@article{HirschKraussOpferkuchetal.2016,
  author    = {Hirsch, Martin and Krauss, Manuel E. and Opferkuch, Toby and Porod, Werner and Staub, Florian},
  title     = {A constrained supersymmetric left-right model},
  series = {JOURNAL OF HIGH ENERGY PHYSICS},
  volume    = {03},
  journal   = {JOURNAL OF HIGH ENERGY PHYSICS},
  number    = {009},
  doi       = {10.1007/JHEP03(2016)009},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-168016},
  year      = {2016},
  abstract  = {We present a supersymmetric left-right model which predicts gauge coupling unification close to the string scale and extra vector bosons at the TeV scale. The subtleties in constructing a model which is in agreement with the measured quark masses and mixing for such a low left-right breaking scale are discussed. It is shown that in the constrained version of this model radiative breaking of the gauge symmetries is possible and a SM-like Higgs is obtained. Additional CP-even scalars of a similar mass or even much lighter are possible. The expected mass hierarchies for the supersymmetric states differ clearly from those of the constrained MSSM. In particular, the lightest down-type squark, which is a mixture of the sbottom and extra vector-like states, is always lighter than the stop. We also comment on the model's capability to explain current anomalies observed at the LHC.},
  language  = {en}
}
@article{HollenhorstJurastowNandigamaetal.2020,
  author    = {Hollenhorst, Monika I. and Jurastow, Innokentij and Nandigama, Rajender and Appenzeller, Silke and Li, Lei and Vogel, J{\"o}rg and Wiederhold, Stephanie and Althaus, Mike and Empting, Martin and Altm{\"u}ller, Janine and Hirsch, Anna K. H. and Flockerzi, Veit and Canning, Brendan J. and Saliba, Antoine-Emmanuel and Krasteva-Christ, Gabriela},
  title     = {Tracheal brush cells release acetylcholine in response to bitter tastants for paracrine and autocrine signaling},
  series = {The FASEB Journal},
  volume    = {34},
  journal   = {The FASEB Journal},
  number    = {1},
  doi       = {10.1096/fj.201901314RR},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-213516},
  pages     = {316 -- 332},
  year      = {2020},
  abstract  = {For protection from inhaled pathogens many strategies have evolved in the airways such as mucociliary clearance and cough. We have previously shown that protective respiratory reflexes to locally released bacterial bitter "taste" substances are most probably initiated by tracheal brush cells (BC). Our single-cell RNA-seq analysis of murine BC revealed high expression levels of cholinergic and bitter taste signaling transcripts (Tas2r108, Gnat3, Trpm5). We directly demonstrate the secretion of acetylcholine (ACh) from BC upon stimulation with the Tas2R agonist denatonium. Inhibition of the taste transduction cascade abolished the increase in [Ca\(^{2+}\)]\(_{i}\) in BC and subsequent ACh-release. ACh-release is regulated in an autocrine manner. While the muscarinic ACh-receptors M3R and M1R are activating, M2R is inhibitory. Paracrine effects of ACh released in response to denatonium included increased [Ca\(^{2+}\)]\(_{i}\) in ciliated cells. Stimulation by denatonium or with Pseudomonas quinolone signaling molecules led to an increase in mucociliary clearance in explanted tracheae that was Trpm5- and M3R-mediated. We show that ACh-release from BC via the bitter taste cascade leads to immediate paracrine protective responses that can be boosted in an autocrine manner. This mechanism represents the initial step for the activation of innate immune responses against pathogens in the airways.},
  language  = {en}
}