@article{JaggiLutzLuethyetal.1980, author = {Jaggi, W. and Lutz, Werner K. and L{\"u}thy, J. and Zweifel, U. and Schlatter, C.}, title = {In vivo covalent binding of aflatoxin metabolites isolated from animal tissue to rat-liver DNA}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61101}, year = {1980}, abstract = {Ring-labelled [\(^{14}\)C)aflatoxin B\(_1\) (AFB\(_1\)), prepared by biosynthesis. or generally labelled [\(^3\)H]AFB\(_1\) was administered by oral gavage to young adult male rats. After 6 hr. the liver was removed and two fractions were isolated, namely macromolecules, which contamed about 3 \% of the initial dose of AFB\(_1\) radioactivity. and water-soluble, low-molecular aftatoxin conjugates containing about0·2\% of the administered radioactivity. These two fractions were administered orally to other rats in order to determine the potential of radioactive aftatoxin residues for covalent binding to DNA. Such binding can be used as an indicator for carcinogenic potency. Liver DNA was isolated 9-12 hr after admmistration of the aflatoxin derivatives and in no case was any radioactivity detected on the DNA. It can be deduced on the basis of the limit of detection of radioactivity on the DNA, that macromolecule bound AFB\(_1\) derivatives are at least 4000 times less active than AFB\(_1\) with respect to covalent binding to rat-liver DNA. and that the water-soluble conjugates are at least 100 times less potent than AFB, itself. It is concluded that the carcinogenic risk for humans who consume liver or meat. containing such aflatoxin residues is negligible when compared with the risk from intake of aftatoxins in other food items.}, subject = {Toxikologie}, language = {en} } @article{VivianiDaenikenSchlatteretal.1980, author = {Viviani, A. and D{\"a}niken, A. von and Schlatter, C. and Lutz, Werner K.}, title = {Effect of selected induction of microsomal and nuclear aryl hydrocarbon monooxygenase and epoxide hydrolase as well as cytoplasmic glutathione S-epoxide transferase on the covalent binding of the carcinogen benzo(a)pyrene to rat liver DNA in vivo}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61114}, year = {1980}, abstract = {Groups of four adult male rats [ZUR:SIV -Z] were pretreated with corn oil (control; 2 ml/kg/day i. p. for 3 days), trans-stilbene-oxide (SO; 200 mg/kg/day i. p. for 2 days), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; 10 \(\mu\)g/kg i. p. once, 4 days before killing), phenobarbital (PB; 1 gjliter in the drinking water for 8 days), and dieldrin (20 mg/kg/day i. p. for 3 or 9 days). They received an injection of [G-\(^3\)H]benzo(a)pyrene (BaP, 31 \(\mu\)g/kg, 7.4. 10\(^9\) dpm/kg; i. v.) 16 h before killing. In the liver of each rat, five enzymatic activities and the covalent binding of BaP to DNA have been determined. The rnicrosomal aryl hydrocarbon monooxygenase activity (AHM) ranged frorn 75\% of control (SO) to 356\% (TCDD), the nuclear AHM from 63\% (SO) to 333\% (TCDD). Microsomal epoxide hydrolase activity (EH) was induced up to 238\% (PB), nuclear EH ranged from 86\% (TCDD) to 218\% (PB). A different extent of induction was observed in the two compartments. Highest induction of glutathione S-epoxide transferase activity (GST) was found with PB (202\%). The DNA binding of BaP was modulated within 79\% (dieldrin, 9 days) and 238\% of control (TCDD). An enzyme digest of control DNA was analysed by Sephadex LH-20 chromatography. Multiple linear regression analysis with all data expressedas o/o of control yielded the following equation: DNA Binding = 1.49 · Microsomal AHM- 1.07 · Nuclear AHM+ 0.33 · Microsomal EH- 0.52 · N uclear EH+ 0.11 · Cytoplasmic GST + 58.2. From this analysis it is concluded that (1) AHM located in the endoplasmic reticulum is most important in the formation of DNA-binding metabolites, (2) EH in the same compar.tment is not determinative in thls respect nor has it a protective effect, (3) both membrane-bound enzyme activities located in the nucleus may inactivate potential ultimate carcinogens, and ( 4) cytoplasmic GST probably cannot reduce DNA binding due to its subcellular localization.}, subject = {Toxikologie}, language = {en} } @article{AckermannTackeWannagatetal.1980, author = {Ackermann, J. and Tacke, Reinhold and Wannagat, U. and Koke, U. and Meyer, F.}, title = {Sila-Analoga des Chlorphencyclans}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63633}, year = {1980}, abstract = {Sila-Chlorphencyclan (8b), ein Sila-Analogon des Chlorphencyclans (8a), die Derivate 7 und 9, deren Ammoniumsalze 11, 12, 13 und 14b, das Hydrolyseprodukt 10 sowie die Vorstufen 3-6 wurden erstmalig dargestellt. Die neuen Verbindungen wurden in ihren chemischen und physikalischen Eigenschaften charakterisiert, ihre Struktur wurde sichergestellt. Chlorphencyclan, Sila-Chlorphencyclan und einige seiner Derivate wurden vergleichend pharmakologisch und toxikologisch untersucht.}, subject = {Anorganische Chemie}, language = {de} } @article{TackeHeegBerndt1980, author = {Tacke, Reinhold and Heeg, E. and Berndt, B}, title = {Sila-Analogon des Rythmols}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63642}, year = {1980}, abstract = {Sila-Rythmol (llb), ein Sila-Analogon des Antiarrhythmieums Rythmol (lla), wurde erstmalig dargestellt. llb sowie die Vorstufen und Nebenprodukte 4, 5, 6, 7, 9b und lOb wurden in ihren physikalischen und chemischen Eigenschaften charakterisiert und in ihrer Struktur sichergestellt. Die pharmakologischen und toxikologischen Eigenschaften der Analoga lla und llb wurden vergleichend untersucht.}, subject = {Anorganische Chemie}, language = {de} } @article{TackeStreckerSheldricketal.1980, author = {Tacke, Reinhold and Strecker, M. and Sheldrick, W. S. and Ernst, L. and Heeg, E. and Berndt, B. and Knapstein, C.-M. and Niedner, R.}, title = {Sila-Pridinol und Pridinol: Darstellung und Eigenschaften sowie Strukturen im kristallinen und gel{\"o}sten Zustand}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63654}, year = {1980}, abstract = {Sila-Pridinol (2 b), ein Sila-Analogon des Anticholinergicums Pridinol (2a), wurde auf zwei verschiedenen Wegen dargestellt. Die Kristall- und Molek{\"u}lstrukturen von 2 a und 2 b wurden r{\"o}ntgenstrukturanalytisch bestimmt. 2a bildet im festen Zustand intramolekulare Wasserstoffbr{\"u}ckenbindungen aus, w{\"a}hrend sich in kristallinem 2 b zentrosymmetrische, durch intermolekulare H-Br{\"u}ckenbindungen verkn{\"u}pfte cyclische Dimere finden. IR- und \8^1\)H-NMR-spektroskopische sowie kryoskopische Untersuchungen ergaben Informationen {\"u}ber die Strukturen von 2a und 2 b in verschiedenen L{\"o}sungsmitteln. - Die pharmakologischen und toxikologischen Eigen" schaften von 2a und 2b wurden unter dem Gesichtspunkt bekannter Struktur-Wirkungs-Beziehungen vergleichend untersucht. 2 b erwies sich als ein etwa f{\"u}nfmal so starkes Anticholincrgicum wie 2a.}, subject = {Anorganische Chemie}, language = {de} } @article{TackeZimonyiHegeduesStreckeretal.1980, author = {Tacke, Reinhold and Zimonyi-Heged{\"u}s, E. and Strecker, M. and Heeg, E. and Berndt, B. and Langner, R.}, title = {Sila-Analogon des Tiemoniumiodids}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63669}, year = {1980}, abstract = {Sila-Tiemoniumiodid (16b), ein Sila-Analogon des Anticholinergicums Tiemoniumiodid (16a), und das Sila-Analogon 14b der entsprechenden Tiemonium-Base 14a wurden erstmalig synthetisiert.14b und 16b sowie die Vorstufen 10-13 und 15 wurden in ihren physikalischen und chemischen Eigenschaften charakterisiert und in ihrer Struktur durch Elementaranalysen sowie \(^1\)H-NMR- und Massenspektren sichergestellt. Die spasmolytischen Eigenschaften der Paare 14a/14b und 16a/16b wurden am isolierten Meerschweinchendarm vergleichend untersucht.}, subject = {Anorganische Chemie}, language = {de} } @article{TackeNiednerFrohneckeetal.1980, author = {Tacke, Reinhold and Niedner, R. and Frohnecke, J. and Ernst, L. and Sheldrick, W. S.}, title = {Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, II}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63670}, year = {1980}, abstract = {Die potentiell curarewirksamen Silicium-Verbindungen Sa, Sc, Sd, Sg, Sh und 9a-9d wurden dargestellt. \(^1\)H-NMR-spektroskopische Untersuchungen ergaben Informationen {\"u}ber die Konformationen von 5 a- Sc in L{\"o}sung. Die Kristall- und Molek{\"u}lstruktur von 5 c wurde r{\"o}ntgenstrukturanalytisch bestimmt. Die muskelrelaxierenden Eigenschaften von S a- 5 h und 9 a-9 d wurden vergleichend an der Maus (i.v., LD50-Werte) untersucht. Die ermittelten Struktur-WirkungsBeziehungen werden in Hinblick auf die unterschiedlichen kovalenten Radien des Kohlenstoffund Siliciumatoms und die hieraus resultierenden N ... N-Abst{\"a}nde diskutiert.}, subject = {Anorganische Chemie}, language = {de} } @article{LeiningerChristl1980, author = {Leininger, H. and Christl, Manfred}, title = {Oxidationsreaktionen am Benzvalen: Ozonolyse, cis-Hydroxylierung, Epoxidation und Singulettsauerstoff-Addition}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58088}, year = {1980}, abstract = {No abstract available}, subject = {Organische Chemie}, language = {de} } @article{ChristlLangHerbertetal.1980, author = {Christl, Manfred and Lang, R. and Herbert, R. and Freitag, G.}, title = {Zusammenhang zwischen Orbitalcharakter und Reaktionsprodukt bei der Umsetzung von Benzvalen und Homobenzvalen mit Thiophenol}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58065}, year = {1980}, abstract = {No abstract available}, subject = {Organische Chemie}, language = {de} } @article{ChristlLangLechner1980, author = {Christl, Manfred and Lang, R. and Lechner, M.}, title = {Tetra- und pentacyclische Tricyclo[4.1.0.0\(^{2,7}\)]hept-3-en-Derivate; Abfangprodukte des Tricyclo[4.1.0.0\(^{2,7}\)]hepta-3,4-diens}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58078}, year = {1980}, abstract = {No abstract available}, subject = {Organische Chemie}, language = {de} } @misc{OPUS4-3477, title = {Jahresbericht 1979}, organization = {Universit{\"a}tsbibliothek W{\"u}rzburg}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-42223}, year = {1980}, abstract = {Die Entwicklung der Universit{\"a}tsbibliothek W{\"u}rzburg im Jahr 1979.}, subject = {W{\"u}rzburg}, language = {de} } @inproceedings{Krueger1980, author = {Kr{\"u}ger, Hans-Peter}, title = {Selbst- und Fremdbeurteilung in Diagnostik und Psychotherapie}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40964}, year = {1980}, abstract = {No abstract available}, language = {de} } @inproceedings{KruegerKohnen1980, author = {Kr{\"u}ger, Hans-Peter and Kohnen, Ralph}, title = {Evaluierung gruppentherapeutischer Situationen durch physiologische Parameter und Selbsteinsch{\"a}tzungen}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40971}, year = {1980}, abstract = {No abstract available}, language = {de} } @article{KruegerLienert1980, author = {Kr{\"u}ger, Hans-Peter and Lienert, Gustav A.}, title = {Eine exakte nonparametrische Pr{\"u}fung auf Kovariation zweier autokorrelierter Zeitreihen}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-41049}, year = {1980}, abstract = {H{\"a}ufig tritt in der psychologischen und psychiatrischen Forschung die Frage nach dem Zusammenhang zwischen zwei oder mehreren Zeitreihen auf. {\"u}bliche Kovariationsmaße versagen dabei vor allem deshalb, weil sie nicht inferentiell ausgewertet werden k{\"o}nnen. An einem Beispiel aus der Pharmakopsychologie wird ein auf Pfanzagl (1963) zur{\"u}ckgehendes Verfahren vorgeschlagen, das es erlaubt, voraussetzungsfrei den Zusammenhang zwischen autokorrelierten Meßwertreihen zu pr{\"u}fen. Als Unabh{\"a}ngigkeit zweier Zeitreihen wird definiert, daß zwischen ihnen bei Erhaltung der Autokorrelation kein h{\"o}herer Zusammenhang besteht als nach dem Zufall zu erwarten.}, language = {de} } @article{KruegerKohnenLienert1980, author = {Kr{\"u}ger, Hans-Peter and Kohnen, Ralf and Lienert, Gustav A.}, title = {Lautst{\"a}rke ungleich Lautheit: Wirkung von Psychopharmaka auf das L{\"a}rmerleben}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-41026}, year = {1980}, abstract = {No abstract available}, language = {de} } @article{KruegerKohnenLienert1980, author = {Kr{\"u}ger, Hans-Peter and Kohnen, Ralf and Lienert, Gustav A.}, title = {Aufgabenvariation als Aktivationsparameter in Tranqualizer-Untersuchungen}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-41016}, year = {1980}, abstract = {No abstract available}, language = {de} } @article{BurschkaLeonhardWerner1980, author = {Burschka, Christian and Leonhard, K. and Werner, H.}, title = {Basische Metalle. XIV. Synthese und Kristallstruktur von C\(_5\)H\(_5\)(PMe\(_3\))CoS\(_5\) : Ein neuer Metallapentathia-Heterocyclus}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-31407}, year = {1980}, abstract = {Der Zweikernkomplex C\(_5\)H\(_5\)(PMe\(_3\))Co(\(\mu\)-CO)\(_2\)Mn(CO)C\(_5\)H\(_4\)Me (8) reagiert mit st{\"o}chiometrischen Mengen S\(_8\) in praktisch quantitativer Ausbeute zu C\(_5\)H\(_5\)(PMe\(_3\))CoS\(_5\) (4). Der Koba.ltapentathia-Heterocyclus 4 ist ebenfalls aus C\(_5\)H\(_5\)(PMe\(_3\))Co(h\(^2\)-CS\(_2\)) (5) und S\(_8\) zug{\"a}nglich. 4 kristallisiert monoklin mit den Gitterkonstanten a = 8,467(3) A, b = 12,128(4) A, c = 14,210(4) A und \(\beta\) = 102,20(2)°_ Die Sesselform des sechsgliedrigen CoS\(_5\)-Rings entspricht derjenigen in den bekannten Verbindungen (C\(_5\)H\(_5\))\(_2\)TiS\(_5\) und (C\(_5\)H\(_5\))\(_2\)VS\(_5\) , wobei in 4 der Cyclopentadienylligand die axiale und die Trimethylphosphingruppe die {\"a}.quatoriale Position einnehmen.}, subject = {Chemie}, language = {de} } @article{Burschka1980, author = {Burschka, Christian}, title = {CsCu\(_4\)S\(_3\) und CsCu\(_3\)S\(_2\) : Sulfide mit tetraedrisch und linear koordiniertem Kupfer}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-31366}, year = {1980}, abstract = {No abstract available}, subject = {Chemie}, language = {de} } @article{ScheerSommervilleMueller1980, author = {Scheer, Ulrich and Sommerville, John and M{\"u}ller, Ulrike}, title = {DNA is assembled into globular supranucleosomal chromatin structures by nuclear contents of amphibian oocytes}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-39671}, year = {1980}, abstract = {The assembly of DNA into nucleosomal and supranucleosomal chromatin structures has been studied (i) by injection of circular DNA molecules (plasmids) into nuclei of Pleurodeles waltlii oocytes; and (ii) by in vitro incubation of plasmid molecules with the supernatant fraction from oocyte nuclei of Pleurodeles and Xenopus laevis, followed by purification of nucleoprotein structures formed with sucrose gradient centrifugation. [n both types of experiments , spread preparations of the newly assembled and transcriptionally inactive chromatin , examined by electron microscopy , show dense globular higher order (supranucleosomal) packing forms. Under partially relaxing (low salt) preparation conditions granular chromatin subunits of about 30 nm diameter can be seen either as widely spaced particles or in closely packed aggregates. The transcriptionally inactive endogenous chromatin of chromomeres of lampbrush chromosomes is arranged in similar higher order chromatin units. A correlation is found between the sizes of the DN A molecule probes used and the numbers of nucleosomes and higher order globules in the assembled chromatin structures. After prolonged dispersion in low salt buffers , these globular chromatin units unfold into chains of7-12 nucleosomes. The results support the concept that chromatin is arranged , under physiological ion concentrations as they are present in the nucleus , in supranucleosomal units of globular morphology.}, language = {en} } @incollection{Wilhelm1980, author = {Wilhelm, Gernot}, title = {Die Fortsetzungstafel eines Briefes aus Kamid el-Loz (KL 72 : 600)}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-78079}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1980}, abstract = {No abstract available}, subject = {Arch{\"a}ologie}, language = {de} } @incollection{Wilhelm1980, author = {Wilhelm, Gernot}, title = {Ein Gef{\"a}ßfragment mit alphabetischer Keilinschrift}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-78068}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1980}, abstract = {No abstract available}, subject = {Arch{\"a}ologie}, language = {de} } @article{Schneider1980, author = {Schneider, Wolfgang}, title = {Kausalmodelle in der P{\"a}dagogischen Psychologie - Erg{\"a}nzende Analysen zu zwei einschl{\"a}gigen Untersuchungen}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87249}, year = {1980}, abstract = {In the present secondary analysis the results of studies by Simons et al. (1975) and Schwarzer (1979) were critically reanalyzed. The central point of the reanalysis concerned the test of the causal models used, especially the question, if the technique of path analysis was correctly applied. Whereas some modifications seemed necessary in both srudies, there was no reason to question their main results.}, subject = {P{\"a}dagogische Psychologie}, language = {de} } @article{TackeBentlagemTowartetal.1980, author = {Tacke, Reinhold and Bentlagem, A. and Towart, R. and Meyer, H. and Bossert, F. and Vater, W. and Stoepe, K.}, title = {Sila-Analoga von Nifedipin-{\"a}hnlichen 4-Aryl-2.6-dimethyl-1.4-dihydropyridin-3.5-dicarbons{\"a}ure-dialkylestern, I}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-82430}, year = {1980}, abstract = {no abstract available}, subject = {Chemie}, language = {de} } @article{Wilhelm1980, author = {Wilhelm, Gernot}, title = {Der Komitativ des Urart{\"a}ischen}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-82771}, year = {1980}, abstract = {No abstract available}, subject = {Minoische Kultur}, language = {de} } @book{WolfDomroeseLiebel1980, author = {Wolf, Norbert Richard and Domr{\"o}se, Gerd and Liebel, Hermann}, title = {List Sprachbuch 5}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-41637}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1980}, abstract = {No abstract available}, subject = {Deutschunterricht}, language = {de} } @incollection{FrankeScheerZentgrafetal.1980, author = {Franke, Werner W. and Scheer, Ulrich and Zentgraf, Hanswalter and Trendelenburg, Michael F. and M{\"u}ller, U. and Krohne, G. and Spring, H.}, title = {Organization of transcribed and nontranscribed chromatin}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40656}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1980}, abstract = {No abstract available}, subject = {Tumor / Zellteilung}, language = {en} } @article{Scheer1980, author = {Scheer, Ulrich}, title = {Structural organization of spacer chromatin between transcribed ribosomal RNA genes in amphibian oocytes}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-41057}, year = {1980}, abstract = {Transcribed nucleolar chomatin, including the spacer regions interspersed between the rRNA genes, is different from the bulk of nontranscribed chromatin in that the DNA of these regions appears to be in an extended (B) conformation when examined by electron microscopy. The possibility that this may reflect artificial unfolding of nucleosomes during incubation in very low salt buffers as routinely used in such spread preparations has been examined by studying the influence of various ion concentrations on nucleolar chromatin structure. Amplified nucleolar chromatin of amphibian oocytes (Xenopus laevis, Pleurodeles waltlii, Triturus cristatus) was spread in various concentrations of NaCl (range 0 to 20 mM). Below 1 mM salt spacer chromatin frequently revealed a variable number of irregularly shaped beads, whereas above this concentration the chromatin axis appeared uniformly smooth. At all salt concentrations studied, however, the length distribution of spacer and gene regions was identical. Preparations fixed with glutaraldehyde instead of formaldehyde, or unftxed preparations, were indistinguishable in this respect. The observations indicate that (i) rDNA spacer regions are not compacted into nucleosomal particles and into supranucleosomal structures when visualized at chromatin stabilizing salt concentrations (e.g., 20 mM NaCl), and (ii) spacer DNA is covered by a uniform layer of proteins of unknown nature which, at very low salt concentrations (below 1 mM NaCl), can artificially give rise to the appearance of small granular particles of approximately nucleosome-like sizes. These particles, however, are different from nucleosomes in that they do not foreshorten the associated spacer DNA. The data support the concept of an altered nucleohistone conformation not only in transcribed chromatin but also in the vicinity of transcriptional events.}, subject = {Cytologie}, language = {en} } @article{vonJagowSebald1980, author = {von Jagow, Gerhard and Sebald, Walter}, title = {b-Type cytochromes}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-47383}, year = {1980}, abstract = {No abstract available}, subject = {Biochemie}, language = {en} } @article{SebaldMachleidtWachter1980, author = {Sebald, Walter and Machleidt, Werner and Wachter, Elmar}, title = {N,N'-dicyclohexylcarbodiimide binds specifically to a single glutamyl residue of the proteolipid subunit of the mitochondrial adenosinetriphosphatases from Neurospora crassa and Saccharomyces cerevisiae}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-47394}, year = {1980}, abstract = {T~e N,N'-dicrclohexylcarbodiimide-binding proteolipid subumt of the mitochondrial adenosinetriphosphatases (ATP phosphohydrolase, EC 3.6.1.3) of Neurosporacrassa and Saccharomyces cerevisiae were purified from mitochondria incubated with the radioactively labeled inhibitor. The specifically labeled subunit was cleaved with cyanogen bromide and N-bromosuccinimide, and the resultant fragments were separated by gel chromatography in the presence of 80\% (vol/vol) formic acid. The N,N'-dicyclohexylcarbodiimide label was recovered in each organism exclusively in a 17-residue fragment. Further analysis by automated solid-phase Edman degrada.ti.on revealed tha~ the bound label was present at only one positIOn, correspondmg to a glutamyl residue. The NN'~ icyc~ohexyl~a~bodiiJ?1~de-'!l0dified glutamyl residue is the ~nly Id~ntIcal aCidic posItIon m both proteins and occurs in the middle of a hydrophobic sequence of about 25 residues.}, subject = {Dicyclohexylcarbodiimid}, language = {en} } @book{Koller1980, author = {Koller, Erwin}, title = {Totentanz: Versuch einer Textembeschreibung}, isbn = {3-85124-077-4}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-47239}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1980}, abstract = {No abstract available}, subject = {Deutsch}, language = {de} } @book{BachWolff1980, author = {Bach, Ulrich and Wolff, Dieter}, title = {Ausgew{\"a}hlte Bibliographie zur Psycholinguistik und Sprachpsychologie}, isbn = {3-589-20757-4}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-47220}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1980}, abstract = {No abstract available}, subject = {Psycholinguistik}, language = {de} } @incollection{WeinertSchneiderTreiber1980, author = {Weinert, Franz E. and Schneider, Wolfgang and Treiber, Bernhard}, title = {Bedingungsanalysen von (erwartungswidrigen) Schulleistungen}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87261}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1980}, abstract = {No abstract available.}, subject = {Schulleistung}, language = {de} } @article{TreiberSchneider1980, author = {Treiber, Bernhard and Schneider, Wolfgang}, title = {Qualifizierende und varianzreduzierende Wirkungen von Schulklassenunterricht}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87259}, year = {1980}, abstract = {Schulklassenunterricht soll m{\"o}glichst vielen Sch{\"u}lern ein m{\"o}glichst hohes kognitives Leistungsniveau erreichen helfen. Nur wenige Unterrichtsstudien haben bisher jedoch zur Aufkl{\"a}rung jener Lehr-Lern-Bedingungen beigerragen, unter denen sich hohe qualifikatorische und varianzreduktive Wirkungen gleichzeitig erreichen lassen. Die vorliegende Studie greift daf{\"u}r auf Merkmale einer adaptiv-remedialen Lehr-Lern-Organisation zur{\"u}ck und {\"u}berpr{\"u}ft ihren Erkl{\"a}rungsgehalt im Mathematikunterricht von 58 f{\"u}nften Hauptschulklassen. Zur systematischen Entwicklung komplexer Erkl{\"a}rungen und ihrer einzelfallartigen Beurteilung wird ein neu entwickeltes Programmsystem (HYPAG) angewandt. Es f{\"u}hn zur Auswahl einer Annahmenstruktur, in der Instrumental- und Rahmenbedingungen von Schulklassenunterricht in Wechselwirkung stehen, f{\"u}r sich genommen aber nur mehr hinreichende und darin substiruierbare Bedingungen qualifizierender und varianzreduktiver Unterrichtseffekte sind.}, subject = {Schulklasse}, language = {de} } @inproceedings{Hommers1980, author = {Hommers, Wilfried}, title = {Recht und Psychologie - Ein wechselseitiges Verh{\"a}ltnis}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-43938}, year = {1980}, abstract = {Traditionally psychological research had assisted (de lege lata and de lege ferenda) jurisdiction, legislation, and law enforcement. However, the fol1owing three examp1es support the thesis that certain areas of psycho1ogica1 research gain new concepts and hypotheses by considering re1ated juristic thought. First, a developmenta1 study on the judgment about neg1igent damages suggested a three-step deve10pment of the evaluation of neg1igence. That threestep development wou1d contradict Heider's sequence of responsibi1ity levels. Second, a cognitive algebra approach to asses the chi1d's understanding of the duty to compensate the victim for his 1055 caused by a culpab1e actor suggested a two-step deve10pment of understanding that duty. The chi1d of the first deve10pment a1 step wou1d regard giving on1y half compensation of the 10ss as doing his duty to repair damages. Third, the concept of cul pa and the "Strafzumes sungs 1 ehre" in the German juri 5 ti c thought are d i scussed as key concepts for innovating psycho1ogica1 research on a moral algebra. Insofar juristic thought proved to assist psycho1ogica1 theory bui1ding what would make the relation of juristic thought and psycho1ogy a relation of interdependence.}, language = {de} } @incollection{KruegerWolfrum1980, author = {Kr{\"u}ger, Hans-Peter and Wolfrum, Christine}, title = {Die Homogenit{\"a}t von Interaktion als Skalierungskriterium}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-41288}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1980}, abstract = {No abstract available}, language = {de} } @article{KruegerKohnen1980, author = {Kr{\"u}ger, Hans-Peter and Kohnen, Ralf}, title = {Eine neue Methode zur Pr{\"u}fung der Wirkung von Psychopharmaka - Die "Weltbeschreibung"}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-41566}, year = {1980}, abstract = {Kompensation und das Problem der Zuggebbarkeit werden als die beiden wichtigsten St{\"o}rquellen bei der Erfassung pharmakonbedingter Befindlichkeits{\"a}nderungen dargestellt. Gef{\"o}rdert werden diese Prozesse durch eine Zentrierung der Methode auf die Selbstbeobachtung. Es wird die Hypothese aufgestellt, daß die Selbstbeobachtung ersetzbar ist durch eine Beschreibung der "Welt draußen". Die Person kann sich nur in der Welt erleben - folglich werden Ver{\"a}nderungen dieses Erlebnis auch Ver{\"a}nderungen in der Beschreibung der Welt nach sich ziehen. Ausgehend von dieser Hypothese wird ein Experiment konzipiert, in dem die Vpn lediglich die experimentelle Situation und die am Experiment beteiligten anderen Vpn beschreiben, nicht aber sich selbst. Es kann gezeigt werden, daß mit den so gewonnenen Maßen eindeutige Wirkungen des eingesetzten Tranquilizers nachgewiesen werden k{\"o}nnen, ebenso eindeutige Dosis-Wirkungs-Beziehungen. Die Konsequenzen f{\"u}r eine pharmakopsychologische Methodik werden diskutiert. Zudem wird herausgehoben, daß Tranquilantien dann als positiv bewertet werden k{\"o}nnen, wenn sie die Reagibilit{\"a}t der Vpn auf die Situation erh{\"o}hen und durch eine Verringerung des allgemeinen Aktivierungsniveaus eine ad{\"a}quate Verarbeitung angstinduzierender Situatonen erm{\"o}glichen.}, language = {de} } @article{KruegerBuchta1980, author = {Kr{\"u}ger, Hans-Peter and Buchta, Herbert}, title = {Nichtparametrischer Vergleich von Testprofilen und Verlaufskurven bei unabh{\"a}ngigen Stichproben}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-41513}, year = {1980}, abstract = {Werden k Testwerte an zwei oder mehreren Stichproben von Pbn erhoben, stellt sich das Problem des Vergleichs von Testprofilen. {\"A}hnliche Fragen treten auf, wenn statt k verschiedenen Testwerten ein Meßwert zu k Zeitpunkten an einem Pb erhoben wird. Zur Auswertung dieser Fragestellung wird ein Vorgehen nach dem WILCOXON-Rangsummentest vorgeschlagen, der es erlaubt (1) Unterschiede aller Art (2) Unterschiede in der Lage und (3) Unterschiede in der Form der Profile zu pr{\"u}fen. Das Vorgehen wird an einem Beispiel aufgezeigt. Erweiterungen auf andere F{\"a}lle werden diskutiert.}, language = {de} } @misc{Krueger1980, author = {Kr{\"u}ger, Hans-Peter}, title = {Grundlagen und Probleme von Dimensionen in der Psychologie / Heinrich Wottawa}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-41546}, year = {1980}, abstract = {Buchbesprechung von Grundlagen und Probleme von Dimensionen in der Psychologie / Heinrich Wottawa. - Meisenheim am Glan: Hain, 1979. - 122 S., ISBN: 3-445-01927-4. - (Psychologia universalis ; 40)}, subject = {Dimension}, language = {de} } @article{Daut1980, author = {Daut, Volker}, title = {Die Entwicklung der Todesvorstellung bei Kindern und Jugendlichen}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-36069}, year = {1980}, abstract = {No abstract available}, language = {de} } @incollection{ClarkeEllgringWagner1980, author = {Clarke, AH and Ellgring, Johann Heinrich and Wagner, H.}, title = {Situational effects on the syntax of speech and gaze behaviour in dyads}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-50316}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1980}, abstract = {A substantial literature exists on the coordination of speaking and looking behaviour and their significance as indicators for the production and reception of social information. Within this framework, the temporal organisation of such behaviour has been 'shown to reflect both the coordination within the individual and between participants in a situation. In this paper, it is proposed that observed behavioural sequences may be formally described by rules of syntax, thus implying the likelihood of structural organisation as opposed to, for example, linear time dependence between behavioural states. This being the case, differing sets of rules and grammars respectively can be expected for various social situations. Clinical interviews and discu~sions between couples on a topic of marital conflict were analysed, the on-off patterns of speech and gaze being taken as data. The resulting behavioural repertoire was regarded, in the sense of a formal grammar, as the terminal vocabulary. A set of rewriting rules was determined and their associated probabilities inferred. The situational conditions were found to be reflectedin the syntactic features of the grammatical model - the terminal vocabulary, the production rules and the production probabilities.}, subject = {Psychologie}, language = {en} } @inproceedings{KruegerRausche1980, author = {Kr{\"u}ger, Hans-Peter and Rausche, A.}, title = {Die Pr{\"u}fung von Verlaufskurven auf das Vorliegen von Trends {\"u}ber die exakte Verteilung von Spearman's S}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-79827}, year = {1980}, abstract = {no abstract available}, subject = {Psychologie}, language = {de} } @article{KruegerKohnen1980, author = {Kr{\"u}ger, Hans-Peter and Kohnen, Ralf}, title = {Wirkungen von Psychopharmaka auf das L{\"a}rmerleben}, isbn = {0044-2712}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-41305}, year = {1980}, abstract = {In allgemeinpsychologischen L{\"a}rmexperimenten ist eine monotone Beziehung zwischen physikalischer Lautst{\"a}rke und erlebter Lautheit bestens abgesichert. In der vorliegenden Arbeit wird gezeigt, daß diese Beziehung unter Medikationsbedingungen nicht gilt. In einem 3 X 3 X 2-faktoriellen Versuchsplan mit den Faktoren physikalische Lautst{\"a}rke (weißes Rauschen in 76, 79 und 82 dB), Medikation (Tranquilizer, Plazebo, Stimulizer) und (niedere bzw. hohe) Ansprechbarkeit auf Medikamente beurteilten insgesamt 54 junge weibliche Versuchspersonen in sechs Durchg{\"a}ngen eine Serie von 12 gleichabst{\"a}ndigen L{\"a}rmstufen von 58 bis 92 dB in bezug auf die erlebte Lautheit. Es war weder eine Hauptwirkung Physikalische Lautst{\"a}rke noch Medikation aufgetreten, daf{\"u}r differenzierte die Schichtungsvariable Ansprechbarkeit auf beiden Faktoren. Eine Interpretation der Ergebnisse sensu Eysencks Drogenpostulat und im Sinne einer Aktivierungstheorie wird vorgenommen. Als Konsequenz f{\"u}r pharmakopsychologisches Experimentieren wird die Forderung erhoben, die in das Experiment eingebrachten Unabh{\"a}ngigen Variablen in ihrer Wirkung auf das Erleben der Vpn zu kontrollieren (subjektive Repr{\"a}sentation des experimentellen Angebotes).}, language = {de} } @article{EllgringWagnerClarke1980, author = {Ellgring, Johann Heinrich and Wagner, Helmut and Clarke, Andrew H.}, title = {Bin{\"a}re Kodierung von Sprechen und Blicken: Validit{\"a}t, Reliabilit{\"a}t und ihre Abh{\"a}ngigkeit von der zeitlichen Aufl{\"o}sung}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-43163}, year = {1980}, abstract = {Validit{\"a}t und Reliabilit{\"a}t der Sprechkodierung einer Beobachtergruppe wurden in Abh{\"a}ngigkeit von der zeitlichen Aufl{\"o}sung untersucht. Die Validit{\"a}t wurde anhand der {\"U}bereinstimmung der Beobachter mit einem automatischen Sprachdetektor berechnet. Die Reliabilit{\"a}tswerte f{\"u}r die Kodierung von Sprechen und Blikken ergaben sich aus der {\"U}bereinstimmung der Beobachter untereinander. Im wesentlichen zeigten sich folgende Ergebnisse: 1. Die Validit{\"a}t/Reliabilit{\"a}t der Sprechkodierung ist eine monotone, nichtlineare Funktion der gew{\"a}hlten Aufl{\"o}sung. Die systematischen Fehler, die auf Latenz und Tr{\"a}gheit der menschlichen Beobachter zur{\"u}ckgehen, werden bei einer Aufl{\"o}sung von 400 msec nahezu vollst{\"a}ndig unterdr{\"u}ckt. 2. Weder bei der Erfassung des Sprech- noch des Blickverhaltens lassen sich Anzeichen f{\"u}r Observer-Drift feststellen. Trainierte und untrainierte Beobachter unterscheiden sich nicht signifikant. 3. Die Kodierung des Sprechverhaltens ist geringf{\"u}gig reliabler als die des Blickverhaltens. Dieser Unterschied kann in der Praxis vernachl{\"a}ssigt werden.}, language = {de} } @book{Schneider1980, author = {Schneider, Wolfgang}, title = {Bedingungsanalysen des Rechtschreibens}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87151}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1980}, abstract = {No abstract available.}, subject = {Rechtschreibung}, language = {de} } @incollection{Ellgring1980, author = {Ellgring, Johann Heinrich}, title = {Video in der Verhaltenstherapie}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-42048}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1980}, abstract = {No abstract available}, language = {de} } @incollection{EllgringWagnerClarke1980, author = {Ellgring, Johann Heinrich and Wagner, H. and Clarke, AH}, title = {Psychopathological states and their effects on speech and gaze behaviour}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-50323}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1980}, abstract = {Internal characteristics such as depressed mood, anxiety and general negative emotions are accompanied, particularly during depressive illness, by changes in observable behaviour. Accordingly, the following questions may be examined: are intra-individual changes in speech and gaze behaviour related to changes in the internal psychopathological state? Further, do these changes occur synchronously to changes in the state of subjective well-being? A longitudinal study was made on depressed patients. Their behaviour was observed during standardised interviews and diagnostic-therapeutic discussions held at regu~ lar intervals. Various speech and gaze parameters were examined with respect to their coordination and their relationship to the subjective state of well-being. Considerable variation was found in the temporal relationship amongst these variables. The results are discussed with respect to the relevance of speech parameters and the coordination of verbal and nonverbal behaviour as indicators of the psychopathological condition.}, subject = {Psychologie}, language = {en} } @incollection{Ruhe1980, author = {Ruhe, Ernstpeter}, title = {Vorwort zu "De l´art de parler"}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-36784}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1980}, abstract = {No abstract available}, language = {de} } @article{BurschkaStroppelJutzi1981, author = {Burschka, Christian and Stroppel, Klaus and Jutzi, Peter}, title = {Die Struktur von μ-Dibromgermandiyl-bis(pentacarbonylwolfram)(W-W)}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-31852}, year = {1981}, abstract = {No abstract available}, subject = {Chemie}, language = {de} } @article{Siren1981, author = {Sir{\´e}n, Anna-Leena}, title = {Central cardiovascular and thermal effects of prostacyclin in rats}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-47943}, year = {1981}, abstract = {Prostacyclin (PGI2) induced a dose-dependent decrease in blood pressure with slight increases in heart rate and body temperature, when administered at the doses of 0.1-100 ~g into the lateral cerebral ventricle (i.c.v.) of the urethane-anaesthetised rat. When the same doses were administered intravenously, both the blood pressure and heart rate decreased. Central pretreatment wib~ sodiurn meclofenamate (1 mg/rat i.c.v.) antagonised the central hypotensive effect of PGI2 but i.c.v. pretreatrnent of the rats with indomethacin (1 mg/rat) failed to affect the PGI 2-induced hypotension. Central pretreatment with two histamine H2-receptor antagonists, cimetidine (500 ~g/rat i.c.v.) or metiamide (488 ~g/rat i.c.v.), antagonised the blood pressure lowering effect of 0.1 ~g dose of PGI2 but failed to affect the hypotension induced by higher PGI2 doses. Therefore the main central hypotensive effect of PGI2 seems not to be associated with the stimulation of histamine H2 -receptors in the brain. The hypotensive effect of i.c.v. administered PGI2 appears to be due to an action upon the central nervous system rather than to a leakage into the peripheral circulation. This assurnption is supported by the fact that sodiurn meclofenamate i.c.v. antagonised the effect of PGI 2. In addition, the chronotropic response to i.c.v. PGI2 was opposite to that induced by intravenous administration. The results also suggest that there may be differences in the mode of action between sodiurn meclofenamate and indomethacin.}, subject = {Prostaglandine}, language = {en} } @article{JutziKarlBurschka1981, author = {Jutzi, Peter and Karl, Alfons and Burschka, Christian}, title = {Synthese, Reaktionen und Struktur von Tricarbonyl(1R,1R',2,3,4,5-Tetraphenyl-1-Germacyclopentadien) Eisen-Komplexen}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-46723}, year = {1981}, abstract = {Die Tricarbonyl(germacy~lopentadien)eisen-Komplexe VI-X werden durch Umsetzung der Germacyclopentadiene I-V niit Fe(CO)\(_5\) dargestellt. In l,l-Dialkyl- und -Diaryl-l-gemiacyclopentadien-Komplexen kann die Ge-C( exo )-Bindung durch verschiedene Elementhaloge~de gespalten werden, wobei die I-Halogen-l-germacyclopentadien-Komplexe XII, XIII, XV-XVII gebildet werden. Eine Entkomplexierung des Komplexes XI tritt bei der Reaktion mit Me\(_3\)NO oder TiCl\(_4\) ein. Das Tricarbonyl(l-chlor-l-germacyclopentadien)eisen XII reagiert mit AgF, NaJ, NaOMe und LiAIH\(_4\) zu den Komplexen XIXXXII. Das German XXII kann mit CCl\(_4)\ in XII {\"u}berf{\"u}hrt werden. Die Tricarbonyleisen-Komplexe XI, XII, XVI, XVII und XIX reagieren photochemisch mit Trimethylphosphan zu den Dicarbonyl(trimethylphosphan)-Komplexen XXIII-XXVII. Die Kristallstruktur des Tricarbonyl(l-exo-fluor-1-endo-methyl-2,3,4,5-tetraphenyl-1-germacyclopentadien)eisen wird beschrieben.}, subject = {Chemie}, language = {de} } @article{Wilhelm1981, author = {Wilhelm, Gernot}, title = {Die Siegel des K{\"o}nigs Itḫi-teššup von Arrapḫa}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-51174}, year = {1981}, abstract = {No abstract available}, subject = {Orientalistik}, language = {de} } @article{DeltzMuellerHermelinkUlrichsetal.1981, author = {Deltz, E. and M{\"u}ller-Hermelink, HK and Ulrichs, Karin and Thiede, A. and M{\"u}ller-Ruchholtz, W.}, title = {Development of graft-versus-host reaction in various target organs after small intestine transplantation}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45459}, year = {1981}, abstract = {The GVHRIL foHowing transplantation of small intestine are different from those found after bone marrow transplantation or spleen cell injections in that they show a remarka ble, significant prevalence of lesions within the intestinal mucosa. These findings are consistent with the observation that jntestinal lymphocytes newly formed in mesenteric lymph nodes predominantly home in on the intestine again.\& The degree of histologic alteration within different tissues indicates that the graft and the host may survive the lesions of the lymphatic tissues, whereas the severe intestinal lesions following GVHR may easily cause death of the recipient. With regard to clinical sman bowel transplantation two statements can be made: (l) GVHRIL play a significant role in small bowel trans~ plantation. (2) To minimize their biologic importance, a selective elimination of the graft's Jymph nodes by irradiation or surgical resection should be considered in view of the remarkable difference between GVHRIL in lymph nodes and in the graft's intestinal wall itself.}, subject = {Chirurgie}, language = {en} } @article{DaenikenFriederichLutzetal.1981, author = {D{\"a}niken, A. von and Friederich, U. and Lutz, Werner K. and Schlatter, C.}, title = {Tests for mutagenicity in Salmonella and covalent binding to DNA and protein in the rat of the riot control agent o-chlorobenzylidene malononitrile (CS)}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61073}, year = {1981}, abstract = {The aim of this study was to determine whether o-chlorobenzylidene malononitrile ( CS) exhibits any genotoxic activity towards Salmonella or mammalian DNA in vivo. CS was synthesized with a [\(^{14}\)C]-label at the benzylic carbon atom. It was administered i. p. at a dose level of 13 mg/kg (1 mCi/kg) to young adult male rats. Liverand kidney DNA was isolated after 8, 25, and 75 h. The radioactivity was at (liver, 8 and 75 h) or below (all other samples) the limit of detection of 3 dpm. Therefore, a possible binding of CS to DNA is at least 10\(^5\) times lower than that of the strong hepatocarcinogen aflatoxin B1, and 4,000 times lower than that of vinyl chloride. In contrast to this lack of DNA binding, but in agreement with the chemical reactivity of CS, a binding to nuclear proteins could be detected with specific activities ranging between 50 and 121 dpm/mg for liver and between 3 and 41 dpm/mg for kidney. Protein binding could well be responsible for its pronounced cytotoxic effects. Cs was also tested in the Ames Salmonella/microsome assay. Strains TA 1535, TA 1537, TA 1538, TA 98, and TA 100 were used with or without pre-incubation. Only with strain TA 100 and only without pre-incubation, a doubling of the number of revertants was detectable at the highest dose Ievels used, 1,000 and 2,000 !lg CS per plate. With pre-incubation of TA 100 with CS, a slight increase of the number of revertants was seen at 100 and 500 !lg per plate, and a subsequent fall below control values at 1,000 J.tg. A check for the number of surviving bacteria revealed a strong bacteriotoxicity of the higher doses of es so that the calculated mutation frequencies, i.e., the oumber of revertants per number of surviving bacteria, increased with doses up to 500 !J.g. This toxicity could be counteracted in part by the addition of increasing amounts of rat liver microsomes. In the view of these results, and taking into account the rare and low exposure of man, it is concluded that CS will not create a risk for the induction of point mutations or of carcinogenic processes mediated by DNA binding.}, subject = {Toxikologie}, language = {en} } @article{DaenikenLutzSchlatter1981, author = {D{\"a}niken, A. von and Lutz, Werner K. and Schlatter, C.}, title = {Lack of covalent binding to rat liver DNA of the hypolipidemic drugs clofibrate and fenofibrate}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61087}, year = {1981}, abstract = {\(^{14}\)C-Labelled clofibric acid and fenofibric acid were administered p.o. to 200 g male and female rats. After 10 h, liver nuclear DNA and protein were isolated and the radioactivity was determined. Binding to protein was clearly measurable whereas no binding to DNA could be detected from any drug. A comparison of the Iimit of detection of such DNA binding with well-known chemical carcinogens revealed that the known hepatocarcinogenicity of clofibrate cannot be based upon an initiating, DNA damaging, mode of action but must be due to other, nongenotoxic, mechanisms such as peroxisome proliferation, hepatomegaly, or cytotoxicity due to protein binding. The risk assessment in man and the interpretation of the carcinogenicity data for rodents are discussed.}, subject = {Toxikologie}, language = {en} } @article{TackeStreckerNiedner1981, author = {Tacke, Reinhold and Strecker, M. and Niedner, R.}, title = {Cholinesterase-hemmende Organophosphors{\"a}ureester und ihre Sila-Analoga}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63689}, year = {1981}, abstract = {Die Organophosphors{\"a}ureester la-4a und ihre Sila-Analoga lb-4b des Typs R\(^1\)R\(^2\)P(O)( p-OC\(_6\)H\(_4\)ElMe\(_3\)) (EI = C, Si) wurden synthetisiert. Die Kohlenstoff-Verbindungen 1 a- 4a zeigen hinsichtlich ihrer Anticholinesterase-Aktivit{\"a}t die gleichen Struktur-Wirkungs-Beziehungen wie die Silicium-Verbindungen 1 b- 4 b. Letztere sind jeweils wirksamer als die entsprechenden C-Analoga.}, subject = {Anorganische Chemie}, language = {de} } @article{WieseTackeWannagat1981, author = {Wiese, D. and Tacke, Reinhold and Wannagat, U.}, title = {9,9-Dimethyl-10-(3-dimethylaminopropyl)-9-silaacridan, ein Sila-Analogon des Dimetacrins, und strukturverwandte Verbindungen}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63691}, year = {1981}, abstract = {Das Sila-Dimetacrin (3a), ein Sila-Analogon des Psychopharmakons Dimetacrin (2), und sein N,N-Diethylderivat 3 b sowie sein 3-Chlorderivat 3 c wurden, von den o-Halogenanilinen 4 a- c ausgehend, {\"u}ber die teilweise unbekannten Stufen 5 a- c bis 10a- d synthetisiert, in ihren Eigenschaften beschrieben und in ihrer Struktur {\"u}ber Elementaranalysen, \(^1\)H-NMR- und Massenspektren sichergestellt. Die Synthese des Zwischenproduktes Bis(2-bromphenyl)amin (9a) konnte optimiert werden.}, subject = {Anorganische Chemie}, language = {de} } @article{ChristlBrunn1981, author = {Christl, Manfred and Brunn, E.}, title = {Tetracyclo[4.1.0.0\(^{2,4}\).0\(^{3,5}\)]heptane aus 7,8-Diazatetracyclo[4.3.0.0\(^{2,4}\).0\(^{3,5}\)]non-7-enen}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58094}, year = {1981}, abstract = {No abstract available}, subject = {Organische Chemie}, language = {de} } @article{Heinsen1981, author = {Heinsen, Helmut}, title = {Regional differences in the distribution of lipofuscin in Purkinje cell perikarya : a quantitative Pigmentarchitectonic study of the Cerebellar Cortexof Senile Albino Rats}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-59904}, year = {1981}, abstract = {The distribution of lipofuscin in the perikarya of Purkin je cells of vermal and hemispheric lobules has been determined quantitatively in 7 rats, 30-38 months old, by the point-counting method. On the basis of morphologically and statistically significant differences a pigmentarchitectonics of the cerebellar cortex is established. The Purkinje cells of lobule VIa (Larsell 1952) are extremely lipofuscin-rich. The Purkinje cells of the hemispheres, lobules V, Vlb + c and VII contain considerable amounts of a finely granular lipofuscin, the Purkinje cells of lobules I-III and VIII- IXa a globular type of lipofuscin. The Purkinje cells of sublobule XI d c and X are lipofuscin-poor cells. Three types of lipofuscin ha ve been identified in the light microscope.}, subject = {Medizin}, language = {en} } @article{ScheerZentgrafSauer1981, author = {Scheer, Ulrich and Zentgraf, Hanswalter and Sauer, Helmut W.}, title = {Different chromatin structures in Physarum polycephalum: a special form of transcriptionally active chromatin devoid of nucleosomal particles}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-33148}, year = {1981}, abstract = {Nonnucleolar chromatin from interphase nuclei of Physarum polycephalum plasmodia occurs in two different structural configurations as seen in electron microscopic spread preparations. While the majority of the chromatin is devoid of nascent ribonucleoprotein (RNP) fibrils and compacted into nucleosomal particles, a minor proportion (10- 20\%) is organized differently and reveals a smooth contour. It is this form of smooth chromatin which is rich in transcription units (mean length: 1.36±0.21 11m). Only occasionally are solitary nascent RNP fibrils observed which are associated with beaded strands of chromatin. In transcribed smooth chromatin nucleosomal particles are not only absent from the transcription units but also from their nontranscribed flan king regions, indicating that this special structural aspect is not merely a direct consequence of the transcriptional process. The existence of ca. 10- 20\% of Physarum chromatin in the smoothly contoured form is discussed in relation to reports of a preferential digestibility of a similar proportion of Physarum chromatin by DNAse I (Jalouzot et al. , 1980) and to the altered configuration of "peak A" chromatin subunits after micrococcal nuclease digestion (Johnson et al., 1978a, b).}, language = {en} } @misc{Koenig1981, author = {K{\"o}nig, Dorothea}, title = {Wortindex zum Psalterium Sinaiticum / Maria Dumitrescu, Sinajskij Paterik}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-38758}, year = {1981}, abstract = {Maria Dumitrescu, Sinajskij Paterik : Wortindex zum Psalterium Sinaiticum, Bucuresti, 1980}, language = {de} } @misc{OPUS4-3478, title = {Jahresbericht 1980}, organization = {Universit{\"a}tsbibliothek W{\"u}rzburg}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-42232}, year = {1981}, abstract = {Die Entwicklung der Universit{\"a}tsbibliothek W{\"u}rzburg im Jahr 1980.}, subject = {W{\"u}rzburg}, language = {de} } @article{ChristlLanzendoerferFreund1981, author = {Christl, Manfred and Lanzend{\"o}rfer, Ulrike and Freund, Silke}, title = {Olefinadditionen an 2,5-Diphenyl-1,3,4-oxadiazin-6-on}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-41525}, year = {1981}, abstract = {No abstract available}, language = {de} } @incollection{Krueger1981, author = {Kr{\"u}ger, Hans-Peter}, title = {Nachuntersuchungen zur Ausbildung des Wollens}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40995}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1981}, abstract = {D{\"u}kers Ergebnisse zur Wirkung von zwangsl{\"a}ufiger Arbeit bei wollensschwachen Vpn konnten wieder eingebracht werden. Die Variation des Versuchsger{\"a}ts ergab, daß das Gelingen dieser Untersuchungen wesentlich von der methodisch einzuf{\"u}hrenden Unausweichlichkeit der Situation abh{\"a}ngt. Je weniger dies verwirklicht wird, desto geringer ist der Leistungsanstieg, um so mehr tritt die Person des Vls in den Vordergrund, um so schwerer f{\"a}llt es den Vpn, die Leistungssteigerung der eigenen Person zu attribuieren. Ferner konnte gezeigt werden, daß das Schreiben von Achten in freier und zwangsl{\"a}ufiger Arbeit zumindest dieselbe Wirkung auf andere Leistungen hat wie das direkte {\"u}ben dieser Leistungen. Offensichtlich wird mit dieser Methode eine zentrale Funktion der Leistung ge{\"u}bt.}, language = {de} } @article{AgranovskyDolyaGorboulevetal.1981, author = {Agranovsky, A. A. and Dolya, V. V. and Gorboulev, Valentin G. and Kozlov, J. V. and Atabekov, J. G.}, title = {Aminoacylation of barley stripe mosaic virus RNA: polyadenylate-containing RNA has a 3'-terminal tyrosine-accepting structure}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-32566}, year = {1981}, abstract = {Barley stripe mosaic virus (BSMV) RNA which was previously reported to contain poly(A) sequences (Agranovsky et al., 1978) can be specifically esterified with tyrosine in vitro in the presence of an aminoacyl-tRNA synthetase fraction from wheat embryos. All the three RNA components of the BSMV strain with a three-component genome (Norwich) and both RNA components of a two-component strain (Russian) can be tyrosylated. The poly(A)-containing (bound to oligo(dT)-cellulose) and poly(A)-deficient(not bound to oligo(dT)-cellulose) fractions of BSMV RNA display a similar amino acidaccepting ability. The nucleotide sequence which accepts tyrosine is coupled with the intact genomic polyadenylated BSMV RNA. The viral RNA isolated after sucrose density gradient centrifugation under drastic denaturing conditions retains its aminoacylating activity, which suggests that this activity is not due to the presence in a BSMV RNA preparation of a tyrosine tRNA associated with BSMV RNA. Inhibition of aminoacylation of the 3'-oxidized (treated with sodium metaperiodate) BSMV RNA suggests that the tyrosine-accepting structure is localized at the 3' terminus of BSMV RNA molecules. It is shown that segments of different lengths obtained upon random fragmentation can be tyrosylated. The 3'-terminal (tyrosine-accepting) poly(A)+ segments can be isolated. The shortest segments of viral RNA capable of being aminoacylated [i.e., containing both tRNA-like structure and poly(A)] consists of approximately 150-200 nucleotides. The analysis of the oligonucleotides derived from individual BSMV RNA components labeled with 32P at the 3' end revealed two types of 3'-terminal sequences different from poly(A). It is suggested that a poly(A) sequence is intercalated between a 3'-terminal tyrosineaccepting structure and the 5'-terminal portion of poly(A)+ BSMV RNA.}, language = {en} } @article{KozlovGorboulevKurmanovaetal.1981, author = {Kozlov, J. V. and Gorboulev, Valentin G. and Kurmanova, A. G. and Bayev, Alexander A. and Shilov, A. A. and Zhdanov, V. M.}, title = {On the origin of the H1N1 (A/USSR/90/77) influenza virus}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-32556}, year = {1981}, abstract = {The influenza virus H1N1 (the A/USSR/90/77 strain) that reappeared in 1977 after the H1N1 influenza viruses had disappeared from the human population, is compared with the A/FM/1/47 and the A/FW/1/50 influenza viruses by the method of oligonucleotide mapping of individual segments of the viral RNAs. Seven genes of the A/USSR/90/77 virus appear to be very similar to the corresponding genes of the A/FW/1/50 virus, whereas the gene coding for the M protein displays considerable homology to the corresponding gene of the A/FM/1/47 virus. The data demonstrate that the A/USSR/90/77 strain is a recombinant virus.}, language = {en} } @article{ScheerSommerville1981, author = {Scheer, Ulrich and Sommerville, J.}, title = {Structural organization of nascent transcripts and hnRNA molecules in amphibian oocytes}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-39765}, year = {1981}, abstract = {Comparisons ofrelative lengths oflampbrush loops, nascent RNP transcripts and hnRNA molecules from oocytes of amphibia with different C-values show that there is an increasing trend in loop, and transcriptional unit, length with increase in genome size but no increasing trend with respect to RN A contour length.The formation of duplex regions and circles in RNP fibrils indicates that RNA processing may occur within the nascent fibrils. The hnRNA molecules from oocytes of the various amphibia readily form intermolecular duplex structures. These complementary sequences have a low kinetic complexity and are transcribed from highly repetitive sequences distributed throughout the genome. Their possible function is considered.}, language = {en} } @article{BurschkaSchenk1981, author = {Burschka, Christian and Schenk, W. A.}, title = {Die Kristallstruktur von Tetramethylammonium-Chloropentacarbonylwolframat}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-31417}, year = {1981}, abstract = {Die Struktur von Tetramethylammoniumchloropentacarbonylwolframat wurde rontgenographisch aue Einkristalldaten bestimmt. Die Verbindung kristallisiert mit vier Formeleinheiten in del' monoklinen Elementarzelle (Raumgruppe P2Jc) folgender Dimensionen: a = 1111,3(4) pm, b = 1110,3(4) pm, c = 1204,1(3) pm, f3 = 99,63(3)°, V = 1464,8 . 106 pm' (R = 0,028). Das Anion besitzt annahernd C4v·Symmetrie mit d(W -C(ois» = 203 pm, d(WC( trans» = 197 pm, d(W-Cl) = 256,6 pm. Zwischen Kation undAnion treten keine ungewohnliche Kontakte auf.}, subject = {Chemie}, language = {de} } @article{AlbertBerningBurschkaetal.1981, author = {Albert, Bernhard and Berning, Wilfried and Burschka, Christian and H{\"u}nig, Siegfried and Martin, Hans-Dieter and Prokschy, Frank,}, title = {Transanulare Wechselwirkung des Azo-Chromophors inisodrinanalogen Systemen}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-31328}, year = {1981}, abstract = {No abstract available}, subject = {Chemie}, language = {de} } @article{Christl1981, author = {Christl, Manfred}, title = {Benzvalen - Eigenschaften und Synthesepotential}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-30041}, year = {1981}, abstract = {No abstract available}, language = {de} } @article{ZentgrafMuellerScheeretal.1981, author = {Zentgraf, H. and M{\"u}ller, U. and Scheer, Ulrich and Franke, W. W.}, title = {Evidence for the existence of globular units in the supranucleosomal organization of chromatin}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-34123}, year = {1981}, abstract = {No abstract available}, language = {en} } @article{BonaScheerBautz1981, author = {Bona, Marion and Scheer, Ulrich and Bautz, Ekkehard K. F.}, title = {Antibodies to RNA polymerase II (B) inhibit transcription in lampbrush chromosomes after microinjection into living amphibian oocytes}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-33128}, year = {1981}, abstract = {Antibodies directed against RNA polymerase II (B) from Drosophila melanogaster were obtained from rabbit sera and, as monoclonal immunoglobulins, from mouse hybridomas and shown to cross-react with the amphibian enzyme protein. Localization by indirect immunofluorescence microscopy revealed the association of this enzyme with chromatin of interphase nuclei of amphibian cells and its absence in nucleoli. Purified immunoglobulins were microinjected in to nuclei ofliving vitellogenic oocytes of Ple1lrodeles waltlii and X enopus laevis and their effects on transcriptional processes were monitored by biochemical and light and electron microscopic stud ies. RNA polymerase II antibodies from rabbit sera caused a rapid and almost complete release of nascent transcripts from the chromatin axis of the loops of lampbrush chromosomes, followed by collapse of the loops and their retraction on the main chromosome axis. Monoclonal murine antibodies to the Iarge RNA polymerase II subunits also inhibited transcription in chromosome Ioops but appeared to inhibit initiation rather than elongation events. Activities of class land III RNA polymerases were not significantly affected by injection of antibodies to polymerase II, indicating immunological differences between the three RNA polymerases. The potential value of the in vitro test system described , as a very sensitive assay for detecting proteins involved in transcription in living cells, is discussed. 1}, language = {en} } @article{FrankeScheerKrohneetal.1981, author = {Franke, Werner W. and Scheer, Ulrich and Krohne, Georg and Jarasch, Ernst-Dieter}, title = {The nuclear envelope and the architecture of the nuclear periphery}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-33108}, year = {1981}, abstract = {No abstract available}, language = {en} } @article{FrankeKleinschmidtSpringetal.1981, author = {Franke, Werner W. and Kleinschmidt, J{\"u}rgen A. and Spring, Herbert and Krohne, Georg and Grund, Christine and Trendelenburg, Michael F. and St{\"o}hr, Michael and Scheer, Ulrich}, title = {A nucleolar skeleton of protein filaments demonstrated in amplified nucleoli of Xenopus laevis}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-33130}, year = {1981}, abstract = {The amplified, extrachromosomal nucleoli of Xenopus oocytes contain a meshwork of -4-nm-thick filaments, which are densely coiled into higher-order fibrils of diameter 30-40 nm and are resistant to treatment with high- and low-salt concentrations, nucleases (DNase I, pancreatic RNase, micrococcal nuclease), sulfhydryl agents, and various nonionic detergents. This filamentous "skeleton" has been prepared from manually isolated nuclear contents and nucleoli as weil as from nucleoli isolated by fluorescence-activated particle sorting. The nucleolar skeletons are observed in light and electron microscopy and are characterized by ravels of filaments that are especially densely packed in the nucleolar cortex. DNA as weil as RNA are not constituents of this structure, and precursors to ribosomal RNAs are completely removed from the extraction-resistant filaments by treatment with high-salt buffer or RN ase. Fractions of isolated nucleolar skeletons show specific enrichment of an acidic major protein of 145,000 mol wt and an apparent pi value of -6.15, accompanied in some preparations by various amounts of minor proteins. The demonstration of this skeletal structure in "free" extrachromosomal nucleoli excludes the problem of contaminations by nonnucleolar material such as perinucleolar heterochromatin normally encountered in studies of nucleoli from somatic cells. It is suggested that this insoluble protein filament complex forms a skeleton specific to the nucleolus proper that is different from other extraction-resistant components of the nucleus such as matrix and lamina and is involved in the spatial organization of the nucleolar chromatin and its transcriptional products. In studies of the organization of the interphase nucleus, considerable progress has been made in the elucidation of the arrangement of chromatin components and transcriptional products. However, relatively little is known about the composition and function of another category of nuclear structures, the nonnucleoproteinaceous architectural components that are insoluble in solutions of low and high ionic strength, despite numerous studies dedicated to this problem. Such structures include (a) the nuclear envelope and its pore complexes (I, 15, 18, 23, 37, 41), (b) a peripheral layer of insoluble protein ("lamina"; I, 15, 22, 23, 59), (e) certain skeletal proteins related to the chromosome "scaffold" described by Laemmli and coworkers (see references 2 and 3), and (d) ill-defined tangles of fibrillar structures of the nuclear interior that are collectively described as residual "matrix" (6, 21 ; for reviews, see references THE JOURNAL OF CEll BrOlOGY . VOlUME 90 AUGUST 1981 289-299 © The RockefeIler University Press · 0021 -9525/ 81 / 08/ 0289/ 11 \$1 .00 4 and 12). The latter, preparatively}, language = {en} } @article{Scheer1981, author = {Scheer, Ulrich}, title = {Identification of a novel class of tandemly repeated genes transcribed on lampbrush chromosomes of Pleurodeles waltlii}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-33153}, year = {1981}, abstract = {Electron microscope preparations of lampbrush chromosomes from oocytes of Pleurodeles waltl;; have revealed a new class of tandemly repeated genes. These genes are highly active, as judged by the close spacing of nascent transcripts. They occur in clusters of >100 copies and are transcribed in units containing roughly 940 base pairs of DNA that are separated by nontranscribed spacers of an estimated DNA content of 2,410 base pairs. The size and the pattern of arrangement of these transcription units can not be correlated with any of the repetitious genes so far described.}, language = {en} } @inproceedings{KruegerKohnen1981, author = {Kr{\"u}ger, Hans-Peter and Kohnen, Ralph}, title = {Kognitive, emotionale und physiologische Determinanten sozialer Zust{\"a}nde}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86055}, year = {1981}, abstract = {The psychological and physiological effects of a socially oriented sensitivity training were evaluated. It is shown that decreased physical distance as well as increased intimacy yields high activation, both in psychological measures (experienced stress) and in pulse frequences. One result (highly significant and replicated in other experiments) was paradoxical: when Ss had to caress the face of a heterosexual vis-a-vis, they reported high experienced stress, but pulse frequences dropped rapidely below the resting pulse. Some suggestions are made to explain these findings. The question arises whether an autonomic somatic process, induced by social Stimulation, but independent of the cognitive coping is responsible for these results.}, subject = {Psychologie}, language = {de} } @article{TreiberSchneider1981, author = {Treiber, Bernhard and Schneider, Wolfgang}, title = {Schulisches Lernen im sozial{\"o}kologischen Kontext}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87271}, year = {1981}, abstract = {No abstract available.}, subject = {Lernen}, language = {de} } @inproceedings{SchartlSchartlAnders1981, author = {Schartl, A. and Schartl, Manfred and Anders, F.}, title = {Phenotypic conversion of malignant melanoma to benign melanoma and vice versa in Xiphophorus}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86662}, year = {1981}, abstract = {No abstract available.}, subject = {Schwertk{\"a}rpfling}, language = {en} } @book{WolfDomroeseLiebel1981, author = {Wolf, Norbert Richard and Domr{\"o}se, Gerd and Liebel, Hermann}, title = {List Sprachbuch 6 [Hauptband]}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-41688}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1981}, abstract = {No abstract available}, subject = {Deutschunterricht}, language = {de} } @book{Ante1981, author = {Ante, Ulrich}, title = {Politische Geographie}, isbn = {3-14-160278-6}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-36058}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1981}, abstract = {No abstract available}, subject = {Geopolitik}, language = {de} } @article{WernerSebald1981, author = {Werner, S. and Sebald, Werner}, title = {Immunological techniques for studies on the biogenesis of mitochondrial membrane proteins}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-82044}, year = {1981}, abstract = {no abstract available}, subject = {Biochemie}, language = {en} } @incollection{KruegerLehmacherWall1981, author = {Kr{\"u}ger, Hans-Peter and Lehmacher, Walter and Wall, K. - D.}, title = {The Fourfold Table up to N=80}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87053}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1981}, abstract = {No abstract available.}, subject = {Psychologie}, language = {en} } @inproceedings{AndersSchollSchartl1981, author = {Anders, F. and Scholl, E. and Schartl, Manfred}, title = {Environmental and hereditary factors in the causation of neoplasia, based on studies of the Xiphophorus fish melanoma system}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86402}, year = {1981}, abstract = {Neoplasia in Xiphophorus can be classified into: a) a Jarge group triggered by carcinogens; b) a large group triggered by promoters; and c) a small group that develops "spontaneously" according to Mendelian Jaw. The process leading to susceptibility for neoplasia is represented by the disintegration of gene systems that normally protect the fish from neoplasia. Interpopulational arid interracial hybridization is the most effective process that Ieads to disintegration of the protective gene systems. Environmental factors may complete disintegration in somatic cells and thus may trigger neoplasia. The applications of the findings on Xiphophorus to humans are discussed.}, subject = {Schwertk{\"a}rpfling}, language = {en} } @inproceedings{AndersSchartlScholl1981, author = {Anders, F. and Schartl, Manfred and Scholl, E.}, title = {Evaluation of environmental and hereditary factors in carcinogenesis, based on studies in Xiphophorus}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-72741}, year = {1981}, abstract = {Neoplasia in Xiphophorus can be classified into a) a large group that is triggered by carcinogens; b) a large group triggered by promoters; c) a small group that develops "spontaneously" following interpopulational and interracial hybridizations; and d) a small group that develops "spontaneously" following germ line mutation. The process leading to susceptibility for neoplasia is represented by the disintegration of gene systems that normally protect the fish from neoplasia. Hybridization is the most effective process that leads to disintegration of the protection gene systems. Environmental factors may complete disintegration and thus may trigger neoplasia. It is discussed whether the findings on Xiphophorus may also apply to humans.}, subject = {Schwertk{\"a}rpfling}, language = {en} } @book{Wolf1981, author = {Wolf, Nobert Richard}, title = {Althochdeutsch - Mittelhochdeutsch}, isbn = {3-494-02133-3}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-41654}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1981}, abstract = {No abstract available}, subject = {Deutsch}, language = {de} } @inproceedings{KohnenKrueger1981, author = {Kohnen, Ralph and Kr{\"u}ger, Hans-Peter}, title = {Soziale Situationen als experimentelle Bedingungen der Pharmakopsychologie}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86041}, year = {1981}, abstract = {Summary (Social Situations as Experimental Conditions in Psychopharmacology): To reduce a great variability of drug effects in healthy subjects, stress conditions are used often in pharmacopsychology. However, empirical results show that the desired stress effects are failing. This paper suggests to realize social stress Situations as interactions between subjects, expecting higher challenging effects than experimentator-subject-interactions, usually used in experimental designs. Two experimental studies are reported: the call-upsituation and the group-therapy situation. The experimental effects were measured by changes of pulse-frequencies. The results indicate that in the two situations high and low dosages of tranquilizing drugs lead to comparable (and so predictable) effects only, if a Situation is high challenging for the experimental subjects. The call-up situation, which proves performance, challenges male subjects highly. The emotional or social competence demanding group-therapy situation is a high challenging situation for warnen. It is concluded that no situation is stressing a person generally. Depending from personality characteristics, differential stressor effects appear. Consequences for experiments in pharmacopsychology are discussed.}, subject = {Soziale Situation}, language = {de} } @misc{Hommers1981, author = {Hommers, Wilfried}, title = {Ber{\"u}cksichtigung der Intelligenz im multiplen Zusammenhang von Pers{\"o}nlichkeitsmerkmalen, sozio{\"o}konomischen Daten und Schulniveau entbehrlich?}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-43390}, year = {1981}, abstract = {No abstract available}, subject = {Sonderp{\"a}dagogik / Zeitschrift}, language = {de} } @incollection{Krueger1981, author = {Kr{\"u}ger, Hans-Peter}, title = {Differentielle Pharmakopsychologie ohne Differentielle Psychologie?}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-34163}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1981}, abstract = {Die Differentielle Pharmakopsychologie st{\"u}tzt sich weitgehend auf Konzepte der Differentiellen Psychologie. Ihre Ergebnisse m{\"u}ssen sich deshalb auch voll der Diskussion stellen, in der die verwendeten Pers{\"o}nlichkeitskonzepte stehen. Es wird die Auffassung vertreten, daß diese Vorgehensweise nicht zwingend ist. Vielmehr sollte die Pharmakopsychologie die differentiellen Wirkungen ihrer experimentellen Anordnungen mit eigenen Methoden bestimmen. Sie leistet damit einen eigenst{\"a}ndigen Beitrag zur Differentiellen Psychologie. Paradigmatisch f{\"u}r eine solche Vorgehensweise wird ein Experiment vorgestellt, in dem die Wirkung von Psychopharmaka (Tranquilizer, Stimulizer) auf Erleben und Leistung in einer Streßsituation (Lernen unter weißem Rauschen) untersucht wird. Dabei zeigt sich, daß die Wirkung in einen generellen Anteil und einen differentiellen Anteil des individuellen "copings" zerlegt werden muß. Die Konsequenzen f{\"u}r die pharmakopsychologische Methodik werden diskutiert.}, language = {de} } @article{Wilhelm1981, author = {Wilhelm, Gernot}, title = {Zusammenschl{\"u}sse von Nuzi-Texten}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-70323}, year = {1981}, abstract = {no Abstract available}, subject = {Nusi}, language = {de} } @inproceedings{KruegerKohnenLienert1981, author = {Kr{\"u}ger, Hans-Peter and Kohnen, Ralf and Lienert, Gustav A.}, title = {Drei Forderungen zur Pr{\"u}fung der Homogenit{\"a}t von Zentren bei Multicenter-Studien}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-101730}, year = {1981}, abstract = {Es wird argumentiert, daß bei der Pr{\"u}fung der Homgenit{\"a}t von Zentren in mehrfaktoriellen Multicenter-Studien vor allem entscheidend ist, daß sich die Zentren in den faktoriellen Variablen nicht unterscheiden, deren Effekte in der sp{\"a}teren Auswertung interpretiert werden sollen. Dazu wird folgendes Procedere vorgeschlagen: (1) {\"u}berpr{\"u}fe, ob in allen Zentren die Randomisierungsbedingungen eingehalten wurden, (2) {\"u}berpr{\"u}fe, ob die Zentren homogen bezogen auf die eingebrachten Schichtvariablen (z.B. Geschlecht, Indikation) sind und (3) {\"u}berpr{\"u}fe, ob die Zentren homogen sind bezogen auf die Wechselwirkungen zwischen den eingebrachten faktoriellen Variablen. Es wird gezeigt, daß vor allem Forderung (3) f{\"u}r die Interpretationsf{\"a}higkeit der Ergebnisse von entscheidender Bedeutung ist. M{\"o}glichkeiten der statistischen Pr{\"u}fung dieser Voraussetzungen werden an einem Beispiel aus der klinischen Pr{\"u}fung eines Psychopharmakons vorgestellt.}, subject = {Psychologie}, language = {de} } @incollection{Ellgring1981, author = {Ellgring, Johann Heinrich}, title = {Psychische Beanspruchung durch Sprache und Blickzuwendung in Gespr{\"a}chs- und Leistungssituationen}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-42112}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1981}, abstract = {Die Koordination von Blickverhalten und Sprechaktivit{\"a}t wurde unter folgender Hypothese untersucht: Die durch Sprechvorbereitung und Sprechaktivit{\"a}t bedingte kognitive Belastung f{\"u}hrt dazu, daß die simultane Aufnahme bedeutsamer visueller Information reduziert wird. Generell wendet ein Sprecher nach der Darbietung einer verbalen Aufgabe den Blick von einer Informationsquelle zunehmend ab und wendet ihn erst zum Ende der gesprochenen Antwort wieder zu. Mit gr{\"o}ßerer Schwierigkeit der Aufgaben erh{\"o}ht sich die Wahrscheinlichkeit einer Abwendung. Nach diesen und weiteren Ergebnissen scheinen Sprechen und Blickzuwendung zumindest teilweise {\"a}hnlichen Regeln zu folgen wie andere simultan ablaufende T{\"a}tigkeiten.}, language = {de} } @inproceedings{Ellgring1981, author = {Ellgring, Johann Heinrich}, title = {Entwicklungen in video-unterst{\"u}tzter Diagnostik und Therapie}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-42127}, year = {1981}, abstract = {No abstract available}, language = {de} } @inproceedings{ClarkeWagnerEllgring1981, author = {Clarke, A. H. and Wagner, H. and Ellgring, Johann Heinrich}, title = {Eine syntaktische Analyse von Sprechen und Blickverhalten bei dyadischer Interaktion}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-42093}, year = {1981}, abstract = {No abstract available}, language = {de} } @incollection{ClarkeEllgringWagner1981, author = {Clarke, Andrew H. and Ellgring, Johann Heinrich and Wagner, Helmut}, title = {Analyse des Blickverhaltens in sozialen Situationen}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-43012}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1981}, abstract = {Der vorliegende Beitrag behandelt inhaltliche und methodische Probleme einer L{\"a}ngsschnittstudie, die derzeit am MPI f{\"u}r Psychiatrie in M{\"u}nchen an depressiven Patienten durchgef{\"u}hrt wird. Diese Untersuchung hat einen diagnostischen und einen kommunikationstheoretischen Aspekt. Von diagnostischem Interesse sind die depressionsspezifischen Ver{\"a}nderungen des kommunikativen Verhaltens. Kommunikationstheoretisch gewendet lautet die Frage, wie sich der interne Zustand einer Person in ihrem Verhalten reflektiert. In diesem Beitrag wird die Fragestellung konzentriert auf tonische Eigenschaften des Blickverhaltens im Interaktionsprozeß und deren Stabilit{\"a}t im Krankheitsverlauf. Zun{\"a}chst wird die theoretische Grundlage referiert, die wir f{\"u}r das Blickverhalten entwickelt haben. Im zweiten Abschnitt wird auf Datenerhebung und Reliabilit{\"a}tskontrolle eingegangen. Die Struktur der Daten bestimmt die Auswertungsmethoden. Einige der Methoden, mit denen wir derzeit arbeiten, werden im Zusammenhang mit umschriebenen Problemstellungen erl{\"a}utert: Deskription und Interpretation des tonischen Blickverhaltens depressiver Patienten im Krankheitsverlauf (Abschnitt 3). Zusammenhang der individuellen Blickniveaus von Interaktionspartnern (Abschnitt 4) Deskription eines Dialogs (Interviews) als Sequenz von distinkten Zust{\"a}nden. In den Zust{\"a}nden werden Sprech- und Blickverhalten beider Interaktionspartner miteinander kombiniert (Abschnitt 5) Analyse der intraindividuellen Wechselwirkung zwischen Blick- und Sprechverhalten (Abschnitt 6). Die Abschnitte 3 mit 6 werden durch vorl{\"a}ufige Ergebnisse illustriert.}, language = {de} } @inproceedings{EllgringWinkler1981, author = {Ellgring, Johann Heinrich and Winkler, Barbara}, title = {Codierung und Analyse der Sprachinhalte klinischer Interviews}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-46273}, year = {1981}, abstract = {No abstract available}, language = {de} } @misc{Ellgring1981, author = {Ellgring, Johann Heinrich}, title = {Nonverbal communication - A review of research in Germany}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-42022}, year = {1981}, abstract = {This paper presents an overview of the research on nonverbal communication that has appeared in the German-language literature during the past decade, and gives some treatment of its relationship to Ausdruckspsychologie. Empirical studies, recent theoretical issues, and methodological developments are discussed. - Although nonverbal communication often plays an essential role in diagnosis and treatment, it has been widely neglected in academic training for the past 20 years. This inconsistency may partly be due to the outright rejection of the classical Ausdruckspsychologie during the 1960's. In order to avoid the fate of Ausdruckspsychologie, it will be necessary to extend our knowledge of nonverbal communication by means of further methodological development and empirical investigation}, language = {en} } @article{Schneider1981, author = {Schneider, Wolfgang}, title = {Rechtschreibdiagnose in der Grundschule - Theoretische und empirische Analysen zur spezifischen Problematik}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-50535}, year = {1981}, abstract = {Theoretische Analysen zum Problem des Recht-Schreibens weisen darauf hin, daß weniger Intelligenzmerkmale als vielmehr Ged{\"a}chtnis'eistungen bei dem Erwerb der Schriftsprache von Bedeutung sind. Daraus folgt, daß f{\"u}r die Pr{\"u}fw{\"o}rter in normierten Rechtschreibtests zumindest hinreichende Vorkommensfrequenz gew{\"a}hrleistet sein sollte. Diese Frage wird in der vorliegenden Untersuchung am Beispiel des Allgemeinen Schulleistungstests {\"u}berpr{\"u}ft: f{\"u}r die ausgew{\"a}hlten Klassenstufen kann gezeigt INerden, daß die Vorkommensh{\"a}ufigkeit der Pr{\"u}fW{\"O}fter nicht ausreicht und damit wenig geeignet ist, um die tats{\"a}chliche Rechtschreibfertigkeit zu erfassen. Der Vergleich mit mehreren eng am Curriculum orientierten Diktatproben kann gleichzeitig die Schwierigkeiten verdeutlichen, die dann entstehen, wenn zuverl{\"a}ssige Bestimmungen der individuellen Rechtschreibkompetenz vorgenommen werden sollen.}, subject = {Psychologie}, language = {de} } @incollection{Ruhe1981, author = {Ruhe, Ernstpeter}, title = {Appendice: Textes d'Arthur Adamov des ann{\´e}es 1926 {\`a} 1929. Edition des premiers textes.}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-43964}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1981}, abstract = {No abstract available}, subject = {Adamov}, language = {fr} } @article{Siren1982, author = {Sir{\´e}n, Anna-Leena}, title = {Differences in central actions of arachidonic acid and prostaglandin F\(_{2\alpha}\) between spontaneously hypertensive and normotensive rats}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63324}, year = {1982}, abstract = {Prostag1andin F\(_{2\alpha}\) (PGF\(_{2\alpha}\)) is one of the most common metabo1ites of arachidonic acid (M) in rat brain. When administered intracerebroventricularly (i.c.v.) to rats, both AA and PGFal exert dose-related hypertensive, tachycardic and hyperthermic effects. Metabolie alterations in the endogenaus formation of some prostaglandins in the brain-stem of spontaneously hypertensive rats (SHR) have been reported. Therefore the central effects of AA and PGF \(_{2\alpha}\) on blood pressure, heart rate and body temperature were studied both in SHR and nonootensive Wistar rats (NR) under urethane-anaesthesia. The hypertensive effect of AA i.c.v. (0.01-100 \(\mu\)g/rat) was larger in magni tude in SHR than in NR, but there was no significant difference in the M-induced changes of heart rate and body temperature between the groups. Pretreatment of NR wi th soditm1 :meclofenamate (1 mg/rat i.c.v.) antagonised the central effects of M indicating that these effects are not due to M itself but to its conversion to prostaglandins. Unlike the effects of AA, the central hypertensive, tachycardic and hyperthennic responses to PGF\(_{2\alpha}\) (0.5-50 l-lg/rat i.c.v .) were significantly attenuated in SHR. The present results obtained with M are conpatible with the previous assumption that the synthesis of prostaglandins in the brain of SHR might differ from that in NR. The results also demonstrate that the central effects of PGF\(_{2\alpha}\) are reduced in SHR.}, subject = {Neurobiologie}, language = {en} } @article{SchairerHoppeSebaldetal.1982, author = {Schairer, H. U. and Hoppe, J. and Sebald, Walter and Friedl, P.}, title = {Topological and functional aspects of the proton conductor, F\(_0\), of the Escherichia coli ATP-synthase}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62721}, year = {1982}, abstract = {The isolated H\(^+\) conductor, F\(_0\) , of the Escherichia co1i ATP-synthase consists of three subunits, a, b, and c. H\(^+\) -permeable liposomes can be reconstit~ted with F\(_0\) and lipids; addition of F\(_1\)-ATPase reconstitutes a functional ATP-synthase. Mutants with altered or misslng F\(_0\) subunits are defective in H\(^+\) conduction. Thus, all three subunits are necessary for the expression of H\(^+\) conduction. The subunits a and b contain binding sites for F\(_1\)• Computer calculations, cross-links, membrane-permeating photo-reactive labels, and proteases were used to develop tentative structural models for the individual F\(_0\) subunits.}, subject = {Biochemie}, language = {en} } @article{SebaldFriedlSchaireretal.1982, author = {Sebald, Walter and Friedl, P. and Schairer, H. U. and Hoppe, J.}, title = {Structure and genetics of the H\(^+\)-conducting F\(_0\) portion of the ATP synthase}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62733}, year = {1982}, abstract = {The ATP synthase occurs in remarkably conserved form in procaryotic and eucaryotic cells. Thus, our present knowledge of ATP synthase is derived from sturlies of the enzyme from different organisms, each affering specific experimental possibilities. In recent tim es, research on the H\(^+\) -conducting F0 part of the ATP synthase has been greatly stimulated by two developments in the Escherichio coli system. Firstly, the purification and reconstitution of the whole ATP synthase as weil as the proton conductor Fa from E. coli have been achieved. These functionally active preparations are well defined in terms of subunit composition, similar to the thermophilic enzyme from PS-3 studied by Kagawa's group.u Secondly, the genetics and the molecular cloning of the genes of all the F\(_0\) subunits from E. coli yielded information on the function of subunit polypeptides and essential amino acid residues. Furthermore, the amino acid sequence of hydrophobic F\(_0\) subunits, which are difficult to analyze by protein-chemical techniques, could be derived from the nucleotide sequence of the genes. These achievements, which shall be briefly summarized in the next part of this communication, provide the framework to study specific aspects of the structure and function of the F\(_0\) subunits.}, subject = {Biochemie}, language = {en} }