@article{TiuDavernGarciaetal.1989,
  author    = {Tiu, W. U. and Davern, K. M. and Garcia, E. G. and Moll, Heidrun and Mitchell, Graham F.},
  title     = {Monoclonal antibodies reacting with Schistosoma japonicum eggs and their target epitopes},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-30916},
  year      = {1989},
  abstract  = {Ten monoclonal antibodies (McAbs) raised to Schistosoma japonicum eggs could be assigned using several serological and immunochemical techniques to 3 groups. The McAbs, termed A, B and C-McAbs, apparently recognize carbohydrate epitopes that can be located on the same antigen molecule. The antibodies, generally of IgM isotype, are idiotypically related. They are distinct from another IgM McAb (Group D-McAb) the carbohydrate target epitope of which can also be associated with the epitopes of A. B and C-McAbs. The McAbs produce large vacuolated bleb reactions in the circumoval precipitin test (COPT) and target epitopes have different representations in various life cycle stages such as immature and mature eggs, male and female worms (including S. mansoni). Antigens affinity purified on columns containing A, B, C and D-McAbs stimulate proliferation of T cells from egg-sensitized mice and elicit DTH reactions in such mice. This raises the possibility that the target antigens of these carbohydrate-reactive monoclonal antibodies are immunopathologic and involved in egg-induced granuloma formation.},
  language  = {en}
}
@article{MollRoellinghoff1991,
  author    = {Moll, Heidrun and R{\"o}llinghoff, Martin},
  title     = {T-cell reactivity to purified lipophosphoglycan from Leishmania major: A model for analysis of the cellular immune response to microbial carbohydrates.},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-33022},
  year      = {1991},
  abstract  = {The major macromolecule on the surface o/Leishmania majorpromastigotes is a lipophosphoglycan (LPG). This glycoconjugate plays a key role in determining infectivity and survival of para-sites in the mammalian host cell. In addition, L. major LPG is able to induce a host-protective immune response. In this article, we summarise the evidence for recognition of highly purified LPG by T cells and we discuss the potential mechanisms of T-cell Stimulation by this non-protein antigen.},
  language  = {en}
}
@incollection{HandmanMitchellMcConvilleetal.1987,
  author    = {Handman, E. and Mitchell, G. F. and McConville, M. J. and Moll, Heidrun},
  title     = {Towards a carbohydrate-based vaccine against leishmaniasis},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-33827},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1987},
  abstract  = {No abstract available},
  language  = {en}
}
@article{EmmrichMollSimon1985,
  author    = {Emmrich, F. and Moll, Heidrun and Simon, Markus M.},
  title     = {Recombinant human interleukin 2 acts as a B cell growth and differentiation promoting factor},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-34132},
  year      = {1985},
  abstract  = {Human B cells appropriately activated by a B cell mitogen are rendered susceptible to human Interleukin 2 (IL-2) as demonstrated with recombinant human IL-2 (rec. h IL-2). They show increased proliferation and drastically enhanced immunoglobulin secretion. Susceptibility to IL-2 is accompanied with the expression of the IL-2 receptor (Tac antigen) on B cells. The data suggest that IL-2 is one of the lymphokines directly involved in the activation of B lymphocytes.},
  language  = {en}
}
@misc{GillitzerBergerMoll1990,
  author    = {Gillitzer, Reinhard and Berger, Rudolf and Moll, Heidrun},
  title     = {A reliable method for simultaneous demonstration of two antigens using a novel combination of immunogold-silver staining with immunoenzymatic labeling},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-31092},
  year      = {1990},
  abstract  = {We have developed a reliable and sensitive immunohistochemical staining technique which allows the simultaneous demonstration of two different antigens expressed in or on the same cell (referred to as mixed labeling), together with the evaluation of the general histopathological appearance of the tissue. The staining procedure combines a three-step (streptavidin-biotin) immunogold-silver staining (IGSS) with a three-step immunoenzymatic labeling. For this purpose, we investigated the compatibility ofIGSS with various substrates of peroxidase or alkaline phosphatase (AP). Highly reliable and discernible mixed labeling was achieved only after iniriallabeling with IGSS followed by AP labeling using the substrates naphthol AS-MX phosphate/Fast Blue or naphthol AS-HI phosphate/New Fuchsin, respectively. To ensure utmost specificity, we applied FlTC-conjugated mouse monoclonal antibodies and rabbit anti-FlTC immunoglobulins visualized by AP-labeled immunoglobulins and the respective substrate in a final step. This novel approach provides an excellent means for demonstration of immunocompetent cells and unequivocal determination of the percentage of specific cell subsets in infiltrated tissue. The advantages of this method, as compared with double immunofluorescence or double immunoenzymatic labeling, were investigated and are discussed. (J Histochem Cytochem 38:307-313, 1990)},
  language  = {en}
}
@article{GlaserSchultheisHazraetal.2014,
  author    = {Glaser, Jan and Schultheis, Martina and Hazra, Sudipta and Hazra, Banazri and Moll, Heidrun and Schurigt, Uta and Holzgrabe, Ulrike},
  title     = {Antileishmanial Lead Structures from Nature: Analysis of Structure-Activity Relationships of a Compound Library Derived from Caffeic Acid Bornyl Ester},
  doi       = {10.3390/molecules19021394},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-112835},
  year      = {2014},
  abstract  = {Bioassay-guided fractionation of a chloroform extract of Valeriana wallichii (V. wallichii) rhizomes lead to the isolation and identification of caffeic acid bornyl ester (1) as the active component against Leishmania major (L. major) promastigotes (IC50 = 48.8 µM). To investigate the structure-activity relationship (SAR), a library of compounds based on 1 was synthesized and tested in vitro against L. major and L. donovani promastigotes, and L. major amastigotes. Cytotoxicity was determined using a murine J774.1 cell line and bone marrow derived macrophages (BMDM). Some compounds showed antileishmanial activity in the concentration range of pentamidine and miltefosine which are the standard drugs in use. In the L. major amastigote assay compounds 15, 19 and 20 showed good activity with relatively low cytotoxicity against BMDM, resulting in acceptable selectivity indices. Molecules with adjacent phenolic hydroxyl groups exhibited elevated cytotoxicity against murine cell lines J774.1 and BMDM. The Michael system seems not to be essential for antileishmanial activity. Based on the results compound 27 can be regarded as new lead structure for further structure optimization},
  language  = {en}
}