@article{PetritschKoestlerWengetal.2016,
  author    = {Petritsch, B. and K{\"o}stler, H. and Weng, A. M. and Horn, M. and Gassenmaier, T. and Kunz, A. S. and Weidemann, F. and Wanner, C. and Bley, T. A. and Beer, M.},
  title     = {Myocardial lipid content in Fabry disease: a combined \(^1\)H-MR spectroscopy and MR imaging study at 3 Tesla},
  series = {BMC Cardiovascular Disorders},
  volume    = {16},
  journal   = {BMC Cardiovascular Disorders},
  number    = {205},
  doi       = {10.1186/s12872-016-0382-4},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-146693},
  year      = {2016},
  abstract  = {Background Fabry disease is characterized by a progressive deposition of sphingolipids in different organ systems, whereby cardiac involvement leads to death. We hypothesize that lysosomal storage of sphingolipids in the heart as occurring in Fabry disease does not reflect in higher cardiac lipid concentrations detectable by \(^1\)H magnetic resonance spectroscopy (MRS) at 3 Tesla. Methods Myocardial lipid content was quantified in vivo by \(^1\)H-MRS in 30 patients (12 male, 18 female; 18 patients treated with enzyme replacement therapy) with genetically proven Fabry disease and in 30 healthy controls. The study protocol combined \(^1\)H-MRS with cardiac cine imaging and LGE MRI in a single examination. Results Myocardial lipid content was not significantly elevated in Fabry disease (p = 0.225). Left ventricular (LV) mass was significantly higher in patients suffering from Fabry disease compared to controls (p = 0.019). Comparison of patients without signs of myocardial fibrosis in MRI (LGE negative; n = 12) to patients with signs of fibrosis (LGE positive; n = 18) revealed similar myocardial lipid content in both groups (p > 0.05), while the latter showed a trend towards elevated LV mass (p = 0.076). Conclusions This study demonstrates the potential of lipid metabolic investigation embedded in a comprehensive examination of cardiac morphology and function in Fabry disease. There was no evidence that lysosomal storage of sphingolipids influences cardiac lipid content as measured by \(^1\)H-MRS. Finally, the authors share the opinion that a comprehensive cardiac examination including three subsections (LGE; \(^1\)H-MRS; T\(_1\) mapping), could hold the highest potential for the final assessment of early and late myocardial changes in Fabry disease.},
  language  = {en}
}
@article{SauerGoltzGassenmaieretal.2014,
  author    = {Sauer, Stephanie and Goltz, Jan P. and Gassenmaier, Tobias and Kunz, Andreas S. and Bley, Thorsten A. and Klein, Detlef and Petritsch, Bernhard},
  title     = {Partial Segmental Thrombosis of the Corpus Cavernosum (PSTCC) diagnosed by contrast-enhanced ultrasound: a case report},
  series = {BMC Urology},
  volume    = {14},
  journal   = {BMC Urology},
  number    = {100},
  doi       = {10.1186/1471-2490-14-100},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-126495},
  year      = {2014},
  abstract  = {Background Partial segmental thrombosis of the corpus cavernosum (PSTCC) is a rare disease predominantly occurring in young men. Cardinal symptoms are pain and perineal swelling. Although several risk factors are described in the literature, the exact etiology of penile thrombosis remains unclear in most cases. MRI or ultrasound (US) is usually used for diagnosing this condition. Case presentation We report a case of penile thrombosis after left-sided varicocele ligature in a young patient. The diagnosis was established using contrast-enhanced ultrasound (CEUS) and was confirmed by contrast-enhanced magnetic resonance imaging (ceMRI). Successful conservative treatment consisted of systemic anticoagulation using low molecular weight heparin and acetylsalicylic acid. Conclusion PSTCC is a rare condition in young men and appears with massive pain and perineal swelling. In case of suspected PSTCC utilization of CEUS may be of diagnostic benefit.},
  language  = {en}
}
@article{PetritschKoestlerGassenmaieretal.2016,
  author    = {Petritsch, Bernhard and K{\"o}stler, Herbert and Gassenmaier, Tobias and Kunz, Andreas S and Bley, Thorsten A and Horn, Michael},
  title     = {An investigation into potential gender-specific differences in myocardial triglyceride content assessed by \(^{1}\)H-Magnetic Resonance Spectroscopy at 3Tesla},
  series = {Journal of International Medical Research},
  volume    = {44},
  journal   = {Journal of International Medical Research},
  number    = {3},
  doi       = {10.1177/0300060515603884},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-168808},
  pages     = {585-591},
  year      = {2016},
  abstract  = {Objective: Over the past decade, myocardial triglyceride content has become an accepted biomarker for chronic metabolic and cardiac disease. The purpose of this study was to use proton (hydrogen 1)-magnetic resonance spectroscopy (\(^{1}\)H-MRS) at 3Tesla (3 T) field strength to assess potential gender-related differences in myocardial triglyceride content in healthy individuals. Methods: Cardiac MR imaging was performed to enable accurate voxel placement and obtain functional and morphological information. Double triggered (i.e., ECG and respiratory motion gating) \(^{1}\)H-MRS was used to quantify myocardial triglyceride levels for each gender. Two-sample t-test and Mann-Whitney U-test were used for statistical analyses. Results: In total, 40 healthy volunteers (22 male, 18 female; aged >18 years and age matched) were included in the study. Median myocardial triglyceride content was 0.28\% (interquartile range [IQR] 0.17-0.42\%) in male and 0.24\% (IQR 0.14-0.45\%) in female participants, and no statistically significant difference was observed between the genders. Furthermore, no gender-specific difference in ejection fraction was observed, although on average, male participants presented with a higher mean ± SD left ventricular mass (136.3 ± 25.2 g) than female participants (103.9 ± 16.1 g). Conclusions: The study showed that \(^{1}\)H-MRS is a capable, noninvasive tool for acquisition of myocardial triglyceride metabolites. Myocardial triglyceride concentration was shown to be unrelated to gender in this group of healthy volunteers.},
  language  = {en}
}