@article{HofmannFayezScheineretal.2020,
  author    = {Hofmann, Julian and Fayez, Shaimaa and Scheiner, Matthias and Hoffmann, Matthias and Oerter, Sabrina and Appelt-Menzel, Antje and Maher, Pamela and Maurice, Tangui and Bringmann, Gerhard and Decker, Michael},
  title     = {Sterubin: Enantioresolution and Configurational Stability, Enantiomeric Purity in Nature, and Neuroprotective Activity in Vitro and in Vivo},
  series = {Chemistry - A European Journal},
  volume    = {26},
  journal   = {Chemistry - A European Journal},
  number    = {32},
  doi       = {10.1002/chem.202001264},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-215993},
  pages     = {7299 -- 7308},
  year      = {2020},
  abstract  = {Alzheimer′s disease (AD) is a neurological disorder with still no preventive or curative treatment. Flavonoids are phytochemicals with potential therapeutic value. Previous studies described the flavanone sterubin isolated from the Californian plant Eriodictyon californicum as a potent neuroprotectant in several in vitro assays. Herein, the resolution of synthetic racemic sterubin (1) into its two enantiomers, (R)-1 and (S)-1, is described, which has been performed on a chiral chromatographic phase, and their stereochemical assignment online by HPLC-ECD coupling. (R)-1 and (S)-1 showed comparable neuroprotection in vitro with no significant differences. While the pure stereoisomers were configurationally stable in methanol, fast racemization was observed in the presence of culture medium. We also established the occurrence of extracted sterubin as its pure (S)-enantiomer. Moreover, the activity of sterubin (1) was investigated for the first time in vivo, in an AD mouse model. Sterubin (1) showed a significant positive impact on short- and long-term memory at low dosages.},
  language  = {en}
}
@article{DechHolzwarthAsametal.2021,
  author    = {Dech, Stefan and Holzwarth, Stefanie and Asam, Sarah and Andresen, Thorsten and Bachmann, Martin and Boettcher, Martin and Dietz, Andreas and Eisfelder, Christina and Frey, Corinne and Gesell, Gerhard and Gessner, Ursula and Hirner, Andreas and Hofmann, Matthias and Kirches, Grit and Klein, Doris and Klein, Igor and Kraus, Tanja and Krause, Detmar and Plank, Simon and Popp, Thomas and Reinermann, Sophie and Reiners, Philipp and Roessler, Sebastian and Ruppert, Thomas and Scherbachenko, Alexander and Vignesh, Ranjitha and Wolfmueller, Meinhard and Zwenzner, Hendrik and Kuenzer, Claudia},
  title     = {Potential and challenges of harmonizing 40 years of AVHRR data: the TIMELINE experience},
  series = {Remote Sensing},
  volume    = {13},
  journal   = {Remote Sensing},
  number    = {18},
  issn      = {2072-4292},
  doi       = {10.3390/rs13183618},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-246134},
  year      = {2021},
  abstract  = {Earth Observation satellite data allows for the monitoring of the surface of our planet at predefined intervals covering large areas. However, there is only one medium resolution sensor family in orbit that enables an observation time span of 40 and more years at a daily repeat interval. This is the AVHRR sensor family. If we want to investigate the long-term impacts of climate change on our environment, we can only do so based on data that remains available for several decades. If we then want to investigate processes with respect to climate change, we need very high temporal resolution enabling the generation of long-term time series and the derivation of related statistical parameters such as mean, variability, anomalies, and trends. The challenges to generating a well calibrated and harmonized 40-year-long time series based on AVHRR sensor data flown on 14 different platforms are enormous. However, only extremely thorough pre-processing and harmonization ensures that trends found in the data are real trends and not sensor-related (or other) artefacts. The generation of European-wide time series as a basis for the derivation of a multitude of parameters is therefore an extremely challenging task, the details of which are presented in this paper.},
  language  = {en}
}
@article{BochSpiessHeinzetal.2019,
  author    = {Boch, Tobias and Spiess, Birgit and Heinz, Werner and Cornely, Oliver A. and Schwerdtfeger, Rainer and Hahn, Joachim and Krause, Stefan W. and Duerken, Matthias and Bertz, Hartmut and Reuter, Stefan and Kiehl, Michael and Claus, Bernd and Deckert, Peter Markus and Hofmann, Wolf-Karsten and Buchheidt, Dieter and Reinwald, Mark},
  title     = {Aspergillus specific nested PCR from the site of infection is superior to testing concurrent blood samples in immunocompromised patients with suspected invasive aspergillosis},
  series = {Mycoses},
  volume    = {62},
  journal   = {Mycoses},
  number    = {11},
  doi       = {10.1111/myc.12983},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-214065},
  pages     = {1035 -- 1042},
  year      = {2019},
  abstract  = {Invasive aspergillosis (IA) is a severe complication in immunocompromised patients. Early diagnosis is crucial to decrease its high mortality, yet the diagnostic gold standard (histopathology and culture) is time-consuming and cannot offer early confirmation of IA. Detection of IA by polymerase chain reaction (PCR) shows promising potential. Various studies have analysed its diagnostic performance in different clinical settings, especially addressing optimal specimen selection. However, direct comparison of different types of specimens in individual patients though essential, is rarely reported. We systematically assessed the diagnostic performance of an Aspergillus-specific nested PCR by investigating specimens from the site of infection and comparing it with concurrent blood samples in individual patients (pts) with IA. In a retrospective multicenter analysis PCR was performed on clinical specimens (n = 138) of immunocompromised high-risk pts (n = 133) from the site of infection together with concurrent blood samples. 38 pts were classified as proven/probable, 67 as possible and 28 as no IA according to 2008 European Organization for Research and Treatment of Cancer/Mycoses Study Group consensus definitions. A considerably superior performance of PCR from the site of infection was observed particularly in pts during antifungal prophylaxis (AFP)/antifungal therapy (AFT). Besides a specificity of 85\%, sensitivity varied markedly in BAL (64\%), CSF (100\%), tissue samples (67\%) as opposed to concurrent blood samples (8\%). Our results further emphasise the need for investigating clinical samples from the site of infection in case of suspected IA to further establish or rule out the diagnosis.},
  language  = {en}
}
@techreport{BaumgartBredebachHermetal.2022,
  author    = {Baumgart, Michael and Bredebach, Patrick and Herm, Lukas-Valentin and Hock, David and Hofmann, Adrian and Janiesch, Christian and Jankowski, Leif Ole and Kampik, Timotheus and Keil, Matthias and Kolb, Julian and Kr{\"o}hn, Michael and Pytel, Norman and Schaschek, Myriam and St{\"u}bs, Oliver and Winkelmann, Axel and Zeiß, Christian},
  title     = {Plattform f{\"u}r das integrierte Management von Kollaborationen in Wertsch{\"o}pfungsnetzwerken (PIMKoWe)},
  editor    = {Winkelmann, Axel and Janiesch, Christian},
  issn      = {2199-0328},
  doi       = {10.25972/OPUS-29335},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-293354},
  pages     = {248},
  year      = {2022},
  abstract  = {Das Verbundprojekt „Plattform f{\"u}r das integrierte Management von Kollaborationen in Wertsch{\"o}pfungsnetzwerken" (PIMKoWe - F{\"o}rderkennzeichen „02P17D160") ist ein Forschungsvorhaben im Rahmen des Forschungsprogramms „Innovationen f{\"u}r die Produktion, Dienstleistung und Arbeit von morgen" der Bekanntmachung „Industrie 4.0 - Intelligente Kollaborationen in dynamischen Wertsch{\"o}pfungs-netzwerken" (InKoWe). Das Forschungsvorhaben wurde mit Mitteln des Bundesministeriums f{\"u}r Bildung und Forschung (BMBF) gef{\"o}rdert und durch den Projekttr{\"a}ger des Karlsruher Instituts f{\"u}r Technologie (PTKA) betreut. Ziel des Forschungsprojekts PIMKoWe ist die Entwicklung und Bereitstellung einer Plattforml{\"o}sung zur Flexibilisierung, Automatisierung und Absicherung von Kooperationen in Wertsch{\"o}pfungsnetzwerken des industriellen Sektors.},
  subject      = {Blockchain},
  language  = {de}
}
@article{HofmannGinexEspargaroetal.2021,
  author    = {Hofmann, Julian and Ginex, Tiziana and Espargar{\´o}, Alba and Scheiner, Matthias and Gunesch, Sandra and Arag{\´o}, Marc and Stigloher, Christian and Sabat{\´e}, Raimon and Luque, F. Javier and Decker, Michael},
  title     = {Azobioisosteres of Curcumin with Pronounced Activity against Amyloid Aggregation, Intracellular Oxidative Stress, and Neuroinflammation},
  series = {Chemistry - A European Journal},
  volume    = {27},
  journal   = {Chemistry - A European Journal},
  number    = {19},
  doi       = {10.1002/chem.202005263},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-238988},
  pages     = {6015 -- 6027},
  year      = {2021},
  abstract  = {Many (poly-)phenolic natural products, for example, curcumin and taxifolin, have been studied for their activity against specific hallmarks of neurodegeneration, such as amyloid-β 42 (Aβ42) aggregation and neuroinflammation. Due to their drawbacks, arising from poor pharmacokinetics, rapid metabolism, and even instability in aqueous medium, the biological activity of azobenzene compounds carrying a pharmacophoric catechol group, which have been designed as bioisoteres of curcumin has been examined. Molecular simulations reveal the ability of these compounds to form a hydrophobic cluster with Aβ42, which adopts different folds, affecting the propensity to populate fibril-like conformations. Furthermore, the curcumin bioisosteres exceeded the parent compound in activity against Aβ42 aggregation inhibition, glutamate-induced intracellular oxidative stress in HT22 cells, and neuroinflammation in microglial BV-2 cells. The most active compound prevented apoptosis of HT22 cells at a concentration of 2.5 μm (83 \% cell survival), whereas curcumin only showed very low protection at 10 μm (21 \% cell survival).},
  language  = {en}
}
@article{SchmidtSticherlingSardyetal.2020,
  author    = {Schmidt, Enno and Sticherling, Michael and S{\´a}rdy, Mikl{\´o}s and Eming, R{\"u}diger and Goebeler, Matthias and Hertl, Michael and Hofmann, Silke C. and Hunzelmann, Nicolas and Kern, Johannes S. and Kramer, Harald and Nast, Alexander and Orzechowski, Hans-Dieter and Pfeiffer, Christiane and Schuster, Volker and Sitaru, Cassian and Zidane, Miriam and Zillikens, Detlef and Worm, Margitta},
  title     = {S2k guidelines for the treatment of pemphigus vulgaris/foliaceus and bullous pemphigoid: 2019 update},
  series = {JDDG: Journal der Deutschen Dermatologischen Gesellschaft},
  volume    = {18},
  journal   = {JDDG: Journal der Deutschen Dermatologischen Gesellschaft},
  number    = {5},
  doi       = {10.1111/ddg.14097},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-217806},
  pages     = {516 -- 526},
  year      = {2020},
  language  = {en}
}