@article{ManchiaAdliAkulaetal.2013,
  author    = {Manchia, Mirko and Adli, Mazda and Akula, Nirmala and Arda, Raffaella and Aubry, Jean-Michel and Backlund, Lena and Banzato, Claudio E. M. and Baune, Bernhard T. and Bellivier, Frank and Bengesser, Susanne and Biernacka, Joanna M. and Brichant-Petitjean, Clara and Bui, Elise and Calkin, Cynthia V. and Cheng, Andrew Tai Ann and Chillotti, Caterina and Cichon, Sven and Clark, Scott and Czerski, Piotr M. and Dantas, Clarissa and Del Zompo, Maria and DePaulo, J. Raymond and Detera-Wadleigh, Sevilla D. and Etain, Bruno and Falkai, Peter and Fris{\´e}n, Louise and Frye, Mark A. and Fullerton, Jan and Gard, S{\´e}bastien and Garnham, Julie and Goes, Fernando S. and Grof, Paul and Gruber, Oliver and Hashimoto, Ryota and Hauser, Joanna and Heilbronner, Urs and Hoban, Rebecca and Hou, Liping and Jamain, St{\´e}phane and Kahn, Jean-Pierre and Kassem, Layla and Kato, Tadafumi and Kelsoe, John R. and Kittel-Schneider, Sarah and Kliwicki, Sebastian and Kuo, Po-Hsiu and Kusumi, Ichiro and Laje, Gonzalo and Lavebratt, Catharina and Leboyer, Marion and Leckband, Susan G. and L{\´o}pez Jaramillo, Carlos A. and Maj, Mario and Malafosse, Alain and Martinsson, Lina and Masui, Takuya and Mitchell, Philip B. and Mondimore, Frank and Monteleone, Palmiero and Nallet, Audrey and Neuner, Maria and Nov{\´a}k, Tom{\´a}s and O'Donovan, Claire and {\"O}sby, Urban and Ozaki, Norio and Perlis, Roy H. and Pfennig, Andrea and Potash, James B. and Reich-Erkelenz, Daniela and Reif, Andreas and Reininghaus, Eva and Richardson, Sara and Rouleau, Guy A. and Rybakowski, Janusz K. and Schalling, Martin and Schofield, Peter R. and Schubert, Oliver K. and Schweizer, Barbara and Seem{\"u}ller, Florian and Grigoroiu-Serbanescu, Maria and Severino, Giovanni and Seymour, Lisa R. and Slaney, Claire and Smoller, Jordan W. and Squassina, Alessio and Stamm, Thomas and Steele, Jo and Stopkova, Pavla and Tighe, Sarah K. and Tortorella, Alfonso and Turecki, Gustavo and Wray, Naomi R. and Wright, Adam and Zandi, Peter P. and Zilles, David and Bauer, Michael and Rietschel, Marcella and McMahon, Francis J. and Schulze, Thomas G. and Alda, Martin},
  title     = {Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report},
  series = {PLoS ONE},
  volume    = {8},
  journal   = {PLoS ONE},
  number    = {6},
  doi       = {10.1371/journal.pone.0065636},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-130938},
  pages     = {e65636},
  year      = {2013},
  abstract  = {Objective: The assessment of response to lithium maintenance treatment in bipolar disorder (BD) is complicated by variable length of treatment, unpredictable clinical course, and often inconsistent compliance. Prospective and retrospective methods of assessment of lithium response have been proposed in the literature. In this study we report the key phenotypic measures of the "Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder" scale currently used in the Consortium on Lithium Genetics (ConLiGen) study. Materials and Methods: Twenty-nine ConLiGen sites took part in a two-stage case-vignette rating procedure to examine inter-rater agreement [Kappa (\(\kappa\))] and reliability [intra-class correlation coefficient (ICC)] of lithium response. Annotated first-round vignettes and rating guidelines were circulated to expert research clinicians for training purposes between the two stages. Further, we analyzed the distributional properties of the treatment response scores available for 1,308 patients using mixture modeling. Results: Substantial and moderate agreement was shown across sites in the first and second sets of vignettes (\(\kappa\) = 0.66 and \(\kappa\) = 0.54, respectively), without significant improvement from training. However, definition of response using the A score as a quantitative trait and selecting cases with B criteria of 4 or less showed an improvement between the two stages (\(ICC_1 = 0.71\) and \(ICC_2 = 0.75\), respectively). Mixture modeling of score distribution indicated three subpopulations (full responders, partial responders, non responders). Conclusions: We identified two definitions of lithium response, one dichotomous and the other continuous, with moderate to substantial inter-rater agreement and reliability. Accurate phenotypic measurement of lithium response is crucial for the ongoing ConLiGen pharmacogenomic study.},
  language  = {en}
}
@article{GrabenhenrichReichFischeretal.2014,
  author    = {Grabenhenrich, Linus B. and Reich, Andreas and Fischer, Felix and Zepp, Fred and Forster, Johannes and Schuster, Antje and Bauer, Carl-Peter and Bergmann, Renate L. and Bergmann, Karl E. and Wahn, Ulrich and Keil, Thomas and Lau, Susanne},
  title     = {The Novel 10-Item Asthma Prediction Tool: External Validation in the German MAS Birth Cohort},
  series = {PLOS ONE},
  volume    = {9},
  journal   = {PLOS ONE},
  number    = {12},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0115852},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-114202},
  pages     = {e115852},
  year      = {2014},
  abstract  = {Background: A novel non-invasive asthma prediction tool from the Leicester Cohort, UK, forecasts asthma at age 8 years based on 10 predictors assessed in early childhood, including current respiratory symptoms, eczema, and parental history of asthma. Objective: We aimed to externally validate the proposed asthma prediction method in a German birth cohort. Methods: The MAS-90 study (Multicentre Allergy Study) recorded details on allergic diseases prospectively in about yearly follow-up assessments up to age 20 years in a cohort of 1,314 children born 1990. We replicated the scoring method from the Leicester cohort and assessed prediction, performance and discrimination. The primary outcome was defined as the combination of parent-reported wheeze and asthma drugs (both in last 12 months) at age 8. Sensitivity analyses assessed model performance for outcomes related to asthma up to age 20 years. Results: For 140 children parents reported current wheeze or cough at age 3 years. Score distribution and frequencies of later asthma resembled the Leicester cohort: 9\% vs. 16\% (MAS-90 vs. Leicester) of children at low risk at 3 years had asthma at 8 years, at medium risk 45\% vs. 48\%. Performance of the asthma prediction tool in the MAS-90 cohort was similar (Brier score 0.22 vs. 0.23) and discrimination slightly better than in the original cohort (area under the curve, AUC 0.83 vs. 0.78). Prediction and discrimination were robust against changes of inclusion criteria, scoring and outcome definitions. The secondary outcome 'physicians' diagnosed asthma at 20 years' showed the highest discrimination (AUC 0.89). Conclusion: The novel asthma prediction tool from the Leicester cohort, UK, performed well in another population, a German birth cohort, supporting its use and further development as a simple aid to predict asthma risk in clinical settings.},
  language  = {en}
}
@phdthesis{Reich2023,
  author    = {Reich, Susanne},
  title     = {Der Erwerb prosodischer Grundbausteine im Rahmen der vorsprachlichen Entwicklung - Schreieigenschaften Neugeborener von M{\"u}ttern mit einer Tonakzentsprache (Japanisch) oder einer tonalen Sprache (Lamnso)},
  doi       = {10.25972/OPUS-29896},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-298963},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2023},
  abstract  = {Das Ziel der vorliegenden Arbeit war es, intervallartige Strukturen in Melodien von Neugeborenenlauten der ersten Lebenswoche in unterschiedlichen Umgebungssprachen zu identifizieren und quantitativ zu untersuchen. Es wurden Neugeborene von M{\"u}ttern mit einer Tonakzentsprache (Japanisch) und einer tonalen Sprache (Lamnso) untersucht und die Befunde miteinander verglichen. Die Frage nach einem sprachlichen Einfluss auf die Auftrittsh{\"a}ufigkeit und die Eigenschaften von Melodieintervallen im Weinen standen im Fokus der Arbeit. Dabei sollte auch die Komplexit{\"a}t der Melodieintervalle bez{\"u}glich eines sprachlichen Einflusses untersucht werden. Neben diesen H{\"a}ufigkeitsanalysen wurden auch temporale Eigenschaften der gefundenen Intervalle sowie die Intervallgr{\"o}ßen ermittelt. Nach einer strengen Vorselektion des Gesamtdatenkorpus von 1664 Einzellauten von 40 Probanden (20 Neugeborene der Nso, 20 japanische Neugeborene) wurden 1213 geeignete Melodien auf Intervalle untersucht und die Ergebnisse verglichen. Langfristig sollen so potenzielle Risikomarker zur nicht-invasiven vorsprachlichen Diagnostik von Sprech- und Sprachentwicklungsst{\"o}rungen gefunden werden. In der Auftrittsh{\"a}ufigkeit von Melodieintervallen zeigten sich keine signifikanten Sprachgruppenunterschiede zwischen japanischen Neugeborenen und den Neugeborenen der Nso. Dies wurde mit einer physiologischen Eigenschaft als Ausdruck der Reife des laryngealen Regelsystems in diesem fr{\"u}hen Alter interpretiert. Der Einfluss der tonalen Sprache zeigte sich aber in der Auftrittsh{\"a}ufigkeit komplexer Intervalle in der Sprachgruppe Lamnso, die in Anwendung eines verallgemeinerten linearen gemischten Modells signifikant gr{\"o}ßer war als bei den japanischen Neugeborenen. Die Komplexit{\"a}t der Intervalle, die durch den Intervallkomplexit{\"a}tsindex (ICI) ausgedr{\"u}ckt wurde, zeigte auf Neugeborenenlevel einen signifikanten Unterschied, in der Sprachgruppe Lamnso wurden mehr komplexe Melodieintervalle gefunden. Die temporalen Eigenschaften zeigten teilweise signifikante Unterschiede. Diese betrafen die L{\"a}ngenverh{\"a}ltnisse der Plateaul{\"a}ngen und die Frequenzverh{\"a}ltnisse der Plateaus. Die Frequenzverh{\"a}ltnisse (Intervallgr{\"o}ße) ergaben sehr {\"a}hnliche Befunde. Das vorherrschende Melodieintervall im spontanen Weinen der Neugeborenen beider Sprachgruppen war das Einzelintervall der Gr{\"o}ße eines Halbtons. Zusammenfassend kann man sagen, dass Melodieintervalle bei gesunden Neugeborenen bereits in der ersten Lebenswoche regelhaft auftreten. Sprachliche Besonderheiten der vokalen Regelleistung scheinen sich in der Komplexit{\"a}t der Melodieintervalle zu zeigen.},
  subject      = {Intervall},
  language  = {de}
}