@article{RohlfingLuekeLiszkowskietal.2022,
  author    = {Rohlfing, Katharina J. and L{\"u}ke, Carina and Liszkowski, Ulf and Ritterfeld, Ute and Grimminger, Angela},
  title     = {Developmental paths of pointing for various motives in infants with and without language delay},
  series = {International Journal of Environmental Research and Public Health},
  volume    = {19},
  journal   = {International Journal of Environmental Research and Public Health},
  number    = {9},
  issn      = {1660-4601},
  doi       = {10.3390/ijerph19094982},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-270727},
  year      = {2022},
  abstract  = {Pointing is one of the first conventional means of communication and infants have various motives for engaging in it such as imperative, declarative, or informative. Little is known about the developmental paths of producing and understanding these different motives. In our longitudinal study (N = 58) during the second year of life, we experimentally elicited infants' pointing production and comprehension in various settings and under pragmatically valid conditions. We followed two steps in our analyses and assessed the occurrence of canonical index-finger pointing for different motives and the engagement in an ongoing interaction in pursuit of a joint goal revealed by frequency and multimodal utterances. For understanding the developmental paths, we compared two groups: typically developing infants (TD) and infants who have been assessed as having delayed language development (LD). Results showed that the developmental paths differed according to the various motives. When comparing the two groups, for all motives, LD infants produced index-finger pointing 2 months later than TD infants. For the engagement, although the pattern was less consistent across settings, the frequency of pointing was comparable in both groups, but infants with LD used less canonical forms of pointing and made fewer multimodal contributions than TD children.},
  language  = {en}
}
@article{BartholdJurkutatGoetzetal.2023,
  author    = {Barthold, Martina and Jurkutat, Anne and Goetz, Regina and Schubring, Lucia and Spiegler, Juliane and Fries, Ann-Sophie and Kiesel, Lucia and Klepper, Joerg},
  title     = {Timing of ketogenic dietary therapy (KDT) introduction and its impact on cognitive profiles in children with Glut1-DS — a preliminary study},
  series = {Children},
  volume    = {10},
  journal   = {Children},
  number    = {4},
  issn      = {2227-9067},
  doi       = {10.3390/children10040681},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-313569},
  year      = {2023},
  abstract  = {The aim of this research was to characterize cognitive abilities in patients with Glut1-Deficiency syndrome (Glut1DS) following ketogenic diet therapy (KDT). Methods: The cognitive profiles of eight children were assessed using the Wechsler Intelligence Scale (WISC-IV). The effect of ketogenic diet therapy (KDT) on individual subareas of intelligence was analyzed considering the potential influence of speech motor impairments. Results: Patients with Glut1DS showed a wide range of cognitive performance levels. Some participants showed statistically and clinically significant discrepancies between individual subdomains of intelligence. Both variables, KDT initiation as well as duration, had a positive effect on the overall IQ score. Significant correlations were partially found between the time of KDT initiation and the level of IQ scores, depending on the presence of expressive language test demands of the respective subtests of the WISC-IV. Accordingly, the participants benefited les in the linguistic cognitive domain. The discrepancies in cognitive performance profiles of patients with Glut1DS can be attributed to the possibility of a negative distortion of the results due to the influence of speech motor impairments. Conclusions: The individual access skills of test persons should be more strongly considered in test procedures for the assessment of intelligence to reduce the negative influence of motor deficits on test performance. Specific characterization and systematization of the speech disorder are indispensable for determining the severity of speech motor impairment in Glut1DS. Therefore, a stronger focus on dysarthria during diagnosis and therapy is necessary.},
  language  = {en}
}