@article{StraubFreudenbergSchleicheretal.2018,
  author    = {Straub, Tobias and Freudenberg, Marina A. and Schleicher, Ulrike and Bogdan, Christian and Gasteiger, Georg and Pircher, Hanspeter},
  title     = {Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells},
  series = {Nature Communications},
  volume    = {9},
  journal   = {Nature Communications},
  doi       = {10.1038/s41467-018-06609-z},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-240075},
  year      = {2018},
  abstract  = {Infection of specific pathogen-free mice with lymphocytic choriomeningitis virus (LCMV) is a widely used model to study antiviral T-cell immunity. Infections in the real world, however, are often accompanied by coinfections with unrelated pathogens. Here we show that in mice, systemic coinfection with E. coli suppresses the LCMV-specific cytotoxic T-lymphocyte (CTL) response and virus elimination in a NK cell- and TLR2/4-dependent manner. Soluble TLR4 ligand LPS also induces NK cell-mediated negative CTL regulation during LCMV infection. NK cells in LPS-treated mice suppress clonal expansion of LCMV-specific CTLs by a NKG2D- or NCR1-independent but perforin-dependent mechanism. These results suggest a TLR4-mediated immunoregulatory role of NK cells during viral-bacterial coinfections.},
  language  = {en}
}