@article{BinderMayBaronetal.2011,
  author    = {Binder, Andreas and May, Denisa and Baron, Ralf and Maier, Christoph and T{\"o}lle, Thomas R. and Treede, Rolf-Detlef and Berthele, Achim and Faltraco, Frank and Flor, Herta and Gierthm{\"u}hlen, Janne and Haenisch, Sierk and Huge, Volker and Magerl, Walter and Maih{\"o}fner, Christian and Richter, Helmut and Rolke, Roman and Scherens, Andrea and {\"U}{\c{c}}eyler, Nurcan and Ufer, Mike and Wasner, Gunnar and Zhu, Jihong and Cascorbi, Ingolf},
  title     = {Transient Receptor Potential Channel Polymorphisms Are Associated with the Somatosensory Function in Neuropathic Pain Patients},
  series = {PLoS ONE},
  volume    = {6},
  journal   = {PLoS ONE},
  number    = {3},
  doi       = {10.1371/journal.pone.0017387},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-142782},
  pages     = {e17387},
  year      = {2011},
  abstract  = {Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic pain is unknown. We investigated the frequency of transient receptor potential ankyrin 1, transient receptor potential melastin 8 and transient receptor potential vanilloid 1 single nucleotide polymorphisms and their impact on somatosensory abnormalities in neuropathic pain patients. Within the German Research Network on Neuropathic Pain (Deutscher Forscbungsverbund Neuropathischer Schmerz) 371 neuropathic pain patients were phenotypically characterized using standardized quantitative sensory testing. Pyrosequencing was employed to determine a total of eleven single nucleotide polymorphisms in transient receptor potential channel genes of the neuropathic pain patients and a cohort of 253 German healthy volunteers. Associations of quantitative sensory testing parameters and single nucleotide polymorphisms between and within groups and subgroups, based on sensory phenotypes, were analyzed. Single nucleotide polymorphisms frequencies did not differ between both the cohorts. However, in neuropathic pain patients transient receptor potential ankyrin 1 710G>A (rs920829, E179K) was associated with the presence of paradoxical heat sensation (p=0.03), and transient receptor potential vanilloid 1 1911A>G (rs8065080, I585V) with cold hypoalgesia (p=0.0035). Two main subgroups characterized by preserved (1) and impaired (2) sensory function were identified. In subgroup 1 transient receptor potential vanilloid 1 1911A>G led to significantly less heat hyperalgesia, pinprick hyperalgesia and mechanical hypaesthesia (p=0.006, p=0.005 and p<0.001) and transient receptor potential vanilloid 1 1103C>G (rs222747, M315I) to cold hypaesthesia (p=0.002), but there was absence of associations in subgroup 2. In this study we found no evidence that genetic variants of transient receptor potential channels are involved in the expression of neuropathic pain, but transient receptor potential channel polymorphisms contributed significantly to the somatosensory abnormalities of neuropathic pain patients.},
  language  = {en}
}
@phdthesis{Maier2015,
  author    = {Maier, Frank},
  title     = {Das H{\"o}rspiel. Eine technische Kunstform?},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-139717},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2015},
  abstract  = {Die hier vorliegende Arbeit besch{\"a}ftigt sich mit dem Thema H{\"o}rspiel und der Fragestellung, wie die Technik diese Kunstform beeinflusst hat. Um dies zu untersuchen, wurden verschiedene H{\"o}rspiele aus den unterschiedlichsten Bereichen herangezogen und unter drei wesentlichen Aspekten untersucht: 1.) „Der H{\"o}rer und das H{\"o}rspiel": Dieser Bereich umfasst eine Darstellung der Zusammenh{\"a}nge des H{\"o}ren und Wahrnehmens eines H{\"o}rspiels durch den H{\"o}rer und die Beeinflussung der Wiedergabe entsprechender Schallvorg{\"a}nge im Raum des H{\"o}rers durch technische und r{\"a}umliche Aspekte. 2.) „Prim{\"a}r-formative Prozesse": Innerhalb dieser Kapitel wurde die Beeinflussung der origin{\"a}ren Schallereignisse durch den Vorgang der Aufnahme und die dabei stattfindenden Prozesse untersucht. Die wesentlichen und ber{\"u}cksichtigten, die Schallaufnahme beeinflussenden Parameter waren hierbei das H{\"o}rspielstudio „im Ganzen", die Schallwandlung im technischen Sinne, der Einfluss der Stereofonie auf das H{\"o}rspiel sowie verschiedene daraus resultierende Formen der Inszenierungen. 3.) „Sekund{\"a}r-formative Prozesse": In diesem Bereich wurden gestaltende Prozesse erfasst und untersucht, die die aufgenommenen Schallereignisse beeinflussen und/oder zu g{\"a}nzlich neuen Klangkonstrukten formen. Dies reicht vom Schnitt oder der Blende bis hin zu komplexen Modifikationen mit einer Vielzahl von radiofonen Effekten. Die Analysen der einzelnen H{\"o}rspiele fanden dabei nicht nur aus technischer Sicht statt, sondern standen stets in einem engen Zusammenhang mit den dramaturgischen Vorg{\"a}ngen des entsprechenden Werkes. Dar{\"u}ber hinaus wurden aktuelle Produktionsaspekte f{\"u}r ein H{\"o}rspiel ber{\"u}cksichtigt, die zugleich in die Diskussion mit entsprechender Literatur gestellt wurden. Zusammengefasst hat sich gezeigt, dass das H{\"o}rspiel eine Kunstform ist, die permanent durch die Technik beeinflusst wurde und wird. Der Zusammenhang zwischen Technik und auditiver Kunstform hat eigene dramaturgische Formen hervorgebracht, die das H{\"o}rspiel vor allem als eine eigenst{\"a}ndige, von anderen Fachdisziplinen losgel{\"o}ste Gattung definiert und im Umkehrschluss verschiedenste Fachbereiche f{\"u}r sich beansprucht.},
  subject      = {H{\"o}rspiel},
  language  = {de}
}
@article{WeidemannMaierStoerketal.2016,
  author    = {Weidemann, Frank and Maier, Sebastian K. G. and St{\"o}rk, Stefan and Brunner, Thomas and Liu, Dan and Hu, Kai and Seydelmann, Nora and Schneider, Andreas and Becher, Jan and Canan-K{\"u}hl, Sima and Blaschke, Daniela and Bijnens, Bart and Ertl, Georg and Wanner, Christoph and Nordbeck, Peter},
  title     = {Usefulness of an implantable loop recorder to detect clinically relevant arrhythmias in patients with advanced fabry cardiomyopathy},
  series = {The American Journal of Cardiology},
  volume    = {118},
  journal   = {The American Journal of Cardiology},
  number    = {2},
  doi       = {10.1016/j.amjcard.2016.04.033},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-188093},
  pages     = {264-274},
  year      = {2016},
  abstract  = {Patients with genetic cardiomyopathy that involves myocardial hypertrophy often develop clinically relevant arrhythmias that increase the risk of sudden death. Consequently, guidelines for medical device therapy were established for hypertrophic cardiomyopathy, but not for conditions with only anecdotal evidence of arrhythmias, like Fabry cardiomyopathy. Patients with Fabry cardiomyopathy progressively develop myocardial fibrosis, and sudden cardiac death occurs regularly. Because 24-hour Holier electrocardiograms (ECGs) might not detect clinically important arrhythmias, we tested an implanted loop recorder for continuous heart rhythm surveillance and determined its impact on therapy. This prospective study included 16 patients (12 men) with advanced Fabry cardiomyopathy, relevant hypertrophy, and replacement fibrosis in "loco typico." No patients previously exhibited clinically relevant arrhythmias on Holier ECGs. Patients received an implantable loop recorder and were prospectively followed with telemedicine for a median of 1.2 years (range 0.3 to 2.0 years). The primary end point was a clinically meaningful event, which required a therapy change, captured with the loop recorder. Patients submitted data regularly (14 +/- 11 times per month). During follow-up, 21 events were detected (including 4 asystole, i.e., ECG pauses >= 3 seconds) and 7 bradycardia events; 5 episodes of intermittent atrial fibrillation (>3 minutes) and 5 episodes of ventricular tachycardia (3 sustained and 2 nonsustained). Subsequently, as defined in the primary end point, 15 events leaded to a change of therapy. These patients required therapy with a pacemaker or cardioverter defibrillator implantation and/or anticoagulation therapy for atrial fibrillation. In conclusion, clinically relevant arrhythmias that require further device and/or medical therapy are often missed with Holier ECGs in patients with advanced stage Fabry cardiomyopathy, but they can be detected by telemonitoring with an implantable loop recorder.},
  language  = {en}
}