@article{Stein1992,
  author    = {Stein, Roland},
  title     = {Zur Raumvorstellungs-F{\"a}higkeit Lernbeeintr{\"a}chtigter - eine Untersuchung mit dem LPS-Untertest 8},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40137},
  year      = {1992},
  abstract  = {Die hier untersuchten Lernbeeintr{\"a}chtigten, die eine vereinfachte Ausbildung zum Dreher oder Fr{\"a}ser absolvieren, liegen bereits zu Ausbildungsbeginn hinsichtlich der Gruppen-Ergebnisse im LPS-Untertest 82, der das r{\"a}umliche Vorstellen untersucht, gemessen an der Eichstichprobe gut im Bev{\"o}lkerungsdurchschnitt. Es wurde vergleichend eine Variante des LPS-8 eingesetzt, die eine Erleichterung f{\"u}r die Probanden bedeuten sollte. Sie erbrachte jedoch keine Verbesserung der Testergebnisse. Die Durchf{\"u}hrung einer "power" -Variante des Tests bel{\"a}ßt f{\"u}r einen Teil der Stichprobe die Rangreihen, verglichen mit einer Durchf{\"u}hrung der Original-( speed)Version, auf signifikantem Niveau gleich. F{\"u}r einen zweiten Teil der Stichprobe findet sich diese Signifikanz allerdings nicht.},
  subject      = {Sonderp{\"a}dagogik},
  language  = {de}
}
@article{KleberStein1993,
  author    = {Kleber, Eduard W. and Stein, Roland},
  title     = {Konzentrationsprobleme: Fehldiagnose oder Zeitkrankheit?},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40116},
  year      = {1993},
  abstract  = {Konzentration ist ein psychologisches Konstrukt, das hochkomplexe Interaktions-Situations-Ph{\"a}nomene bezeichnet. Die hohe Komplexit{\"a}t l{\"a}ßt unmittelbare Folgerungen f{\"u}r therapeutische Maßnahmen nicht zu und enth{\"a}lt spezielle Probleme der Validit{\"a}t bei niedrigen Leistungswerten in Tests. Die Diagnose von Konzentrationsproblemen dient nicht selten Lehrern, Sch{\"u}lern und Eltern als Entlastung. Dabeif{\"u}hren oberfl{\"a}chliche Analysen oft zu Mißverst{\"a}ndnissen und Fehldiagnosen. Bei solchen Diagnosen werden dann Konzentration, Interesse, Motivation, Belastbarkeit, "aus dem Felde gehen" und "auswandern" konfundiert. Ohne eine sorgf{\"a}ltige und m{\"o}glichst umfassende Analyse der Aufmerksamkeitssituation k{\"o}nnen Maßnahmen zur Beseitigung oder Reduktion der Schwierigkeiten nicht effektiv ausgew{\"a}hlt werden.},
  subject      = {Sonderp{\"a}dagogik},
  language  = {de}
}
@article{Stein1994,
  author    = {Stein, Roland},
  title     = {Lernbeeintr{\"a}chtigte nach der Schule - Arbeit oder Sozialhilfe? : Erfahrungen aus der Berufsausbildung ehemaliger Sondersch{\"u}ler},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40091},
  year      = {1994},
  abstract  = {Nach der Schulzeit droht Lernbeeintr{\"a}chtigten durch die allgemeine Entwicklung auf dem Arbeits- und Ausbildungsmarkt eine schwierige Berufsfindung, hochgradig unbefriedigende Hilfsarbeiter-T{\"a}tigkeit und - in erheblich zunehmendem Maße - Arbeitslosigkeit und der Verlust von Lebensperspektiven. Der Beitrag zeigt M{\"o}glichkeiten und Grenzen der qualifizierten und zukunfts orientierten Berufsausbildung dieser Gruppe auf, wobei sowohl moderne technologische Entwicklungen als auch die F{\"o}rderung personaler und sozialer Kompetenzen Ber{\"u}cksichtigung finden. Die Fragestellung der Integration Lernbeeintr{\"a}chtigter wird nicht mit der Schulzeit abgeschlossen - sie stellt sich umso st{\"a}rker danach.},
  subject      = {Sonderp{\"a}dagogik / Zeitschrift},
  language  = {de}
}
@incollection{KleberStein1991,
  author    = {Kleber, Eduard W. and Stein, Roland},
  title     = {Neue Wege f{\"u}r die Integration Lernbehinderter ins Berufsleben},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40127},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1991},
  abstract  = {No abstract available},
  subject      = {Integrationsp{\"a}dagogik / Deutsches Sprachgebiet / Kongress / Saarbr{\"u}cken <1990>},
  language  = {de}
}
@incollection{Stein1994,
  author    = {Stein, Roland},
  title     = {Werkstatt f{\"u}r Behinderte},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40239},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Sonderp{\"a}dagogik / W{\"o}rterbuch},
  language  = {de}
}
@incollection{Stein1994,
  author    = {Stein, Roland},
  title     = {Verhaltensauff{\"a}lligkeit},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40222},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Sonderp{\"a}dagogik / W{\"o}rterbuch},
  language  = {de}
}
@article{KleberStein1991,
  author    = {Kleber, Eduard W. and Stein, Roland},
  title     = {Neue Wege in die moderne Berufswelt},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40157},
  year      = {1991},
  abstract  = {No abstract available},
  language  = {de}
}
@article{KleberStein1991,
  author    = {Kleber, Eduard W. and Stein, Roland},
  title     = {Neue Wege in die moderne Berufswelt},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40105},
  year      = {1991},
  abstract  = {In Hessen wurde 1989 ein Modellversuch zum Einsatz neuer Technologien in der Berufsausbildung lernbehinderter Jugendlicher gestartet. Die Chancen Lernbehinderter f{\"u}r qualifizierte Arbeitspl{\"a}tze im Bereich Metall der Fachrichtungen Drehen, Fr{\"a}sen und Produktionstechnik sollen dadurch verbessert werden.},
  subject      = {Sonderp{\"a}dagogik},
  language  = {de}
}
@article{DiessnerWischnewskyStueberetal.2016,
  author    = {Diessner, Joachim and Wischnewsky, Manfred and St{\"u}ber, Tanja and Stein, Roland and Krockenberger, Mathias and H{\"a}usler, Sebastian and Janni, Wolfgang and Kreienberg, Rolf and Blettner, Maria and Schwentner, Lukas and W{\"o}ckel, Achim and Bartmann, Catharina},
  title     = {Evaluation of clinical parameters influencing the development of bone metastasis in breast cancer},
  series = {BMC Cancer},
  volume    = {16},
  journal   = {BMC Cancer},
  number    = {307},
  doi       = {10.1186/s12885-016-2345-7},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-161173},
  year      = {2016},
  abstract  = {Background The development of metastases is a negative prognostic parameter for the clinical outcome of breast cancer. Bone constitutes the first site of distant metastases for many affected women. The purpose of this retrospective multicentre study was to evaluate if and how different variables such as primary tumour stage, biological and histological subtype, age at primary diagnosis, tumour size, the number of affected lymph nodes as well as grading influence the development of bone-only metastases. Methods This retrospective German multicentre study is based on the BRENDA collective and included 9625 patients with primary breast cancer recruited from 1992 to 2008. In this analysis, we investigated a subgroup of 226 patients with bone-only metastases. Association between bone-only relapse and clinico-pathological risk factors was assessed in multivariate models using the tree-building algorithms "exhausted CHAID (Chi-square Automatic Interaction Detectors)" and CART(Classification and Regression Tree), as well as radial basis function networks (RBF-net), feedforward multilayer perceptron networks (MLP) and logistic regression. Results Multivariate analysis demonstrated that breast cancer subtypes have the strongest influence on the development of bone-only metastases (χ2 = 28). 29.9 \% of patients with luminal A or luminal B (ABC-patients) and 11.4 \% with triple negative BC (TNBC) or HER2-overexpressing tumours had bone-only metastases (p < 0.001). Five different mathematical models confirmed this correlation. The second important risk factor is the age at primary diagnosis. Moreover, BC subcategories influence the overall survival from date of metastatic disease of patients with bone-only metastases. Patients with bone-only metastases and TNBC (p < 0.001; HR = 7.47 (95 \% CI: 3.52-15.87) or HER2 overexpressing BC (p = 0.007; HR = 3.04 (95 \% CI: 1.36-6.80) have the worst outcome compared to patients with luminal A or luminal B tumours and bone-only metastases. Conclusion The bottom line of different mathematical models is the prior importance of subcategories of breast cancer and the age at primary diagnosis for the appearance of osseous metastases. The primary tumour stage, histological subtype, tumour size, the number of affected lymph nodes, grading and NPI seem to have only a minor influence on the development of bone-only metastases.},
  language  = {en}
}
@article{SteinWollschlaegerKreienbergetal.2016,
  author    = {Stein, Roland Gregor and Wollschl{\"a}ger, Daniel and Kreienberg, Rolf and Janni, Wolfgang and Wischnewsky, Manfred and Diessner, Joachim and St{\"u}ber, Tanja and Bartmann, Catharina and Krockenberger, Mathias and Wischhusen, J{\"o}rg and W{\"o}ckel, Achim and Blettner, Maria and Schwentner, Lukas},
  title     = {The impact of breast cancer biological subtyping on tumor size assessment by ultrasound and mammography - a retrospective multicenter cohort study of 6543 primary breast cancer patients},
  series = {BMC Cancer},
  volume    = {16},
  journal   = {BMC Cancer},
  number    = {549},
  doi       = {10.1186/s12885-016-2426-7},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-161050},
  year      = {2016},
  abstract  = {Background Mammography and ultrasound are the gold standard imaging techniques for preoperative assessment and for monitoring the efficacy of neoadjuvant chemotherapy in breast cancer. Maximum accuracy in predicting pathological tumor size non-invasively is critical for individualized therapy and surgical planning. We therefore aimed to assess the accuracy of tumor size measurement by ultrasound and mammography in a multicentered health services research study. Methods We retrospectively analyzed data from 6543 patients with unifocal, unilateral primary breast cancer. The maximum tumor diameter was measured by ultrasound and/or mammographic imaging. All measurements were compared to final tumor diameter determined by postoperative histopathological examination. We compared the precision of each imaging method across different patient subgroups as well as the method-specific accuracy in each patient subgroup. Results Overall, the correlation with histology was 0.61 for mammography and 0.60 for ultrasound. Both correlations were higher in pT2 cancers than in pT1 and pT3. Ultrasound as well as mammography revealed a significantly higher correlation with histology in invasive ductal compared to lobular cancers (p < 0.01). For invasive lobular cancers, the mammography showed better correlation with histology than ultrasound (p = 0.01), whereas there was no such advantage for invasive ductal cancers. Ultrasound was significantly superior for HR negative cancers (p < 0.001). HER2/neu positive cancers were also more precisely assessed by ultrasound (p < 0.001). The size of HER2/neu negative cancers could be more accurately predicted by mammography (p < 0.001). Conclusion This multicentered health services research approach demonstrates that predicting tumor size by mammography and ultrasound provides accurate results. Biological tumor features do, however, affect the diagnostic precision.},
  language  = {en}
}
@article{DiessnerWischnewskyBlettneretal.2016,
  author    = {Diessner, Joachim and Wischnewsky, Manfred and Blettner, Maria and H{\"a}usler, Sebastian and Janni, Wolfgang and Kreienberg, Rolf and Stein, Roland and St{\"u}ber, Tanja and Schwentner, Lukas and Bartmann, Catharina and W{\"o}ckel, Achim},
  title     = {Do Patients with Luminal A Breast Cancer Profit from Adjuvant Systemic Therapy? A Retrospective Multicenter Study},
  series = {PLoS ONE},
  volume    = {11},
  journal   = {PLoS ONE},
  number    = {12},
  doi       = {10.1371/journal.pone.0168730},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-178217},
  year      = {2016},
  abstract  = {Background Luminal A breast cancers respond well to anti-hormonal therapy (HT), are associated with a generally favorable prognosis and constitute the majority of breast cancer subtypes. HT is the mainstay of treatment of these patients, accompanied by an acceptable profile of side effects, whereas the added benefit of chemotherapy (CHT), including anthracycline and taxane-based programs, is less clear-cut and has undergone a process of critical revision. Methods In the framework of the BRENDA collective, we analyzed the benefits of CHT compared to HT in 4570 luminal A patients (pts) with primary diagnosis between 2001 and 2008. The results were adjusted by nodal status, age, tumor size and grading. Results There has been a progressive reduction in the use of CHT in luminal A patients during the last decade. Neither univariate nor multivariate analyses showed any statistically significant differences in relapse free survival (RFS) with the addition of CHT to adjuvant HT, independent of the nodal status, age, tumor size or grading. Even for patients with more than 3 affected lymph nodes, there was no significant difference (univariate: p = 0.865; HR 0.94; 95\% CI: 0.46-1.93; multivariate: p = 0.812; HR 0.92; 95\% CI: 0.45-1.88). Conclusions The addition of CHT to HT provides minimal or no clinical benefit at all to patients with luminal A breast cancer, independent of the RFS-risk. Consequently, risk estimation cannot be the initial step in the decisional process. These findings-that are in line with several publications-should encourage the critical evaluation of applying adjuvant CHT to patients with luminal A breast cancer.},
  language  = {en}
}
@article{LopezKleinheinzAukemaetal.2019,
  author    = {L{\´o}pez, Cristina and Kleinheinz, Kortine and Aukema, Sietse M. and Rohde, Marius and Bernhart, Stephan H. and H{\"u}bschmann, Daniel and Wagener, Rabea and Toprak, Umut H. and Raimondi, Francesco and Kreuz, Markus and Waszak, Sebastian M. and Huang, Zhiqin and Sieverling, Lina and Paramasivam, Nagarajan and Seufert, Julian and Sungalee, Stephanie and Russell, Robert B. and Bausinger, Julia and Kretzmer, Helene and Ammerpohl, Ole and Bergmann, Anke K. and Binder, Hans and Borkhardt, Arndt and Brors, Benedikt and Claviez, Alexander and Doose, Gero and Feuerbach, Lars and Haake, Andrea and Hansmann, Martin-Leo and Hoell, Jessica and Hummel, Michael and Korbel, Jan O. and Lawerenz, Chris and Lenze, Dido and Radlwimmer, Bernhard and Richter, Julia and Rosenstiel, Philip and Rosenwald, Andreas and Schilhabel, Markus B. and Stein, Harald and Stilgenbauer, Stephan and Stadler, Peter F. and Szczepanowski, Monika and Weniger, Marc A. and Zapatka, Marc and Eils, Roland and Lichter, Peter and Loeffler, Markus and M{\"o}ller, Peter and Tr{\"u}mper, Lorenz and Klapper, Wolfram and Hoffmann, Steve and K{\"u}ppers, Ralf and Burkhardt, Birgit and Schlesner, Matthias and Siebert, Reiner},
  title     = {Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma},
  series = {Nature Communications},
  volume    = {10},
  journal   = {Nature Communications},
  organization    = {ICGC MMML-Seq Consortium},
  doi       = {10.1038/s41467-019-08578-3},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-237281},
  year      = {2019},
  abstract  = {Burkitt lymphoma (BL) is the most common B-cell lymphoma in children. Within the International Cancer Genome Consortium (ICGC), we performed whole genome and transcriptome sequencing of 39 sporadic BL. Here, we unravel interaction of structural, mutational, and transcriptional changes, which contribute to MYC oncogene dysregulation together with the pathognomonic IG-MYC translocation. Moreover, by mapping IGH translocation breakpoints, we provide evidence that the precursor of at least a subset of BL is a B-cell poised to express IGHA. We describe the landscape of mutations, structural variants, and mutational processes, and identified a series of driver genes in the pathogenesis of BL, which can be targeted by various mechanisms, including IG-non MYC translocations, germline and somatic mutations, fusion transcripts, and alternative splicing.},
  language  = {en}
}