@article{MuellerBuchholtzLeyhausenPetersonetal.1987, author = {M{\"u}ller-Buchholtz, W. and Leyhausen, G. and Peterson, P. and Schubert, G. and Ulrichs, Karin}, title = {A simple methodological principle for large scale extraction and purification of collagenase-digested islets}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44770}, year = {1987}, abstract = {No abstract available}, subject = {Chirurgie}, language = {en} } @article{BreitkreuzUlrichsEcksteinetal.1993, author = {Breitkreuz, A. and Ulrichs, Karin and Eckstein, V. and M{\"u}ller-Ruchholz, W.}, title = {Long-term suppression of natural and graft-induced xenophile antibodies by short-term antigen-cyclophosphamide treatment}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45262}, year = {1993}, abstract = {No abstract available}, subject = {Chirurgie}, language = {en} } @article{UlrichsEulerSchroederetal.1992, author = {Ulrichs, Karin and Euler, HH and Schroeder, JO and M{\"u}ller-Ruchhholtz, W.}, title = {Long-term specific suppression of antibody production by plasmapheresis and a short-term course of cyclophosphamide}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45198}, year = {1992}, abstract = {No abstract available}, subject = {Chirurgie}, language = {en} } @inproceedings{EcksteinUlrichsMeinckeetal.1991, author = {Eckstein, V. and Ulrichs, Karin and Meincke, G. and M{\"u}lller-Ruchholtz, W.}, title = {Transplantation of Diabetic Patients With Xenogeneic Pancreatic Islets Has to Consider Natural Xenophile Antibodies (NXA) In Patients Sera As a Major Obstacle to Success}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45707}, year = {1991}, abstract = {No abstract available}, subject = {Immunbiologie}, language = {en} } @inproceedings{WinotoMorbachUlrichsMuellerRuchholtz1991, author = {Winoto-Morbach, S. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.}, title = {New Developments in Biodegradable Microspheres For Magnetic Separation Techniques}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45712}, year = {1991}, abstract = {No abstract available}, subject = {Immunbiologie}, language = {en} } @article{UlrichsYuDunckeretal.1984, author = {Ulrichs, Karin and Yu, MY and Duncker, D. and M{\"u}ller-Ruchholtz, W.}, title = {Immunosuppression by cytostatic drugs?}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45574}, year = {1984}, abstract = {In the present study, an attempt was made to characterize the immunomodulating abilities of the cytostatic drugs cydophosphamide, ifosfamide, vinblastine, vincristine, procarbazine, dacarbazine, 6-mercaptopurine, methotrexate, 5-f/uor-uracil and adriamycine in a defined experimental model. Varying combinations of drug plus transplantation alloantigen, (C3H-lymphocytes) were injected into Balb/c mice at different time intervals in vivo. The resulting T-effector cell reactivity was determined in vitro with the microcytotoxicity assay on day + 5 for primary (r) and day + 7 for secondary (2°) sensitized mice. According to the type of drug (alkylating agent vs. vinca alkaloid vs. antimetabolite vs. cytostatic antibiotic), the dosage (20\% LD50 vs. 60\% LD50), the state of sensitization (r vs. 2° sensitized recipients), and the time of drug application in relation to the antigen treatment on day 0 (in varying steps from day -6 to day +4), so-called "pharmaconantigen- variation-effects" (PA VE) were established for each of the investigated drugs in form of reaction profiles. The results were as folIows: (1) For almost alt substances, characteristic reaction profiles involving immunostimulation and/or immunosuppression could be established. Similarities in the profiles of different substances made it possible to classify the drugs according to different reaction types. The reaction type however is not definitely correlated to the biochemical mechanism of drug action. (2) The PA VE are decisively inf/uenced by so me of the biological parameters, such as the time of drug application in relation to the antigen treatment and the state of sensitization but relatively !ittle by the dosage of the drug. (3) Considering the different processes occurring du ring primary and secondary immune responses, the PAVE may give hints for a distinct manipulation of the immunoregulation and thus information on the immunobiological mechanism of drug action.}, subject = {Immunologie}, language = {en} } @article{EngemannUlrichsThiedeetal.1990, author = {Engemann, R. and Ulrichs, Karin and Thiede, A. and M{\"u}ller-Ruchholtz, W. and Hamelmann, H.}, title = {Value of a physiological liver transplant model in rats. Induction of specific graft tolerance in a fully allogeneic strain combination}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45622}, year = {1990}, abstract = {No abstract available}, language = {en} } @article{HeiserUlrichsMuellerRuchholtz1994, author = {Heiser, A. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.}, title = {Prophylactic trypsin inhibition during the isolation procedure guarantees reproducible, high porcine islet yields}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45531}, year = {1994}, abstract = {Abstract: For isolating islets from the porcine pancreas, we established a semiautomated digestion method. Although the isolation technique was standardized and collagenase of controlled quality was used, until now the reproducibility of high islet yields was unsatisfactory. Our hypothesis was that pancreatic trypsin was responsible for this failure. The aim of this study was to investigate the effect of endogenous trypsin on islet yield. Our results demonstrate that a high trypsin level correlates with poor islet yield, whereas low trypsin activity always correlates with high islet yield. Specific inhibition of trypsin results in low trypsin activity and reproducible, high islet yields.}, language = {en} } @article{EngemannGasselUlrichsetal.1986, author = {Engemann, R. and Gassel, HJ and Ulrichs, Karin and Thiede, A. and Hamelmann, H.}, title = {Suppressorzellmechanismen nach Cyclosporin A (CsA) induzierter Toleranz allogener Rattenlebertransplantate}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45503}, year = {1986}, abstract = {No abstract available}, language = {de} } @inproceedings{UlrichsEulerMuellerRuchholtz1991, author = {Ulrichs, Karin and Euler, HH and M{\"u}ller-Ruchholtz, W.}, title = {A Clinically Successful Protocol to Suppress Autoantibody Production in SLE Patients Is Analyzed For Its Efficacy To Inhibit Natural Xenophile Antibodies (NXA)}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45693}, year = {1991}, abstract = {No abstract available}, language = {en} }