@article{KlinkSauerKoerberetal.2015,
  author    = {Klink, Thomas and Sauer, Johannes and K{\"o}rber, Norbert J and Grehn, Franz and Much, Martin M and Thederan, Luisa and Matlach, Juliane and Salgado, Josefina Parente},
  title     = {Quality of life following glaucoma surgery: canaloplasty versus trabeculectomy},
  series = {Clinical Ophthalmology},
  volume    = {9},
  journal   = {Clinical Ophthalmology},
  doi       = {10.2147/OPTH.S72357},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-149520},
  pages     = {7-16},
  year      = {2015},
  abstract  = {Purpose: To evaluate quality of life (QoL) with a new questionnaire after canaloplasty (CP) and trabeculectomy (TE). Patients and methods: We assessed outcomes of surgery, rate of revision surgeries, patients' mood, and influence of postoperative care on QoL, surgery interference with daily activities, and postsurgical complaints. Patients completed the QoL questionnaire 24 months after surgery. Results: Patients who underwent CP (n=175) were compared to TE patients (n=152). In the CP group, 57\% of patients expressed high satisfaction, while 41\% of patients in the TE group said they were highly satisfied. The satisfaction difference was statistically significant (P=0.034). Significantly fewer second surgeries were needed after CP (8\% CP versus 35\% TE, P<0.001). Patients were more positive in the CP group (54\% CP versus 37\% TE, P<0.009). Stress related to postoperative care was lower in the CP group compared to the TE group (14\% versus 46\%). Difficulties with activities of daily living, such as reading, were much lower or even nonexistent after CP, and complaints like eye burning or stinging were significantly lower in the CP group. Conclusions: Compared with TE, CP is associated with less QoL impairment and higher patient satisfaction after surgery. However, long-term data on intraocular pressure reduction after surgery are needed to confirm long-term patient satisfaction with this surgery.},
  language  = {en}
}
@article{MayerRabindranathBoerneretal.2013,
  author    = {Mayer, Matthias and Rabindranath, Raman and B{\"o}rner, Juliane and H{\"o}rner, Eva and Bentz, Alexander and Salgado, Josefina and Han, Hong and B{\"o}se, Holger and Probst, J{\"o}rn and Shamonin, Mikhail and Monkman, Gereth J. and Schlunck, G{\"u}nther},
  title     = {Ultra-Soft PDMS-Based Magnetoactive Elastomers as Dynamic Cell Culture Substrata},
  series = {PLOS ONE},
  volume    = {8},
  journal   = {PLOS ONE},
  number    = {10},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0076196},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128246},
  pages     = {e76196},
  year      = {2013},
  abstract  = {Mechanical cues such as extracellular matrix stiffness and movement have a major impact on cell differentiation and function. To replicate these biological features in vitro, soft substrata with tunable elasticity and the possibility for controlled surface translocation are desirable. Here we report on the use of ultra-soft (Young's modulus <100 kPa) PDMS-based magnetoactive elastomers (MAE) as suitable cell culture substrata. Soft non-viscous PDMS (<18 kPa) is produced using a modified extended crosslinker. MAEs are generated by embedding magnetic microparticles into a soft PDMS matrix. Both substrata yield an elasticity-dependent (14 vs. 100 kPa) modulation of alpha-smooth muscle actin expression in primary human fibroblasts. To allow for static or dynamic control of MAE material properties, we devise low magnetic field (approximate to 40 mT) stimulation systems compatible with cell-culture environments. Magnetic field-instigated stiffening (14 to 200 kPa) of soft MAE enhances the spreading of primary human fibroblasts and decreases PAX-7 transcription in human mesenchymal stem cells. Pulsatile MAE movements are generated using oscillating magnetic fields and are well tolerated by adherent human fibroblasts. This MAE system provides spatial and temporal control of substratum material characteristics and permits novel designs when used as dynamic cell culture substrata or cell culture-coated actuator in tissue engineering applications or biomedical devices.},
  language  = {en}
}
@article{KlinkSauerKoerberetal.2014,
  author    = {Klink, Thomas and Sauer, Johannes and K{\"o}rber, Norbert J. and Grehn, Franz and Much, Martin M. and Thederan, Luisa and Matlach, Juliane and Salgado, Josefina Parente},
  title     = {Quality of life following glaucoma surgery: canaloplasty versus trabeculectomy},
  doi       = {10.2147/OPTH.S72357},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-113596},
  year      = {2014},
  abstract  = {Purpose: To evaluate quality of life (QoL) with a new questionnaire after canaloplasty (CP) and trabeculectomy (TE). Patients and methods: We assessed outcomes of surgery, rate of revision surgeries, patients' mood, and influence of postoperative care on QoL, surgery interference with daily activities, and postsurgical complaints. Patients completed the QoL questionnaire 24 months after surgery. Results: Patients who underwent CP (n=175) were compared to TE patients (n=152). In the CP group, 57\% of patients expressed high satisfaction, while 41\% of patients in the TE group said they were highly satisfied. The satisfaction difference was statistically significant (P=0.034). Significantly fewer second surgeries were needed after CP (8\% CP versus 35\% TE, P<0.001). Patients were more positive in the CP group (54\% CP versus 37\% TE, P<0.009). Stress related to postoperative care was lower in the CP group compared to the TE group (14\% versus 46\%). Difficulties with activities of daily living, such as reading, were much lower or even nonexistent after CP, and complaints like eye burning or stinging were significantly lower in the CP group. Conclusions: Compared with TE, CP is associated with less QoL impairment and higher patient satisfaction after surgery. However, long-term data on intraocular pressure reduction after surgery are needed to confirm long-term patient satisfaction with this surgery.},
  language  = {en}
}