@article{HanitschBaumannBoztugetal.2020, author = {Hanitsch, Leif and Baumann, Ulrich and Boztug, Kaan and Burkhard-Meier, Ulrike and Fasshauer, Maria and Habermehl, Pirmin and Hauck, Fabian and Klock, Gerd and Liese, Johannes and Meyer, Oliver and M{\"u}ller, Rainer and Pachlopnik-Schmid, Jana and Pfeiffer-Kascha, Dorothea and Warnatz, Klaus and Wehr, Claudia and Wittke, Kirsten and Niehues, Tim and von Bernuth, Horst}, title = {Treatment and management of primary antibody deficiency: German interdisciplinary evidence-based consensus guideline}, series = {European Journal of Immunology}, volume = {50}, journal = {European Journal of Immunology}, number = {10}, doi = {10.1002/eji.202048713}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-225731}, pages = {1432 -- 1446}, year = {2020}, abstract = {This evidence-based clinical guideline provides consensus-recommendations for the treatment and care of patients with primary antibody deficiencies (PADs). The guideline group comprised 20 clinical and scientific expert associations of the German, Swiss, and Austrian healthcare system and representatives of patients. Recommendations were based on results of a systematic literature search, data extraction, and evaluation of methodology and study quality in combination with the clinical expertise of the respective representatives. Consensus-based recommendations were determined via nominal group technique. PADs are the largest clinically relevant group of primary immunodeficiencies. Most patients with PADs present with increased susceptibility to infections, however immune dysregulation, autoimmunity, and cancer affect a significant number of patients and may precede infections. This guideline therefore covers interdisciplinary clinical and therapeutic aspects of infectious (e.g., antibiotic prophylaxis, management of bronchiectasis) and non-infectious manifestations (e.g., management of granulomatous disease, immune cytopenia). PADs are grouped into disease entities with definitive, probable, possible, or unlikely benefit of IgG-replacement therapy. Summary and consensus-recommendations are provided for treatment indication, dosing, routes of administration, and adverse events of IgG-replacement therapy. Special aspects of concomitant impaired T-cell function are highlighted as well as clinical data on selected monogenetic inborn errors of immunity formerly classified into PADs (APDS, CTLA-4-, and LRBA-deficiency).}, language = {en} } @book{Ott2020, author = {Ott, Christine}, title = {Bibliographie Schulbuchforschung zum Aspekt Geschlecht}, edition = {3., {\"u}berarb. Auflage}, doi = {10.25972/OPUS-20771}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-207715}, publisher = {Universit{\"a}t W{\"u}rzburg}, pages = {23}, year = {2020}, abstract = {Die Bibliographie dokumentiert die Entwicklung des deutschsprachigen Forschungsfelds Schulbuchanalysen zum Aspekt Geschlecht von seinen Anf{\"a}ngen in den sp{\"a}ten 1960er Jahren bis in die Gegenwart.}, subject = {Schulbuchanalyse}, language = {de} } @article{SchlagenhaufRehderGelbrichetal.2020, author = {Schlagenhauf, Ulrich and Rehder, Juliane and Gelbrich, G{\"o}tz and Jockel-Schneider, Yvonne}, title = {Consumption of Lactobacillus reuteri-containing lozenges improves periodontal health in navy sailors at sea: A randomized controlled trial}, series = {Journal of Periodontology}, volume = {91}, journal = {Journal of Periodontology}, number = {10}, doi = {10.1002/JPER.19-0393}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-215577}, pages = {1328 -- 1338}, year = {2020}, abstract = {Background The objective of this trial was to evaluate whether the regular consumption of probiotics may improve the known deterioration of periodontal health in navy sailors during deployments at sea. Methods 72 healthy sailors of a naval ship on a practicing mission at sea were recruited and randomly provided with a blinded supply of lozenges to be consumed twice daily for the following 42 days containing either the probiotic strains Lactobacillus reuteri (DSM 17938 and L. reuteri (ATTC PTA 5289) (test n = 36) or no probiotics (placebo n = 36). At baseline, at day 14 and day 42 bleeding on probing (primary outcome), gingival index, plaque control record, probing attachment level, and probing pocket depth were assessed at the Ramfjord teeth. Results At baseline there were no significant differences between the groups. At day 14 and day 42 test group scores of all assessed parameters were significantly improved (P < 0.001) compared to baseline and to the placebo group which by contrast showed a significant (P < 0.001) deterioration of all parameters at the end of the study. Conclusions The consumption of probiotic L. reuteri-lozenges is an efficacious measure to improve and maintain periodontal health in situations with waning efficacy of personal oral hygiene.}, language = {en} } @article{SamperAgreloSchiraHeinenBeyeretal.2020, author = {Samper Agrelo, Iria and Schira-Heinen, Jessica and Beyer, Felix and Groh, Janos and B{\"u}termann, Christine and Estrada, Veronica and Poschmann, Gereon and Bribian, Ana and Jadasz, Janusz J. and Lopez-Mascaraque, Laura and Kremer, David and Martini, Rudolf and M{\"u}ller, Hans Werner and Hartung, Hans Peter and Adjaye, James and St{\"u}hler, Kai and K{\"u}ry, Patrick}, title = {Secretome analysis of mesenchymal stem cell factors fostering oligodendroglial differentiation of neural stem cells in vivo}, series = {International Journal of Molecular Sciences}, volume = {21}, journal = {International Journal of Molecular Sciences}, number = {12}, issn = {1422-0067}, doi = {10.3390/ijms21124350}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-285465}, year = {2020}, abstract = {Mesenchymal stem cell (MSC)-secreted factors have been shown to significantly promote oligodendrogenesis from cultured primary adult neural stem cells (aNSCs) and oligodendroglial precursor cells (OPCs). Revealing underlying mechanisms of how aNSCs can be fostered to differentiate into a specific cell lineage could provide important insights for the establishment of novel neuroregenerative treatment approaches aiming at myelin repair. However, the nature of MSC-derived differentiation and maturation factors acting on the oligodendroglial lineage has not been identified thus far. In addition to missing information on active ingredients, the degree to which MSC-dependent lineage instruction is functional in vivo also remains to be established. We here demonstrate that MSC-derived factors can indeed stimulate oligodendrogenesis and myelin sheath generation of aNSCs transplanted into different rodent central nervous system (CNS) regions, and furthermore, we provide insights into the underlying mechanism on the basis of a comparative mass spectrometry secretome analysis. We identified a number of secreted proteins known to act on oligodendroglia lineage differentiation. Among them, the tissue inhibitor of metalloproteinase type 1 (TIMP-1) was revealed to be an active component of the MSC-conditioned medium, thus validating our chosen secretome approach.}, language = {en} } @misc{TortMitrevaBrehmetal.2020, author = {Tort, Jose F. and Mitreva, Makedonka and Brehm, Klaus R. and Rinaldi, Gabriel}, title = {Editorial: Novel Frontiers in Helminth Genomics}, series = {Frontiers in Genetics}, volume = {11}, journal = {Frontiers in Genetics}, number = {791}, issn = {1664-8021}, doi = {10.3389/fgene.2020.00791}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-210209}, year = {2020}, abstract = {No abstract available.}, language = {en} } @masterthesis{Marx2020, type = {Bachelor Thesis}, author = {Marx, Philipp}, title = {Aus der Isolation zur Regionalmacht - Eine Analyse der Außenpolitik Burkina Fasos unter Blaise Compaor{\´e}}, issn = {2199-4315}, doi = {10.25972/OPUS-20464}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-204647}, school = {Universit{\"a}t W{\"u}rzburg}, pages = {1-50}, year = {2020}, abstract = {Ganze 27 Jahre lang regierte Blaise Compaor{\´e} die westafrikanische Republik Burkina Faso. Am 15. Oktober 1987 putschte er sich mit Hilfe eines von ihm angeleiteten Staatsstreichs, bei dem sein Vorg{\"a}nger Thomas Sankara ermordet wurde, an die Macht. Die außenpolitische Ausgangssituation Burkina Fasos zu Beginn der Amtszeit Blaise Compaor{\´e}s war verheerend: Die anti-kapitalistische Außenpolitik Sankaras hatte den rohstoffarmen Binnenstaat von seinen wichtigsten politischen und wirtschaftlichen Partnern isoliert und die neue Regierung war durch den gewaltt{\"a}tigen Staatsstreich international gebrandmarkt. Trotz dieser außenpolitisch schwierigen Ausgangslage entwickelte sich Blaise Compaor{\´e} im Zeitverlauf seiner pr{\"a}sidialen Amtszeit zu der zentralen Figur der regionalen Diplomatie in Westafrika. Er konnte in den 2000er Jahren durch Konfliktmediationen im unmittelbaren geografischen Umfeld Burkina Fasos eine F{\"u}hrungsrolle in der westafrikanischen Subregion einnehmen. Die vorliegende Arbeit analysiert die außenpolitischen Entwicklungen Burkina Fasos w{\"a}hrend der pr{\"a}sidialen Amtszeit Blaise Compaor{\´e}s. Der Fokus der Analyse liegt auf der Frage, wie sich Burkina Faso unter Blaise Compaor{\´e} als Regionalmacht in Westafrika etablieren konnte. In diesem Zusammenhang werden die außenpolitischen Mittel, mit denen Blaise Compaor{\´e} die Grundsituation der politischen Isolation seines Amtsantritts in eine regionale F{\"u}hrungsrolle in Westafrika umwandeln konnte, herausgestellt.}, subject = {Burkina Faso}, language = {de} } @article{KemmlerKohlFroehlichetal.2020, author = {Kemmler, Wolfgang and Kohl, Matthias and Fr{\"o}hlich, Michael and Jakob, Franz and Engelke, Klaus and von Stengel, Simon and Schoene, Daniel}, title = {Effects of High-Intensity Resistance Training on Osteopenia and Sarcopenia Parameters in Older Men with Osteosarcopenia—One-Year Results of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial (FrOST)}, series = {Journal of Bone and Mineral Research}, volume = {35}, journal = {Journal of Bone and Mineral Research}, number = {9}, doi = {10.1002/jbmr.4027}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-214609}, pages = {1634 -- 1644}, year = {2020}, abstract = {Dynamic resistance exercise (DRT) might be the most promising agent for fighting sarcopenia in older people. However, the positive effect of DRT on osteopenia/osteoporosis in men has still to be confirmed. To evaluate the effect of low-volume/high-intensity (HIT)-DRT on bone mineral density (BMD) and skeletal muscle mass index (SMI) in men with osteosarcopenia, we initiated the Franconian Osteopenia and Sarcopenia Trial (FrOST). Forty-three sedentary community-dwelling older men (aged 73 to 91 years) with osteopenia/osteoporosis and SMI-based sarcopenia were randomly assigned to a HIT-RT exercise group (EG; n = 21) or a control group (CG; n = 22). HIT-RT provided a progressive, periodized single-set DRT on machines with high intensity, effort, and velocity twice a week, while CG maintained their lifestyle. Both groups were adequately supplemented with whey protein, vitamin D, and calcium. Primary study endpoint was integral lumbar spine (LS) BMD as determined by quantitative computed tomography. Core secondary study endpoint was SMI as determined by dual-energy X-ray absorptiometry. Additional study endpoints were BMD at the total hip and maximum isokinetic hip-/leg-extensor strength (leg press). After 12 months of exercise, LS-BMD was maintained in the EG and decreased significantly in the CG, resulting in significant between-group differences (p < 0.001; standardized mean difference [SMD] = 0.90). In parallel, SMI increased significantly in the EG and decreased significantly in the CG (p < 0.001; SMD = 1.95). Total hip BMD changes did not differ significantly between the groups (p = 0.064; SMD = 0.65), whereas changes in maximum hip-/leg-extensor strength were much more prominent (p < 0.001; SMD = 1.92) in the EG. Considering dropout (n = 2), attendance rate (95\%), and unintended side effects/injuries (n = 0), we believe our HIT-RT protocol to be feasible, attractive, and safe. In summary, we conclude that our combined low-threshold HIT-RT/protein/vitamin D/calcium intervention was feasible, safe, and effective for tackling sarcopenia and osteopenia/osteoporosis in older men with osteosarcopenia.}, language = {en} } @article{PeterkaOdorferSchwabetal.2020, author = {Peterka, Manuel and Odorfer, Thorsten and Schwab, Michael and Volkmann, Jens and Zeller, Daniel}, title = {LSVT-BIG therapy in Parkinson's disease: physiological evidence for proprioceptive recalibration}, series = {BMC Neurology}, volume = {20}, journal = {BMC Neurology}, doi = {10.1186/s12883-020-01858-2}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-230084}, year = {2020}, abstract = {Background There is growing evidence for proprioceptive dysfunction in patients with Parkinson's disease (PD). The Lee Silvermann Voice Treatment-BIG therapy (LSVT-BIG), a special training program aiming at an increase of movement amplitudes in persons with PD (PwPD), has shown to be effective on motor symptoms. LSVT-BIG is conceptionally based on improving bradykinesia, in particular the decrement of repetitive movements, by proprioceptive recalibration. Objective To assess proprioceptive impairment in PwPD as compared to matched controls and to probe potential recalibration effects of the LSVT-BIG therapy on proprioception. Methods Proprioceptive performance and fine motor skills were assessed in 30 PwPD and 15 matched controls. Measurements with significant impairment in PwPD were chosen as outcome parameters for a standardized 4 weeks amplitude-based training intervention (LSVT-BIG) in 11 PwPD. Proprioceptive performance served as primary outcome measure. Secondary outcome measures included the motor part of the MDS-UPDRS, the nine-hole-peg test, and a questionnaire on quality of life. Post-interventional assessments were conducted at weeks 4 and 8. Results Compared to the control group, PwPD showed significantly larger pointing errors. After 4 weeks of LSVT-BIG therapy and even more so after an additional 4 weeks of continued training, proprioceptive performance improved significantly. In addition, quality of life improved as indicated by a questionnaire. Conclusion LSVT-BIG training may achieve a recalibration of proprioceptive processing in PwPD. Our data indicates a probable physiological mechanism of a symptom-specific, amplitude-based behavioral intervention in PwPD.}, language = {en} } @article{WinkelbeinerWandtEbertetal.2020, author = {Winkelbeiner, Nicola and Wandt, Viktoria K. and Ebert, Franziska and Lossow, Kristina and Bankoglu, Ezgi E. and Martin, Maximilian and Mangerich, Aswin and Stopper, Helga and Bornhorst, Julia and Kipp, Anna P. and Schwerdtle, Tanja}, title = {A multi-endpoint approach to base excision repair incision activity augmented by PARylation and DNA damage levels in mice: impact of sex and age}, series = {International Journal of Molecular Sciences}, volume = {21}, journal = {International Journal of Molecular Sciences}, number = {18}, issn = {1422-0067}, doi = {10.3390/ijms21186600}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-285706}, year = {2020}, abstract = {Investigation of processes that contribute to the maintenance of genomic stability is one crucial factor in the attempt to understand mechanisms that facilitate ageing. The DNA damage response (DDR) and DNA repair mechanisms are crucial to safeguard the integrity of DNA and to prevent accumulation of persistent DNA damage. Among them, base excision repair (BER) plays a decisive role. BER is the major repair pathway for small oxidative base modifications and apurinic/apyrimidinic (AP) sites. We established a highly sensitive non-radioactive assay to measure BER incision activity in murine liver samples. Incision activity can be assessed towards the three DNA lesions 8-oxo-2'-deoxyguanosine (8-oxodG), 5-hydroxy-2'-deoxyuracil (5-OHdU), and an AP site analogue. We applied the established assay to murine livers of adult and old mice of both sexes. Furthermore, poly(ADP-ribosyl)ation (PARylation) was assessed, which is an important determinant in DDR and BER. Additionally, DNA damage levels were measured to examine the overall damage levels. No impact of ageing on the investigated endpoints in liver tissue were found. However, animal sex seems to be a significant impact factor, as evident by sex-dependent alterations in all endpoints investigated. Moreover, our results revealed interrelationships between the investigated endpoints indicative for the synergetic mode of action of the cellular DNA integrity maintaining machinery.}, language = {en} } @misc{Paetzold2020, type = {Master Thesis}, author = {P{\"a}tzold, Simon}, title = {Dachbegr{\"u}nung in W{\"u}rzburg: GIS-basierte Potentialanalyse als Planungsgrundlage im st{\"a}dtischen Begr{\"u}nungsinstrumentarium}, doi = {10.25972/OPUS-21067}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-210674}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2020}, abstract = {Nach aktuellem Stand der Forschung ist die Dachbegr{\"u}nung eine geeignete Klimaanpassungsmaßnahme, mit der die Folgen des rezenten Klimawandels in verdichteten und versiegelten Stadtgebieten abgeschw{\"a}cht werden k{\"o}nnen. Vor dem Hintergrund schrumpfender Fl{\"a}chenreserven und wachsender Fl{\"a}chenkonkurrenz k{\"o}nnen auf D{\"a}chern alternative Fl{\"a}chenressourcen zur Expansion urbanen Gr{\"u}ns erschlossen werden. Zudem besitzt diese Begr{\"u}nungsart vielf{\"a}ltige {\"o}kologische und {\"o}konomische Vorteile (K{\"u}hlwirkung, Biodiversit{\"a}t, Wasserr{\"u}ckhaltung, Geb{\"a}uded{\"a}mmung und -schutz). Mit Bebauungspl{\"a}nen und Innenbereichssatzungen sowie F{\"o}rderprogrammen und indirekter F{\"o}rderung (gesplittete Abwassergeb{\"u}hren) stehen den Kommunen harte und weiche Instrumente zur Verf{\"u}gung, um Geb{\"a}udeeigent{\"u}mer f{\"u}r Dachbegr{\"u}nungsmaßnahmen im Neubau, aber auch im Bestandsbau zu mobilisieren. F{\"u}r eine Aktivierung bereits bestehender Dachfl{\"a}chen eignet sich besonders die Extensivbegr{\"u}nung dank ihrer anspruchslosen Vegetation, des minimalen Pflegeaufwands sowie den geringeren statischen und formspezifischen Anforderungen an die Dachkonstruktion gegen{\"u}ber der Intensivbegr{\"u}nung. Auf Basis von Untersuchungen mit Fernerkundungsdaten und amtlichen Geodaten konnten f{\"u}r deutsche Groß- und Mittelst{\"a}dte enorme Fl{\"a}chenpotentiale f{\"u}r die nachtr{\"a}gliche Dachbegr{\"u}nung festgestellt werden. Zur Stadt W{\"u}rzburg, in der als Hotspot des Klimawandels eine hohe Dringlichkeit f{\"u}r Klimaanpassungsmaßnahmen besteht, lagen bis dato keine Daten zu diesem Potential vor. Im Rahmen dieser Arbeit wurden Luftbilder, H{\"o}hendaten (LiDAR) und amtliche Geb{\"a}udeumriss-Daten in einem Geoinformationssystem (GIS) zu einer dreidimensionalen Dachlandschaft verarbeitet, hinsichtlich relevanter Begr{\"u}nungskriterien (Neigung, Homogenit{\"a}t, Gr{\"o}ße, Funktion) analysiert und in Form von Karten, Bildern und Statistiken ausgegeben. F{\"u}r das konkrete Untersuchungsgebiet der stadtklimatisch besonders kritischen Stadtbezirke Altstadt und Sanderau konnte eine empirische Grundlage zur Quantifizierung der Potentialfl{\"a}che geschaffen werden. Rund ein Drittel der {\"u}ber 5.000 untersuchten innerst{\"a}dtischen D{\"a}cher kommen mit einer Fl{\"a}che von {\"u}ber 300.000 m² f{\"u}r eine nachtr{\"a}gliche Begr{\"u}nung in Betracht. Zudem wurden Aussagen zur st{\"a}dtebaulichen Qualifizierung (Denkmalschutz) dieser Fl{\"a}chen getroffen und die Aktivierbarkeit mit dem einschl{\"a}gigen stadtplanerischem Begr{\"u}nungsinstrumentarium (F{\"o}rderprogramm, Satzung bzw. Bebauungsplan) bewertet. So konnten die f{\"u}r die Umsetzung der geeigneten Dachfl{\"a}chen n{\"o}tigen F{\"o}rderkosten auf Basis der geltenden F{\"o}rderrichtlinie approximiert werden. Zudem wurde unter Verwendung amtlicher Baustatistik und einschl{\"a}giger Bebauungspl{\"a}ne ein zeitlicher Horizont gesch{\"a}tzt, bis zu welchem sich Eigent{\"u}mer an die Vorgaben einer hypothetischen Dachbegr{\"u}nungssatzung anpassen w{\"u}rden. Die Arbeit bietet Anreize f{\"u}r die Methodik geoinformatischer Analysen sowie f{\"u}r st{\"a}dteplanerische Analyse- und Handlungsm{\"o}glichkeiten. Nat{\"u}rlich kann die fernerkundliche Messung keine bautechnische Begutachtung vor Ort ersetzen, sie kann aber im Vorfeld einen Eindruck der teils versteckten Fl{\"a}chenreserven kosteng{\"u}nstig und fl{\"a}chendeckend verschaffen und zudem die M{\"o}glichkeit darauf aufbauender Untersuchungen der {\"o}kologischen oder st{\"a}dtebaulichen Wirkung er{\"o}ffnen.}, subject = {Dachbegr{\"u}nung}, language = {de} }