@article{KorhonenParkkinenHackeretal.1986, author = {Korhonen, T. K. and Parkkinen, J. and Hacker, J{\"o}rg and Finne, J. and Pere, A. and Rhen, M. and Holth{\"o}fer, H}, title = {Binding of Escherichia coli S fimbriae to human kidney epithelium}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-59415}, year = {1986}, abstract = {Purified S fimbriae and an Escherichia coli strain carrying the recombinant plasmid pANN801-4 that encodes S fimbriae were tested for adhesion to frozen sections of human kidney. The fimbrlae and the bacteria bound to the same tissue domains, and in both cases the binding was specifically inhibited by the receptor analog of S fimbria, sialyl(a2-3)1actose. S fimbriae bound specifically to the epithelial elements in the kidneys; to the epithelial cells of proximal and distal tubules as weil as of the collecting ducts and to the visceral and parietal glomerular epithelium. In addition, they bound to the vascular endothelium of glomerull and of the renal Interstitium. No blnding to connective tissue elements was observed. The results suggest that the biological functlon of S fimbriae is to mediate the adheslon of E. coli to human epithelial and vascular endothellal ceUs.}, subject = {Infektionsbiologie}, language = {en} } @article{PippiasStelDiezetal.2015, author = {Pippias, Maria and Stel, Vianda S. and Diez, Jos{\´e} Maria Abad and Afentakis, Nikolaos and Herrero-Calvo, Jose Antonio and Arias, Manuel and Tomilina, Natalia and Caama{\~n}o, Encarnaci{\´o}n Bouzas and Buturovic-Ponikvar, Jadranka and Čala, Svjetlana and Caskey, Fergus J. and de la Nuez, Pablo Castro and Cernevskis, Harijs and Collart, Frederic and de la Torre, Ram{\´o}n Alonso and de los {\´A}ngeles Garc{\´i}a Bazaga, Maria and De Meester, Johan and D{\´i}az, Joan Manuel and Djukanovic, Ljubica and Alamar, Manuel Ferrer and Finne, Patrik and Garneata, Liliana and Golan, Eliezer and Gonz{\´a}lez Fern{\´a}ndez, Raquel and Guti{\´e}rrez Avila, Gonzalo and Heaf, James and Hoitsma, Andries and Kantaria, Nino and Kolesnyk, Mykola and Kramar, Reinhard and Kramer, Anneke and Lassalle, Mathilde and Leivestad, Torbj{\o}rn and Lopot, Frantisek and Mac{\´a}rio, Fernando and Magaz, Angela and Mart{\´i}n-Escobar, Eduardo and Metcalfe, Wendy and Noordzij, Marlies and Palsson, Runolfur and Pechter, {\"U}lle and Pr{\"u}tz, Karl G. and Ratkovic, Marina and Resić, Halima and Rutkowski, Boleslaw and de Pablos, Carmen Santiuste and Spustov{\´a}, Viera and S{\"u}leymanlar, G{\"u}ltekin and Van Stralen, Karlijn and Thereska, Nestor and Wanner, Christoph and Jager, Kitty J.}, title = {Renal replacement therapy in Europe: a summary of the 2012 ERA-EDTA Registry Annual Report}, series = {Clinical Kidney Journal}, volume = {8}, journal = {Clinical Kidney Journal}, number = {3}, doi = {10.1093/ckj/sfv014}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-150054}, pages = {248-261}, year = {2015}, abstract = {Background This article summarizes the 2012 European Renal Association—European Dialysis and Transplant Association Registry Annual Report (available at www.era-edta-reg.org) with a specific focus on older patients (defined as ≥65 years). Methods Data provided by 45 national or regional renal registries in 30 countries in Europe and bordering the Mediterranean Sea were used. Individual patient level data were received from 31 renal registries, whereas 14 renal registries contributed data in an aggregated form. The incidence, prevalence and survival probabilities of patients with end-stage renal disease (ESRD) receiving renal replacement therapy (RRT) and renal transplantation rates for 2012 are presented. Results In 2012, the overall unadjusted incidence rate of patients with ESRD receiving RRT was 109.6 per million population (pmp) (n = 69 035), ranging from 219.9 pmp in Portugal to 24.2 pmp in Montenegro. The proportion of incident patients ≥75 years varied from 15 to 44\% between countries. The overall unadjusted prevalence on 31 December 2012 was 716.7 pmp (n = 451 270), ranging from 1670.2 pmp in Portugal to 146.7 pmp in the Ukraine. The proportion of prevalent patients ≥75 years varied from 11 to 32\% between countries. The overall renal transplantation rate in 2012 was 28.3 pmp (n = 15 673), with the highest rate seen in the Spanish region of Catalonia. The proportion of patients ≥65 years receiving a transplant ranged from 0 to 35\%. Five-year adjusted survival for all RRT patients was 59.7\% (95\% confidence interval, CI: 59.3-60.0) which fell to 39.3\% (95\% CI: 38.7-39.9) in patients 65-74 years and 21.3\% (95\% CI: 20.8-21.9) in patients ≥75 years.}, language = {en} }