@article{WernerLeonhardBurschka1978,
author = {Werner, H. and Leonhard, K. and Burschka, Christian},
title = {Basische Metalle: IX. Synthese und Kristallstruktur von C\(_5\)H\(_5\)Co(PMe\(_3\))CS\(_2\) : Reaktionen zu zweikernkomplexen mit Co(SCS)Cr- und Co(SCS)Mn-Br{\"u}ckenbindungen},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-70444},
year = {1978},
abstract = {Durch Reaktion von C\(_5\)H\(_5\)Co(PMe\(_3\))\(_2\) (I) oder des Hetero-Zweikernkomplexes C\(_5\)H\(_5\)(PMe\(_3\))Co(CO)\(_2\)Mn(CO)C\(_3\)H .. Me (III) mit CS\(_2\) entsteht in praktisch quantitativer Ausbeute C\(_5\)H\(_5\)Co(PMe\(_3\))CS\(_2\) (IV). Die Kristallstruktur zeigt, dass der Carbondisulfid-Ligal'ld iiber Kohlenstoff und ein Schwefelatom (S(2)) dihaptogebunden vorliegt (Co-C = 1.89, Co-S(2) = 2.24 A, S(2)-C-S(1) = 141.2°). Die beiden C-S-AbsUinde in IV (C-S(2) = 1.68, C-S(l) = 1.60 A) sind gegenliber dem C-S-Abstand in freiem CS\(_2\) (1.554 A) aufgeweitet, was in Einklang mit dem aus spektroskopischen Daten zu folgernden starken 1T-Akzeptorcharakter von h\(^2\)-CS\(_2\) steht. IV reagiert mit Cr(CO)\(_5\)THF und C\(_5\)H\(_5\)Mn(CO)\(_2\)THF zu den Komplexen C\(_5\)H\(_5\)(PMe\(_3\))Co(SCS)Cr(CO)\(_5\) (V) bzw. C\(_5\)H\(_5\)(PMe\(_3\))Co(SCS)Mn(CO)\(_2\)C\(_5\)H\(_5\) (VI), in den en das in IV nicht am Cobalt gebundene Schwefelatom S(l) als Koordinationspartner gegen{\"u}ber den 16-Elektronen-Fragmenten Cr(CO)\(_5\) und Mn(CO)\(_2\)C\(_5\)H\(_5\) fungierl. Die spektroskopischen Daten von IV, V und VI werden diskutiert.},
subject = {Anorganische Chemie},
language = {de}
}
@article{VolzShinPrinzbachetal.1978,
author = {Volz, H. and Shin, J.-H. and Prinzbach, H. and Babsch, H. and Christl, Manfred},
title = {Stability of Tricyclo[4.1.0.0\(^{2,7}\)]heptenyl-Cations},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58001},
year = {1978},
abstract = {No abstract available},
subject = {Organische Chemie},
language = {en}
}
@article{ChristlFreitagBruentrup1978,
author = {Christl, Manfred and Freitag, G. and Br{\"u}ntrup, G.},
title = {Der Aufbau des Tetracyclo[4.1.0.0\(^{2,4}\).0\(^{3,5}\)]heptan-Systems durch Addition halogensubstituierter Carbene an Benzvalen},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58019},
year = {1978},
abstract = {No abstract available},
subject = {Organische Chemie},
language = {de}
}
@article{ChristlFreitagBruentrup1978,
author = {Christl, Manfred and Freitag, G. and Br{\"u}ntrup, G.},
title = {Tricyclo[4.1.0.0\(^{2,7}\)]hept-3-ene durch Umlagerung von 7-endo-Brom- und 7-endo-Chlortetracyclo[4.1.0.0\(^{2,4}\).0\(^{3,5}\)]heptanen},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58029},
year = {1978},
abstract = {No abstract available},
subject = {Organische Chemie},
language = {de}
}
@incollection{LanglotzHommers1978,
author = {Langlotz, Maren and Hommers, Wilfried},
title = {Ziele, Aufbau und Durchf{\"u}hrung des MURT},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-73113},
publisher = {Universit{\"a}t W{\"u}rzburg},
year = {1978},
abstract = {No abstract available},
subject = {MURT},
language = {de}
}
@article{GrafSebald1978,
author = {Graf, T. and Sebald, Walter},
title = {The dicyclohexylcarbodiimide-binding protein of the mitochondrial ATPase complex from beef heart. Isolation and amino acid composition},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62806},
year = {1978},
abstract = {No abstract available},
subject = {Biochemie},
language = {en}
}
@article{WieberBurschkaBaudis1978,
author = {Wieber, Markus and Burschka, Christian and Baudis, Ulrich},
title = {Darstellung und Molek{\"u}lstruktur von 2-Methylthio-1,3,2-benzodithiastibol},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-46772},
year = {1978},
abstract = {No abstract available},
subject = {Chemie},
language = {de}
}
@article{KreftBernhardGoebel1978,
author = {Kreft, J{\"u}rgen and Bernhard, K. and Goebel, Werner},
title = {Recombinant plasmids capable to replication in B. subtilis and E. coli},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-47000},
year = {1978},
abstract = {The plasmid pBC16 (4.25 kbases), ongtnally isolated from Bacillus cereus, determines tetracycline resistance and can be transformed into competent cells of B. subtilis. A miniplasmid of pBCl6 (pBCI6-1), 2,7 kb) which has lost an EcoRI fragment of pBCI6 retains the replication functions and the tetracycline resistance. This plasmid which carries only one EcoRI site has been joined in vitro to pBS], a cryptic plasmid previously isolated from B. subtilis and shown to carry also a single EcoRI site (Bernhard et aI., 1978). The recombinant plasmid is unstable and dissociates into the plasmid pBSl61 (8.2 kb) and the smaller plasmid pBS162 (2. I kb). Plasmid pBS161 retains the tetracycline resistance. It possesses a single EcoRI site and 6 HindlII sites. The largest HindIII fragment of pBS161 carries the tetracycline resistance gene and the replication function. After circularization in vitro of this fragment a new plasmid, pBS161-l is generated, which can be used as a HindlII and EcoRI cloning vector in Bacillus suhtilis. Hybrid plasmids consisting of the E. coli plasmids pBR322, p WL 7 or pACl84 and different HindlII fragments of pBSI61 were constructed in vitro. Hybrids containing together with the E. coli plasmid the largest HindlII fragment of pBS161 can replicate in E. coli and B. sublilis. In E. coli only the replicon of the E. coli plasmid part is functioning whereas in B. suhtilis replication of the hybrid plasmid is under the control of the Bacillus replicon. The tetracycline resistance of the B. subtilis plasmid is expressed in E. coli, but several antibiotic resistances of the E. coli plasmids (ampicillin, kanamycin and chloramphenicol) are not expressed in B. suhtilis. The hybrid plasmids seem to be more unstable in B. subtilis than in E. coli.},
language = {en}
}
@article{LutzBraendleZbinden1978,
author = {Lutz, Werner K. and Br{\"a}ndle, E. and Zbinden, G.},
title = {Effect of gum Arabic on aminopyrine demethylation in rats},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61146},
year = {1978},
abstract = {Stimulation of aminopyrine demethylation induced in rats by oral or i.p. administration of phenobarbital was partially inhibited in animals receiving daily treatments of 2 x 200 mg/kg gum Arabic p.o.},
subject = {Toxikologie},
language = {en}
}
@article{VivianiLutz1978,
author = {Viviani, A. and Lutz, Werner K.},
title = {Modulation of the binding of the carcinogen benzo(a)pyrene to rat liver DNA in vivo by selective induction of microsomal and nuclear aryl hydrocarbon hydroxylase activity},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61150},
year = {1978},
abstract = {The lnfluence of mlcrosomal and nuclear aryl hydrocarbon hydroxylase (AHH) actlvlty on the covalent blndlng of [G·3H]benzo(a )pyrene to rat llver DNA was evaluated in viWJ. lnductlon of mlcrosomal AHH was obtalned alter phenobarbltal treatment (160\% of control), whlch also lncreased DNA blndlng to 190\%, but left the nuclear actlvlty unchanged. Nuclear AHH was lnduced wlth dleldrln (150\%), and the blndlng was decreased to 75\%, whereaa the mlcrosomal AHH was at control Ievei. The lncreaslng effect of mlcrosomal AHH lnductlon as weil as the decreaslng effect of nuclear AHH lnductlon on the blndlng was shown clearly when the data of the Individual rata were uaed to solve the equatlon Binding = e•(mlcroeomal AHH) + b•(nuclear AHH) + c Multiple linear regresslon analysls wlth the data from 10 anlmala reaulted ln positive valuea for a and c, a negative value for b, and a good multiple correlatlon coefflclent of r = 0.974. Pretreatment wlth 3-methylcholanthrene ln· duced mlcrosomal AHH to 380\% of control and nuclear AHH to 590\% and lncreased the blndlng' to 175,.-o. The blndlng was hlgher than predlcted by the formula found, probably because the lncreaslng lnfluence of lnduced mlcrosomal AHH overahadowed the decreaslng effect of the nuclear AHH. The study ahows clearly that the blndlng of a forelgn compound to DNA in viWJ Ia dependent not only on mlcrosomal enzyme actlvltles but also on nuclear actlvltles even lf the latter are conslderably lower than thoae of mlcrosomes.},
subject = {Toxikologie},
language = {en}
}
@article{JaggiLutzSchlatter1978,
author = {Jaggi, W. and Lutz, Werner K. and Schlatter, C.},
title = {Covalent binding of ethinylestradiol and estrone to rat liver DNA in vivo},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61162},
year = {1978},
abstract = {Thecovalent bindingof [6,7-\(^3\)H]ethinylestradiol (EE)and [6,7-\(^3\)H]estrone (E) to liver DNA of 200 g female ratswas measured 8 h after the administration of 80 \(\mu\)g (9.2 mCi) estrogen by gavage. The binding is 1.5 for EE and 1.1 for E, expressedas binding to DNA/dose, in units of \(\mu\)mol hormonefmol DNA phosphate/mmole honnone/kg body wt. It is in the same order of magnitude as for benzene and about 10 000 tim es below the binding of typical liver carcinogens, such as aflatoxin B\(_1\) or N,N-dimethylnitrosamine.},
subject = {Toxikologie},
language = {en}
}
@article{LutzViviantSchlatter1978,
author = {Lutz, Werner K. and Viviant, A. and Schlatter, C.},
title = {Nonlinear dose-response relationship for the binding of the carcinogen benzo(a)pyrene to rat liver DNA in vivo},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61179},
year = {1978},
abstract = {Wlth radioactive compound of high specific activity, the binding of carcinogene to DNA can be measured wlth doses that are ineffective ln long-term studies. The binding of tritiated benzo(a )pyrene to liver DNA of adult male rats has been determined 50 hr after a singie l.p. injection of doses between 40 1'9/kg and 4 mg/kg. The doseresponse relationship is linear up to 1 mg/kg, shows a step towards 2 mg/kg, and gives a shallow linear slope above that value. The observed binding ranges from 1.7 to 180 nmoles benzo(a)pyrene per mole DNA phosphate. The nonlinearity could be due to an induction of metabolizing enzymes. The microsomal aryl hydrocarbon hydroxylase activity increases significantly 24 hr after a single dose of 4 mg/kg and 48 hr after doses of 2 and 4 mg/kg, but no induction Ia found with 1 mg/kg. The binding from an equimolar dose is 35 times lower than the one found on mouse skin DNA and 300 times lower than that of N,Ndlmethylnitrosamine in rat liver. A good correlatlon exiats to the respective tumor formation in long-term studles.},
subject = {Toxikologie},
language = {en}
}
@article{VivianiLutzSchlatter1978,
author = {Viviani, A. and Lutz, Werner K. and Schlatter, C.},
title = {Time course of the induction of aryl hydrocarbon hydroxylase in rat liver nuclei and microsomes by phenobarbital, 3-methylcholanthrene, 2,3,7,8-tetrachloro-dibenzo-p-dioxin, dieldrin and other inducers},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61182},
year = {1978},
abstract = {Aryl hydrocarbon hydroxylase (AHH) has been measured in male rat Jiver nucJei and microsomes after treatment of adult animals with various inducers for up to 14 days. After daily i.p. injections of 3-methylcholanthrene (MC, 20 mg/kg) the nuclear activity increased to a maximum of 600 per cent of the control activity after 4 days whereas the microsomal activity was 400 per cent of control at the same date. After 12 days, both activities equilibrated at 400 per cent. A similar time course was found after a single i.p. injection of 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD, 0.01 mg/kg) with an induction to .500 and 300 per cent for nuclei and microsomes, respectiveJy. after 2 days, and to 400 per cent for both after 12 days. PhenobarbitaJ (PB) was given continuously in the drinking water (I g/1) and induced the microsomal activity to 200 per cent after 8 days and 170 per cent after 14 days. The nuclear activity was only slightly induced to a constant Ievei of 130 per cent between day 8 and 14. Dieldrin did not significantly increase the microsomal activity after daiJy i.p. injections (20 mg/kg), but the nuclear activity raised to 200 per cent after 3 days and levelled down tocontrol valuesafter 12 days. Other inducers tested were benz[a)anthracene (BA), hexachlorobenzene (HCB} and 1,1.1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT). The induction pattern with BA was similar tothat of MC, a modeJ compound for the group of cytochrome P448 inducers. The induction by HCB and DDT resembled that by PB. a typical cytochrome P450 inducer.},
subject = {Toxikologie},
language = {en}
}
@article{TackeNiederer1978,
author = {Tacke, Reinhold and Niederer, Reinhold},
title = {Sila-Pharmaka, 9. Mitt. [1] Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, I},
series = {Zeitschrift f{\"u}r Naturforschung B},
volume = {33},
journal = {Zeitschrift f{\"u}r Naturforschung B},
number = {4},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128277},
pages = {412-416},
year = {1978},
abstract = {Organosilicon compounds 8, 9 and 10 with potential curare-like action and their precursors 0, 6 and 7 were synthesized for the first time. 0-10 were characterized by their physical and chemical properties, and their structures were confirmed by analyses, IH NMR and mass spectroscopy (only for 0-7). The pharmacological and toxicological data of 8, 9 and 10 are reported.},
language = {de}
}
@misc{OPUS4-3475,
title = {Jahresbericht 1977},
organization = {Universit{\"a}tsbibliothek W{\"u}rzburg},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-42204},
year = {1978},
abstract = {Die Entwicklung der Universit{\"a}tsbibliothek W{\"u}rzburg im Jahr 1977.},
subject = {W{\"u}rzburg},
language = {de}
}
@article{FrankeScheer1978,
author = {Franke, Werner W. and Scheer, Ulrich},
title = {Morphology of transcriptional units at different states of activity},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-41363},
year = {1978},
abstract = {The morphology of two forms of transcription ally active chromatin, the nucleoli and the loops of lampbrush chromosomes, has been examined after fixation in situ or after isolation and dispersion of the material in media of low ionic strengths, using a variety of electron microscopic preparation techniques (e.g. spread preparations with positive or negative staining or without any staining at all, with bright and dark field illumination, with autoradiography, after pretreatment of the chromatin with specific detergents such as Sarkosyl NL-30; transmission and scanning transmission electron microscopy of ultrathin sections). Nucleolar chromatin and chromosomes from oocytes of various amphibia and insects as well as from green algae of the family of the Dasycladaceae were studied in particular detail. The morphology of transcriptional units that are densely packed with lateral ribonucleoprotein fibrils, indicative of great transcriptional activity, was compared with that of chromatin of reduced lateral fibril density, including stages of drug-induced inhibition. The micrographs showed that under conditions which preserve the nucleosomal organization in condensed chromatin studied in parallel, nucleosomes are not recognized in transcriptionally active chromatin. This holds for the transcribed regions as well as for apparently untranscribed (i.e. fibril-free) regions interspersed between ('spacer') and/or adjacent to transcribed genes and for the fibril-free regions within transcriptional units of reduced fibril density. In addition, comparison oflengths of repeating units of isolated rDNA with those observed in spread nucleolar chromatin indicated that this DNA is not foreshortened and packed into nucleosomal structures. Granular particles which were observed, at irregular frequencies and in variable patterns, in some spacer regions, did not result in a proportional shortening of the spacer axis, and were found to be resistant to detergent treatment effective in removing most of the chromatin associated proteins including histones. Thus, these particles behave like RNA polymerases rather than nucleosomes. It is suggested that structural changes from nucleosomal packing to an extended form of DNA are involved in the transcriptional activation of chromatin.},
language = {en}
}
@article{EllgringAsendorpf1978,
author = {Ellgring, Johann Heinrich and Asendorpf, Jens},
title = {Ein ost-westliches Theoriegef{\"a}lle in der Sozialpsychologie? Eine empirische Notiz},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-41961},
year = {1978},
abstract = {F{\"u}nf Jahre nach der programmatischen Aufforderung von ISRAEL \& TAJFEL (1972), mit dem Datensammeln aufzuh{\"o}ren und die theoretische Konfrontation zu suchen, stellt sich die Frage, ob der "Wind der Ver{\"a}nderung" (GRAUMANN, 1975) in der "Europ{\"a}ischen Sozialpsychologie" inzwischen kr{\"a}ftig geblasen hat. Uns interessierte speziell, wie sich heute das Verh{\"a}ltnis von Theorie zu Empirie und von Grundlagen zu Anwendungen einem wohl an Sozialpsychologie interessierten, nicht aber auf Sozialpsychologie spezialisierten deutschen Psychologen darstellt: {\"A}ndert sich dieses Verh{\"a}ltnis von "Ost nach West", d.h. von deutschsprachigen {\"u}ber nicht deutschsprachige "europ{\"a}ische" zu "amerikanischen" Ver{\"o}ffentlichungen? Ausserdem fragten wir, ob sich unterschiedliche thematische Sch werpunkte ausfindig machen lassen.},
language = {de}
}
@article{HellerKrueger1978,
author = {Heller, Dieter and Kr{\"u}ger, Hans-Peter},
title = {Die Sinnentnahme aus Texten in Abh{\"a}ngigkeit von der Schriftart},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-41004},
year = {1978},
abstract = {Texte in drei Schriftarten (Normalschrift, Großschrift und Kleinschrift) wurden 215 Kindern der 5. Jahrgangsstufe vorgelegt mit dem Ziel, die Leistung bei der Sinnentnahme zu vergleichen. Gleichzeitig wurden von den Vpn Urteile {\"u}ber die Erm{\"u}dung, die Anstrengung und die Schriftschwere abgegeben. Die schlechteste Sinnentnahme-Leistung trat auf bei Texten, die nur aus Großbuchstaben bestanden. Die Urteile der Vpn deckten sich mit den Leistungen bei der Sinnentnahme. Eine Aufteilung der Vpn nach Leistungsgruppen zeigte, daß gute Leser auf die Variation der Schrift in der Leistung wie in den Urteilen ausgepr{\"a}gter reagierten.},
language = {de}
}
@article{HommersStellerZienert1978,
author = {Hommers, Wilfried and Steller, Max and Zienert, Hans-Joachim},
title = {{\"U}ber die Verbesserung des Rollenspiels von jugendlichen Inhaftierten in sozialen Interaktionen durch Modellunterst{\"u}tztes Rollenspiel},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-43763},
year = {1978},
abstract = {15 jugendliche Inhaftierte einer Entlassungsabteilung nahmen an einem Modellunterst{\"u}tzten Rollentraining in schwierigen Situationen nach der Entlassung teil. Videoaufnahmen von nicht ge{\"u}bten Szenen wurden im Paarvergleich von Ratern auf die Besserung des Rollenspielverhaltens beurteilt. Die Ergebnisse sprechen f{\"u}r eine Verhaltensbesserung, die auf das Modellunterst{\"u}tzte Rollentraining zur{\"u}ckgef{\"u}hrt werden kann.},
subject = {Kinderpsychologie},
language = {de}
}
@article{HommersGloth1978,
author = {Hommers, Wilfried and Gloth, Ingola},
title = {Alternativenart, pers{\"o}nliche Gl{\"u}ckszahl und magisch animistische Begr{\"u}ndungen von Entscheidungen bei Risiko},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-43822},
year = {1978},
abstract = {Durch Variation des Konfliktgehalts zwischen zwei Alternativen und damit der Begr{\"u}ndbarkeit von Entscheidungen sollte gepr{\"u}ft werden, ob das Auftreten magisch-animistischer Begr{\"u}ndungen bei Schulkindern nur Begr{\"u}ndungsschwierigkeiten anzeigt und nicht magisch-animistisches Denken. Mit Hilfe einer erfragten Gl{\"u}ckszahl beim W{\"u}rfeln sollte außerdem die Validit{\"a}t des magisch-animistisehen Gehalts von derartigen Begr{\"u}ndungen untersucht werden. Es zeigte sich bei 61 11j{\"a}hrigen Vpn, daß magisch-animistisch klassifizierte Antworten mit dem Konfliktgehalt der Alternativen zusammenhingen und bei eine Gl{\"u}ckszahl besitzenden Vpn, die diese in den Entscheidungen ber{\"u}cksichtigen, h{\"a}ufiger vorkommen als bei Vpn zweier Vergleichsgruppen.},
subject = {Angewandte Psychologie},
language = {de}
}
@article{Scheer1978,
author = {Scheer, Ulrich},
title = {Changes of nucleosome frequency in nucleolar and non-nucleolar chromatin as a function of transcription: an electron microscopic study},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-39750},
year = {1978},
abstract = {The morphology of nucleolar and non-nucleolar (Iampbrush chromosome loops) chromatin was studied in the electron microscope during states of reduced transcriptional activity in amphibian oocytes (Xenopus laevis, Triturus alpestris, T. cristatus). Reduced transcriptional activity was observed in maturing stages of oocyte development and after treatment with an inhibitor, actinomycin D. Strands of nucleolar chromatin appear smooth and thin, and contain only few, if any, nucleosomal particles in the transcribed units. This is true whether they are densely or only sparsely covered with lateral ribonucleoprotein fibrils. This smooth and non-nucleosomal character is also predominant in the interspersed, apparently nontranscribed rDNA spacer regions. During inactivation, however, nucleolar chromatin frequently and progressively assumes a beaded appearance in extended fibril-free-that is, apparently nontranscribed - regions. I n either fUll-grown 00- cytes or late after drug treatment, most of the nucleolar chromatin is no longer smooth and thin, but rather shows a beaded configuration indistinguishable from inactive non - nucleolar chromatin. In many chromatin strands, transitions of fibril-associated regions of smooth character into beaded regions wihout lateral fibrils are seen. Similarly, in the non-nucleolar chromatin of the retracting lampbrush chromosome loops, reduced transcriptional activity is correlated with a change from smooth to beaded morphology. Here, however, beaded regions are also commonly found interspersed between the more or less distant bases of the lateral fibrils, the putative transcriptional complexes. I n both sorts of chromatin, detergents (in particular Sarkosyl) that remove most of the chromatin proteins including histones from the DNA axis but leave the RNA polymerases of the transcriptional complexes attached were used to discriminate between polymerases and nucleosomal particles. The results suggest that nucleosomes are absent in heavily transcribed chromatin regions but are reformed after inactivation. In contrast to the findings with inactivated nucleolar genes, in lampbrush chromosome loops the beaded nucleosomal configuration appears to be assumed also in regions within transcriptional units that, perhaps temporarily, are not involved in transcription.},
language = {en}
}
@article{Burschka1978,
author = {Burschka, Christian},
title = {Intermolekulare Koordination bei zyklischen Esternder stibonigen und der thiostibonigen S{\"a}ure},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-31374},
year = {1978},
abstract = {Die Struktur von EinkristalIen des 2-Methoxi-l,3, 2-benzodioxastibols und des 2-Methylthio-l, 3, 2-benzodithiastibols konnte {\"u}ber R{\"o}ntgendiffraktometermessungen ermittelt werden. Die Verbindungen kristallisieren beide monoklin mit Elementarzellen, die jeweils 4 Formeleinheiten enthalten, sie sind jedoch nicht isomorph. Als Raumgruppe ergibt sich P21/n bzw. P21/c. Ungew{\"o}hnlich kurze intermolekulare Antimon-Chalkogen-Abst{\"a}nde lassen in der Struktur des Oxastibols koordinative Bindungen erkennen, die in dieser St{\"a}rke beim Thiastibol nicht auftreten.},
subject = {Chemie},
language = {de}
}
@inproceedings{FrankeZentgrafScheer1978,
author = {Franke, Werner W. and Zentgraf, Hanswalter and Scheer, Ulrich},
title = {Supranucleosomal and non-nucleosomal chromatin configurations},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-39447},
year = {1978},
abstract = {A significant contribution to the understanding of chromatin organization was the d iscovery of the nucleosome as a globular repeating unit of the package of DNA (Hewish and Burgoyne, 1973; Woodcock, 1973; Kornberg, 1974; Olins and Olins, 1974; for review see Oudet et al., 1978 a) . In accord with the original definition and in ag reement with most workers in this field of research we identify a nucleosome as a spheric alor slightly oblate gr anular particle 10-13 nm in diameter, containing about 200 base pairs of DNA and two of each of the four his tones H2a, H2b, H3 and H4. It is this structure in which the bulk of the nuclear chroma tin is organized in most eukaryotic cells, with the exception of the dinofl age llates (Rae and Steele, 1977; dinofl agellate DNA, however, c an be packed into nucleosoma l structures in vitro by addition of the appropriate amounts of histones;the same reference). Although it seems clear from the work reported that condensed and transcriptiona lly inactive chroma tin is contained in nucleosomes as the principle for first order p acking of DNA there are two important questions onto which we are focusing in the present study: ( i ) What is the higher order of p a cking present in - and perhaps typical-of - the condensed sta te of chromatin, and (ii) what is the specific form of arrangement of transcriptionally a ctive chromatin?},
language = {en}
}
@article{LutzSchlatter1978,
author = {Lutz, Werner K. and Schlatter, C.},
title = {A closed inhalation system for pharmacokinetic and metabolism studies of volatile compounds with small laboratory animals},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-80145},
year = {1978},
abstract = {In the inhalation system described an animal can be kept in the same atmosphere of a 2-liter desiccator for up to 24 h. The expired carbon dioxide is adsorbed with soda lime and the resulting reduced pressure is balanced by a supply of oxygen also used for the inflow of the chemical to be investigated. Urine and faeces can be collected ~eparately and the system allows a periodical control of the concentration of the chemical by sampling the air with needle and syringe.},
subject = {Toxikologie},
language = {en}
}
@article{ChristlBuchner1978,
author = {Christl, Manfred and Buchner, Wolfgang},
title = {13C-NMR-Spektren von Tetracyclo[4.1.0.02,4.03,5]heptanen, Tetracyclo[5.1.0.02,4.03,5]octanen und Tricyclo[4.1.0.02,7]hept-3-enen. Ungew{\"o}hnliche beta- und gamma-Substituenteneffekte},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-30087},
year = {1978},
abstract = {No abstract available},
language = {de}
}
@article{RunggerCrippaTrendelenburgetal.1978,
author = {Rungger, M. and Crippa, M. and Trendelenburg, M. F. and Scheer, Ulrich and Franke, Werner W.},
title = {Visualization of rDNA spacer transcription in Xenopus oocytes treated with fluorouridine},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-33082},
year = {1978},
abstract = {Under the intluence of 5-tluoro-uridine, the ultrastructure of the rDNA transcription units in Xenopus oocytes is altered. Whereas part of the matrix units maintains anormal aspect or shows various degrees of inhibition, in a strong proportion of the transcription units the alternating pattern of matrix units and fibril-free spacer regions is no longer recognized. Transcriptional complexes are found along the entire DNP axis, including the regions of the spacers. These observations support biochemical data on transcription in rDNA spacer region.},
language = {en}
}
@article{KrohneFrankeScheer1978,
author = {Krohne, Georg and Franke, Werner W. and Scheer, Ulrich},
title = {The major polypeptides of the nuclear pore complex},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-33078},
year = {1978},
abstract = {Nuclear envelopes of maturing oocytes of various amphibia contain an unusually high number of pore complexes in very close packing. Consequently, nuclear envelopes , which can be manually isolated in great purity, provide a remarkable enrichment of nuclear pore complex material, relative to membranous and other interporous structures. When the polypeptides of nuclear envelopes isolated from oocytes of Xenopl/s la evis and Triturus alpestris are examined by gel electrophoresis, visualized either by staining with Coomassie blue or by radiotluorography after in vitro reaction with [3H]dansyl chloride , a characteristic pattern is obtained (10 major and 15 minor bands). This polypeptide pattern is radically different from that of the nuclear contents isolated from the same cell. Extraction of the nuclear envelope with high salt concentrations and moderateIy ac tive detergents such as Triton X- 100 results in the removal of membrane material but leaves most of the non-membranous structure of the pore complexes. The dry weight of the pore complex (about 0.2 femtograms) remains essentially unchanged during such extractions as measured by quantitative electron microscopy . The extracted preparations which are highly enriched in nuclear pore complex material contain only two major polypeptide components with apparent molecular weights of 150000 and 73000. Components of such an electrophoretic mobility are not present as major bands , if at all , in nuclear contents extracted in the same way. lt is concluded that these two polypeptides are the major constituent protein(s) of the oocyte nuclear pore complex and are specific for this structure. When nuclear envelopes are isolated from rat liver and extracted with high salt buffers and Triton X- 100 similar bands are predominant, but two additional major components of molecular weights of 78000 and 66000 are also recognized. When the rat liver nuclear membranes are further subfractionated material enriched in the 66000 molecular weight component can be separated from the membrane material, indicating that this is relatively loosely associated material , probably a part of the nuclear matrix . The results suggest that the nuclear pore complex is not only a characteristic ubiquitous structure but also contains similar, if not identical , skeletal proteins that are remarkably re sistant to drastic changes of ionic strength as weil as to treatments with detergents and thiol reagents.},
language = {en}
}
@article{ScheerZentgraf1978,
author = {Scheer, Ulrich and Zentgraf, Hanswalter},
title = {Nucleosomal and supranucleosomal organization of transcriptionally inactive rDNA circles in Dytiscus oocytes},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-33188},
year = {1978},
abstract = {Oocytes of the water beetle, Dytiscus marginalis, contain large amounts of rDNA most of which is present in the form of rings containing one or several pre-rRNA genes. Electron microscopy of spread preparations of vitellogenic oocytes has shown that the rDNA is extended in chromatin rings with transcribed pre- rRNA genes and is not packed into nucleosomes (Trendelenburg eta!. , 1976). When similar preparations are made from previtellogenic ooytes in which a large proportion of the nuc1eolar chromatin is transcriptionally inactive, a different morphological form of this chromatin is recognized. In contrast to the transcribed chromatin rings the inactive nucleolar chromatin circles show the characteristic beaded configuration, indicative of nucleosomal packing. Nuc1eosomal packing is also indicated by the comparison of the lengths of these chromatin rings with both iso lated rDNA circ1es and transcribed chromatin rings. In addition, these inactive nuc1eofilaments often appear to be compacted into globular higher order structures of diameters from 21 to 34nm, each composed of an aggregate of 6-9 nuc1eosomes. While the estimated reduction of the overall length of rDNA, as seen in our preparations, is, on the average, only 2.2 - 2.4 fold in the nuc1eosomal state it is 10- 13 fold when supranuc1eosomal globules are present. These data show that the extrachromosomal rDNA of these oocytes goes through a cycle of condensation and extensio n, as a function of the specific transcriptional activity, and that the beaded state described here is exc1usively found in the non-transcribed state.},
language = {en}
}
@article{Wilhelm1978,
author = {Wilhelm, Gernot},
title = {D{\´e}couvertes {\´e}pigraphiques {\`a} Kāmid el-Lōz},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-78183},
year = {1978},
abstract = {No abstract available},
subject = {Geschichte},
language = {fr}
}
@inproceedings{LutzSchlatter1978,
author = {Lutz, Werner K. and Schlatter, C.},
title = {Extrapolation of carcinogenicity data to low doses with a dose-response study of the binding of benzo(a)pyrene to rat liver DNA},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-80157},
year = {1978},
abstract = {The binding of tritiated benzo(a)pyrene (BP) to liver DNA of 25 adult male rats (SIV 50) has been determined 50 h after a single intraperitoneal injection of doses between 40 ug/kg and 4; mg/kg. The dose-response relations~ ip is linear up to i mg/kg, shows a sigmoid step towards 2 mg/kg and a shallow linear. slope above that value. TlJe 0 bserved bin ding ranges from 1.7 to 180 nmoles BP per mole DNA phosphate. The non-linearity between 1 and 2 mg/kg could be explained 0):1 the basis of an induction of metabolizing enzymes. A pure1y mathematical extrapolation of therumour incidence from a carcinogenic dose (1 x 40mg/kg for a 20\% hepatoma incidence in newborn mice) to human exposure levels (aboilt 0.1 ug/kg per day) would never have followed a step like the on~ found in our experiments. Our dose-effect study therefore shows how carcinogenitity data could be extrapolated in a biologically founded way to low doses.},
subject = {Toxikologie},
language = {en}
}
@article{Wilhelm1978,
author = {Wilhelm, Gernot},
title = {Zur Rolle des Großgrundbesitzes in der hurritischen Gesellschft},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-82759},
year = {1978},
abstract = {No abstract available},
subject = {hurritische Gesellschft},
language = {de}
}
@article{WeissSebald1978,
author = {Weiss, H. and Sebald, Walter},
title = {Purification of cytochrome oxidase from Neurospora crassa and other sources},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-82082},
year = {1978},
abstract = {A chromatographic procedure 1 is described by means of which cytochrome oxidase has been purified from a variety of organisms including the fungus N eurospora crassa,2,3 the unicellular alga Po/ytoma mirum, 4 the insect Locusta migratoria ,5 the frog Xenopus muel/eri,4 and the mammal Rattus norwegicus. 4 This procedure can be used to equal effect for large-scale preparations, starting from grams of mitochondrial protein, or for small-scale preparations starting from milligrams. The cytochrome oxidase preparations from the different organisms are enzymically active. They show similar subunit compositions.},
subject = {Biochemie},
language = {en}
}
@inproceedings{FrankeScheerTrendelenburgetal.1978,
author = {Franke, Werner W. and Scheer, Ulrich and Trendelenburg, Michael F. and Zentgraf, H. and Spring, H.},
title = {Morphology of transcriptionally active chromatin},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-41097},
year = {1978},
abstract = {Some decades ago it was noted by cytologists that within the interphase nucleus large portions of the transcriptionally ("genetically," in their terms) inactive chromosomal material are contained in aggregates of condensed chromatin, the "chromocenters," whereas transcriptionally active regions of chromosomes appear in a more dispersed form and are less intensely stained with DNA-directed staining procedures (Heitz 1929, 1932, 1956; Bauer 1933). The hypothesis that condensed chromatin is usually characterized by very low or no transcriptional activity, and that transcription occurs in loosely packed forms of chromatin (including, in most cells, the nucleolar chromatin) has received support from studies of ultrathin sections in the electron microscope and from the numerous attempts to separate transcriptionally active from inactive chromatin biochemically (for references, see Anderson et al. 1975; Berkowitz and Doty 1975; Krieg and Wells 1976; Rickwood and Birnie 1976; Gottesfeld 1977). Electron microscopic autoradiography has revealed that sites of RNA synthesis are enriched in dispersed chromatin regions located at the margins of condensed chromatin (Fakan and Bernhard 1971, 1973; Bouteille et al. 1974; Bachellerie et al. 1975) and are characterized by the occurrence of distinct granular and fibrillar ribonucleoprotein (RNP) structures, such as perichromatin granules and fibrils. The discovery that, in most eukaryotic nuclei, major parts of the chromatin are organized in the form of nucleosomes (Olins and Olins 1974; Kornberg 1974; Baldwin et al. 1975) has raised the question whether the same nucleosomal packing of DNA is also present in transcriptionally active chromatin strands. Recent detailed examination of the morphology of active and inactive chromatin involving a diversity of electron microscopic methods, particularly the spreading technique by Miller and coworkers (Miller and Beatty 1969; Miller and Bakken 1972), has indicated that the DNA of some actively transcribed regions is not packed into nucleosomal particles but is present in a rather extended form within a relatively thin (4-7 nm) chromatin fiber.},
language = {en}
}
@article{SchneiderSpringer1978,
author = {Schneider, Wolfgang and Springer, Adolf},
title = {Individualisierendes Rechtschreibtraining auf verhaltenstherapeutischer Basis},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87220},
year = {1978},
abstract = {14 rechtschreibschwache Sch{\"u}ier des 4. und 5. Schuljahrs nahmen an einem f{\"u}nfmonatigen Rechtschreib-F{\"o}rderprogramm auf verhaltenstherapeutischer und instruktionspsychologischer Grundlage teil. Das Training bestand aus einem individualisierenden Verfahren unter Anwendung eines M{\"u}nzverst{\"a}rkungsprogramms. Gegen{\"u}ber einer unbehandelten Kontrollgruppe zeigte sich f{\"u}r die Experimentalgruppe eine insgesamt deutliche Abnahme in der Fehlerh{\"a}ufigkeit, die sich statistisch absichern ließ. Zus{\"a}tzlich wird ein statistisches Verfahren vorgestellt, mit dem sich die Ver{\"a}nderung auf der Individualebene auf ihre Signifikanz hin {\"u}berpr{\"u}fen l{\"a}ßt.},
subject = {Rechtschreibung},
language = {de}
}
@article{Hommers1978,
author = {Hommers, Wilfried},
title = {Multinomiale und Bayes-statistische konfigurale Klassifikation},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-43798},
year = {1978},
abstract = {Ein Verfahren zur Klassifikation von Pbn aufgrund individueller Abweichung von der Annahme wiederholter multinornialer Zufallsereignisse und aufgrund individueller maximaler Likelihood der Zugeh{\"o}rigkeit zu einer bestimmten Gruppe wird nebst Modelltest dargelegt. Als Anwendungsbeispiel wird {\"u}ber die Ergebnisse bei zwei denkbaren Klassifikationen in verschiedenen Therapiemotivationsgruppen berichtet},
subject = {Psychologie},
language = {de}
}
@article{HommersTrempler1978,
author = {Hommers, Wilfried and Trempler, Volker},
title = {Zum Verhalten von Lernbehinderten in Zwei-Personen-Spielen},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-43921},
year = {1978},
abstract = {Die Methode der Matrix-Spiele, die in sozialpsychologischen Untersuchungen zur Erfassung von Kooperativit{\"a}t und Kompetitivit{\"a}t verwendet wurde, sollte auf ihre Tragf{\"a}higkeit in der Lernbehinderten-Forschung gepr{\"u}ft werden. Es wird {\"u}ber eine Untersuchung berichtet, in der zwei Nicht-Nullsummenspiele und ein Nullsummenspiel mit 56 lernbehinderten und 40 Normalsch{\"u}ler-Vpn durchgeftihrt wurden. Der Vergleich von Wahlh{\"a}ufigkeiten zwischen Lernbehinderten und Normalsch{\"u}lern zeigte einige Unterschiede, die auf Retardierungen im-Bereich der Kooperativit{\"a}t-Kompetitivit{\"a}t-Entwicklung hinwiesen. Die Diskussion der Ergebnisse unterst{\"u}tzt aber an Hand der Wahlbegr{\"u}ndungen nicht eine sozialpsychologische, sondern eine risikobezogene Interpretation des Verhaltens der Vpn.},
subject = {Sonderp{\"a}dagogik},
language = {de}
}
@article{Wilhelm1978,
author = {Wilhelm, Gernot},
title = {Ist das Elamische eine Ergativsprache?},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-82762},
year = {1978},
abstract = {No abstract available},
subject = {Iran},
language = {de}
}
@inproceedings{ClarkeEllgring1978,
author = {Clarke, A. H. and Ellgring, Johann Heinrich},
title = {Verfahren zur halbautomatischen Bearbeitung von Videoaufzeichnungen},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-33750},
year = {1978},
abstract = {No abstract available},
language = {de}
}
@inproceedings{EllgringClarke1978,
author = {Ellgring, Johann Heinrich and Clarke, A. H.},
title = {Verlaufsbeobachtungen anhand standardisierter Videoaufzeichnungen bei depressiven Patienten},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-33744},
year = {1978},
abstract = {No abstract available},
language = {de}
}
@misc{Ellgring1978,
author = {Ellgring, Johann Heinrich},
title = {Comment to J. Rojahn: "Validity and reliability of data from naturalistic observational studies - problems and alternatives"},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-42520},
year = {1978},
abstract = {No abstract available},
language = {en}
}
@article{Ruhe1978,
author = {Ruhe, Ernstpeter},
title = {Caliban als Dialektiker},
url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-36850},
year = {1978},
abstract = {No abstract available},
language = {de}
}