@article{BauerGoebelerWeissbrichetal.2015, author = {Bauer, Boris and Goebeler, Matthias and Weissbrich, Benedikt and Kerstan, Andreas}, title = {Kerinokeratosis papulosa of childhood}, series = {Dermatology}, volume = {231}, journal = {Dermatology}, number = {1}, issn = {1018-8665}, doi = {10.1159/000381539}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-198997}, pages = {1 -- 4}, year = {2015}, abstract = {Background: Kerinokeratosis papulosa (KP) is considered an extremely rare genodermatosis presenting usually as waxy papules on the trunk in childhood. Objective: To describe and analyze the clinical, histological and potential etiopathological aspects of KP. Methods: The dermatoscopic features of a new case of KP of childhood are investigated. The presence of human papillomavirus (HPV) DNA in lesional skin was studied by polymerase chain reaction. Furthermore, all cases of KP of childhood reported so far were reviewed. Results: As a diagnostic tool, we describe for the first time a dermatoscopic feature, namely a cribriform pattern of KP, in an 11-year-old boy. In addition, we detected HPV (type 57) in his KP lesions. Conclusions: Dermatoscopic examination might be a useful tool to distinguish KP from other skin lesions, e.g. common warts. The detection of HPV type 57 might hint to an etiological role of HPV for KP.}, language = {en} } @phdthesis{Bauer2011, author = {Bauer, Boris Alexander}, title = {Induktion von NF-κB durch Albumin in immortalisierten humanen proximalen Tubuluszellen (IHKE-1)}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-56996}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2011}, abstract = {Hintergurnd: Erh{\"o}hte glomerul{\"a}re Filtration von Proteinen im Rahmen chronoischer Nierenenerkrankungen geht mit tubulointerstitiellem Schaden einschließlich Entz{\"u}ndung und fortschreitendem Funktionsverlust der Nierenfunktion einher. Proteine wie Albumin scheinen dabei per se eine pathogenetische Rolle zu spielen. Der Transkriptionsfaktor nuclear factor kappa B (NF-kB) scheint an den durch Protein{\"u}berladung verursachten Pathomechanismen der Nierenentz{\"u}ndung beteiligt zu sein. Um die Albumin-induzierte Expression von NF-kB sowie die Expression des NF-kB-regulierten proinflammatorischen Zytokins Tumor Necrosis Faktor alpha (TNF-a) nach Exposition mit Albumin in humanen proximalen Tubuluszellen zu {\"u}berpr{\"u}fen, exponierten wir humane, von proximalen Tubuluszellen abstammende Zellen (IHKE-1) mit bovinem Serumalbumin (BSA: 50 und 500 microg/ml). Die NF-KB- und TNF-a-spezifische mRNA-Expression wurde durch RT-PCR bestimmt. NF-kB-spezifische Proteinexpression wurde mit Western-Blot-Verfahren analysiert. Ergebnisse: Albumin-induziert einen Anstieg der NF-kB-spezifischen mRNA-Expression und NF-kB-spezifischen Proteinexpression. Diese Effekte werden durch den Protein Kinase C-Inhibitor Bisindolylmaleimid und den Tyrosin Kinase Inhibitor Herbimycin A gehemmt. Ein Albumin.induzierter Anstieg der TNF-a-spezifischen mRNA-Expression als biologischer inflammatorischer Parameter war als mit der NF-B-Aktivit{\"a}t assoziiert messbar.}, subject = {Nierenfunktion}, language = {de} } @article{SchaeferBauerDonhauseretal.2017, author = {Sch{\"a}fer, Kristina and Bauer, Boris and Donhauser, Julian and Kerstan, Andreas and Hamm, Henning}, title = {Becker Naevus Syndrome of the Lower Body: A New Case and Review of the Literature}, series = {Acta Dermato-Venereologica}, volume = {97}, journal = {Acta Dermato-Venereologica}, number = {4}, doi = {10.2340/00015555-2589}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-171057}, pages = {499-504}, year = {2017}, abstract = {Becker naevus syndrome is a rare epidermal naevus syndrome defined by the co-occurrence of a Becker naevus with various cutaneous, muscular and skeletal anomalies. In the majority of cases, abnormalities exclusively consist of ipsilateral hypoplasia of the breast, areola and/or nipple in addition to the naevus. Here, we report on a 42-year-old woman with an extensive Becker naevus reaching from the left buttock to the left calf verified on histological examination. In addition, there was marked hypoplasia of the fatty tissue of the left thigh confirmed by magnetic resonance imaging in contrast to hyperplasia of the fatty tissue of the left gluteal area. Underlying muscles and bones were not affected. There was no difference in leg lengths. In addition, we review and discuss the features of Becker naevus syndrome with emphasis on 10 reported cases with involvement of the lower body.}, language = {en} }