@article{WiegeringSchlegelWinkleretal.2015,
  author    = {Wiegering, V. and Schlegel, P. G. and Winkler, B. and Lazarus, M. and Wirth, C. and Ernestus, K. and Walles, T. and Liese, J.},
  title     = {Persisting Cough as the Single Presenting Symptom of an Intrathoracic Tumor in a Nine-Month-Old Child with Adenovirus Airway Infection},
  series = {Journal of Case Reports and Studies},
  volume    = {3},
  journal   = {Journal of Case Reports and Studies},
  number    = {2},
  doi       = {10.15744/2348-9820.2.504},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-125536},
  pages     = {204},
  year      = {2015},
  abstract  = {We report on a nine-month-old girl who presented with persisting cough, and diminished ventilation of the left hemithorax. Viral pneumonia was suspected after Adenovirus detection by PCR, but chest X-rays showed a persistent shadowing of the left hemithorax and persistent coughing despite clinical improvement. Because of the discrepancy between clinical and radiological signs further investigations by ultrasound and CT scan were performed, which visualized an intrathroracic tumor. Histopathology confirmed diagnosis of a teratoma. This case highlights the need for careful evaluation by the treating physicians. If the chest X-ray provides a discrepancy to the clinical findings or persistent pathologies exist, differential diagnosis should be discussed and further diagnostics be performed.},
  language  = {en}
}
@article{RadakovicReboredoHelmetal.2017,
  author    = {Radakovic, D. and Reboredo, J. and Helm, M. and Weigel, T. and Sch{\"u}rlein, S. and Kupczyk, E. and Leyh, R. G. and Walles, H. and Hansmann, J.},
  title     = {A multilayered electrospun graft as vascular access for hemodialysis},
  series = {PLoS ONE},
  volume    = {12},
  journal   = {PLoS ONE},
  number    = {10},
  doi       = {10.1371/journal.pone.0185916},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-159102},
  pages     = {e0185916},
  year      = {2017},
  abstract  = {Despite medical achievements, the number of patients with end-stage kidney disease keeps steadily raising, thereby entailing a high number of surgical and interventional procedures to establish and maintain arteriovenous vascular access for hemodialysis. Due to vascular disease, aneurysms or infection, the preferred access—an autogenous arteriovenous fistula—is not always available and appropriate. Moreover, when replacing small diameter blood vessels, synthetic vascular grafts possess well-known disadvantages. A continuous multilayered gradient electrospinning was used to produce vascular grafts made of collagen type I nanofibers on luminal and adventitial graft side, and poly-ɛ-caprolactone as medial layer. Therefore, a custom-made electrospinner with robust environmental control was developed. The morphology of electrospun grafts was characterized by scanning electron microscopy and measurement of mechanical properties. Human microvascular endothelial cells were cultured in the graft under static culture conditions and compared to cultures obtained from dynamic continuous flow bioreactors. Immunofluorescent analysis showed that endothelial cells form a continuous luminal layer and functional characteristics were confirmed by uptake of acetylated low-density-lipoprotein. Incorporation of vancomycin and gentamicin to the medial graft layer allowed antimicrobial inhibition without exhibiting an adverse impact on cell viability. Most striking a physiological hemocompatibility was achieved for the multilayered grafts.},
  language  = {en}
}