@article{KaiserBrambrinkBenditzetal.2022,
  author    = {Kaiser, Moritz and Brambrink, Sara and Benditz, Achim and Achenbach, Leonard and Gehentges, Matthias and K{\"o}nig, Matthias Alexander},
  title     = {Increase in lower limb strength after multimodal pain management in patients with low back pain},
  series = {Medicina},
  volume    = {58},
  journal   = {Medicina},
  number    = {7},
  issn      = {1648-9144},
  doi       = {10.3390/medicina58070837},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-284264},
  year      = {2022},
  abstract  = {Background and Objectives: The aim of the present study was to evaluate the efficacy of a multimodal pain therapy (MPM) regarding the objective parameter muscle strength of segment-dependent lower limb muscle groups before and after such a treatment. Materials and Methods: 52 patients with a history of low back pain and/or leg pain received standardized multimodal pain management. Strength of segment indicating lower limb muscles were assessed for each patient before and after ten days of treatment by handheld dynamometry. Results: Overall strength increased significantly from 23.6 kg ± 6.6 prior to treatment to 25.4 ± 7.3 after treatment, p ≤ 0.001. All muscle groups significantly increased in strength with exception of great toe extensors. Conclusions: Despite lower basic strength values at the beginning of treatment, all investigated muscle groups, except for the great toe extensors, showed a significant increase of overall strength after completion of the multimodal pain management concept. Increased overall strength could help with avoiding further need of medical care by supporting patients' autonomy in daily life activities, as well as maintaining working abilities. Thus, our study is the first to show a significant positive influence on lower limb strength in patients with low back pain after a conservative MPM program.},
  language  = {en}
}
@article{JobsVontheinKoenigetal.2020,
  author    = {Jobs, Alexander and Vonthein, Reinhard and K{\"o}nig, Inke R. and Sch{\"a}fer, Jane and Nauck, Matthias and Haag, Svenja and Fichera, Carlo Federico and Stiermaier, Thomas and Ledwoch, Jakob and Schneider, Alisa and Valentova, Miroslava and von Haehling, Stephan and St{\"o}rk, Stefan and Westermann, Dirk and Lenz, Tobias and Arnold, Natalie and Edelmann, Frank and Seppelt, Philipp and Felix, Stephan and Lutz, Matthias and Hedwig, Felix and Borggrefe, Martin and Scherer, Clemens and Desch, Steffen and Thiele, Holger},
  title     = {Inferior vena cava ultrasound in acute decompensated heart failure: design rationale of the CAVA-ADHF-DZHK10 trial},
  series = {ESC Heart Failure},
  volume    = {7},
  journal   = {ESC Heart Failure},
  number    = {3},
  doi       = {10.1002/ehf2.12598},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-212692},
  pages     = {973 -- 983},
  year      = {2020},
  abstract  = {Aims Treating patients with acute decompensated heart failure (ADHF) presenting with volume overload is a common task. However, optimal guidance of decongesting therapy and treatment targets are not well defined. The inferior vena cava (IVC) diameter and its collapsibility can be used to estimate right atrial pressure, which is a measure of right-sided haemodynamic congestion. The CAVA-ADHF-DZHK10 trial is designed to test the hypothesis that ultrasound assessment of the IVC in addition to clinical assessment improves decongestion as compared with clinical assessment alone. Methods and results CAVA-ADHF-DZHK10 is a randomized, controlled, patient-blinded, multicentre, parallel-group trial randomly assigning 388 patients with ADHF to either decongesting therapy guided by ultrasound assessment of the IVC in addition to clinical assessment or clinical assessment alone. IVC ultrasound will be performed daily between baseline and hospital discharge in all patients. However, ultrasound results will only be reported to treating physicians in the intervention group. Treatment target is relief of congestion-related signs and symptoms in both groups with the additional goal to reduce the IVC diameter ≤21 mm and increase IVC collapsibility >50\% in the intervention group. The primary endpoint is change in N-terminal pro-brain natriuretic peptide from baseline to hospital discharge. Secondary endpoints evaluate feasibility, efficacy of decongestion on other scales, and the impact of the intervention on clinical endpoints. Conclusions CAVA-ADHF-DZHK10 will investigate whether IVC ultrasound supplementing clinical assessment improves decongestion in patients admitted for ADHF.},
  language  = {en}
}
@article{KoenigBaenningerGarciaetal.2013,
  author    = {K{\"o}nig, Markus and Baenninger, Matthias and Garcia, Andrei G. F. and Harjee, Nahid and Pruitt, Beth L. and Ames, C. and Leubner, Philipp and Br{\"u}ne, Christoph and Buhmann, Hartmut and Molenkamp, Laurens W. and Goldhaber-Gordon, David},
  title     = {Spatially Resolved Study of Backscattering in the Quantum Spin Hall State},
  series = {Physical Review X},
  volume    = {3},
  journal   = {Physical Review X},
  number    = {2},
  issn      = {2160-3308},
  doi       = {10.1103/PhysRevX.3.021003},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-127225},
  pages     = {21003},
  year      = {2013},
  abstract  = {The discovery of the quantum spin Hall (QSH) state, and topological insulators in general, has sparked strong experimental efforts. Transport studies of the quantum spin Hall state have confirmed the presence of edge states, showed ballistic edge transport in micron-sized samples, and demonstrated the spin polarization of the helical edge states. While these experiments have confirmed the broad theoretical model, the properties of the QSH edge states have not yet been investigated on a local scale. Using scanning gate microscopy to perturb the QSH edge states on a submicron scale, we identify well-localized scattering sites which likely limit the expected nondissipative transport in the helical edge channels. In the micron-sized regions between the scattering sites, the edge states appear to propagate unperturbed, as expected for an ideal QSH system, and are found to be robust against weak induced potential fluctuations.},
  language  = {en}
}
@article{MaCalvoWangetal.2015,
  author    = {Ma, Eric Yue and Calvo, M. Reyes and Wang, Jing and Lian, Biao and M{\"u}hlbauer, Mathias and Br{\"u}ne, Christoph and Cui, Yong-Tao and Lai, Keji and Kundhikanjana, Worasom and Yang, Yongliang and Baenninger, Matthias and K{\"o}nig, Markus and Ames, Christopher and Buhmann, Hartmut and Leubner, Philipp and Molenkamp, Laurens W. and Zhang, Shou-Cheng and Goldhaber-Gordon, David and Kelly, Michael A. and Shen, Zhi-Xun},
  title     = {Unexpected edge conduction in mercury telluride quantum wells under broken time-reversal symmetry},
  series = {Nature Communications},
  volume    = {6},
  journal   = {Nature Communications},
  number    = {7252},
  doi       = {10.1038/ncomms8252},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-143185},
  year      = {2015},
  abstract  = {The realization of quantum spin Hall effect in HgTe quantum wells is considered a milestone in the discovery of topological insulators. Quantum spin Hall states are predicted to allow current flow at the edges of an insulating bulk, as demonstrated in various experiments. A key prediction yet to be experimentally verified is the breakdown of the edge conduction under broken time-reversal symmetry. Here we first establish a systematic framework for the magnetic field dependence of electrostatically gated quantum spin Hall devices. We then study edge conduction of an inverted quantum well device under broken time-reversal symmetry using microwave impedance microscopy, and compare our findings to a noninverted device. At zero magnetic field, only the inverted device shows clear edge conduction in its local conductivity profile, consistent with theory. Surprisingly, the edge conduction persists up to 9 T with little change. This indicates physics beyond simple quantum spin Hall model, including material-specific properties and possibly many-body effects.},
  language  = {en}
}
@article{AlzheimerSvenssonKoenigetal.2020,
  author    = {Alzheimer, Mona and Svensson, Sarah L. and K{\"o}nig, Fabian and Schweinlin, Matthias and Metzger, Marco and Walles, Heike and Sharma, Cynthia M.},
  title     = {A three-dimensional intestinal tissue model reveals factors and small regulatory RNAs important for colonization with Campylobacter jejuni},
  series = {PLoS Pathogens},
  volume    = {16},
  journal   = {PLoS Pathogens},
  number    = {2},
  doi       = {10.1371/journal.ppat.1008304},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-229454},
  year      = {2020},
  abstract  = {The Gram-negative Epsilonproteobacterium Campylobacter jejuni is currently the most prevalent bacterial foodborne pathogen. Like for many other human pathogens, infection studies with C. jejuni mainly employ artificial animal or cell culture models that can be limited in their ability to reflect the in-vivo environment within the human host. Here, we report the development and application of a human three-dimensional (3D) infection model based on tissue engineering to study host-pathogen interactions. Our intestinal 3D tissue model is built on a decellularized extracellular matrix scaffold, which is reseeded with human Caco-2 cells. Dynamic culture conditions enable the formation of a polarized mucosal epithelial barrier reminiscent of the 3D microarchitecture of the human small intestine. Infection with C. jejuni demonstrates that the 3D tissue model can reveal isolate-dependent colonization and barrier disruption phenotypes accompanied by perturbed localization of cell-cell junctions. Pathogenesis-related phenotypes of C. jejuni mutant strains in the 3D model deviated from those obtained with 2D-monolayers, but recapitulated phenotypes previously observed in animal models. Moreover, we demonstrate the involvement of a small regulatory RNA pair, CJnc180/190, during infections and observe different phenotypes of CJnc180/190 mutant strains in 2D vs. 3D infection models. Hereby, the CJnc190 sRNA exerts its pathogenic influence, at least in part, via repression of PtmG, which is involved in flagellin modification. Our results suggest that the Caco-2 cell-based 3D tissue model is a valuable and biologically relevant tool between in-vitro and in-vivo infection models to study virulence of C. jejuni and other gastrointestinal pathogens.},
  language  = {en}
}
@article{StepulaKoenigWangetal.2020,
  author    = {Stepula, Elzbieta and K{\"o}nig, Matthias and Wang, Xin-Ping and Levermann, Janina and Schimming, Tobias and Kasimir-Bauer, Sabine and Schilling, Bastian and Schl{\"u}cker, Sebastian},
  title     = {Localization of PD-L1 on single cancer cells by iSERS microscopy with Au/Au core/satellite nanoparticles},
  series = {Journal of Biophotonics},
  volume    = {13},
  journal   = {Journal of Biophotonics},
  number    = {3},
  doi       = {10.1002/jbio.201960034},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-212655},
  year      = {2020},
  abstract  = {Programmed cell death-ligand 1 (PD-L1) is an important predictive biomarker. The detection of PD-L1 can be crucial for patients with advanced cancer where the use of immunotherapy is considered. Here, we demonstrate the use of immuno-SERS microscopy (iSERS) for localizing PD-L1 on single cancer SkBr-3 cells. A central advantage of iSERS is that the disturbing autofluorescence from cells and tissues can be efficiently minimized by red to near-infrared laser excitation. In this study we employed Au/Au core/satellite nanoparticles as SERS nanotags because of their remarkable signal brightness and colloidal stability upon red laser excitation. False-color iSERS images of the positive and negative controls clearly reveal the specific localization of PD-L1 with SERS nanotag-labeled antibodies.},
  language  = {en}
}