@article{MontoyaPelaezSierraAlzateetal.2013,
  author    = {Montoya Pel{\´a}ez, Guillermo L. and Sierra, Jelver A. and Alzate, Fernando and Holzgrabe, Ulrike and Ramirez-Pineda, Jos{\´e} R.},
  title     = {Pentacyclic triterpenes from Cecropia telenitida with immunomodulatory activity on dendritic cells},
  series = {Revista Brasileira de Farmacognosia - Brazilian Journal of Pharmacognosy},
  volume    = {23},
  journal   = {Revista Brasileira de Farmacognosia - Brazilian Journal of Pharmacognosy},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-131851},
  pages     = {754-761},
  year      = {2013},
  abstract  = {Pentacyclic triterpenes are a large family of plant metabolites that exhibit a wide array of biological activities. The genus Cecropia, which encompasses many plant species, has been used as traditional medicine for the treatment of inflammatory diseases and is known to produce many active pentacyclic triterpenes. In this study we investigated the chemical composition of a pentacyclic triterpene fraction from the roots of Cecropia telenitida Cuatrec., Urticaceae. A novel compound, which we termed yarumic acid, and four known molecules (serjanic acid, spergulagenic acid A, 20-hydroxy-ursolic acid and goreishic acid I) were isolated and characterised. In a dendritic cell (DC)-based assay, we demonstrated that non-toxic doses of these pentacyclic triterpenes inhibited the secretion of at least one of the proinflammatory cytokines tested (IL-1 beta, IL-12p40, IL-12p70, TNF-alpha). Spergulagenic acid A also inhibited nitric oxide production in lipopolysaccharide-stimulated dendritic cell. Serjanic acid and spergulagenic acid A, which were the most potent abundant compounds in the pentacyclic triterpene fraction, showed the most activity in the dendritic cell-based assay. These results show that all pentacyclic triterpenes might contribute to the anti-inflammatory activities of C. telenitida. Moreover, yarumic acid as well as the four known pentacyclic triterpenes, can be exploited as potential immunomodulatory/anti-inflammatory agents.},
  language  = {en}
}
@article{GutierrezGiraldoDavilaCombarizaetal.2020,
  author    = {Guti{\´e}rrez, Gustavo and Giraldo-D{\´a}vila, Deisy and Combariza, Marianny Y. and Holzgrabe, Ulrike and Tabares-Guevara, Jorge Humberto and Ram{\´i}rez-Pineda, Jos{\´e} Robinson and Ac{\´i}n, Sergio and Mu{\~n}oz, Diana Lorena and Montoya, Guillermo and Balcazar, Norman},
  title     = {Serjanic acid improves immunometabolic markers in a diet-induced obesity mouse model},
  series = {Molecules},
  volume    = {25},
  journal   = {Molecules},
  number    = {7},
  issn      = {1420-3049},
  doi       = {10.3390/molecules25071486},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-203253},
  year      = {2020},
  abstract  = {Plant extracts from Cecropia genus have been used by Latin-American traditional medicine to treat metabolic disorders and diabetes. Previous reports have shown that roots of Cecropia telenitida that contains serjanic acid as one of the most prominent and representative pentacyclic triterpenes. The study aimed to isolate serjanic acid and evaluate its effect in a prediabetic murine model by oral administration. A semi-pilot scale extraction was established and serjanic acid purification was followed using direct MALDI-TOF analysis. A diet induced obesity mouse model was used to determine the impact of serjanic acid over selected immunometabolic markers. Mice treated with serjanic acid showed decreased levels of cholesterol and triacylglycerols, increased blood insulin levels, decreased fasting blood glucose and improved glucose tolerance, and insulin sensitivity. At transcriptional level, the reduction of inflammation markers related to adipocyte differentiation is reported.},
  language  = {en}
}
@article{PenagosCalveteDuqueMarimonetal.2019,
  author    = {Penagos-Calvete, Diana and Duque, Valeria and Marimon, Claudia and Parra, Diana M. and Restrepo-Arango, Sandra K. and Scherf-Clavel, Oliver and Holzgrabe, Ulrike and Montoya, Guillermo and Salamanca, Constain H.},
  title     = {Glycerolipid composition and advanced physicochemical considerations of sacha inchi oil toward cosmetic products formulation},
  series = {Cosmetics},
  volume    = {6},
  journal   = {Cosmetics},
  number    = {4},
  issn      = {2079-9284},
  doi       = {10.3390/cosmetics6040070},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-193857},
  year      = {2019},
  abstract  = {Sacha inchi oil is a premier raw material with highly nutritional and functional features for the foodstuff, pharmaceutical, beauty, and personal care industries. One of the most important facts about this oil is the huge chemical content of unsaturated and polyunsaturated fatty acids. However, the current available information on the characterization of the triglyceride composition and the advance physicochemical parameters relevant to emulsion development is limited. Therefore, this research focused on providing a detailed description of the lipid composition using high-resolution tandem mass spectrometry and thorough physicochemical characterization to find the value of the required hydrophilic-lipophilic balance (HLB). For this, a study in the interfacial tension was evaluated, followed by the assessment of different parameters such as creaming index, droplet size, viscosity, zeta potential, pH, and electrical conductivity for a series emulsified at thermal stress condition. The results show that fatty acids are arranged into glycerolipids and the required HLB to achieve the maximum physical stability is around 8.},
  language  = {en}
}