@misc{OPUS4-6520,
  title     = {einBlick - Ausgabe 13 - 02. April 2013},
  volume    = {13/2013},
  organization    = {Julius-Maximilians-Universit{\"a}t W{\"u}rzburg},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-77233},
  year      = {2013},
  abstract  = {Nachrichten aus der Julius-Maximilians-Universit{\"a}t W{\"u}rzburg},
  subject      = {W{\"u}rzburg},
  language  = {de}
}
@phdthesis{Niederlechner2013,
  author    = {Niederlechner, Stefanie},
  title     = {Assessment of the basic molecular mechanisms underlying L-glutamine's cytoprotective effects after intestinal injury},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-77399},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2013},
  abstract  = {Critical illness like sepsis, shock, and intestinal bowel disease are one of the leading causes of morbidity and mortality in the US and around the world. At present, studies to define new therapeutic interventions that can protect tissues and cells against injury and attenuate inflammation are fields of intense investigation. While research over the past decade has clearly identified GLN as a vital stress substrate facilitating cellular survival following injury, the initiation steps in GLN's cytoprotective molecular mechanism still remain elusive. Previously published work suggested that stabilization of ECM proteins and activation of ECM receptor osmosignaling may play a central role in the orchestration of many cellular pathways following stress. Thus, I hypothesized that preservation of ECM protein and EGFR levels as well as ECM receptor signaling play key roles in the molecular mechanisms underlying GLN's protection against thermal injury in the intestine. I was able to confirm via Western blotting and by using silencing RNA against FN, Ntn-1, EGFR, and their negative controls, that GLN-mediated preservation of FN, Ntn-1, and EGFR levels is critical in GLN's protection against hyperthermia in IEC-6 cells. By using a selective FN-Integrin interaction inhibitor GRGDSP, its negative control peptide GRGESP, and Src-kinase inhibitor PP2, I showed that FN-Integrin signaling and Src-kinase activation are essential in GLN-mediated protection in the intestine. This applied to EGFR signaling as demonstrated using the EGFR tyrosine kinase inhibitor AG1478. In addition to GRGDSP and AG1478, ERK1/2 inhibitors PD98059 and UO126 as well as the p38MAPK inhibitor SB203580 revealed that GLN is protective by activating ERK1/2 and dephosphorylating p38MAPK via FN-Integrin and EGFR signaling. However, GLN-mediated PI3-K/Akt/Hsp70 activation seems to occur independently of FN-Integrin and EGFR signaling as indicated by Western blots as well as experiments using the PI3-K inhibitor LY294002, GRGDSP, and AG1478. The results showed that GLN activates cell survival signaling pathways via integrins as well as EGFRs after hyperthermia. Moreover, I found that GLN-mediated preservation of FN expression after HS is regulated via PI3-K signaling. Whether GLN-mediated PI3-K signaling happens simultaneously to FN-Integrin and EGFR signaling or whether PI3-K signaling coordinates FN-Integrin and EGFR signaling needs to be investigated in future studies. Further, experiments with PD98059 and GRGDSP revealed that ERK1/2 assists in mediating transactivation of HSF-1 following HS. This leads to increases in Hsp70 expression via FN-Integrin signaling, which is known to attenuate apoptosis after thermal injury. Fluorescence microscopy results indicated that HS and GLN regulate cell are size changes and the morphology of F-actin via FN-Integrin signaling. Experiments using GRGDSP and GRGESP showed that GLN enhances cellular survival via FN-Integrin signaling in a manner that does not require increased intracellular GLN concentrations (as quantified using LC-MS/MS). In summary, my thesis work gives new and potentially clinically relevant mechanistic insights into GLN-mediated molecular cell survival pathways. These results warrant clinical translation to assess if clinical outcome of critically ill patients suffering from gastrointestinal diseases can be improved by GLN treatment and/or by targeting the molecular pathways found in my studies.},
  subject      = {Glutamin},
  language  = {en}
}
@misc{OPUS4-6504,
  title     = {einBlick - Ausgabe 12 - 26. M{\"a}rz 2013},
  volume    = {12/2013},
  organization    = {Julius-Maximilians-Universit{\"a}t W{\"u}rzburg},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-77129},
  year      = {2013},
  abstract  = {Nachrichten aus der Julius-Maximilians-Universit{\"a}t W{\"u}rzburg},
  subject      = {W{\"u}rzburg},
  language  = {de}
}
@misc{OPUS4-6683,
  title     = {einBlick - Ausgabe 25 - 25. Juni 2013},
  volume    = {25/2013},
  organization    = {Julius-Maximilians-Universit{\"a}t W{\"u}rzburg},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-78599},
  year      = {2013},
  abstract  = {Nachrichten aus der Julius-Maximilians-Universit{\"a}t W{\"u}rzburg},
  subject      = {W{\"u}rzburg},
  language  = {de}
}
@book{OPUS4-27197,
  title     = {R{\"u}ck-Blick Alfred Forchel : Pr{\"a}sident der Julius-Maximilians-Unversit{\"a}t W{\"u}rzburg, Oktober 2009 - M{\"a}rz 2021},
  editor    = {Bartsch, Gunnar and Emmerich, Robert and Knemeyer, Esther and Popp-Orth, Liane},
  organization    = {Julius-Maximilians-Universit{\"a}t W{\"u}rzburg, Das Pr{\"a}sidium},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-271973},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2022},
  abstract  = {Kein Abstract verf{\"u}gbar.},
  subject      = {Forchel, Alfred},
  language  = {de}
}
@misc{OPUS4-28994,
  title     = {BLICK 2021 - Jahrbuch der Julius-Maximilians-Universit{\"a}t W{\"u}rzburg},
  volume    = {2021},
  organization    = {Julius-Maximilians-Universit{\"a}t W{\"u}rzburg},
  issn      = {2192-1431},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-289945},
  year      = {2022},
  abstract  = {Die Entwicklung der Universit{\"a}t W{\"u}rzburg im Jahr 2021.},
  subject      = {Bericht},
  language  = {de}
}
@misc{OPUS4-11835,
  title     = {Campus Uni W{\"u}rzburg Juni 2015},
  volume    = {06/2015},
  organization    = {Julius-Maximilians-Universit{\"a}t W{\"u}rzburg},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-118350},
  year      = {2015},
  abstract  = {Der Weg in die Wissenschaft - Jura, Germanistik, Informatik? Die Auswahl spannender Studieng{\"a}nge an der Uni W{\"u}rzburg ist riesig. Experten helfen dir, das Richtige zu finden.},
  language  = {de}
}
@article{KerwagenFuchsUllrichetal.2023,
  author    = {Kerwagen, Fabian and Fuchs, Konrad F. and Ullrich, Melanie and Schulze, Andres and Straka, Samantha and Krop, Philipp and Latoschik, Marc E. and Gilbert, Fabian and Kunz, Andreas and Fette, Georg and St{\"o}rk, Stefan and Ertl, Maximilian},
  title     = {Usability of a mHealth solution using speech recognition for point-of-care diagnostic management},
  series = {Journal of Medical Systems},
  volume    = {47},
  journal   = {Journal of Medical Systems},
  number    = {1},
  doi       = {10.1007/s10916-022-01896-y},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-324002},
  year      = {2023},
  abstract  = {The administrative burden for physicians in the hospital can affect the quality of patient care. The Service Center Medical Informatics (SMI) of the University Hospital W{\"u}rzburg developed and implemented the smartphone-based mobile application (MA) ukw.mobile1 that uses speech recognition for the point-of-care ordering of radiological examinations. The aim of this study was to examine the usability of the MA workflow for the point-of-care ordering of radiological examinations. All physicians at the Department of Trauma and Plastic Surgery at the University Hospital W{\"u}rzburg, Germany, were asked to participate in a survey including the short version of the User Experience Questionnaire (UEQ-S) and the Unified Theory of Acceptance and Use of Technology (UTAUT). For the analysis of the different domains of user experience (overall attractiveness, pragmatic quality and hedonic quality), we used a two-sided dependent sample t-test. For the determinants of the acceptance model, we employed regression analysis. Twenty-one of 30 physicians (mean age 34 ± 8 years, 62\% male) completed the questionnaire. Compared to the conventional desktop application (DA) workflow, the new MA workflow showed superior overall attractiveness (mean difference 2.15 ± 1.33), pragmatic quality (mean difference 1.90 ± 1.16), and hedonic quality (mean difference 2.41 ± 1.62; all p < .001). The user acceptance measured by the UTAUT (mean 4.49 ± 0.41; min. 1, max. 5) was also high. Performance expectancy (beta = 0.57, p = .02) and effort expectancy (beta = 0.36, p = .04) were identified as predictors of acceptance, the full predictive model explained 65.4\% of its variance. Point-of-care mHealth solutions using innovative technology such as speech-recognition seem to address the users' needs and to offer higher usability in comparison to conventional technology. Implementation of user-centered mHealth innovations might therefore help to facilitate physicians' daily work.},
  language  = {en}
}
@misc{OPUS4-36110,
  title     = {BLICK 2023 - Jahrbuch der Julius-Maximilians-Universit{\"a}t W{\"u}rzburg},
  volume    = {2023},
  organization    = {Julius-Maximilians-Universit{\"a}t W{\"u}rzburg},
  issn      = {2192-1431},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-361103},
  year      = {2024},
  abstract  = {Die Entwicklung der Universit{\"a}t W{\"u}rzburg im Jahr 2023.},
  subject      = {Bericht},
  language  = {de}
}
@misc{OPUS4-31745,
  title     = {BLICK 2022 - Jahrbuch der Julius-Maximilians-Universit{\"a}t W{\"u}rzburg},
  volume    = {2022},
  organization    = {Julius-Maximilians-Universit{\"a}t W{\"u}rzburg},
  issn      = {2192-1431},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-317455},
  year      = {2023},
  abstract  = {Die Entwicklung der Universit{\"a}t W{\"u}rzburg im Jahr 2022.},
  subject      = {Bericht},
  language  = {de}
}
@article{SteinmannCortegosoValdiviaNowaketal.2022,
  author    = {Steinmann, Rebekka and Cortegoso Valdivia, Pablo and Nowak, Tanja and Koulaouzidis, Anastasios},
  title     = {An overview of the evolution of capsule endoscopy research — text-mining analysis and publication trends},
  series = {Diagnostics},
  volume    = {12},
  journal   = {Diagnostics},
  number    = {9},
  issn      = {2075-4418},
  doi       = {10.3390/diagnostics12092238},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-288515},
  year      = {2022},
  abstract  = {There has been a steady increase (annual percentage growth rate of 19.2\%, average of 18.3 citations per document) in capsule endoscopy (CE) publications from a global, interdisciplinary research community on a growing range of CE applications over the last 20+ years. We here present the status of CE as a field of research, tracing its evolution over time and providing insight into its potential for diagnostics, prevention and treatment of gastrointestinal (GI) tract diseases. To portray the development of the CE research landscape in the 2000-2021 time span, we analyzed 5764 scientific publications. Analyses were performed using the R language and environment for statistical computing and graphics and VOSviewer, a software developed for scientific literature analysis by scientometricians. The aim of this paper is to provide a wide comprehensive analysis of the trends in CE publications. We thus performed subgroup analysis on the selected papers, including indications, annual percentage growth rate, average citations per document, most publications from research areas/interdisciplinary field of the articles, geography, collaboration networks through institutions, specific clinical keywords and device type. The firm increase in CE publications over the last two decades highlights the overall strength of the technology in GI applications. Furthermore, the introduction to the field of artificial intelligence (AI) tools has been promoting a range of technological advances that keep on affecting the diagnostic potential of CE.},
  language  = {en}
}