@article{BrumbergKuestersAlMomanietal.2017,
  author    = {Brumberg, Joachim and K{\"u}sters, Sebastian and Al-Momani, Ehab and Marotta, Giorgio and Cosgrove, Kelly P. and van Dyck, Christopher H. and Herrmann, Ken and Homola, Gy{\"o}rgy A. and Pezzoli, Gianni and Buck, Andreas K. and Volkmann, Jens and Samnick, Samuel and Isaias, Ioannis U.},
  title     = {Cholinergic activity and levodopa-induced dyskinesia: a multitracer molecular imaging study},
  series = {Annals of Clinical and Translational Neurology},
  volume    = {4},
  journal   = {Annals of Clinical and Translational Neurology},
  number    = {9},
  doi       = {10.1002/acn3.438},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-170406},
  pages     = {632-639},
  year      = {2017},
  abstract  = {Objective: To investigate the association between levodopa-induced dyskinesias and striatal cholinergic activity in patients with Parkinson's disease. Methods: This study included 13 Parkinson's disease patients with peak-of-dose levodopa-induced dyskinesias, 12 nondyskinetic patients, and 12 healthy controls. Participants underwent 5-[\(^{123}\)I]iodo-3-[2(S)-2-azetidinylmethoxy]pyridine single-photon emission computed tomography, a marker of nicotinic acetylcholine receptors, [\(^{123}\)I]N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane single-photon emission computed tomography, to measure dopamine reuptake transporter density and 2-[\(^{18}\)F]fluoro-2-deoxyglucose positron emission tomography to assess regional cerebral metabolic activity. Striatal binding potentials, uptake values at basal ganglia structures, and correlations with clinical variables were analyzed. Results: Density of nicotinic acetylcholine receptors in the caudate nucleus of dyskinetic subjects was similar to that of healthy controls and significantly higher to that of nondyskinetic patients, in particular, contralaterally to the clinically most affected side. Interpretation: Our findings support the hypothesis that the expression of dyskinesia may be related to cholinergic neuronal excitability in a dopaminergic-depleted striatum. Cholinergic signaling would play a role in maintaining striatal dopaminergic responsiveness, possibly defining disease phenotype and progression.},
  language  = {en}
}
@article{WestermaierLinsenmannHomolaetal.2016,
  author    = {Westermaier, Thomas and Linsenmann, Thomas and Homola, Gy{\"o}rgy A. and Loehr, Mario and Stetter, Christian and Willner, Nadine and Ernestus, Ralf-Ingo and Soymosi, Laszlo and Vince, Giles H.},
  title     = {3D rotational fluoroscopy for intraoperative clip control in patients with intracranial aneurysms - assessment of feasibility and image quality},
  series = {BMC Medical Imaging},
  volume    = {16},
  journal   = {BMC Medical Imaging},
  number    = {30},
  doi       = {10.1186/s12880-016-0133-0},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-146381},
  year      = {2016},
  abstract  = {Background Mobile 3D fluoroscopes have become increasingly available in neurosurgical operating rooms. In this series, the image quality and value of intraoperative 3D fluoroscopy with intravenous contrast agent for the evaluation of aneurysm occlusion and vessel patency after clip placement was assessed in patients who underwent surgery for intracranial aneurysms. Materials and methods Twelve patients were included in this retrospective analysis. Prior to surgery, a 360° rotational fluoroscopy scan was performed without contrast agent followed by another scan with 50 ml of intravenous iodine contrast agent. The image files of both scans were transferred to an Apple PowerMac® workstation, subtracted and reconstructed using OsiriX® free software. The procedure was repeated after clip placement. Both image sets were compared for assessment of aneurysm occlusion and vessel patency. Results Image acquisition and contrast administration caused no adverse effects. Image quality was sufficient to follow the patency of the vessels distal to the clip. Metal artifacts reduce the assessability of the immediate vicinity of the clip. Precise image subtraction and post-processing can reduce metal artifacts and make the clip-site assessable and depict larger neck-remnants. Conclusion This technique quickly supplies images at adequate quality to evaluate distal vessel patency after aneurysm clipping. Significant aneurysm remnants may be depicted as well. As it does not require visual control of all vessels that are supposed to be evaluated intraoperatively, this technique may be complementary to other intraoperative tools like indocyanine green videoangiography and micro-Doppler, especially for the assessment of larger aneurysms. At the momentary state of this technology, it cannot replace postoperative conventional angiography. However, 3D fluoroscopy and image post-processing are young technologies. Further technical developments are likely to result in improved image quality.},
  language  = {en}
}
@phdthesis{Brasche2019,
  author    = {Brasche, Juliane},
  title     = {Patienten- und Anwenderfreundlichkeit des Safeguard-Druckverbandes im Vergleich zum ET-Druckverband (N{\"u}rnberger Ufo) zur Blutstillung nach transfemoralem Zugang : Studie},
  doi       = {10.25972/OPUS-18092},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-180921},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2019},
  abstract  = {Ziel der Arbeit war der Vergleich von zwei Druckverbandsystemen in Hinblick auf effektive Blutstillung, Patienten- sowie Anwenderfreundlichkeit. Dazu wurden 117 Patienten, die sich zwischen M{\"a}rz 2011 und Dezember 2012 im Klinikum Fulda einer diagnostischen Angiographie unterzogen, in einer randomisierten offenen klinisch kontrollierten Studie untersucht. Die in der Studie untersuchten Druckverb{\"a}nde stellten sich als gleich sicher und effektiv bei der Blutstillung heraus. Es traten in der gesamten Studienpopulation keine schwergradigen Komplikationen auf. Der Safeguard-Druckverband l{\"a}sst sich leichter und schneller anbringen und entfernen, als der mit elastischen Binden fixierte ET-Druckverband. Er wurde zudem durch die Patienten besser toleriert und als bequemer empfunden. Zusammenfassend ist der Safeguard-Druckverband nach unkomplizierten diagnostischen Angiographien ebenso sicher, wie der UFO-Druckverband und zeigte dar{\"u}ber hinaus eine h{\"o}here Anwender- und Patientenfreundlichkeit.},
  subject      = {Druckverband},
  language  = {de}
}
@article{SterkenburgHoffmannReicheletal.2016,
  author    = {Sterkenburg, Anthe S. and Hoffmann, Anika and Reichel, Julia and Lohle, Kristin and Eveslage, Maria and Warmuth-Metz, Monika and M{\"u}ller, Hermann L.},
  title     = {Nuchal skinfold thickness: A novel parameter for assessment of body composition in childhood craniopharyngioma},
  series = {Journal of Clinical Endocrinology \& Metabolism},
  volume    = {101},
  journal   = {Journal of Clinical Endocrinology \& Metabolism},
  number    = {12},
  doi       = {10.1210/jc.2016-2547},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-186562},
  pages     = {4922-4930},
  year      = {2016},
  abstract  = {Context: Hypothalamic obesity, cardiovascular disease (CVD), and relapse/progression have a major impact on prognosis in childhood-onset craniopharyngioma (CP). We analyzed nuchal skinfold thickness (NST) on magnetic resonance imaging performed for follow-up monitoring as a novel parameter for body composition (BC) and CVD in CP. Objective: The objective of the study was to identify the association of NST with body mass index (BMI), waist to height ratio (WHtR), functional capacity, and blood pressure (BP) in CP and controls. Design: This was a cross-sectional and longitudinal prospective study in CP patients. Setting: The study was conducted at HIT-Endo, KRANIOPHARYNGEOM 2000/2007. Patients: Participants included 94 CP patients and 75 controls. Interventions: There were no interventions. Main Outcome Measures: Association of NST with BC and BP in 43 CP and 43 controls was measured. Results: NST correlated with BMI SD score (SDS; r = 0.78; P = .001; n = 169) and WHtR (r = 0.85; P = .001; n = 86) in the total cohort and CP patients (NST-BMI SDS: r = 0.77, P = .001, n = 94); NST-WHtR: r = 0.835, P = .001, n = 43) and controls (NST-BMI SDS: r = 0.792, P = .001, n = 75; NST-WHtR: r = 0.671, P = .001, n = 43). In CP, systolic BP correlated with NST (r = 0.575, P = .001), BMI SDS (r = 0.434, P = .004), and WHtR (r = 0.386, P = .011). Similar results were observed for diastolic BP in CP. In multivariate analyses, NST had a predictive value for hypertension in postpubertal CP and controls (odds ratio 6.98, 95\% confidence interval 1.65, 29.5], P = .008). During a longitudinal follow-up, changes in NST correlated with changes in BMI SDS (P = .001) and WHtR (P = .01) but not with changes in BP and functional capacity. Conclusions: Because monitoring of magnetic resonance imaging and BC is essential for follow-up in CP, NST could serve as a novel and clinically relevant parameter for longitudinal assessment of BC and CVD risk in CP.},
  language  = {en}
}
@phdthesis{Ofenhitzer2019,
  author    = {Ofenhitzer, Kathrin},
  title     = {Stellenwert der pr{\"a}operativen radiologischen Diagnostik vor Cochlea-Implantat-Operation},
  doi       = {10.25972/OPUS-18990},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-189909},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2019},
  abstract  = {Bei Patienten mit hochgradigem sensorineuralem H{\"o}rverlust, der nicht mehr ausreichend mittels H{\"o}rger{\"a}ten kompensiert werden kann, hat sich die CI-Versorgung zur Verbesserung der H{\"o}rf{\"a}higkeit als Standardmethode etabliert und ihr Indikationsbereich w{\"a}chst. Zur Beurteilung des auditorischen Systems sowie seiner angrenzenden Nachbarstrukturen z{\"a}hlt die neuroradiologische Diagnostik mittels spezieller CT- und MRT-Techniken zu den entscheidenden Kriterien zur CI-Indikationsstellung und der Operationsplanung. In der Literatur finden sich verschiedenste Meinungen zur Bedeutung dieser pr{\"a}operativen Bildgebungen vor Cochlea-Implantationen und die Wahl einer CT- und bzw. oder einer MRT-Untersuchung zur pr{\"a}operativen Diagnostik wird diskutiert. So wurden am Universit{\"a}tsklinikum W{\"u}rzburg im Zeitraum von 2005 bis zum Jahr 2015 zur Diagnostik vor der CI-Operation eines Patienten meist sowohl eine CT-Aufnahme des Felsenbeins als auch eine MRT-Aufnahme des Sch{\"a}dels angefertigt. Im Rahmen dieser Arbeit sollte untersucht werden, inwieweit diese beiden pr{\"a}operativen CT- und MRT-Untersuchungen f{\"u}r die CI-Operation und die Ursachenabkl{\"a}rung der H{\"o}rminderung von Relevanz waren und ob eine Empfehlung f{\"u}r die zuk{\"u}nftige Wahl der Diagnostikmethoden abgegeben werden kann. Dazu wurden Anamnesen, Voruntersuchungen, pr{\"a}operative CT- und MRT-Bildgebungen und die Operationsberichte von 705 CI-F{\"a}llen bei 549 Patienten, die in diesem Zeitraum operiert wurden, retrospektiv ausgewertet. Die Darstellbarkeiten verschiedener Pathologien, die mit Hilfe der beiden Bildgebungsverfahren detektiert wurden, wurden miteinander verglichen und es wurde {\"u}berpr{\"u}ft, ob ein Verfahren m{\"o}glicherweise besser zur Diagnostik bestimmter Auff{\"a}lligkeiten geeignet war als das andere. Durch die Auswertung der Operationsberichte wurde evaluiert, ob und wie die Befunde der pr{\"a}operativen Bildgebungen mit den intraoperativen Situationen {\"u}bereinstimmten und ob diese Befunde die Operationsplanung beeinflusst hatten. Die Ergebnisse dieser Arbeit zeigten, dass die bildgebenden Verfahren zur Ursachenfindung einer nicht abgekl{\"a}rten H{\"o}rminderung beitragen k{\"o}nnen. Des Weiteren konnte gefolgert werden, dass ein Großteil von Auff{\"a}lligkeiten im Bereich des Felsenbeins, die mit sensorineuralen Schwerh{\"o}rigkeiten assoziiert sind, mit hoher Wahrscheinlichkeit sowohl mittels CT- als auch mittels MRT-Untersuchung diagnostiziert werden kann. F{\"u}r einzelne L{\"a}sionen konnte vermutet werden, dass diese nur durch die CT und umgekehrt bestimmte L{\"a}sionen nur durch die MRT detektiert werden k{\"o}nnen. Außerdem zeigte sich, dass die beiden bildgebenden Verfahren auf bestimmte Schwierigkeiten, die w{\"a}hrend einer CI-Operation auftreten k{\"o}nnen, pr{\"a}operativ hinweisen k{\"o}nnen. Zus{\"a}tzlich konnte festgestellt werden, dass die Wahl der Implantations-Seite bei einseitig operierten aber beidseits schwerh{\"o}rigen Patienten neben den CT- und MRT-Untersuchungen in den meisten F{\"a}llen von weiteren Faktoren abhing. Aus den Ergebnissen dieser Arbeit konnte gefolgert werden, dass die Durchf{\"u}hrung einer pr{\"a}operativen CT- und einer MRT-Untersuchung die umfangreichste radiologische Diagnostikmethode ist, um eine CI-Operation zu planen, m{\"o}glichst alle Auff{\"a}lligkeiten, die zu Schwierigkeiten in der Operation f{\"u}hren k{\"o}nnen, zu detektieren und Ursachen f{\"u}r eine nicht abgekl{\"a}rte H{\"o}rminderung zu finden. Dennoch sollte, insbesondere unter Ber{\"u}cksichtigung der Strahlenbelastung, die ein Patient im Rahmen eines Felsenbein-CTs erf{\"a}hrt, die {\"U}berlegung zugelassen werden, ob zuk{\"u}nftig nur die Durchf{\"u}hrung einer MRT-Untersuchung als routinem{\"a}ßiges Diagnostikverfahren ausreichen k{\"o}nnte. Eine zus{\"a}tzliche CT-Untersuchung w{\"a}re dann nur unter bestimmten Voraussetzungen (z. B. Traumaanamnese des Sch{\"a}dels oder Hinweise auf ein Cholesteatom) indiziert. Weitere Untersuchungen, die zeigen, welche genauen Kriterien dazu seitens des Patienten gegeben sein m{\"u}ssten, sowie Langzeitergebnisse nach erfolgreichen CI-Operationen sollten Gegenstand weiterer Studien sein.},
  subject      = {Cochlear-Implantat},
  language  = {de}
}
@phdthesis{Schneckenburger2014,
  author    = {Schneckenburger, Manuel},
  title     = {Was bedeutet eine {\"A}nderung der Kontrastmittelaufnahme in niedrig malignen Gliomen bei Kindern?},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-145403},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2014},
  abstract  = {Bei niedriggradigen Gliomen WHO I° und II° ist das Kontrastmittelverhalten variabel und nicht mit der Prognose assoziiert. Andererseits wurde bei spontanen Regressionen von niedriggradigen Gliomen bei Patienten sowohl mit als auch ohne eine Neurofibromatose Typ I eine Abnahme der Kontrastmittelaufnahme berichtet. Vielleicht deswegen verleitet eine Zunahme des Enhancements oder ein neu aufgetretenes Enhancement nicht selten zur Diagnose einer Tumorprogression. Es stellt sich also die Frage, ob eine Kontrastmittelaufnahme bei LGGs mit einer Gr{\"o}ßenzunahme somit einem Tumorprogress assoziiert ist. Es l{\"a}sst sich eine {\"u}berdurchschnittliche Assoziation einer {\"A}nderung der Kontrastmittelaufnahme mit dem Wachstumsverhalten bei LGGs nachweisen. Allerdings ist das Maß f{\"u}r eine Progression oder Regression weiterhin die Gr{\"o}ßen{\"a}nderung des Tumors. Auch eine neue Kontrastmittelaufnahme innerhalb eines Tumors hat keine Bedeutung f{\"u}r das aktuelle Staging. Sie findet sich zwar h{\"a}ufiger bei Wachstum aber auch bei regredienten Tumoren.},
  subject      = {Gliom},
  language  = {de}
}
@article{vonBuerenOehlerShalabyetal.2011,
  author    = {von Bueren, Andr{\´e} O. and Oehler, Christoph and Shalaby, Tarek and von Hoff, Katja and Pruschy, Martin and Seifert, Burkhardt and Gerber, Nicolas U. and Warmuth-Metz, Monika and Stearns, Duncan and Eberhart, Charles G. and Kortmann, Rolf D. and Rutkowski, Stefan and Grotzer, Michael A.},
  title     = {c-MYC expression sensitizes medulloblastoma cells to radio- and chemotherapy and has no impact on response in medulloblastoma patients},
  series = {BMC Cancer},
  volume    = {11},
  journal   = {BMC Cancer},
  number    = {74},
  doi       = {10.1186/1471-2407-11-74},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-134185},
  pages     = {1-11},
  year      = {2011},
  abstract  = {Background: To study whether and how c-MYC expression determines response to radio-and chemotherapy in childhood medulloblastoma (MB). Methods: We used DAOY and UW228 human MB cells engineered to stably express different levels of c-MYC, and tested whether c-MYC expression has an effect on radio-and chemosensitivity using the colorimetric 3-(4,5-dimethylthiazol- 2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium inner salt (MTS) assay, clonogenic survival, apoptosis assays, cell cycle analysis, and western blot assessment. In an effort to validate our results, we analyzed c-MYC mRNA expression in formalin-fixed paraffin-embedded tumor samples from well-documented patients with postoperative residual tumor and compared c-MYC mRNA expression with response to radio-and chemotherapy as examined by neuroradiological imaging. Results: In DAOY -and to a lesser extent in UW228 -cells expressing high levels of c-MYC, the cytotoxicity of cisplatin, and etoposide was significantly higher when compared with DAOY/UW228 cells expressing low levels of c-MYC. Irradiation-and chemotherapy-induced apoptotic cell death was enhanced in DAOY cells expressing high levels of c-MYC. The response of 62 of 66 residual tumors was evaluable and response to postoperative radio-(14 responders (CR, PR) vs. 5 non-responders (SD, PD)) or chemotherapy (23 CR/PR vs. 20 SD/PD) was assessed. c-MYC mRNA expression was similar in primary MB samples of responders and non-responders (Mann-Whitney U test, p = 0.50, ratio 0.49, 95\% CI 0.008-30.0 and p = 0.67, ratio 1.8, 95\% CI 0.14-23.5, respectively). Conclusions: c-MYC sensitizes MB cells to some anti-cancer treatments in vitro. As we failed to show evidence for such an effect on postoperative residual tumors when analyzed by imaging, additional investigations in xenografts and larger MB cohorts may help to define the exact function of c-MYC in modulating response to treatment.},
  language  = {en}
}
@article{NeubauerHassoldWarmuthMetzetal.2014,
  author    = {Neubauer, Henning and Hassold, Nicole and Warmuth-Metz, Monika and Winkler, Beate and Kreissl, Michael C. and Ernestus, Karen and Beer, Meinrad},
  title     = {Hit the mark with diffusion-weighted imaging: metastases of rhabdomyosarcoma to the extraocular eye muscles},
  doi       = {10.1186/1471-2431-14-57},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-110106},
  year      = {2014},
  abstract  = {Background Rhabdomyosarcoma is the most frequent malignant intraorbital tumour in paediatric patients. Differentiation of tumour recurrence or metastases from post-therapeutic signal alteration can be challenging, using standard MR imaging techniques. Diffusion-weighted MRI (DWI) is increasingly considered a helpful supplementary imaging tool for differentiation of orbital masses. Case presentation We report on a 15-year-old female adolescent of Caucasian ethnicity who developed isolated bilateral thickening of extraocular eye muscles about two years after successful multimodal treatment of orbital alveolar rhabdomyosarcoma. Intramuscular restricted diffusion was the first diagnostic indicator suggestive of metastatic disease to the eye muscles. DWI subsequently showed signal changes consistent with tumour progression, complete remission under chemoradiotherapy and tumour recurrence. Conclusions Restricted diffusivity is a strong early indicator of malignancy in orbital tumours. DWI can be the key to correct diagnosis in unusual tumour manifestations and can provide additional diagnostic information beyond standard MRI and PET/CT. Diffusion-weighted MRI is useful for monitoring therapy response and for detecting tumour recurrence.},
  language  = {en}
}
@article{NguemeniHiewKoegleretal.2021,
  author    = {Nguemeni, Carine and Hiew, Shawn and K{\"o}gler, Stefanie and Homola, Gy{\"o}rgy A. and Volkmann, Jens and Zeller, Daniel},
  title     = {Split-belt training but not cerebellar anodal tDCS improves stability control and reduces risk of fall in patients with multiple sclerosis},
  series = {Brain Sciences},
  volume    = {12},
  journal   = {Brain Sciences},
  number    = {1},
  issn      = {2076-3425},
  doi       = {10.3390/brainsci12010063},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-252179},
  year      = {2021},
  abstract  = {The objective of this study was to examine the therapeutic potential of multiple sessions of training on a split-belt treadmill (SBT) combined with cerebellar anodal transcranial direct current stimulation (tDCS) on gait and balance in People with Multiple Sclerosis (PwMS). Twenty-two PwMS received six sessions of anodal (PwMS\(_{real}\), n = 12) or sham (PwMS\(_{sham}\), n = 10) tDCS to the cerebellum prior to performing the locomotor adaptation task on the SBT. To evaluate the effect of the intervention, functional gait assessment (FGA) scores and distance walked in 2 min (2MWT) were measured at the baseline (T0), day 6 (T5), and at the 4-week follow up (T6). Locomotor performance and changes of motor outcomes were similar in PwMS\(_{real}\) and PwMS\(_{sham}\) independently from tDCS mode applied to the cerebellum (anodal vs. sham, on FGA, p = 0.23; and 2MWT, p = 0.49). When the data were pooled across the groups to investigate the effects of multiple sessions of SBT training alone, significant improvement of gait and balance was found on T5 and T6, respectively, relative to baseline (FGA, p < 0.001 for both time points). The FGA change at T6 was significantly higher than at T5 (p = 0.01) underlining a long-lasting improvement. An improvement of the distance walked during the 2MWT was also observed on T5 and T6 relative to T0 (p = 0.002). Multiple sessions of SBT training resulted in a lasting improvement of gait stability and endurance, thus potentially reducing the risk of fall as measured by FGA and 2MWT. Application of cerebellar tDCS during SBT walking had no additional effect on locomotor outcomes.},
  language  = {en}
}
@article{GuggenbergerBleyVogtetal.2022,
  author    = {Guggenberger, Konstanze V. and Bley, Thorsten A. and Vogt, Marius L. and Urbach, Horst and Meckel, Stephan},
  title     = {High-Resolution Black Blood Vessel Wall Imaging in COVID-19 Encephalopathy-Is it Really Endotheliitis?},
  series = {Clinical Neuroradiology},
  volume    = {32},
  journal   = {Clinical Neuroradiology},
  number    = {1},
  doi       = {10.1007/s00062-021-01109-y},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-264794},
  pages     = {295-296},
  year      = {2022},
  abstract  = {No abstract available.},
  language  = {en}
}