, Max and Klinker, Hartwig and Isberner, Nora and Scherf-Clavel, Oliver},
  title     = {A physiologically-based pharmacokinetic model of ruxolitinib and posaconazole to predict CYP3A4-mediated drug-drug interaction frequently observed in graft versus host disease patients},
  series = {Pharmaceutics},
  volume    = {14},
  journal   = {Pharmaceutics},
  number    = {12},
  issn      = {1999-4923},
  doi       = {10.3390/pharmaceutics14122556},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-297261},
  year      = {2022},
  abstract  = {Ruxolitinib (RUX) is approved for the treatment of steroid-refractory acute and chronic graft versus host disease (GvHD). It is predominantly metabolized via cytochrome P450 (CYP) 3A4. As patients with GvHD have an increased risk of invasive fungal infections, RUX is frequently combined with posaconazole (POS), a strong CYP3A4 inhibitor. Knowledge of RUX exposure under concomitant POS treatment is scarce and recommendations on dose modifications are inconsistent. A physiologically based pharmacokinetic (PBPK) model was developed to investigate the drug-drug interaction (DDI) between POS and RUX. The predicted RUX exposure was compared to observed concentrations in patients with GvHD in the clinical routine. PBPK models for RUX and POS were independently set up using PK-Sim\(^®\) Version 11. Plasma concentration-time profiles were described successfully and all predicted area under the curve (AUC) values were within 2-fold of the observed values. The increase in RUX exposure was predicted with a DDI ratio of 1.21 (C\(_{max}\)) and 1.59 (AUC). Standard dosing in patients with GvHD led to higher RUX exposure than expected, suggesting further dose reduction if combined with POS. The developed model can serve as a starting point for further simulations of the implemented DDI and can be extended to further perpetrators of CYP-mediated PK-DDIs or disease-specific physiological changes.},
  language  = {en}
}
@article{SpangardtKesslerDobrzewskietal.2022,
  author    = {Spangardt, Christoph and Keßler, Christoph and Dobrzewski, Ramona and Tepler, Antonia and Hanio, Simon and Klaubert, Bernd and Meinel, Lorenz},
  title     = {Leveraging dissolution by autoinjector designs},
  series = {Pharmaceutics},
  volume    = {14},
  journal   = {Pharmaceutics},
  number    = {11},
  issn      = {1999-4923},
  doi       = {10.3390/pharmaceutics14112544},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-297271},
  year      = {2022},
  abstract  = {Chemical warfare or terrorism attacks with organophosphates may place intoxicated subjects under immediate life-threatening and psychologically demanding conditions. Antidotes, such as the oxime HI-6, which must be formulated as a powder for reconstitution reflecting the molecule's light sensitivity and instability in aqueous solutions, dramatically improve recovery—but only if used soon after exposure. Muscle tremors, anxiety, and loss of consciousness after exposure jeopardize proper administration, translating into demanding specifications for the dissolution of HI-6. Reflecting the patients' catastrophic situation and anticipated desire to react immediately to chemical weapon exposure, the dissolution should be completed within ten seconds. We are developing multi-dose and single-dose autoinjectors to reliably meet these dissolution requirements. The temporal and spatial course of dissolution within the various autoinjector designs was profiled colorimetrically. Based on these colorimetric insights with model dyes, we developed experimental setups integrating online conductometry to push experiments toward the relevant molecule, HI-6. The resulting blueprints for autoinjector designs integrated small-scale rotor systems, boosting dissolution across a wide range of viscosities, and meeting the required dissolution specifications driven by the use of these drug products in extreme situations.},
  language  = {en}
}
@article{KošćakPeharBožinovićetal.2022,
  author    = {Košćak, Marta and Pehar, Isabela and Božinović, Ksenija and Kole, Goutam Kumar and Sobočanec, Sandra and Podgorski, Iva I. and Pinterić, Marija and M{\"u}ller-Buschbaum, Klaus and Majhen, Dragomira and Piantanida, Ivo and Marder, Todd B.},
  title     = {Para-N-methylpyridinium pyrenes: impact of positive charge on ds-DNA/RNA and protein recognition, photo-induced bioactivity, and intracellular localisation},
  series = {Pharmaceutics},
  volume    = {14},
  journal   = {Pharmaceutics},
  number    = {11},
  issn      = {1999-4923},
  doi       = {10.3390/pharmaceutics14112499},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-297247},
  year      = {2022},
  abstract  = {The 2- and 2,7- substituted para-N-methylpyridinium pyrene cations show high-affinity intercalation into ds-DNAs, whereas their non-methylated analogues interacted with ds-DNA/RNA only in the protonated form (at pH 5), but not at physiological conditions (pH 7). The fluorescence from non-methylated analogues was strongly dependent on the protonation of the pyridines; consequently, they act as fluorescence ratiometric probes for simultaneous detection of both ds-DNA and BSA at pH 5, relying on the ratio between intensities at 420 nm (BSA specific) and 520 nm (DNA specific), whereby exclusively ds-DNA sensing could be switched-off by adjustment to pH 7. Only methylated, permanently charged pyrenes show photoinduced cleavage of circular DNA, attributed to pyrene-mediated irradiation-induced production of singlet oxygen. Consequently, the moderate toxicity of these cations against human cell lines is strongly increased upon irradiation. Detailed studies revealed increased total ROS production in cells treated by the compounds studied, accompanied by cell swelling and augmentation of cellular complexity. The most photo-active 2-para-N-methylpyridinium pyrene showed significant localization at mitochondria, its photo-bioactivity likely due to mitochondrial DNA damage. Other derivatives were mostly non-selectively distributed between various cytoplasmic organelles, thus being less photoactive.},
  language  = {en}
}
@article{HenrikssonCalderonMontanoSolvieetal.2022,
  author    = {Henriksson, Sofia and Calder{\´o}n-Monta{\~n}o, Jos{\´e} Manuel and Solvie, Daniel and Warpman Berglund, Ulrika and Helleday, Thomas},
  title     = {Overexpressed c-Myc sensitizes cells to TH1579, a mitotic arrest and oxidative DNA damage inducer},
  series = {Biomolecules},
  volume    = {12},
  journal   = {Biomolecules},
  number    = {12},
  issn      = {2218-273X},
  doi       = {10.3390/biom12121777},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-297547},
  year      = {2022},
  abstract  = {Previously, we reported that MTH1 inhibitors TH588 and TH1579 selectively induce oxidative damage and kill Ras-expressing or -transforming cancer cells, as compared to non-transforming immortalized or primary cells. While this explains the impressive anti-cancer properties of the compounds, the molecular mechanism remains elusive. Several oncogenes induce replication stress, resulting in under replicated DNA and replication continuing into mitosis, where TH588 and TH1579 treatment causes toxicity and incorporation of oxidative damage. Hence, we hypothesized that oncogene-induced replication stress explains the cancer selectivity. To test this, we overexpressed c-Myc in human epithelial kidney cells (HA1EB), resulting in increased proliferation, polyploidy and replication stress. TH588 and TH1579 selectively kill c-Myc overexpressing clones, enforcing the cancer cell selective killing of these compounds. Moreover, the toxicity of TH588 and TH1579 in c-Myc overexpressing cells is rescued by transcription, proteasome or CDK1 inhibitors, but not by nucleoside supplementation. We conclude that the molecular toxicological mechanisms of how TH588 and TH1579 kill c-Myc overexpressing cells have several components and involve MTH1-independent proteasomal degradation of c-Myc itself, c-Myc-driven transcription and CDK activation.},
  language  = {en}
}
@article{RohmerDobritzTuncbilekDereetal.2022,
  author    = {Rohmer, Carina and Dobritz, Ronja and Tuncbilek-Dere, Dilek and Lehmann, Esther and Gerlach, David and George, Shilpa Elizabeth and Bae, Taeok and Nieselt, Kay and Wolz, Christiane},
  title     = {Influence of Staphylococcus aureus strain background on Sa3int phage life cycle switches},
  series = {Viruses},
  volume    = {14},
  journal   = {Viruses},
  number    = {11},
  issn      = {1999-4915},
  doi       = {10.3390/v14112471},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-297209},
  year      = {2022},
  abstract  = {Staphylococcus aureus asymptomatically colonizes the nasal cavity of mammals, but it is also a leading cause of life-threatening infections. Most human nasal isolates carry Sa3 phages, which integrate into the bacterial hlb gene encoding a sphingomyelinase. The virulence factor-encoding genes carried by the Sa3-phages are highly human-specific, and most animal strains are Sa3 negative. Thus, both insertion and excision of the prophage could potentially confer a fitness advantage to S. aureus. Here, we analyzed the phage life cycle of two Sa3 phages, Φ13 and ΦN315, in different phage-cured S. aureus strains. Based on phage transfer experiments, strains could be classified into low (8325-4, SH1000, and USA300c) and high (MW2c and Newman-c) transfer strains. High-transfer strains promoted the replication of phages, whereas phage adsorption, integration, excision, or recA transcription was not significantly different between strains. RNASeq analyses of replication-deficient lysogens revealed no strain-specific differences in the CI/Mor regulatory switch. However, lytic genes were significantly upregulated in the high transfer strain MW2c Φ13 compared to strain 8325-4 Φ13. By transcriptional start site prediction, new promoter regions within the lytic modules were identified, which are likely targeted by specific host factors. Such host-phage interaction probably accounts for the strain-specific differences in phage replication and transfer frequency. Thus, the genetic makeup of the host strains may determine the rate of phage mobilization, a feature that might impact the speed at which certain strains can achieve host adaptation.},
  language  = {en}
}
@article{KneitzRoseGlutschetal.2022,
  author    = {Kneitz, Hermann and Rose, Christian and Glutsch, Valerie and Goebeler, Matthias},
  title     = {Recurrence of a cellular blue nevus with satellitosis — a diagnostic pitfall with clinical consequences},
  series = {Dermatopathology},
  volume    = {9},
  journal   = {Dermatopathology},
  number    = {4},
  issn      = {2296-3529},
  doi       = {10.3390/dermatopathology9040042},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-297436},
  pages     = {361 -- 367},
  year      = {2022},
  abstract  = {Blue nevus is a benign melanocytic lesion, typically asymptomatic and of unknown etiology. Several histologic and clinical variants have been distinguished, the most frequent being common blue nevus, cellular blue nevus, and combined blue nevus. Although melanocytic nevi with a satellite lesion are usually suggestive of locally advanced malignant melanoma, very few cases of blue nevi with satellite lesions have been reported. The diagnosis of common or cellular blue nevi is generally straightforward; however, the presence of structures such as irregular edges or satellitosis are highly suggestive for malignancy, and differential diagnoses such as locally advanced malignant melanoma and malignant blue nevus should be considered. Recurrent blue nevi can display atypical features not seen in the primary lesion, such as pleomorphism and mitotic activity. They usually tend to follow a benign course; however, in some cases, recurrence may indicate malignant transformation. We here report the unique case of a 64-year-old woman with a recurrent cellular blue nevus accompanied by satellite lesions. Such a biological behavior resulting in a clinical presentation as a melanoma-like lesion is a rarity in blue nevus and has not been described before.},
  language  = {en}
}
@article{SchmitterBoemickeBehnischetal.2022,
  author    = {Schmitter, Marc and B{\"o}micke, Wolfgang and Behnisch, Rouven and Lorenzo Bermejo, Justo and Waldecker, Moritz and Rammelsberg, Peter and Ohlmann, Brigitte},
  title     = {Ceramic crowns and sleep bruxism: first results from a randomized trial},
  series = {Journal of Clinical Medicine},
  volume    = {12},
  journal   = {Journal of Clinical Medicine},
  number    = {1},
  issn      = {2077-0383},
  doi       = {10.3390/jcm12010273},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-301480},
  year      = {2022},
  abstract  = {Background: This randomized clinical trial was conducted to assess whether sleep bruxism (SB) is associated with an increased rate of technical complications (ceramic defects) in lithium disilicate (LiDi) or zirconia (Z) molar single crowns (SCs). Methods: Adult patients were classified as affected or unaffected by SB based on structured questionnaires, clinical signs, and overnight portable electromyography (BruxOff) and block randomized into four groups according to SB status and crown material (LiDi or Z): LiDi-SB (n = 29), LiDi-no SB (n = 24), Z-SB (n = 23), and Z-no SB (n = 27). Differences in technical complications (main outcome) and survival and success rates (secondary outcomes) one year after crown cementation were assessed using Fisher's exact test with significance level α = 0.05. Results: No technical complications occurred. Restoration survival rates were 100\% in the LiDi-SB and LiDi-no SB groups, 95.7\% in the Z-SB group, and 96.3\% in the Z-no SB group (p > 0.999). Success rates were 96.6\% in the LiDi-SB group, 95.8\% in the LiDi-no SB group (p > 0.999), 91.3\% in the Z-SB group, and 96.3\% in the Z-no SB group (p ≥ 0.588). Conclusions: With a limited observation time and sample size, no effect of SB on technical complication, survival, and success rates of molar LiDi and Z SCs was detected.},
  language  = {en}
}
@article{FiedlerMuellenbachRolfesetal.2022,
  author    = {Fiedler, Mascha O. and Muellenbach, Ralf M. and Rolfes, Caroline and Lotz, Christopher and Nickel, Felix and M{\"u}ller-Stich, Beat P. and Supady, Alexander and Lepper, Philipp M. and Weigand, Markus A. and Meybohm, Patrick and Kalenka, Armin and Reyher, Christian},
  title     = {Pumpless extracorporeal hemadsorption technique (pEHAT): a proof-of-concept animal study},
  series = {Journal of Clinical Medicine},
  volume    = {11},
  journal   = {Journal of Clinical Medicine},
  number    = {22},
  issn      = {2077-0383},
  doi       = {10.3390/jcm11226815},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-297347},
  year      = {2022},
  abstract  = {Background: Extracorporeal hemadsorption eliminates proinflammatory mediators in critically ill patients with hyperinflammation. The use of a pumpless extracorporeal hemadsorption technique allows its early usage prior to organ failure and the need for an additional medical device. In our animal model, we investigated the feasibility of pumpless extracorporeal hemadsorption over a wide range of mean arterial pressures (MAP). Methods: An arteriovenous shunt between the femoral artery and femoral vein was established in eight pigs. The hemadsorption devices were inserted into the shunt circulation; four pigs received CytoSorb\(^®\) and four Oxiris\(^®\) hemadsorbers. Extracorporeal blood flow was measured in a range between mean arterial pressures of 45-85 mmHg. Mean arterial pressures were preset using intravenous infusions of noradrenaline, urapidil, or increased sedatives. Results: Extracorporeal blood flows remained well above the minimum flows recommended by the manufacturers throughout all MAP steps for both devices. Linear regression resulted in CytoSorb\(^®\) blood flow [mL/min] = 4.226 × MAP [mmHg] - 3.496 (R-square 0.8133) and Oxiris\(^®\) blood flow [mL/min] = 3.267 × MAP [mmHg] + 57.63 (R-square 0.8708), respectively. Conclusion: Arteriovenous pumpless extracorporeal hemadsorption resulted in sufficient blood flows through both the CytoSorb\(^®\) and Oxiris\(^®\) devices over a wide range of mean arterial blood pressures and is likely an intriguing therapeutic option in the early phase of septic shock or hyperinflammatory syndromes.},
  language  = {en}
}
@article{SeilerEbertRudertetal.2022,
  author    = {Seiler, Jonas and Ebert, Regina and Rudert, Maximilian and Herrmann, Marietta and Leich, Ellen and Weißenberger, Manuela and Horas, Konstantin},
  title     = {Bone metastases of diverse primary origin frequently express the VDR (vitamin D receptor) and CYP24A1},
  series = {Journal of Clinical Medicine},
  volume    = {11},
  journal   = {Journal of Clinical Medicine},
  number    = {21},
  issn      = {2077-0383},
  doi       = {10.3390/jcm11216537},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-297377},
  year      = {2022},
  abstract  = {Active vitamin D (1,25(OH)2D3) is known to exert direct anti-cancer actions on various malignant tissues through binding to the vitamin D receptor (VDR). These effects have been demonstrated in breast, prostate, renal and thyroid cancers, which all have a high propensity to metastasise to bone. In addition, there is evidence that vitamin D catabolism via 24-hydroxylase (CYP24A1) is altered in tumour cells, thus, reducing local active vitamin D levels in cancer cells. The aim of this study was to assess VDR and CYP24A1 expression in various types of bone metastases by using immunohistochemistry. Overall, a high total VDR protein expression was detected in 59\% of cases (39/66). There was a non-significant trend of high-grade tumours towards the low nuclear VDR expression (p = 0.07). Notably, patients with further distant metastases had a reduced nuclear VDR expression (p = 0.03). Furthermore, a high CYP24A1 expression was detected in 59\% (39/66) of bone metastases. There was a significant positive correlation between nuclear VDR and CYP24A1 expression (p = 0.001). Collectively, the VDR and CYP24A1 were widely expressed in a multitude of bone metastases, pointing to a potential role of vitamin D signalling in cancer progression. This is of high clinical relevance, as vitamin D deficiency is frequent in patients with bone metastases.},
  language  = {en}
}
@article{RackeveiBorgesEngstleretal.2022,
  author    = {Rackevei, Antonia S. and Borges, Alyssa and Engstler, Markus and Dandekar, Thomas and Wolf, Matthias},
  title     = {About the analysis of 18S rDNA sequence data from trypanosomes in barcoding and phylogenetics: tracing a continuation error occurring in the literature},
  series = {Biology},
  volume    = {11},
  journal   = {Biology},
  number    = {11},
  issn      = {2079-7737},
  doi       = {10.3390/biology11111612},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-297562},
  year      = {2022},
  abstract  = {The variable regions (V1-V9) of the 18S rDNA are routinely used in barcoding and phylogenetics. In handling these data for trypanosomes, we have noticed a misunderstanding that has apparently taken a life of its own in the literature over the years. In particular, in recent years, when studying the phylogenetic relationship of trypanosomes, the use of V7/V8 was systematically established. However, considering the current numbering system for all other organisms (including other Euglenozoa), V7/V8 was never used. In Maia da Silva et al. [Parasitology 2004, 129, 549-561], V7/V8 was promoted for the first time for trypanosome phylogenetics, and since then, more than 70 publications have replicated this nomenclature and even discussed the benefits of the use of this region in comparison to V4. However, the primers used to amplify the variable region of trypanosomes have actually amplified V4 (concerning the current 18S rDNA numbering system).},
  language  = {en}
}
@article{Gelleri2022,
  author    = {Gelleri, Christian},
  title     = {Creating monetary collaborative spaces for social and ecological transformation},
  series = {Sustainability},
  volume    = {14},
  journal   = {Sustainability},
  number    = {23},
  issn      = {2071-1050},
  doi       = {10.3390/su142315528},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-297191},
  year      = {2022},
  abstract  = {Complementary currencies have spread to many places around the world at the beginning of the 21st century. Creating sustainable economic cycles and short transport routes are often the goals of introducing them. Due to their manageability, regional currencies can be embedded in debates of regional economics and sustainability. Above all, they are suitable for democratic experiments that can show in real environments whether currency designs work as examples of collaborative communities and research. One of these monetary experiments is the climate bonus, which is linked to the local currency Chiemgauer. The research path goes into the daily routine of a real laboratory to find out which methods would be effective enough to deliver carbon savings. The climate bonus creates a monetary network where people can try out new behaviors in a protected space. As a result, three years after the initiation of the project, carbon reductions are above expectations.},
  language  = {en}
}
@article{AnsahAbuKleemannetal.2022,
  author    = {Ansah, Christabel Edena and Abu, Itohan-Osa and Kleemann, Janina and Mahmoud, Mahmoud Ibrahim and Thiel, Michael},
  title     = {Environmental contamination of a biodiversity hotspot — action needed for nature conservation in the Niger Delta, Nigeria},
  series = {Sustainability},
  volume    = {14},
  journal   = {Sustainability},
  number    = {21},
  issn      = {2071-1050},
  doi       = {10.3390/su142114256},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-297214},
  year      = {2022},
  abstract  = {The Niger Delta belongs to the largest swamp and mangrove forests in the world hosting many endemic and endangered species. Therefore, its conservation should be of highest priority. However, the Niger Delta is confronted with overexploitation, deforestation and pollution to a large extent. In particular, oil spills threaten the biodiversity, ecosystem services, and local people. Remote sensing can support the detection of spills and their potential impact when accessibility on site is difficult. We tested different vegetation indices to assess the impact of oil spills on the land cover as well as to detect accumulations (hotspots) of oil spills. We further identified which species, land cover types, and protected areas could be threatened in the Niger Delta due to oil spills. The results showed that the Enhanced Vegetation Index, the Normalized Difference Vegetation Index, and the Soil Adjusted Vegetation Index were more sensitive to the effects of oil spills on different vegetation cover than other tested vegetation indices. Forest cover was the most affected land-cover type and oil spills also occurred in protected areas. Threatened species are inhabiting the Niger Delta Swamp Forest and the Central African Mangroves that were mainly affected by oil spills and, therefore, strong conservation measures are needed even though security issues hamper the monitoring and control.},
  language  = {en}
}
@article{MelfsenJansRomanosetal.2022,
  author    = {Melfsen, Siebke and Jans, Thomas and Romanos, Marcel and Walitza, Susanne},
  title     = {Family relationships in selective mutism — a comparison group study of children and adolescents},
  series = {Children},
  volume    = {9},
  journal   = {Children},
  number    = {11},
  issn      = {2227-9067},
  doi       = {10.3390/children9111634},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-290386},
  year      = {2022},
  abstract  = {Selective mutism (SM) mostly develops early in childhood and this has led to interest into whether there could be differences in relationships in families with SM compared to a control group without SM. Currently, there are merely few empirical studies examining family relationships in SM. A sample of 28 children and adolescents with SM was compared to 33 controls without SM. The groups were investigated using self-report questionnaires (Selective Mutism Questionnaire, Child-Parent Relationship Test—Child Version) for the assessment of SM and family relationships. Children with SM did not report a significantly different relationship to their mothers compared with the control group without SM. However, the scores in respect to the relationship to their fathers were significantly lower in cohesion, identification and autonomy compared with children without SM. Relationships in families with SM should be considered more in therapy.},
  language  = {en}
}
@article{GriebschKernHansenetal.2022,
  author    = {Griebsch, Nora-Isabell and Kern, Johanna and Hansen, Jonas and Rullmann, Michael and Luthardt, Julia and Helfmeyer, Stephanie and Dekorsy, Franziska J. and Soeder, Marvin and Hankir, Mohammed K. and Zientek, Franziska and Becker, Georg-Alexander and Patt, Marianne and Meyer, Philipp M. and Dietrich, Arne and Bl{\"u}her, Matthias and Ding, Yu-Shin and Hilbert, Anja and Sabri, Osama and Hesse, Swen},
  title     = {Central serotonin/noradrenaline transporter availability and treatment success in patients with obesity},
  series = {Brain Sciences},
  volume    = {12},
  journal   = {Brain Sciences},
  number    = {11},
  issn      = {2076-3425},
  doi       = {10.3390/brainsci12111437},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-290294},
  year      = {2022},
  abstract  = {Serotonin (5-hydroxytryptamine, 5-HT) as well as noradrenaline (NA) are key modulators of various fundamental brain functions including the control of appetite. While manipulations that alter brain serotoninergic signaling clearly affect body weight, studies implicating 5-HT transporters and NA transporters (5-HTT and NAT, respectively) as a main drug treatment target for human obesity have not been conclusive. The aim of this positron emission tomography (PET) study was to investigate how these central transporters are associated with changes of body weight after 6 months of dietary intervention or Roux-en-Y gastric bypass (RYGB) surgery in order to assess whether 5-HTT as well as NAT availability can predict weight loss and consequently treatment success. The study population consisted of two study cohorts using either the 5-HTT-selective radiotracer [\(^{11}\)C]DASB to measure 5-HTT availability or the NAT-selective radiotracer [\(^{11}\)C]MRB to assess NAT availability. Each group included non-obesity healthy participants, patients with severe obesity (body mass index, BMI, >35 kg/m\(^2\)) following a conservative dietary program (diet) and patients undergoing RYGB surgery within a 6-month follow-up. Overall, changes in BMI were not associated with changes of both 5-HTT and NAT availability, while 5-HTT availability in the dorsal raphe nucleus (DRN) prior to intervention was associated with substantial BMI reduction after RYGB surgery and inversely related with modest BMI reduction after diet. Taken together, the data of our study indicate that 5-HTT and NAT are involved in the pathomechanism of obesity and have the potential to serve as predictors of treatment outcomes.},
  language  = {en}
}
@article{MertensAndriesKurzetal.2022,
  author    = {Mertens, Griet and Andries, Ellen and Kurz, Anja and Tȧvora-Vieira, Dayse and Calvino, Miryam and Amann, Edda and Anderson, Ilona and Lorens, Artur},
  title     = {Towards a consensus on an ICF-based classification system for horizontal sound-source localization},
  series = {Journal of Personalized Medicine},
  volume    = {12},
  journal   = {Journal of Personalized Medicine},
  number    = {12},
  issn      = {2075-4426},
  doi       = {10.3390/jpm12121971},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-297319},
  year      = {2022},
  abstract  = {The study aimed to develop a consensus classification system for the reporting of sound localization testing results, especially in the field of cochlear implantation. Against the background of an overview of the wide variations present in localization testing procedures and reporting metrics, a novel classification system was proposed to report localization errors according to the widely accepted International Classification of Functioning, Disability and Health (ICF) framework. The obtained HEARRING_LOC_ICF scale includes the ICF graded scale: 0 (no impairment), 1 (mild impairment), 2 (moderate impairment), 3 (severe impairment), and 4 (complete impairment). Improvement of comparability of localization results across institutes, localization testing setups, and listeners was demonstrated by applying the classification system retrospectively to data obtained from cohorts of normal-hearing and cochlear implant listeners at our institutes. The application of our classification system will help to facilitate multi-center studies, as well as allowing better meta-analyses of data, resulting in improved evidence-based practice in the field.},
  language  = {en}
}
@article{RakNedopilSayreetal.2022,
  author    = {Rak, Dominik and Nedopil, Alexander J. and Sayre, Eric C. and Masri, Bassam A. and Rudert, Maximilian},
  title     = {Postoperative inpatient rehabilitation does not increase knee function after primary total knee arthroplasty},
  series = {Journal of Personalized Medicine},
  volume    = {12},
  journal   = {Journal of Personalized Medicine},
  number    = {11},
  issn      = {2075-4426},
  doi       = {10.3390/jpm12111934},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-297322},
  year      = {2022},
  abstract  = {Inpatient rehabilitation (IR) is a common postoperative protocol after total knee replacement (TKA). Because IR is expensive and should therefore be justified, this study determined the difference in knee function one year after TKA in patients treated with IR or outpatient rehabilitation, fast-track rehabilitation (FTR) in particular, which also entails a reduced hospital length of stay. A total of 205 patients were included in this multi-center prospective cohort study. Of the patients, 104 had primary TKA at a German university hospital and received IR, while 101 had primary TKA at a Canadian university hospital and received FTR. Patients receiving IR or FTR were matched by pre-operative demographics and knee function. Oxford Knee Score (OKS), Western Ontario and McMaster Universities Arthritis Index (WOMAC), and EuroQol visual analogue scale (EQ-VAS) determined knee function one year after surgery. Patients receiving IR had a 2.8-point lower improvement in OKS (p = 0.001), a 6.7-point lower improvement in WOMAC (p = 0.063), and a 12.3-point higher improvement in EQ-VAS (p = 0.281) than patients receiving FTR. IR does not provide long-term benefits to patient recovery after primary uncomplicated TKA under the current rehabilitation regime.},
  language  = {en}
}
@article{SappeyMarinierHowellNedopiletal.2022,
  author    = {Sappey-Marinier, Elliot and Howell, Stephen M. and Nedopil, Alexander J. and Hull, Maury L.},
  title     = {The trochlear groove of a femoral component designed for kinematic alignment is lateral to the quadriceps line of force and better laterally covers the anterior femoral resection than a mechanical alignment design},
  series = {Journal of Personalized Medicine},
  volume    = {12},
  journal   = {Journal of Personalized Medicine},
  number    = {10},
  issn      = {2075-4426},
  doi       = {10.3390/jpm12101724},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-290482},
  year      = {2022},
  abstract  = {Background: A concern about kinematically aligned (KA) total knee arthroplasty (TKA) is that it relies on femoral components designed for mechanical alignment (MAd-FC) that could affect patellar tracking, in part, because of a trochlear groove orientation that is typically 6° from vertical. KA sets the femoral component coincident to the patient's pre-arthritic distal and posterior femoral joint lines and restores the Q-angle, which varies widely. Relative to KA and the native knee, aligning the femoral component with MA changes most distal joint lines and Q-angles, and rotates the posterior joint line externally laterally covering the anterior femoral resection. Whether switching from a MAd- to a KAd-FC with a wider trochlear groove orientation of 20.5° from vertical results in radiographic measures known to promote patellar tracking is unknown. The primary aim was to determine whether a KAd-FC sets the trochlear groove lateral to the quadriceps line of force (QLF), better laterally covers the anterior femoral resection, and reduces lateral patella tilt relative to a MAd-FC. The secondary objective was to determine at six weeks whether the KAd-FC resulted in a higher complication rate, less knee extension and flexion, and lower clinical outcomes. Methods: Between April 2019 and July 2022, two surgeons performed sequential bilateral unrestricted caliper-verified KA TKA with manual instruments on thirty-six patients with a KAd- and MAd-FC in opposite knees. An observer measured the angle between a line best-fit to the deepest valley of the trochlea and a line representing the QLF that indicated the patient's Q-angle. When the trochlear groove was lateral or medial relative to the QLF, the angle is denoted + or -, and the femoral component included or excluded the patient's Q-angle, respectively. Software measured the lateral undercoverage of the anterior femoral resection on a Computed Tomography (CT) scan, and the patella tilt angle (PTA) on a skyline radiograph. Complications, knee extension and flexion measurements, Oxford Knee Score, KOOS Jr, and Forgotten Joint Score were recorded pre- and post-operatively (at 6 weeks). A paired Student's T-test determined the difference between the KA TKAs with a KAd-FC and MAd-FC with a significance set at p < 0.05. Results: The final analysis included thirty-five patients. The 20.5° trochlear groove of the KAd-FC was lateral to the QLF in 100\% (15 ± 3°) of TKAs, which was greater than the 69\% (1 ± 3°) lateral to the QLF with the 6° trochlear groove of the MAd-FC (p < 0.001). The KAd-FC's 2 ± 1.9 mm lateral undercoverage of the anterior femoral resection was less than the 4.4 ± 1.5 mm for the MAd-FC (p < 0.001). The PTA, complication rate, knee extension and flexion, and clinical outcome measures did not differ between component designs. Conclusions: The KA TKA with a KAd-FC resulted in a trochlear groove lateral to the QLF that included the Q-angle in all patients, and negligible lateral undercoverage of the anterior femoral resection. These newly described radiographic parameters could be helpful when investigating femoral components designed for KA with the intent of promoting patellofemoral kinematics.},
  language  = {en}
}
@article{TaniniPecchiIgnat’evetal.2022,
  author    = {Tanini, Damiano and Pecchi, Tommaso and Ignat'ev, Nikolai V. and Capperucci, Antonella},
  title     = {Ionic liquids-assisted ring opening of three-membered heterocycles with thio- and seleno-silanes},
  series = {Catalysts},
  volume    = {12},
  journal   = {Catalysts},
  number    = {10},
  issn      = {2073-4344},
  doi       = {10.3390/catal12101259},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-290350},
  year      = {2022},
  abstract  = {Ring opening reactions of strained heterocycles (epoxides, aziridines, thiiranes) by silyl chalcogenides, such as thiosilanes and selenosilanes, can be efficiently performed in a variety of ionic liquids, which can behave as reaction media and in some cases also as catalysts. This protocol enables an alternative access to β-functionalized sulfides and selenides under mild conditions.},
  language  = {en}
}
@article{KistThomaschewskiKecketal.2022,
  author    = {Kist, Markus and Thomaschewski, Michael and Keck, Yannick and Abdalla, Thaer S. A. and Zeissig, Sylke Ruth and Kleihues-van Tol, Kees and Wellner, Ulrich Friedrich and Keck, Tobias and Hoeppner, Jens and Hummel, Richard},
  title     = {Specifics of young gastric cancer patients: a population-based analysis of 46,110 patients with gastric cancer from the German Clinical Cancer Registry Group},
  series = {Cancers},
  volume    = {14},
  journal   = {Cancers},
  number    = {23},
  issn      = {2072-6694},
  doi       = {10.3390/cancers14235927},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-297473},
  year      = {2022},
  abstract  = {Introduction: 2-8\% of all gastric cancer occurs at a younger age, also known as early-onset gastric cancer (EOGC). The aim of the present work was to use clinical registry data to classify and characterize the young cohort of patients with gastric cancer more precisely. Methods: German Cancer Registry Group of the Society of German Tumor Centers—Network for Care, Quality and Research in Oncology (ADT)was queried for patients with gastric cancer from 2000-2016. An approach that stratified relative distributions of histological subtypes of gastric adenocarcinoma according to age percentiles was used to define and characterize EOGC. Demographics, tumor characteristics, treatment and survival were analyzed. Results: A total of 46,110 patients were included. Comparison of different groups of age with incidences of histological subtypes showed that incidence of signet ring cell carcinoma (SRCC) increased with decreasing age and exceeded pooled incidences of diffuse and intestinal type tumors in the youngest 20\% of patients. We selected this group with median age of 53 as EOGC. The proportion of female patients was lower in EOGC than that of elderly patients (43\% versus 45\%; p < 0.001). EOGC presented more advanced and undifferentiated tumors with G3/4 stages in 77\% versus 62\%, T3/4 stages in 51\% versus 48\%, nodal positive tumors in 57\% versus 53\% and metastasis in 35\% versus 30\% (p < 0.001) and received less curative treatment (42\% versus 52\%; p < 0.001). Survival of EOGC was significantly better (five-years survival: 44\% versus 31\% (p < 0.0001), with age as independent predictor of better survival (HR 0.61; p < 0.0001). Conclusion: With this population-based registry study we were able to objectively define a cohort of patients referred to as EOGC. Despite more aggressive/advanced tumors and less curative treatment, survival was significantly better compared to elderly patients, and age was identified as an independent predictor for better survival.},
  language  = {en}
}
@article{PetersFrischStocketal.2022,
  author    = {Peters, Sarah and Frisch, Sabine and Stock, Annika and Merta, Julien and B{\"a}umer, Christian and Blase, Christoph and Schuermann, Eicke and Tippelt, Stephan and Bison, Brigitte and Fr{\"u}hwald, Michael and Rutkowski, Stefan and Fleischhack, Gudrun and Timmermann, Beate},
  title     = {Proton beam therapy for pediatric tumors of the central nervous system — experiences of clinical outcome and feasibility from the KiProReg study},
  series = {Cancers},
  volume    = {14},
  journal   = {Cancers},
  number    = {23},
  issn      = {2072-6694},
  doi       = {10.3390/cancers14235863},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-297489},
  year      = {2022},
  abstract  = {As radiotherapy is an important part of the treatment in a variety of pediatric tumors of the central nervous system (CNS), proton beam therapy (PBT) plays an evolving role due to its potential benefits attributable to the unique dose distribution, with the possibility to deliver high doses to the target volume while sparing surrounding tissue. Children receiving PBT for an intracranial tumor between August 2013 and October 2017 were enrolled in the prospective registry study KiProReg. Patient's clinical data including treatment, outcome, and follow-up were analyzed using descriptive statistics, Kaplan-Meier, and Cox regression analysis. Adverse events were scored according to the Common Terminology Criteria for Adverse Events (CTCAE) 4.0 before, during, and after PBT. Written reports of follow-up imaging were screened for newly emerged evidence of imaging changes, according to a list of predefined keywords for the first 14 months after PBT. Two hundred and ninety-four patients were enrolled in this study. The 3-year overall survival of the whole cohort was 82.7\%, 3-year progression-free survival was 67.3\%, and 3-year local control was 79.5\%. Seventeen patients developed grade 3 adverse events of the CNS during long-term follow-up (new adverse event n = 7; deterioration n = 10). Two patients developed vision loss (CTCAE 4°). This analysis demonstrates good general outcomes after PBT.},
  language  = {en}
}
@phdthesis{Muensterer2022,
  author    = {M{\"u}nsterer, Sascha Ottmar},
  title     = {Prognostische Wertigkeit der Herzfrequenz in Abh{\"a}ngigkeit von implantierten Devices bei akuter Herzinsuffizienz: Ergebnisse des prospektiven AHF-Registers W{\"u}rzburg},
  doi       = {10.25972/OPUS-33029},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-330293},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2022},
  abstract  = {Aims This study investigated, whether an activated R-mode, a surrogate of chronotropic incompetence in patients carrying a cardiovascular implantable electronic device (CIED), is associated with worse prognosis during and after an episode of acutely decompensated heart failure (AHF). Methods and Results Six hundred and twenty-three patients participating in an ongoing prospective cohort study that phenotypes and follows patients admitted for AHF were studied. We compared CIED carriers with R-mode stimulation (n=37) to CIED carriers not in R-mode (n=64) and patients without CIEDs (n=511). Mean heart rate on admission was significantly lower in R-mode patients vs. patients with CIED but without R-mode or patients withour CIED. In-hospital mortality was similar across groups, but age- and sex-adjusted 12-month mortality risk was higher in R-mode group. These effects persisted after multivariable adjustment for comorbidity burden. Conclusion In patients admitted for AHF, R-mode stimulation was associated with a significantly increased 12-month mortality risk. Our findings suggest that chronotropic incompetence per se mediates an adverse outcome and may not be adequately treated through accelerometer-based R-mode stimulation during and after an episode of AHF.},
  subject      = {Herzschrittmacher},
  language  = {de}
}
@article{BroschKorsaTabanetal.2022,
  author    = {Brosch, Philippa K. and Korsa, Tessa and Taban, Danush and Eiring, Patrick and Hildebrand, Sascha and Neubauer, Julia and Zimmermann, Heiko and Sauer, Markus and Shirakashi, Ryo and Djuzenova, Cholpon S. and Sisario, Dmitri and Sukhorukov, Vladimir L.},
  title     = {Glucose and inositol transporters, SLC5A1 and SLC5A3, in glioblastoma cell migration},
  series = {Cancers},
  volume    = {14},
  journal   = {Cancers},
  number    = {23},
  issn      = {2072-6694},
  doi       = {10.3390/cancers14235794},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-297498},
  year      = {2022},
  abstract  = {(1) Background: The recurrence of glioblastoma multiforme (GBM) is mainly due to invasion of the surrounding brain tissue, where organic solutes, including glucose and inositol, are abundant. Invasive cell migration has been linked to the aberrant expression of transmembrane solute-linked carriers (SLC). Here, we explore the role of glucose (SLC5A1) and inositol transporters (SLC5A3) in GBM cell migration. (2) Methods: Using immunofluorescence microscopy, we visualized the subcellular localization of SLC5A1 and SLC5A3 in two highly motile human GBM cell lines. We also employed wound-healing assays to examine the effect of SLC inhibition on GBM cell migration and examined the chemotactic potential of inositol. (3) Results: While GBM cell migration was significantly increased by extracellular inositol and glucose, it was strongly impaired by SLC transporter inhibition. In the GBM cell monolayers, both SLCs were exclusively detected in the migrating cells at the monolayer edge. In single GBM cells, both transporters were primarily localized at the leading edge of the lamellipodium. Interestingly, in GBM cells migrating via blebbing, SLC5A1 and SLC5A3 were predominantly detected in nascent and mature blebs, respectively. (4) Conclusion: We provide several lines of evidence for the involvement of SLC5A1 and SLC5A3 in GBM cell migration, thereby complementing the migration-associated transportome. Our findings suggest that SLC inhibition is a promising approach to GBM treatment.},
  language  = {en}
}
@article{HaistStegeLangetal.2022,
  author    = {Haist, Maximilian and Stege, Henner and Lang, Berenice Mareen and Tsochataridou, Aikaterini and Salzmann, Martin and Mohr, Peter and Schadendorf, Dirk and Ugurel, Selma and Placke, Jan-Malte and Weichenthal, Michael and Gutzmer, Ralf and Leiter, Ulrike and Kaatz, Martin and Haferkamp, Sebastian and Berking, Carola and Heppt, Markus and Tschechne, Barbara and Schummer, Patrick and Gebhardt, Christoffer and Grabbe, Stephan and Loquai, Carmen},
  title     = {Response to first-line treatment with immune-checkpoint inhibitors in patients with advanced cutaneous squamous cell carcinoma: a multicenter, retrospective analysis from the German ADOReg registry},
  series = {Cancers},
  volume    = {14},
  journal   = {Cancers},
  number    = {22},
  issn      = {2072-6694},
  doi       = {10.3390/cancers14225543},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-297506},
  year      = {2022},
  abstract  = {Cutaneous squamous cell carcinoma (cSCC) is a common malignancy of the skin and has an overall favorable outcome, except for patients with an advanced stage of the disease. The efficacy of checkpoint inhibitors (CPI) for advanced cSCC has been demonstrated in recent clinical studies, but data from real-world cohorts and trial-ineligible cSCC patients are limited. We retrospectively investigated patients with advanced cSCC who have been treated with CPI in a first-line setting at eight German skin cancer centers registered within the multicenter registry ADOReg. Clinical outcome parameters including response, progression-free (PFS) and overall survival (OS), time-to-next-treatment (TTNT), and toxicity were analyzed and have been stratified by the individual immune status. Among 39 evaluable patients, the tumor response rate (rwTRR) was 48.6\%, the median PFS was 29.0 months, and the median OS was not reached. In addition, 9 patients showed an impaired immune status due to immunosuppressive medication or hematological diseases. Our data demonstrated that CPI also evoked tumor responses among immunocompromised patients (rwTRR: 48.1 vs. 50.0\%), although these responses less often resulted in durable remissions. In line with this, the median PFS (11 vs. 40 months, p = 0.059), TTNT (12 months vs. NR, p = 0.016), and OS (29 months vs. NR, p < 0.001) were significantly shorter for this patient cohort. CPI therapy was well tolerated in both subcohorts with 15\% discontinuing therapy due to toxicity. Our real-world data show that first-line CPI therapy produced strong and durable responses among patients with advanced cSCC. Immunocompromised patients were less likely to achieve long-term benefit from anti-PD1 treatment, despite similar tumor response rates.},
  language  = {en}
}
@article{FroehlichSassenrathNadjiOhletal.2022,
  author    = {Fr{\"o}hlich, Ellen and Sassenrath, Claudia and Nadji-Ohl, Minou and Unteroberd{\"o}rster, Meike and R{\"u}ckriegel, Stefan and Brelie, Christian von der and Roder, Constantin and Forster, Marie-Therese and Schommer, Stephan and L{\"o}hr, Mario and Pala, Andrej and Goebel, Simone and Mielke, Dorothee and Gerlach, R{\"u}diger and Renovanz, Mirjam and Wirtz, Christian Rainer and Onken, Julia and Czabanka, Marcus and Tatagiba, Marcos Soares and Rohde, Veit and Ernestus, Ralf-Ingo and Vajkoczy, Peter and Gansland, Oliver and Coburger, Jan},
  title     = {Resilience in lower grade glioma patients},
  series = {Cancers},
  volume    = {14},
  journal   = {Cancers},
  number    = {21},
  issn      = {2072-6694},
  doi       = {10.3390/cancers14215410},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-297518},
  year      = {2022},
  abstract  = {Current data show that resilience is an important factor in cancer patients' well-being. We aim to explore the resilience of patients with lower grade glioma (LGG) and the potentially influencing factors. We performed a cross-sectional assessment of adult patients with LGG who were enrolled in the LoG-Glio registry. By phone interview, we administered the following measures: Resilience Scale (RS-13), distress thermometer, Montreal Cognitive Assessment Test for visually impaired patients (MoCA-Blind), internalized stigmatization by brain tumor (ISBI), Eastern Cooperative Oncological Group performance status (ECOG), patients' perspective questionnaire (PPQ) and typical clinical parameters. We calculated correlations and multivariate regression models. Of 74 patients who were assessed, 38\% of those showed a low level of resilience. Our results revealed significant correlations of resilience with distress (p < 0.001, -0.49), MOCA (p = 0.003, 0.342), ECOG (p < 0.001, -0.602), stigmatization (p < 0.001, -0.558), pain (p < 0.001, -0.524), and occupation (p = 0.007, 0.329). In multivariate analyses, resilience was negatively associated with elevated ECOG (p = 0.020, β = -0.383) and stigmatization levels (p = 0.008, β = -0.350). Occupation showed a tendency towards a significant association with resilience (p = 0.088, β = -0.254). Overall, low resilience affected more than one third of our cohort. Low functional status is a specific risk factor for low resilience. The relevant influence of stigmatization on resilience is a novel finding for patients suffering from a glioma and should be routinely identified and targeted in clinical routine.},
  language  = {en}
}