@article{PeissertSauerGrabarczyketal.2020,
  author    = {Peissert, Stefan and Sauer, Florian and Grabarczyk, Daniel B. and Braun, Cathy and Sander, Gudrun and Poterszman, Arnaud and Egly, Jean-Marc and Kuper, Jochen and Kisker, Caroline},
  title     = {In TFIIH the Arch domain of XPD is mechanistically essential for transcription and DNA repair},
  series = {Nature Communications},
  volume    = {11},
  journal   = {Nature Communications},
  number    = {1},
  doi       = {10.1038/s41467-020-15241-9},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-229857},
  year      = {2020},
  abstract  = {The XPD helicase is a central component of the general transcription factor TFIIH which plays major roles in transcription and nucleotide excision repair (NER). Here we present the high-resolution crystal structure of the Arch domain of XPD with its interaction partner MAT1, a central component of the CDK activating kinase complex. The analysis of the interface led to the identification of amino acid residues that are crucial for the MAT1-XPD interaction. More importantly, mutagenesis of the Arch domain revealed that these residues are essential for the regulation of (i) NER activity by either impairing XPD helicase activity or the interaction of XPD with XPG; (ii) the phosphorylation of the RNA polymerase II and RNA synthesis. Our results reveal how MAT1 shields these functionally important residues thereby providing insights into how XPD is regulated by MAT1 and defining the Arch domain as a major mechanistic player within the XPD scaffold.},
  language  = {en}
}
@article{HofmannFayezScheineretal.2020,
  author    = {Hofmann, Julian and Fayez, Shaimaa and Scheiner, Matthias and Hoffmann, Matthias and Oerter, Sabrina and Appelt-Menzel, Antje and Maher, Pamela and Maurice, Tangui and Bringmann, Gerhard and Decker, Michael},
  title     = {Sterubin: Enantioresolution and Configurational Stability, Enantiomeric Purity in Nature, and Neuroprotective Activity in Vitro and in Vivo},
  series = {Chemistry - A European Journal},
  volume    = {26},
  journal   = {Chemistry - A European Journal},
  number    = {32},
  doi       = {10.1002/chem.202001264},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-215993},
  pages     = {7299 -- 7308},
  year      = {2020},
  abstract  = {Alzheimer′s disease (AD) is a neurological disorder with still no preventive or curative treatment. Flavonoids are phytochemicals with potential therapeutic value. Previous studies described the flavanone sterubin isolated from the Californian plant Eriodictyon californicum as a potent neuroprotectant in several in vitro assays. Herein, the resolution of synthetic racemic sterubin (1) into its two enantiomers, (R)-1 and (S)-1, is described, which has been performed on a chiral chromatographic phase, and their stereochemical assignment online by HPLC-ECD coupling. (R)-1 and (S)-1 showed comparable neuroprotection in vitro with no significant differences. While the pure stereoisomers were configurationally stable in methanol, fast racemization was observed in the presence of culture medium. We also established the occurrence of extracted sterubin as its pure (S)-enantiomer. Moreover, the activity of sterubin (1) was investigated for the first time in vivo, in an AD mouse model. Sterubin (1) showed a significant positive impact on short- and long-term memory at low dosages.},
  language  = {en}
}
@article{HoffmannJanssenKannoetal.2020,
  author    = {Hoffmann, Jan V. and Janssen, Jan P. and Kanno, Takayuki and Shibutani, Takayuki and Onoguchi, Masahisa and Lapa, Constantin and Grunz, Jan-Peter and Buck, Andreas K. and Higuchi, Takahiro},
  title     = {Performance evaluation of fifth-generation ultra-high-resolution SPECT system with two stationary detectors and multi-pinhole imaging},
  series = {EJNMMI Physics},
  volume    = {7},
  journal   = {EJNMMI Physics},
  doi       = {10.1186/s40658-020-00335-6},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-230361},
  year      = {2020},
  abstract  = {Background Small-animal single-photon emission computed tomography (SPECT) systems with multi-pinhole collimation and large stationary detectors have advantages compared to systems with moving small detectors. These systems benefit from less labour-intensive maintenance and quality control as fewer prone parts are moving, higher accuracy for focused scans and maintaining high resolution with increased sensitivity due to focused pinholes on the field of view. This study aims to investigate the performance of a novel ultra-high-resolution scanner with two-detector configuration (U-SPECT5-E) and to compare its image quality to a conventional micro-SPECT system with three stationary detectors (U-SPECT\(^+\)). Methods The new U-SPECT5-E with two stationary detectors was used for acquiring data with \(^{99m}\)Tc-filled point source, hot-rod and uniformity phantoms to analyse sensitivity, spatial resolution, uniformity and contrast-to-noise ratio (CNR). Three dedicated multi-pinhole mouse collimators with 75 pinholes each and 0.25-, 0.60- and 1.00-mm pinholes for extra ultra-high resolution (XUHR-M), general-purpose (GP-M) and ultra-high sensitivity (UHS-M) imaging were examined. For CNR analysis, four different activity ranges representing low- and high-count settings were investigated for all three collimators. The experiments for the performance assessment were repeated with the same GP-M collimator in the three-detector U-SPECT\(^+\) for comparison. Results Peak sensitivity was 237 cps/MBq (XUHR-M), 847 cps/MBq (GP-M), 2054 cps/MBq (UHS-M) for U-SPECT5-E and 1710 cps/MBq (GP-M) for U-SPECT\(^+\). In the visually analysed sections of the reconstructed mini Derenzo phantoms, rods as small as 0.35 mm (XUHR-M), 0.50 mm (GP-M) for the two-detector as well as the three-detector SPECT and 0.75 mm (UHS-M) were resolved. Uniformity for maximum resolution recorded 40.7\% (XUHR-M), 29.1\% (GP-M, U-SPECT5-E), 16.3\% (GP-M, U-SPECT\(^+\)) and 23.0\% (UHS-M), respectively. UHS-M reached highest CNR values for low-count images; for rods smaller than 0.45 mm, acceptable CNR was only achieved by XUHR-M. GP-M was superior for imaging rods sized from 0.60 to 1.50 mm for intermediate activity concentrations. U-SPECT5-E and U-SPECT+ both provided comparable CNR. Conclusions While uniformity and sensitivity are negatively affected by the absence of a third detector, the investigated U-SPECT5-E system with two stationary detectors delivers excellent spatial resolution and CNR comparable to the performance of an established three-detector-setup.},
  language  = {en}
}
@article{OorschotIshiiKusomotoetal.2020,
  author    = {Oorschot, Birgitt van and Ishii, Koji and Kusomoto, Yuko and Zetzl, Theresa and Roch, Carmen and Mettenleiter, Andreas and Ozawa, Hiroko and Flentje, Michael},
  title     = {Anxiety, depression and psychosocial needs are the most frequent concerns reported by patients: preliminary results of a comparative explorative analysis of two hospital-based palliative care teams in Germany and Japan},
  series = {Journal of Neural Transmission},
  volume    = {127},
  journal   = {Journal of Neural Transmission},
  issn      = {0300-9564},
  doi       = {10.1007/s00702-020-02186-y},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-235675},
  pages     = {1481-1489},
  year      = {2020},
  abstract  = {In the partnership between the medical departments of W{\"u}rzburg University, Germany, and Nagasaki University, Japan, palliative care is a relevant topic. The aim of the study was to perform a comparative analysis of the hospital-based palliative care teams in W{\"u}rzburg (PCT-W) and Nagasaki (PCT-N). Survey of staff composition and retrospective analysis of PCT patient charts in both PCTs were conducted. Patients self-assessed their symptoms in PCT-W and in Radiation Oncology W{\"u}rzburg (RO-W). The (negative) quality indicator 'percentage of deceased hospitalised patients with PCT contact for less than 3 days before death' (Earle in Int J Qual Health Care 17(6):505-509, 2005) was analysed. Both PCTs follow a multidisciplinary team approach. PCT-N saw 410 cancer patients versus 853 patients for PCT-W (22.8\% non-cancer patients). The Eastern Cooperative Oncology Group Performance Status at first contact with PCT-N was 3 or 4 in 39.3\% of patients versus 79.0\% for PCT-W. PCT-N was engaged in co-management longer than PCT-W (mean 20.7 days, range 1-102 versus mean 4.9 days, range 1-48). The most frequent patient-reported psychological symptom was anxiety (family anxiety: 98.3\% PCT-W and 88.7\% RO-W, anxiety 97.9\% PCT-W and 85.9\% RO-W), followed by depression (98.2\% PCT-W and 80.3\% RO-W). In 14 of the 148 deceased patients, PCT-N contact was initiated less than 3 days before death (9.4\%) versus 121 of the 729 deceased PCT-W patients (16.6\%). Psychological needs are highly relevant in both Germany and Japan, with more than 85\% anxiety and depression in patients in the Japanese IPOS validation study (Sakurai in Jpn J Clin Oncol 49(3):257-262, 2019). This should be taken into account when implementing PCTs.},
  language  = {en}
}
@article{LehmannDechantWehetal.2020,
  author    = {Lehmann, Matthias and Dechant, Moritz and Weh, Dominik and Freytag, Emely},
  title     = {Metal Phthalocyanine-Fullerene Dyads: Promising Lamellar Columnar Donor-Acceptor Liquid Crystal Phases},
  series = {ChemPlusChem},
  volume    = {85},
  journal   = {ChemPlusChem},
  number    = {8},
  doi       = {10.1002/cplu.202000540},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-218531},
  pages     = {1934 -- 1938},
  year      = {2020},
  abstract  = {Liquid crystal (LC) shape-amphiphiles with a disc tethered to a fullerene have been intensely studied for the application in photovoltaics, and helical nanosegregation of C\(_{60}\) has been claimed around the π-stacking disks based on X-ray results. The most promising materials reported to date have been resynthesized and studied comprehensively by XRS, density measurements, modelling, and electron density reconstruction. In contrast to previous reports, the results indicate that metal phthalocyanine-fullerene mesogens pack in lamellar columnar phases with p2gm symmetry. Fullerenes assemble in layers and are flanked by phthalocyanine columns, thus explaining the balanced charge carrier mobility of electrons and holes. Such variable donor-acceptor structures are promising for organic electronic applications.},
  language  = {en}
}
@techreport{Fleckenstein2020,
  type      = {Working Paper},
  author    = {Fleckenstein, Felix},
  title     = {Tugendethische Perspektiven},
  doi       = {10.25972/OPUS-21000},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-210003},
  pages     = {11},
  year      = {2020},
  abstract  = {Der tugendethische Entwurf der nikomachischen Ethik des Aristoteles ist bis heute von außerordentlicher Bedeutung. Die dort ausgef{\"u}hrte Charakterisierung der Tugenden als ethische Grundhaltungen erm{\"o}glicht eine differenzierte Betrachtung des menschlichen Handelns. Dem gegen{\"u}ber l{\"a}sst sich an der Wende vom elften zum zw{\"o}lften Jahrhundert in den Werken Bernhard von Clairvauxs´ ebenfalls ein tugendethisches Lebenskonzept erkennen. Auch Bernhard versucht zu eruieren, wie der Mensch seine eigene Mitte findet und so zum verantwortlichen Handeln bef{\"a}higt ist. Dabei nimmt er jedoch den Menschen explizit als Gesch{\"o}pf Gottes in den Blick. F{\"u}r die systematische Theologie er{\"o}ffnet sich gerade in der Zusammenschau des aristotelischen Entwurfs mit der anthropologischen Analyse Bernhards eine weiterf{\"u}hrende Perspektive. Dieser Beitrag skizziert daher die beiden tugendethischen Ans{\"a}tze und gibt einen ersten weiterf{\"u}hrenden Ausblick f{\"u}r die theologische Anthropologie.},
  subject      = {Tugendethik},
  language  = {de}
}
@misc{StaffeldtThieroff2020,
  author    = {Staffeldt, Sven and Thieroff, Rolf},
  title     = {Fehlerkorrektur zu Staffeldt, Sven und Rolf Thieroff (2020): Oberfl{\"a}chengrammatischer Wald. Syntaktische Baumschule am Beispiel eines authentischen Textes},
  doi       = {10.25972/OPUS-20718},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-207180},
  pages     = {4},
  year      = {2020},
  abstract  = {Erratum zu Staffeldt, Sven und Rolf Thieroff (2020): Oberfl{\"a}chengrammatischer Wald. Syntaktische Baumschule am Beispiel eines authentischen Textes. Online-Publikationsservice der Uni-versit{\"a}t W{\"u}rzburg: Lehrstuhl f{\"u}r deutsche Sprachwissenschaft / Universit{\"a}tsbibliothek. (= W{\"u}rzburger elektronische sprachwissenschaftliche Arbeiten (WespA); 21). DOI: https://doi.org/10.25972/OPUS-20561},
  language  = {de}
}
@article{DeLiraRamanSchulzeetal.2020,
  author    = {De Lira, Maria Nathalia and Raman, Sudha Janaki and Schulze, Almut and Schneider-Schaulies, Sibylle and Avota, Elita},
  title     = {Neutral Sphingomyelinase-2 (NSM 2) Controls T Cell Metabolic Homeostasis and Reprogramming During Activation},
  series = {Frontiers in Molecular Biosciences},
  volume    = {7},
  journal   = {Frontiers in Molecular Biosciences},
  issn      = {2296-889X},
  doi       = {10.3389/fmolb.2020.00217},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-211311},
  year      = {2020},
  abstract  = {Neutral sphingomyelinase-2 (NSM2) is a member of a superfamily of enzymes responsible for conversion of sphingomyelin into phosphocholine and ceramide at the cytosolic leaflet of the plasma membrane. Upon specific ablation of NSM2, T cells proved to be hyper-responsive to CD3/CD28 co-stimulation, indicating that the enzyme acts to dampen early overshooting activation of these cells. It remained unclear whether hyper-reactivity of NSM2-deficient T cells is supported by a deregulated metabolic activity in these cells. Here, we demonstrate that ablation of NSM2 activity affects metabolism of the quiescent CD4\(^+\) T cells which accumulate ATP in mitochondria and increase basal glycolytic activity. This supports enhanced production of total ATP and metabolic switch early after TCR/CD28 stimulation. Most interestingly, increased metabolic activity in resting NSM2-deficient T cells does not support sustained response upon stimulation. While elevated under steady-state conditions in NSM2-deficient CD4\(^+\) T cells, the mTORC1 pathway regulating mitochondria size, oxidative phosphorylation, and ATP production is impaired after 24 h of stimulation. Taken together, the absence of NSM2 promotes a hyperactive metabolic state in unstimulated CD4\(^+\) T cells yet fails to support sustained T cell responses upon antigenic stimulation.},
  language  = {en}
}
@book{Ott2020,
  author    = {Ott, Christine},
  title     = {Bildungsmedien/Lehr-Lernmittel und Deutschunterricht. Eine Auswahlbibliographie},
  edition   = {3., vollst. {\"u}berarb. Auflage},
  doi       = {10.25972/OPUS-20774},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-207745},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  pages     = {40},
  year      = {2020},
  abstract  = {Die Bibliographie f{\"u}hrt Forschungsaktivit{\"a}ten zu Bildungsmedien/Lehr-Lernmitteln f{\"u}r das Fach Deutsch und/oder mit Relevanz f{\"u}r sprachlich-literarische Lehr-Lern-Settings zusammen.},
  subject      = {Bibliografie},
  language  = {de}
}
@article{HanitschBaumannBoztugetal.2020,
  author    = {Hanitsch, Leif and Baumann, Ulrich and Boztug, Kaan and Burkhard-Meier, Ulrike and Fasshauer, Maria and Habermehl, Pirmin and Hauck, Fabian and Klock, Gerd and Liese, Johannes and Meyer, Oliver and M{\"u}ller, Rainer and Pachlopnik-Schmid, Jana and Pfeiffer-Kascha, Dorothea and Warnatz, Klaus and Wehr, Claudia and Wittke, Kirsten and Niehues, Tim and von Bernuth, Horst},
  title     = {Treatment and management of primary antibody deficiency: German interdisciplinary evidence-based consensus guideline},
  series = {European Journal of Immunology},
  volume    = {50},
  journal   = {European Journal of Immunology},
  number    = {10},
  doi       = {10.1002/eji.202048713},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-225731},
  pages     = {1432 -- 1446},
  year      = {2020},
  abstract  = {This evidence-based clinical guideline provides consensus-recommendations for the treatment and care of patients with primary antibody deficiencies (PADs). The guideline group comprised 20 clinical and scientific expert associations of the German, Swiss, and Austrian healthcare system and representatives of patients. Recommendations were based on results of a systematic literature search, data extraction, and evaluation of methodology and study quality in combination with the clinical expertise of the respective representatives. Consensus-based recommendations were determined via nominal group technique. PADs are the largest clinically relevant group of primary immunodeficiencies. Most patients with PADs present with increased susceptibility to infections, however immune dysregulation, autoimmunity, and cancer affect a significant number of patients and may precede infections. This guideline therefore covers interdisciplinary clinical and therapeutic aspects of infectious (e.g., antibiotic prophylaxis, management of bronchiectasis) and non-infectious manifestations (e.g., management of granulomatous disease, immune cytopenia). PADs are grouped into disease entities with definitive, probable, possible, or unlikely benefit of IgG-replacement therapy. Summary and consensus-recommendations are provided for treatment indication, dosing, routes of administration, and adverse events of IgG-replacement therapy. Special aspects of concomitant impaired T-cell function are highlighted as well as clinical data on selected monogenetic inborn errors of immunity formerly classified into PADs (APDS, CTLA-4-, and LRBA-deficiency).},
  language  = {en}
}
@book{Ott2020,
  author    = {Ott, Christine},
  title     = {Bibliographie Schulbuchforschung zum Aspekt Geschlecht},
  edition   = {3., {\"u}berarb. Auflage},
  doi       = {10.25972/OPUS-20771},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-207715},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  pages     = {23},
  year      = {2020},
  abstract  = {Die Bibliographie dokumentiert die Entwicklung des deutschsprachigen Forschungsfelds Schulbuchanalysen zum Aspekt Geschlecht von seinen Anf{\"a}ngen in den sp{\"a}ten 1960er Jahren bis in die Gegenwart.},
  subject      = {Schulbuchanalyse},
  language  = {de}
}
@article{SchlagenhaufRehderGelbrichetal.2020,
  author    = {Schlagenhauf, Ulrich and Rehder, Juliane and Gelbrich, G{\"o}tz and Jockel-Schneider, Yvonne},
  title     = {Consumption of Lactobacillus reuteri-containing lozenges improves periodontal health in navy sailors at sea: A randomized controlled trial},
  series = {Journal of Periodontology},
  volume    = {91},
  journal   = {Journal of Periodontology},
  number    = {10},
  doi       = {10.1002/JPER.19-0393},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-215577},
  pages     = {1328 -- 1338},
  year      = {2020},
  abstract  = {Background The objective of this trial was to evaluate whether the regular consumption of probiotics may improve the known deterioration of periodontal health in navy sailors during deployments at sea. Methods 72 healthy sailors of a naval ship on a practicing mission at sea were recruited and randomly provided with a blinded supply of lozenges to be consumed twice daily for the following 42 days containing either the probiotic strains Lactobacillus reuteri (DSM 17938 and L. reuteri (ATTC PTA 5289) (test n = 36) or no probiotics (placebo n = 36). At baseline, at day 14 and day 42 bleeding on probing (primary outcome), gingival index, plaque control record, probing attachment level, and probing pocket depth were assessed at the Ramfjord teeth. Results At baseline there were no significant differences between the groups. At day 14 and day 42 test group scores of all assessed parameters were significantly improved (P < 0.001) compared to baseline and to the placebo group which by contrast showed a significant (P < 0.001) deterioration of all parameters at the end of the study. Conclusions The consumption of probiotic L. reuteri-lozenges is an efficacious measure to improve and maintain periodontal health in situations with waning efficacy of personal oral hygiene.},
  language  = {en}
}
@article{SamperAgreloSchiraHeinenBeyeretal.2020,
  author    = {Samper Agrelo, Iria and Schira-Heinen, Jessica and Beyer, Felix and Groh, Janos and B{\"u}termann, Christine and Estrada, Veronica and Poschmann, Gereon and Bribian, Ana and Jadasz, Janusz J. and Lopez-Mascaraque, Laura and Kremer, David and Martini, Rudolf and M{\"u}ller, Hans Werner and Hartung, Hans Peter and Adjaye, James and St{\"u}hler, Kai and K{\"u}ry, Patrick},
  title     = {Secretome analysis of mesenchymal stem cell factors fostering oligodendroglial differentiation of neural stem cells in vivo},
  series = {International Journal of Molecular Sciences},
  volume    = {21},
  journal   = {International Journal of Molecular Sciences},
  number    = {12},
  issn      = {1422-0067},
  doi       = {10.3390/ijms21124350},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-285465},
  year      = {2020},
  abstract  = {Mesenchymal stem cell (MSC)-secreted factors have been shown to significantly promote oligodendrogenesis from cultured primary adult neural stem cells (aNSCs) and oligodendroglial precursor cells (OPCs). Revealing underlying mechanisms of how aNSCs can be fostered to differentiate into a specific cell lineage could provide important insights for the establishment of novel neuroregenerative treatment approaches aiming at myelin repair. However, the nature of MSC-derived differentiation and maturation factors acting on the oligodendroglial lineage has not been identified thus far. In addition to missing information on active ingredients, the degree to which MSC-dependent lineage instruction is functional in vivo also remains to be established. We here demonstrate that MSC-derived factors can indeed stimulate oligodendrogenesis and myelin sheath generation of aNSCs transplanted into different rodent central nervous system (CNS) regions, and furthermore, we provide insights into the underlying mechanism on the basis of a comparative mass spectrometry secretome analysis. We identified a number of secreted proteins known to act on oligodendroglia lineage differentiation. Among them, the tissue inhibitor of metalloproteinase type 1 (TIMP-1) was revealed to be an active component of the MSC-conditioned medium, thus validating our chosen secretome approach.},
  language  = {en}
}
@misc{TortMitrevaBrehmetal.2020,
  author    = {Tort, Jose F. and Mitreva, Makedonka and Brehm, Klaus R. and Rinaldi, Gabriel},
  title     = {Editorial: Novel Frontiers in Helminth Genomics},
  series = {Frontiers in Genetics},
  volume    = {11},
  journal   = {Frontiers in Genetics},
  number    = {791},
  issn      = {1664-8021},
  doi       = {10.3389/fgene.2020.00791},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-210209},
  year      = {2020},
  abstract  = {No abstract available.},
  language  = {en}
}
@masterthesis{Marx2020,
  type      = {Bachelor Thesis},
  author    = {Marx, Philipp},
  title     = {Aus der Isolation zur Regionalmacht - Eine Analyse der Außenpolitik Burkina Fasos unter Blaise Compaor{\´e}},
  issn      = {2199-4315},
  doi       = {10.25972/OPUS-20464},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-204647},
  school      = {Universit{\"a}t W{\"u}rzburg},
  pages     = {1-50},
  year      = {2020},
  abstract  = {Ganze 27 Jahre lang regierte Blaise Compaor{\´e} die westafrikanische Republik Burkina Faso. Am 15. Oktober 1987 putschte er sich mit Hilfe eines von ihm angeleiteten Staatsstreichs, bei dem sein Vorg{\"a}nger Thomas Sankara ermordet wurde, an die Macht. Die außenpolitische Ausgangssituation Burkina Fasos zu Beginn der Amtszeit Blaise Compaor{\´e}s war verheerend: Die anti-kapitalistische Außenpolitik Sankaras hatte den rohstoffarmen Binnenstaat von seinen wichtigsten politischen und wirtschaftlichen Partnern isoliert und die neue Regierung war durch den gewaltt{\"a}tigen Staatsstreich international gebrandmarkt. Trotz dieser außenpolitisch schwierigen Ausgangslage entwickelte sich Blaise Compaor{\´e} im Zeitverlauf seiner pr{\"a}sidialen Amtszeit zu der zentralen Figur der regionalen Diplomatie in Westafrika. Er konnte in den 2000er Jahren durch Konfliktmediationen im unmittelbaren geografischen Umfeld Burkina Fasos eine F{\"u}hrungsrolle in der westafrikanischen Subregion einnehmen. Die vorliegende Arbeit analysiert die außenpolitischen Entwicklungen Burkina Fasos w{\"a}hrend der pr{\"a}sidialen Amtszeit Blaise Compaor{\´e}s. Der Fokus der Analyse liegt auf der Frage, wie sich Burkina Faso unter Blaise Compaor{\´e} als Regionalmacht in Westafrika etablieren konnte. In diesem Zusammenhang werden die außenpolitischen Mittel, mit denen Blaise Compaor{\´e} die Grundsituation der politischen Isolation seines Amtsantritts in eine regionale F{\"u}hrungsrolle in Westafrika umwandeln konnte, herausgestellt.},
  subject      = {Burkina Faso},
  language  = {de}
}
@article{KemmlerKohlFroehlichetal.2020,
  author    = {Kemmler, Wolfgang and Kohl, Matthias and Fr{\"o}hlich, Michael and Jakob, Franz and Engelke, Klaus and von Stengel, Simon and Schoene, Daniel},
  title     = {Effects of High-Intensity Resistance Training on Osteopenia and Sarcopenia Parameters in Older Men with Osteosarcopenia—One-Year Results of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial (FrOST)},
  series = {Journal of Bone and Mineral Research},
  volume    = {35},
  journal   = {Journal of Bone and Mineral Research},
  number    = {9},
  doi       = {10.1002/jbmr.4027},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-214609},
  pages     = {1634 -- 1644},
  year      = {2020},
  abstract  = {Dynamic resistance exercise (DRT) might be the most promising agent for fighting sarcopenia in older people. However, the positive effect of DRT on osteopenia/osteoporosis in men has still to be confirmed. To evaluate the effect of low-volume/high-intensity (HIT)-DRT on bone mineral density (BMD) and skeletal muscle mass index (SMI) in men with osteosarcopenia, we initiated the Franconian Osteopenia and Sarcopenia Trial (FrOST). Forty-three sedentary community-dwelling older men (aged 73 to 91 years) with osteopenia/osteoporosis and SMI-based sarcopenia were randomly assigned to a HIT-RT exercise group (EG; n = 21) or a control group (CG; n = 22). HIT-RT provided a progressive, periodized single-set DRT on machines with high intensity, effort, and velocity twice a week, while CG maintained their lifestyle. Both groups were adequately supplemented with whey protein, vitamin D, and calcium. Primary study endpoint was integral lumbar spine (LS) BMD as determined by quantitative computed tomography. Core secondary study endpoint was SMI as determined by dual-energy X-ray absorptiometry. Additional study endpoints were BMD at the total hip and maximum isokinetic hip-/leg-extensor strength (leg press). After 12 months of exercise, LS-BMD was maintained in the EG and decreased significantly in the CG, resulting in significant between-group differences (p < 0.001; standardized mean difference [SMD] = 0.90). In parallel, SMI increased significantly in the EG and decreased significantly in the CG (p < 0.001; SMD = 1.95). Total hip BMD changes did not differ significantly between the groups (p = 0.064; SMD = 0.65), whereas changes in maximum hip-/leg-extensor strength were much more prominent (p < 0.001; SMD = 1.92) in the EG. Considering dropout (n = 2), attendance rate (95\%), and unintended side effects/injuries (n = 0), we believe our HIT-RT protocol to be feasible, attractive, and safe. In summary, we conclude that our combined low-threshold HIT-RT/protein/vitamin D/calcium intervention was feasible, safe, and effective for tackling sarcopenia and osteopenia/osteoporosis in older men with osteosarcopenia.},
  language  = {en}
}
@article{PeterkaOdorferSchwabetal.2020,
  author    = {Peterka, Manuel and Odorfer, Thorsten and Schwab, Michael and Volkmann, Jens and Zeller, Daniel},
  title     = {LSVT-BIG therapy in Parkinson's disease: physiological evidence for proprioceptive recalibration},
  series = {BMC Neurology},
  volume    = {20},
  journal   = {BMC Neurology},
  doi       = {10.1186/s12883-020-01858-2},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-230084},
  year      = {2020},
  abstract  = {Background There is growing evidence for proprioceptive dysfunction in patients with Parkinson's disease (PD). The Lee Silvermann Voice Treatment-BIG therapy (LSVT-BIG), a special training program aiming at an increase of movement amplitudes in persons with PD (PwPD), has shown to be effective on motor symptoms. LSVT-BIG is conceptionally based on improving bradykinesia, in particular the decrement of repetitive movements, by proprioceptive recalibration. Objective To assess proprioceptive impairment in PwPD as compared to matched controls and to probe potential recalibration effects of the LSVT-BIG therapy on proprioception. Methods Proprioceptive performance and fine motor skills were assessed in 30 PwPD and 15 matched controls. Measurements with significant impairment in PwPD were chosen as outcome parameters for a standardized 4 weeks amplitude-based training intervention (LSVT-BIG) in 11 PwPD. Proprioceptive performance served as primary outcome measure. Secondary outcome measures included the motor part of the MDS-UPDRS, the nine-hole-peg test, and a questionnaire on quality of life. Post-interventional assessments were conducted at weeks 4 and 8. Results Compared to the control group, PwPD showed significantly larger pointing errors. After 4 weeks of LSVT-BIG therapy and even more so after an additional 4 weeks of continued training, proprioceptive performance improved significantly. In addition, quality of life improved as indicated by a questionnaire. Conclusion LSVT-BIG training may achieve a recalibration of proprioceptive processing in PwPD. Our data indicates a probable physiological mechanism of a symptom-specific, amplitude-based behavioral intervention in PwPD.},
  language  = {en}
}
@article{WinkelbeinerWandtEbertetal.2020,
  author    = {Winkelbeiner, Nicola and Wandt, Viktoria K. and Ebert, Franziska and Lossow, Kristina and Bankoglu, Ezgi E. and Martin, Maximilian and Mangerich, Aswin and Stopper, Helga and Bornhorst, Julia and Kipp, Anna P. and Schwerdtle, Tanja},
  title     = {A multi-endpoint approach to base excision repair incision activity augmented by PARylation and DNA damage levels in mice: impact of sex and age},
  series = {International Journal of Molecular Sciences},
  volume    = {21},
  journal   = {International Journal of Molecular Sciences},
  number    = {18},
  issn      = {1422-0067},
  doi       = {10.3390/ijms21186600},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-285706},
  year      = {2020},
  abstract  = {Investigation of processes that contribute to the maintenance of genomic stability is one crucial factor in the attempt to understand mechanisms that facilitate ageing. The DNA damage response (DDR) and DNA repair mechanisms are crucial to safeguard the integrity of DNA and to prevent accumulation of persistent DNA damage. Among them, base excision repair (BER) plays a decisive role. BER is the major repair pathway for small oxidative base modifications and apurinic/apyrimidinic (AP) sites. We established a highly sensitive non-radioactive assay to measure BER incision activity in murine liver samples. Incision activity can be assessed towards the three DNA lesions 8-oxo-2'-deoxyguanosine (8-oxodG), 5-hydroxy-2'-deoxyuracil (5-OHdU), and an AP site analogue. We applied the established assay to murine livers of adult and old mice of both sexes. Furthermore, poly(ADP-ribosyl)ation (PARylation) was assessed, which is an important determinant in DDR and BER. Additionally, DNA damage levels were measured to examine the overall damage levels. No impact of ageing on the investigated endpoints in liver tissue were found. However, animal sex seems to be a significant impact factor, as evident by sex-dependent alterations in all endpoints investigated. Moreover, our results revealed interrelationships between the investigated endpoints indicative for the synergetic mode of action of the cellular DNA integrity maintaining machinery.},
  language  = {en}
}
@misc{Paetzold2020,
  type      = {Master Thesis},
  author    = {P{\"a}tzold, Simon},
  title     = {Dachbegr{\"u}nung in W{\"u}rzburg: GIS-basierte Potentialanalyse als Planungsgrundlage im st{\"a}dtischen Begr{\"u}nungsinstrumentarium},
  doi       = {10.25972/OPUS-21067},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-210674},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2020},
  abstract  = {Nach aktuellem Stand der Forschung ist die Dachbegr{\"u}nung eine geeignete Klimaanpassungsmaßnahme, mit der die Folgen des rezenten Klimawandels in verdichteten und versiegelten Stadtgebieten abgeschw{\"a}cht werden k{\"o}nnen. Vor dem Hintergrund schrumpfender Fl{\"a}chenreserven und wachsender Fl{\"a}chenkonkurrenz k{\"o}nnen auf D{\"a}chern alternative Fl{\"a}chenressourcen zur Expansion urbanen Gr{\"u}ns erschlossen werden. Zudem besitzt diese Begr{\"u}nungsart vielf{\"a}ltige {\"o}kologische und {\"o}konomische Vorteile (K{\"u}hlwirkung, Biodiversit{\"a}t, Wasserr{\"u}ckhaltung, Geb{\"a}uded{\"a}mmung und -schutz). Mit Bebauungspl{\"a}nen und Innenbereichssatzungen sowie F{\"o}rderprogrammen und indirekter F{\"o}rderung (gesplittete Abwassergeb{\"u}hren) stehen den Kommunen harte und weiche Instrumente zur Verf{\"u}gung, um Geb{\"a}udeeigent{\"u}mer f{\"u}r Dachbegr{\"u}nungsmaßnahmen im Neubau, aber auch im Bestandsbau zu mobilisieren. F{\"u}r eine Aktivierung bereits bestehender Dachfl{\"a}chen eignet sich besonders die Extensivbegr{\"u}nung dank ihrer anspruchslosen Vegetation, des minimalen Pflegeaufwands sowie den geringeren statischen und formspezifischen Anforderungen an die Dachkonstruktion gegen{\"u}ber der Intensivbegr{\"u}nung. Auf Basis von Untersuchungen mit Fernerkundungsdaten und amtlichen Geodaten konnten f{\"u}r deutsche Groß- und Mittelst{\"a}dte enorme Fl{\"a}chenpotentiale f{\"u}r die nachtr{\"a}gliche Dachbegr{\"u}nung festgestellt werden. Zur Stadt W{\"u}rzburg, in der als Hotspot des Klimawandels eine hohe Dringlichkeit f{\"u}r Klimaanpassungsmaßnahmen besteht, lagen bis dato keine Daten zu diesem Potential vor. Im Rahmen dieser Arbeit wurden Luftbilder, H{\"o}hendaten (LiDAR) und amtliche Geb{\"a}udeumriss-Daten in einem Geoinformationssystem (GIS) zu einer dreidimensionalen Dachlandschaft verarbeitet, hinsichtlich relevanter Begr{\"u}nungskriterien (Neigung, Homogenit{\"a}t, Gr{\"o}ße, Funktion) analysiert und in Form von Karten, Bildern und Statistiken ausgegeben. F{\"u}r das konkrete Untersuchungsgebiet der stadtklimatisch besonders kritischen Stadtbezirke Altstadt und Sanderau konnte eine empirische Grundlage zur Quantifizierung der Potentialfl{\"a}che geschaffen werden. Rund ein Drittel der {\"u}ber 5.000 untersuchten innerst{\"a}dtischen D{\"a}cher kommen mit einer Fl{\"a}che von {\"u}ber 300.000 m² f{\"u}r eine nachtr{\"a}gliche Begr{\"u}nung in Betracht. Zudem wurden Aussagen zur st{\"a}dtebaulichen Qualifizierung (Denkmalschutz) dieser Fl{\"a}chen getroffen und die Aktivierbarkeit mit dem einschl{\"a}gigen stadtplanerischem Begr{\"u}nungsinstrumentarium (F{\"o}rderprogramm, Satzung bzw. Bebauungsplan) bewertet. So konnten die f{\"u}r die Umsetzung der geeigneten Dachfl{\"a}chen n{\"o}tigen F{\"o}rderkosten auf Basis der geltenden F{\"o}rderrichtlinie approximiert werden. Zudem wurde unter Verwendung amtlicher Baustatistik und einschl{\"a}giger Bebauungspl{\"a}ne ein zeitlicher Horizont gesch{\"a}tzt, bis zu welchem sich Eigent{\"u}mer an die Vorgaben einer hypothetischen Dachbegr{\"u}nungssatzung anpassen w{\"u}rden. Die Arbeit bietet Anreize f{\"u}r die Methodik geoinformatischer Analysen sowie f{\"u}r st{\"a}dteplanerische Analyse- und Handlungsm{\"o}glichkeiten. Nat{\"u}rlich kann die fernerkundliche Messung keine bautechnische Begutachtung vor Ort ersetzen, sie kann aber im Vorfeld einen Eindruck der teils versteckten Fl{\"a}chenreserven kosteng{\"u}nstig und fl{\"a}chendeckend verschaffen und zudem die M{\"o}glichkeit darauf aufbauender Untersuchungen der {\"o}kologischen oder st{\"a}dtebaulichen Wirkung er{\"o}ffnen.},
  subject      = {Dachbegr{\"u}nung},
  language  = {de}
}
@misc{Breul2020,
  type      = {Master Thesis},
  author    = {Breul, Andrea},
  title     = {Auf den Spuren des Gelben Sacks - M{\"u}lltrennung in W{\"u}rzburg},
  issn      = {2511-9486},
  doi       = {10.25972/OPUS-20330},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-203302},
  school      = {Universit{\"a}t W{\"u}rzburg},
  pages     = {107},
  year      = {2020},
  abstract  = {Produkte aus Kunststoff geh{\"o}ren heutzutage wie selbstverst{\"a}ndlich zu unserem Alltag. Mit dem vermehrten Einsatz von Verpackungen und Wegwerfprodukten aus Plastik wachsen aber auch die Herausforderungen, die mit der Entsorgung dieses Materials verbunden sind. Umweltverschmutzung durch Plastikabf{\"a}lle, Strategien zur Plastikvermeidung und die Notwendigkeit des Recyclings werden in den Medien in den letzten Jahren verst{\"a}rkt diskutiert. Schon in den 1990er-Jahren wurde in der Bundesrepublik Deutschland mit der Einf{\"u}hrung des Dualen Systems die Schaffung einer umfassenden Infrastruktur zur Sammlung, Sortierung und Wiederverwertung von Verpackungsabf{\"a}llen in die Wege geleitet. Seitdem sammeln Millionen deutsche Haushalte ihre gebrauchten Verpackungen getrennt vom restlichen M{\"u}ll in Gelben S{\"a}cken. Am Beispiel der Stadt W{\"u}rzburg gibt die vorliegende Arbeit Einblicke in die Funktionsweise des Dualen Systems und zeigt die Verkn{\"u}pfungen zwischen den einzelnen beteiligten Akteur*innen auf. Zudem wird untersucht, inwiefern der Gelbe Sack den Umgang mit Verpackungsabf{\"a}llen im allt{\"a}glichen Leben mitbestimmt und welche Rolle seine eigene Materialit{\"a}t hierbei spielt.},
  subject      = {Alltagskultur},
  language  = {de}
}
@misc{Hammer2020,
  type      = {Master Thesis},
  author    = {Hammer, Alexandra},
  title     = {Doing Childhoods - Doing Futures? Ethnografische Perspektiven auf das gemeinsame Werden von Kindern und Eltern},
  issn      = {2511-9486},
  doi       = {10.25972/OPUS-21113},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-211131},
  school      = {Universit{\"a}t W{\"u}rzburg},
  pages     = {102},
  year      = {2020},
  abstract  = {Dass Kinder unsere Zukunft sind, ist ein Allgemeinplatz. Diese vermeintliche Selbstverst{\"a}ndlichkeit nimmt die vorliegende Arbeit zum Anlass, um danach zu fragen, wo und wie Zuk{\"u}nftiges tats{\"a}chlich eine Rolle f{\"u}r kindliche und elterliche Alltage spielt. So geht diese ethnografische Studie zweier Krabbelgruppen der Frage nach, wie sowohl Kindheiten als auch Zuk{\"u}nfte innerhalb konkreter Praktiken erst als solche hervorgebracht werden, und zeichnet hierf{\"u}r unterschiedliche Relationen zwischen diesen beiden Ph{\"a}nomenen nach. Welchen Anteil haben neben den elterlichen auch die kindlichen Akteur*innen sowie nicht-menschliche Andere an diesen Prozessen? Wann und wie werden in der Auseinandersetzung mit Kindheiten neben Zuk{\"u}nften auch Vergangenheiten und Gegenwarten (relevant) gemacht - wann von wem wie Zeitlichkeit hervorgebracht? Ein Zusammendenken von praxistheoretischen Perspektiven der Future Studies mit Konzepten der NaturenKulturenforschung und der Neuen Kindheitsforschung erlaubt es Alexandra Hammer, kleinkindliche Entwicklung als immer auch non-lineares, lebendiges und situatives Unterfangen sichtbar zu machen und zugleich die produktive Rolle dieser jungen Akteur*innen und nichtmenschlicher Anderer aufzuzeigen.},
  subject      = {Kulturanthropologie},
  language  = {de}
}
@article{ChifuHeinzeFussetal.2020,
  author    = {Chifu, Irina and Heinze, Britta and Fuss, Carmina T. and Lang, Katharina and Kroiss, Matthias and Kircher, Stefan and Ronchi, Cristina L. and Altieri, Barbara and Schirbel, Andreas and Fassnacht, Martin and Hahner, Stefanie},
  title     = {Impact of the Chemokine Receptors CXCR4 and CXCR7 on Clinical Outcome in Adrenocortical Carcinoma},
  series = {Frontiers in Endocrinology},
  volume    = {11},
  journal   = {Frontiers in Endocrinology},
  issn      = {1664-2392},
  doi       = {10.3389/fendo.2020.597878},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-216494},
  year      = {2020},
  abstract  = {Chemokine receptors have a negative impact on tumor progression in several human cancers and have therefore been of interest for molecular imaging and targeted therapy. However, their clinical and prognostic significance in adrenocortical carcinoma (ACC) is unknown. The aim of this study was to evaluate the chemokine receptor profile in ACC and to analyse its association with clinicopathological characteristics and clinical outcome. A chemokine receptor profile was initially evaluated by quantitative PCR in 4 normal adrenals, 18 ACC samples and human ACC cell line NCI-H295. High expression of CXCR4 and CXCR7 in both healthy and malignant adrenal tissue and ACC cells was confirmed. In the next step, we analyzed the expression and cellular localization of CXCR4 and CXCR7 in ACC by immunohistochemistry in 187 and 84 samples, respectively. These results were correlated with clinicopathological parameters and survival outcome. We detected strong membrane expression of CXCR4 and CXCR7 in 50\% of ACC samples. Strong cytoplasmic CXCR4 staining was more frequent among samples derived from metastases compared to primaries (p=0.01) and local recurrences (p=0.04). CXCR4 membrane staining positively correlated with proliferation index Ki67 (r=0.17, p=0.028). CXCR7 membrane staining negatively correlated with Ki67 (r=-0.254, p=0.03) but positively with tumor size (r=0.3, p=0.02). No differences in progression-free or overall survival were observed between patients with strong and weak staining intensities for CXCR4 or CXCR7. Taken together, high expression of CXCR4 and CXCR7 in both local tumors and metastases suggests that some ACC patients might benefit from CXCR4/CXCR7-targeted therapy.},
  language  = {en}
}
@article{GrebeMalzahnDonhauseretal.2020,
  author    = {Grebe, S{\"o}ren Jendrik and Malzahn, Uwe and Donhauser, Julian and Liu, Dan and Wanner, Christoph and Krane, Vera and Hammer, Fabian},
  title     = {Quantification of left ventricular mass by echocardiography compared to cardiac magnet resonance imaging in hemodialysis patients},
  series = {Cardiovascular Ultrasound},
  volume    = {18},
  journal   = {Cardiovascular Ultrasound},
  doi       = {10.1186/s12947-020-00217-y},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-229282},
  year      = {2020},
  abstract  = {Background: Left ventricular hypertrophy (LVH), defined by the left ventricular mass index (LVMI), is highly prevalent in hemodialysis patients and a strong independent predictor of cardiovascular events. Compared to cardiac magnetic resonance imaging (CMR), echocardiography tends to overestimate the LVMI. Here, we evaluate the diagnostic performance of transthoracic echocardiography (TTE) compared to CMR regarding the assessment of LVMI in hemodialysis patients. Methods: TTR and CMR data for 95 hemodialysis patients who participated in the MiREnDa trial were analyzed. The LVMI was calculated by two-dimensional (2D) TTE-guided M-mode measurements employing the American Society of Echocardiography (ASE) and Teichholz (Th) formulas, which were compared to the reference method, CMR. Results: LVH was present in 44\% of patients based on LVMI measured by CMR. LVMI measured by echocardiography correlated moderately with CMR, ASE: r = 0.44 (0.34-0.62); Th: r = 0.44 (0.32-0.62). Compared to CMR, both echocardiographic formulas overestimated LVMI (mean increment LVMI (ASE-CMR): 19.5 +/- 19.48 g/m(2),p < 0.001; mean increment LVMI (Th-CMR): 15.9 +/- 15.89 g/m(2),p < 0.001). We found greater LVMI overestimation in patients with LVH using the ASE formula compared to the Th formula. Stratification of patients into CMR LVMI quartiles showed a continuous decrease in increment LVMI with increasing CMR LVMI quartiles for the Th formula (p < 0.001) but not for the ASE formula (p = 0.772). Bland-Altman analysis showed that the Th formula had a constant bias independent of LVMI. Both methods had good discrimination ability for the detection of LVH (ROC-AUC: 0.819 (0.737-0.901) and 0.808 (0.723-0.892) for Th and ASE, respectively). Conclusions: The ASE and Th formulas overestimate LVMI in hemodialysis patients. However, the overestimation is less with the Th formula, particularly with increasing LVMI. The results suggest that the Th formula should be preferred for measurement of LVMI in chronic hemodialysis patients.},
  language  = {en}
}
@article{BreitenbachBorzi2020,
  author    = {Breitenbach, Tim and Borz{\`i}, Alfio},
  title     = {The Pontryagin maximum principle for solving Fokker-Planck optimal control problems},
  series = {Computational Optimization and Applications},
  volume    = {76},
  journal   = {Computational Optimization and Applications},
  issn      = {0926-6003},
  doi       = {10.1007/s10589-020-00187-x},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-232665},
  pages     = {499-533},
  year      = {2020},
  abstract  = {The characterization and numerical solution of two non-smooth optimal control problems governed by a Fokker-Planck (FP) equation are investigated in the framework of the Pontryagin maximum principle (PMP). The two FP control problems are related to the problem of determining open- and closed-loop controls for a stochastic process whose probability density function is modelled by the FP equation. In both cases, existence and PMP characterisation of optimal controls are proved, and PMP-based numerical optimization schemes are implemented that solve the PMP optimality conditions to determine the controls sought. Results of experiments are presented that successfully validate the proposed computational framework and allow to compare the two control strategies.},
  language  = {en}
}
@misc{Neidinger2020,
  author    = {Neidinger, Rico},
  title     = {Europa- und verfassungsrechtliche Rahmenbedingungen der Netzneutralit{\"a}t},
  issn      = {2199-790X},
  doi       = {10.25972/OPUS-19829},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-198293},
  pages     = {53},
  year      = {2020},
  abstract  = {Die Dynamik technischer Entwicklungen ist mannigfaltig und stellt das Recht vor immer neue Herausforderungen. Neben der rechtlichen Einhegung neuer M{\"o}glichkeiten m{\"u}ssen h{\"a}ufig grundlegende Wertentscheidungen getroffen werden. Dies betrifft auch die Funktionsweise des Internets. Urspr{\"u}nglich gew{\"a}hrleistet das „Best-Effort-Prinzip" eine gleichm{\"a}ßige Behandlung des Datenverkehrs im Netz. Neue technische Entwicklungen er{\"o}ffnen Internetzugangsanbietern nun M{\"o}glichkeiten zur Beeinflussung der Daten{\"u}bertragung. Durch diese Entwicklung ist das Thema Netzneutralit{\"a}t in den rechtswissenschaftlichen Fokus ger{\"u}ckt und der Ruf nach Regulierung laut geworden. Mit der Aufgabe des „Best-Effort-Prinzips" wurde nicht weniger als der Untergang des „Internet-Abendlandes" prophezeit. Die den Internetzugangsanbietern m{\"o}gliche Beeinflussung der Meinungsfreiheit der Internetnutzer beschworen einige als ernsthafte Gefahr f{\"u}r die Demokratie. Zugleich pochten die Internetprovider auf ihre unternehmerischen Freiheiten und priesen die neuen Innovationen, welche mit den technischen M{\"o}glichkeiten einhergingen. Nach einer intensiven Diskussion einigte sich der europ{\"a}ische Gesetzgeber mit der Verordnung (EU) 2015/2120 {\"u}ber Maßnahmen zum Zugang zum offenen Internet auf eine Regelung zu diesem Thema, ohne freilich das Wort Netzneutralit{\"a}t zu verwenden. Die offene Formulierung der EUNNVO st{\"o}ßt in der rechtswissenschaftlichen Literatur auf Kritik. Zu unbestimmt seien die Anforderungen, die die Verordnung - gerade mit Blick auf den grundrechtssensiblen Bereich - aufstellt. Tats{\"a}chlich sind die europa- und verfassungsrechtlichen Anforderungen an eine solche Regelung weit weniger eindeutig als erwartet. Grundrechte, Grundfreiheiten, Anforderungen an die Wirtschaftsverfassung schaffen, zumal in Kombination mit den Herausforderungen des Mehrebenensystems, eine komplexe rechtliche Ausgangslage.},
  subject      = {Netzneutralit{\"a}t},
  language  = {de}
}
@unpublished{TitovHumeniukMitric2020,
  author    = {Titov, Evgenii and Humeniuk, Alexander and Mitric, Roland},
  title     = {Comparison of moving and fixed basis sets for nonadiabatic quantum dynamics at conical intersections},
  series = {Chemical Physics},
  journal   = {Chemical Physics},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-198699},
  year      = {2020},
  abstract  = {We assess the performance of two different types of basis sets for nonadiabatic quantum dynamics at conical intersections. The basis sets of both types are generated using Ehrenfest trajectories of nuclear coherent states. These trajectories can either serve as a moving (time-dependent) basis or be employed to sample a fixed (time-independent) basis. We demonstrate on the example of two-state two-dimensional and three-state five-dimensional models that both basis set types can yield highly accurate results for population transfer at intersections, as compared with reference quantum dynamics. The details of wave packet evolutions are discussed for the case of the two-dimensional model. The fixed basis is found to be superior to the moving one in reproducing true nonlocal spreading and maintaining correct shape of the wave packet upon time evolution. Moreover, for the models considered, the fixed basis set outperforms the moving one in terms of computational efficiency.},
  language  = {en}
}
@article{VogelGossnerMergneretal.2020,
  author    = {Vogel, Sebastian and Gossner, Martin M. and Mergner, Ulrich and M{\"u}ller, J{\"o}rg and Thorn, Simon},
  title     = {Optimizing enrichment of deadwood for biodiversity by varying sun exposure and tree species: An experimental approach},
  series = {Journal of Applied Ecology},
  volume    = {57},
  journal   = {Journal of Applied Ecology},
  number    = {10},
  doi       = {10.1111/1365-2664.13648},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-214614},
  pages     = {2075 -- 2085},
  year      = {2020},
  abstract  = {The enrichment of deadwood is essential for the conservation of saproxylic biodiversity in managed forests. However, existing strategies focus on a cost-intensive increase of deadwood amount, while largely neglecting increasing deadwood diversity. Deadwood objects, that is logs and branches, from six tree species were experimentally sun exposed, canopy shaded and artificially shaded for 4 years, after which the alpha-, beta- and gamma-diversity of saproxylic beetles, wood-inhabiting fungi and spiders were analysed. Analyses of beta-diversity included the spatial distance between exposed deadwood objects. A random-drawing procedure was used to identify the combination of tree species and sun exposure that yielded the highest gamma-diversity at a minimum of exposed deadwood amount. In sun-exposed plots, species numbers in logs were higher than in shaded plots for all taxa, while in branches we observed the opposite for saproxylic beetles. Tree species affected the species numbers only of saproxylic beetles and wood-inhabiting fungi. The beta-diversity of saproxylic beetles and wood-inhabiting fungi among logs was influenced by sun exposure and tree species, but beta-diversity of spiders by sun exposure only. For all saproxylic taxa recorded in logs, differences between communities increased with increasing spatial distance. A combination of canopy-shaded Carpinus logs and sun-exposed Populus logs resulted in the highest species numbers of all investigated saproxylic taxa among all possible combinations of tree species and sun-exposure treatments. Synthesis and applications. We recommend incorporating the enrichment of different tree species and particularly the variation in sun exposure into existing strategies of deadwood enrichment. Based on the results of our study, we suggest to combine the logs of softwood broadleaf tree species (e.g. Carpinus, Populus), hardwood broadleaf tree species (e.g. Quercus) and coniferous tree species (e.g. Pinus) under different conditions of sun exposure and distribute them spatially in a landscape to maximize the beneficial effects on overall diversity.},
  language  = {en}
}
@misc{Schroeder2020,
  author    = {Schr{\"o}der, Lina},
  title     = {Schmied, Doris/W{\"u}stenrot Stiftung (Hrsg.): Große D{\"o}rfer - Kleine St{\"a}dte (RURAL, Bd. 9), 148 S., Cuvillier, G{\"o}ttingen 2018},
  series = {Neue Politische Literatur},
  volume    = {65},
  journal   = {Neue Politische Literatur},
  issn      = {0028-3320},
  doi       = {10.1007/s42520-020-00316-0},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-234913},
  pages     = {535-537},
  year      = {2020},
  abstract  = {Keine Zusammenfassung vorhanden.},
  language  = {de}
}
@article{SommerKloseWelschetal.2020,
  author    = {Sommer, Claudia and Klose, Petra and Welsch, Patrick and Petzke, Frank and H{\"a}user, Winfried},
  title     = {Opioids for chronic non-cancer neuropathic pain. An updated systematic review and meta-analysis of efficacy, tolerability and safety in randomized placebo-controlled studies of at least 4 weeks duration},
  series = {European Journal of Pain},
  volume    = {24},
  journal   = {European Journal of Pain},
  number    = {1},
  doi       = {10.1002/ejp.1494},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-218487},
  pages     = {3 -- 18},
  year      = {2020},
  abstract  = {Background and Objective This updated systematic review evaluated the efficacy, tolerability and safety of opioids compared to placebo in chronic non-cancer neuropathic pain. Databases and Data Treatment Clinicaltrials.gov, CENTRAL, PubMed and PsycINFO were searched from October 2013 to June 2019. Randomized controlled trials comparing opioids with placebo and at least 4 weeks double-blinded duration were analysed. Primary outcomes were pain relief of 50\% or greater, disability, tolerability and safety. Effects were summarized by a random effects model using risk differences (RD) or standardized mean differences (SMD). We added four new studies with 662 participants for a total of 16 included studies with 2,199 participants. Study duration ranged between 4 and 12 weeks. Studies with a parallel and cross-over design: Based on low to moderate quality evidence, opioids (buprenorphine, hydromorphone, morphine, oxycodone, tramadol) provided a clinically relevant pain relief of 50\% or greater and reduction of disability compared to placebo. There was no clinically relevant harm with regards to the drop out rate due to adverse and serious adverse events by opioids compared to placebo. Enriched enrolment randomized withdrawal design: Based on low to moderate quality evidence, tapentadol provided a clinically relevant pain relief of 50\% or greater and reduction of disability compared to placebo in diabetic polyneuropathy. There was no clinically relevant harm with regards to the drop out rate due to adverse and serious adverse events by tapentadol compared to placebo. Conclusions Some opioids provided a short-term substantial pain relief in highly selected patients in some neuropathic pain syndromes. Significance Some opioids (buprenorphine, morphine, oxycodone, tramadol, tapentadol) provide substantial pain relief compared to placebo in postherpetic neuralgia and peripheral neuropathies of different aetiologies for 4-12 weeks. There is insufficient evidence to support or refute the suggestion that these drugs are effective in other neuropathic pain conditions. The safety of opioids with regards to abuse and deaths in the studies analysed cannot be extrapolated to routine clinical care.},
  language  = {en}
}
@incollection{Bergengruen2020,
  author    = {Bergengruen, Maximilian},
  title     = {Der ‚Herr der Finsternis' und der Geist des Lichts. Christian Thomasius' Kurtze Lehr-S{\"a}tze gegen die Hexenverfolgung als Bausteine einer spiritualistischen Hermeneutik},
  series = {„[...] damit sich der Leser, gleich wie ich itzt thue, entferne der Thorheit und lebe in Rhue." Festschrift f{\"u}r Peter Heßelmann},
  booktitle = {„[...] damit sich der Leser, gleich wie ich itzt thue, entferne der Thorheit und lebe in Rhue." Festschrift f{\"u}r Peter Heßelmann},
  publisher = {Universit{\"a}ts- und Landesbibliothek M{\"u}nster},
  address   = {M{\"u}nster},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-303222},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  pages     = {359-378},
  year      = {2020},
  abstract  = {No abstract available.},
  language  = {de}
}
@article{PohlmannRotherKuerzingerLipowsky2020,
  author    = {Pohlmann-Rother, Sanna and K{\"u}rzinger, Anja and Lipowsky, Frank},
  title     = {Feedback im Anfangsunterricht der Grundschule - Eine Videostudie zum Feedbackverhalten von Lehrpersonen in der Dom{\"a}ne Schreiben},
  series = {Zeitschrift f{\"u}r Erziehungswissenschaft},
  volume    = {23},
  journal   = {Zeitschrift f{\"u}r Erziehungswissenschaft},
  issn      = {1434-663X},
  doi       = {10.1007/s11618-020-00950-0},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-231828},
  pages     = {591-611},
  year      = {2020},
  abstract  = {Im Beitrag wird das Feedbackverhalten von Grundschullehrkr{\"a}ften als Merkmal der Tiefenstruktur des Unterrichts in der ersten Jahrgangsstufe analysiert. Es wird der Frage nachgegangen, wie h{\"a}ufig und in welcher Form Lehrkr{\"a}fte w{\"a}hrend einer Sch{\"u}lerarbeitsphase beim Schreiben (Texte verfassen) R{\"u}ckmeldungen geben und wie sie diese auf die Sch{\"u}lerinnen und Sch{\"u}ler verteilen. Im Anschluss werden Zusammenh{\"a}nge zwischen einzelnen Feedbackformen und der Qualit{\"a}t der Sch{\"u}lertexte analysiert. Die vorliegenden Analysen stammen aus dem DFG-Projekt NaSch1 („Narrative Schreibkompetenz in Klasse 1") und st{\"u}tzen sich auf 47 ca. 90-min{\"u}tige videografierte Unterrichtseinheiten mit 540 Lernenden aus der PERLE-Videostudie. Die Ergebnisse zeigen deutliche Unterschiede im R{\"u}ckmeldeverhalten der Lehrpersonen. Elaborierte Feedbackformen (z. B. tutorielles Feedback) treten seltener auf als einfache Formen. Tendenziell erhalten Jungen h{\"a}ufiger ein Feedback, wobei die Initiative zur Erteilung eines Feedbacks eher von den Lernenden als von den Lehrkr{\"a}ften ausgeht. In den Mehrebenenanalysen lassen sich keine signifikanten Zusammenh{\"a}nge zwischen einfachen bzw. elaborierten R{\"u}ckmeldeformen und der Textqualit{\"a}t nachweisen. Dagegen zeigt sich ein negativer Zusammenhang zwischen inhaltsbezogenem Feedback und der sprachsystematischen Dimension der Textqualit{\"a}t.},
  language  = {de}
}
@techreport{Samb2020,
  type      = {Working Paper},
  author    = {Samb, Aminata},
  title     = {De la biofiction {\`a} l'exofiction dans «Allah n'est pas oblig{\´e}» d'Ahmadou Kourouma et «Les soldats de Salamine» de Javier Cercas},
  issn      = {2199-4315},
  doi       = {10.25972/OPUS-20301},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-203013},
  pages     = {57},
  year      = {2020},
  abstract  = {Ce pr{\´e}sent m{\´e}moire se donne pour objectif d'analyser le champ d'application et d'{\´e}tude des concepts de biofiction et d'exofiction qui, {\`a} travers le brouillage entre la r{\´e}alit{\´e} la fiction, passeraient pour des r{\´e}cits de vie dans le roman postmoderne. Pour cela, nous avons {\´e}tudi{\´e} les relations entre la fiction et l'(auto)biographie, la fiction et la r{\´e}alit{\´e} ax{\´e}e sur les apports des strat{\´e}gies linguistiques et conceptuelles, entre autres. Gr{\^a}ce {\`a} une m{\´e}thode qualitative se fondant sur une approche hypoth{\´e}tico-d{\´e}ductive pour montrer comment l'(auto)biographie a {\´e}t{\´e} retravaill{\´e}e dans les deux textes, mais aussi de montrer le potentiel fictionnel, dont regorge notre sujet, {\`a} travers le r{\´e}cit de vie. Outre l'int{\´e}r{\^e}t que nous avons port{\´e} aux travaux de Lejeune, Vincent Colonna et Fran{\c{c}}ois Dosse dans leurs textes respectifs Le pacte autobiographique, L'autofiction : essai sur la fictionnalisation de soi en litt{\´e}rature et Le pari biographique pour souligner la connexion avec notre sujet, nous avons {\´e}galement fait appel au concept clefs du domaine, tels que th{\´e}oris{\´e}s par Alexandre Gefen et Alain Buisine (1991).},
  subject      = {Postmoderne},
  language  = {fr}
}
@techreport{Fleckenstein2020,
  type      = {Working Paper},
  author    = {Fleckenstein, Felix},
  title     = {Im Dienst einer Theologie der Heiligen Schrift},
  doi       = {10.25972/OPUS-20846},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-208462},
  pages     = {19},
  year      = {2020},
  abstract  = {1961 {\"a}ußerte sich Karl Rahner mit einem Aufsatz zum Spannungsverh{\"a}ltnis zwischen Exegese und Dogmatik. Diese Spannung entz{\"u}ndet sich vornehmlich am konkreten Umgang mit biblischen Texten. Bis heute scheint es sich hierbei jedoch um ein ungel{\"o}stes Problem zu handeln. Der in diesem Aufsatz vorgestellte methodische Entwurf versucht einen solchen Br{\"u}ckenschlag zwischen den beiden theologischen Fachwissenschaften mittels einer Hermeneutik zur Interpretation alttestamentlicher Texte anzustreben. Dabei nimmt die Fokussierung auf das Alte Testament keine hermeneutische Sonderstellung ein, sondern erweist sich vielmehr als Pr{\"u}fstein und Richtschnur jeder christlichen Interpretation der zweigeteilten Bibel. In den Brennpunkten der Ausf{\"u}hrung dieses hermeneutischen Entwurfs stehen zum einen die Verpflichtung des Auslegers gegen{\"u}ber dem biblischen Text und zum anderen das dialogische Gegen{\"u}ber von Textwelt und konkreter Lebenssituation.},
  subject      = {Hermeneutik},
  language  = {de}
}
@article{GenestRakPetryketal.2020,
  author    = {Genest, Franca and Rak, Dominik and Petryk, Anna and Seefried, Lothar},
  title     = {Physical Function and Health-Related Quality of Life in Adults Treated With Asfotase Alfa for Pediatric-Onset Hypophosphatasia},
  series = {JBMR Plus},
  volume    = {4},
  journal   = {JBMR Plus},
  number    = {9},
  doi       = {10.1002/jbm4.10395},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-218410},
  year      = {2020},
  abstract  = {Hypophosphatasia (HPP) is a rare, inherited, metabolic disease characterized by tissue-nonspecific alkaline phosphatase deficiency resulting in musculoskeletal and systemic clinical manifestations. This observational study evaluated the effectiveness of enzyme replacement therapy with asfotase alfa on physical function and health-related quality of life (HRQoL) among adults with pediatric-onset HPP who received asfotase alfa for 12 months at a single center (ClinicalTrial.gov no.: NCT03418389). Primary outcomes evaluated physical function with the 6-minute walk test (6MWT), timed up-and-go (TUG) test, Short Physical Performance Battery (SPPB), and handheld dynamometry (HHD). Secondary outcome measures included the Lower Extremity Functional Scale (LEFS), pain prevalence/intensity, and pain medication use; HRQoL was evaluated using the 36-Item Short-Form Health Survey version 2 (SF-36v2). Safety data were collected throughout the study. All 14 patients (11 women) had compound heterozygous ALPL gene mutations and ≥1 HPP bone manifestation, including history of ≥1 fracture. Mean (min, max) age was 51 (19 to 78) years. From baseline to 12 months of treatment, median 6MWT distance increased from 267 m to 320 m (n = 13; p = 0.023); median TUG test time improved from 14.4 s to 11.3 s (n = 9; p = 0.008). Specific components of the SPPB also improved significantly: median 4-m gait speed increased from 0.8 m/s to 1.1 m/s (n = 10; p = 0.007) and median repeated chair-rise time improved from 22 s to 13 s (n = 9; p = 0.008). LEFS score improved from 24 points to 53 points (n = 10; p = 0.002). Improvements in HHD were not clinically significant. SF-36v2 Physical Component Score (PCS) improved after 12 months of treatment (n = 9; p = 0.010). Pain level did not change significantly from baseline to 12 months of treatment. There were significant improvements on chair-rise time and SF-36v2 PCS by 3 months, and on TUG test time after 6 months. No new safety signals were identified. These results show the real-world effectiveness of asfotase alfa in improving physical functioning and HRQoL in adults with pediatric-onset HPP. © 2020 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.},
  language  = {en}
}
@article{EiringhausWuenscheTirilomisetal.2020,
  author    = {Eiringhaus, J{\"o}rg and W{\"u}nsche, Christoph M. and Tirilomis, Petros and Herting, Jonas and Bork, Nadja and Nikolaev, Viacheslav O. and Hasenfuss, Gerd and Sossalla, Samuel and Fischer, Thomas H.},
  title     = {Sacubitrilat reduces pro-arrhythmogenic sarcoplasmic reticulum Ca\(^{2+}\) leak in human ventricular cardiomyocytes of patients with end-stage heart failure},
  series = {ESC Heart Failure},
  volume    = {7},
  journal   = {ESC Heart Failure},
  number    = {5},
  doi       = {10.1002/ehf2.12918},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-218479},
  pages     = {2992 -- 3002},
  year      = {2020},
  abstract  = {Aims Inhibition of neprilysin and angiotensin II receptor by sacubitril/valsartan (Val) (LCZ696) reduces mortality in heart failure (HF) patients compared with sole inhibition of renin-angiotensin system. Beneficial effects of increased natriuretic peptide levels upon neprilysin inhibition have been proposed, whereas direct effects of sacubitrilat (Sac) (LBQ657) on myocardial Ca\(^{2+}\) cycling remain elusive. Methods and results Confocal microscopy (Fluo-4 AM) was used to investigate pro-arrhythmogenic sarcoplasmic reticulum (SR) Ca\(^{2+}\) leak in freshly isolated murine and human ventricular cardiomyocytes (CMs) upon Sac (40 μmol/L)/Val (13 μmol/L) treatment. The concentrations of Sac and Val equalled plasma concentrations of LCZ696 treatment used in PARADIGM-HF trial. Epifluorescence microscopy measurements (Fura-2 AM) were performed to investigate effects on systolic Ca\(^{2+}\) release, SR Ca\(^{2+}\) load, and Ca\(^{2+}\)-transient kinetics in freshly isolated murine ventricular CMs. The impact of Sac on myocardial contractility was evaluated using in toto-isolated, isometrically twitching ventricular trabeculae from human hearts with end-stage HF. Under basal conditions, the combination of Sac/Val did not influence diastolic Ca\(^{2+}\)-spark frequency (CaSpF) nor pro-arrhythmogenic SR Ca\(^{2}\) leak in isolated murine ventricular CMs (n CMs/hearts = 80/7 vs. 100/7, P = 0.91/0.99). In contrast, Sac/Val treatment reduced CaSpF by 35 ± 9\% and SR Ca\(^{2+}\) leak by 45 ± 9\% in CMs put under catecholaminergic stress (isoproterenol 30 nmol/L, n = 81/7 vs. 62/7, P < 0.001 each). This could be attributed to Sac, as sole Sac treatment also reduced both parameters by similar degrees (reduction of CaSpF by 57 ± 7\% and SR Ca2+ leak by 76 ± 5\%; n = 101/4 vs. 108/4, P < 0.01 each), whereas sole Val treatment did not. Systolic Ca2+ release, SR Ca\(^{2+}\) load, and Ca\(^{2+}\)-transient kinetics including SERCA activity (k\(_{SERCA}\)) were not compromised by Sac in isolated murine CMs (n = 41/6 vs. 39/6). Importantly, the combination of Sac/Val and Sac alone also reduced diastolic CaSpF and SR Ca\(^{2+}\) leak (reduction by 74 ± 7\%) in human left ventricular CMs from patients with end-stage HF (n = 71/8 vs. 78/8, P < 0.05 each). Myocardial contractility of human ventricular trabeculae was not acutely affected by Sac treatment as the developed force remained unchanged over a time course of 30 min (n trabeculae/hearts = 3/3 vs. 4/3). Conclusion This study demonstrates that neprilysin inhibitor Sac directly improves Ca\(^{2+}\) homeostasis in human end-stage HF by reducing pro-arrhythmogenic SR Ca\(^{2+}\) leak without acutely affecting systolic Ca\(^{2+}\) release and inotropy. These effects might contribute to the mortality benefits observed in the PARADIGM-HF trial.},
  language  = {en}
}
@article{FritscheHoeckendorfAlvermannetal.2020,
  author    = {Fritsche, Alexander and H{\"o}ckendorf, Bastian and Alvermann, Andreas and Fehske, Holger},
  title     = {Real and imaginary edge states in stacked Floquet honeycomb lattices},
  series = {The European Physical Journal B},
  volume    = {93},
  journal   = {The European Physical Journal B},
  number    = {151},
  issn      = {1434-6028},
  doi       = {10.1140/epjb/e2020-10233-0},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-232347},
  year      = {2020},
  abstract  = {We present a non-Hermitian Floquet model with topological edge states in real and imaginaryband gaps. The model utilizes two stacked honeycomb lattices which can be related via four different typesof non-Hermitian time-reversal symmetry. Implementing the correct time-reversal symmetry provides uswith either two counterpropagating edge states in a real gap, or a single edge state in an imaginary gap.The counterpropagating edge states allow for either helical or chiral transport along the lattice perimeter.In stark contrast, we find that the edge state in the imaginary gap does not propagate. Instead, it remainsspatially localized while its amplitude continuously increases. Our model is well-suited for realizing theseedge states in photonic waveguide lattices},
  language  = {en}
}
@article{Schoech2020,
  author    = {Sch{\"o}ch, Christof},
  title     = {Interview mit Prof. Dr. Christof Sch{\"o}ch},
  series = {promptus - W{\"u}rzburger Beitr{\"a}ge zur Romanistik},
  volume    = {6},
  journal   = {promptus - W{\"u}rzburger Beitr{\"a}ge zur Romanistik},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-235128},
  pages     = {7-20},
  year      = {2020},
  abstract  = {Interview mit Prof. Dr. Christof Sch{\"o}ch},
  language  = {de}
}
@article{EidelKuebler2020,
  author    = {Eidel, Matthias and K{\"u}bler, Andrea},
  title     = {Wheelchair Control in a Virtual Environment by Healthy Participants Using a P300-BCI Based on Tactile Stimulation: Training Effects and Usability},
  series = {Frontiers in Human Neuroscience},
  volume    = {14},
  journal   = {Frontiers in Human Neuroscience},
  issn      = {1662-5161},
  doi       = {10.3389/fnhum.2020.00265},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-207775},
  year      = {2020},
  abstract  = {Tactile stimulation is less frequently used than visual for brain-computer interface (BCI) control, partly because of limitations in speed and accuracy. Non-visual BCI paradigms, however, may be required for patients who struggle with vision dependent BCIs because of a loss of gaze control. With the present study, we attempted to replicate earlier results by Herweg et al. (2016), with several minor adjustments and a focus on training effects and usability. We invited 16 healthy participants and trained them with a 4-class tactile P300-based BCI in five sessions. Their main task was to navigate a virtual wheelchair through a 3D apartment using the BCI. We found significant training effects on information transfer rate (ITR), which increased from a mean of 3.10-9.50 bits/min. Further, both online and offline accuracies significantly increased with training from 65\% to 86\% and 70\% to 95\%, respectively. We found only a descriptive increase of P300 amplitudes at Fz and Cz with training. Furthermore, we report subjective data from questionnaires, which indicated a relatively high workload and moderate to high satisfaction. Although our participants have not achieved the same high performance as in the Herweg et al. (2016) study, we provide evidence for training effects on performance with a tactile BCI and confirm the feasibility of the paradigm.},
  language  = {en}
}
@article{KunzKneisel2020,
  author    = {Kunz, Julius and Kneisel, Christof},
  title     = {Glacier - Permafrost Interaction at a Thrust Moraine Complex in the Glacier Forefield Muragl, Swiss Alps},
  series = {Geosciences},
  volume    = {10},
  journal   = {Geosciences},
  number    = {6},
  issn      = {2076-3263},
  doi       = {10.3390/geosciences10060205},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-205830},
  year      = {2020},
  abstract  = {The internal structures of a moraine complex mostly provide information about the manner in which they develop and thus they can transmit details about several processes long after they have taken place. While the occurrence of glacier-permafrost interactions during the formation of large thrust moraine complexes at polar and subpolar glaciers as well as at marginal positions of former ice sheets has been well understood, their role in the formation of moraines on comparatively small alpine glaciers is still very poorly investigated. Therefore, the question arises as to whether evidence of former glacier-permafrost interactions can still be found in glacier forefields of small alpine glaciers and to what extent these differ from the processes in finer materials at larger polar or subpolar glaciers. To investigate this, electrical resistivity tomography (ERT) and ground-penetrating radar (GPR) surveys were carried out in the area of a presumed alpine thrust moraine complex in order to investigate internal moraine structures. The ERT data confirmed the presence of a massive ice core within the central and proximal parts of the moraine complex. Using GPR, linear internal structures were detected, which were interpreted as internal shear planes due to their extent and orientation. These shear planes lead to the assumption that the moraine complex is of glaciotectonic origin. Based on the detected internal structures and the high electrical resistivity values, it must also be assumed that the massive ice core is of sedimentary or polygenetic origin. The combined approach of the two methods enabled the authors of this study to detect different internal structures and to deduce a conceptual model of the thrust moraine formation.},
  language  = {en}
}
@article{ImhoffRahnKuenzeletal.2020,
  author    = {Imhoff, Johannes F. and Rahn, Tanja and K{\"u}nzel, Sven and Keller, Alexander and Neulinger, Sven C.},
  title     = {Osmotic adaptation and compatible solute biosynthesis of phototrophic bacteria as revealed from genome analyses},
  series = {Microorganisms},
  volume    = {9},
  journal   = {Microorganisms},
  number    = {1},
  issn      = {2076-2607},
  doi       = {10.3390/microorganisms9010046},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-220161},
  year      = {2020},
  abstract  = {Osmotic adaptation and accumulation of compatible solutes is a key process for life at high osmotic pressure and elevated salt concentrations. Most important solutes that can protect cell structures and metabolic processes at high salt concentrations are glycine betaine and ectoine. The genome analysis of more than 130 phototrophic bacteria shows that biosynthesis of glycine betaine is common among marine and halophilic phototrophic Proteobacteria and their chemotrophic relatives, as well as in representatives of Pirellulaceae and Actinobacteria, but are also found in halophilic Cyanobacteria and Chloroherpeton thalassium. This ability correlates well with the successful toleration of extreme salt concentrations. Freshwater bacteria in general lack the possibilities to synthesize and often also to take up these compounds. The biosynthesis of ectoine is found in the phylogenetic lines of phototrophic Alpha- and Gammaproteobacteria, most prominent in the Halorhodospira species and a number of Rhodobacteraceae. It is also common among Streptomycetes and Bacilli. The phylogeny of glycine-sarcosine methyltransferase (GMT) and diaminobutyrate-pyruvate aminotransferase (EctB) sequences correlate well with otherwise established phylogenetic groups. Most significantly, GMT sequences of cyanobacteria form two major phylogenetic branches and the branch of Halorhodospira species is distinct from all other Ectothiorhodospiraceae. A variety of transport systems for osmolytes are present in the studied bacteria.},
  language  = {en}
}
@misc{OPUS4-24395,
  title     = {promptus - W{\"u}rzburger Beitr{\"a}ge zur Romanistik. Band 6 (2020)},
  series = {promptus - W{\"u}rzburger Beitr{\"a}ge zur Romanistik},
  volume    = {6/2020},
  journal   = {promptus - W{\"u}rzburger Beitr{\"a}ge zur Romanistik},
  editor    = {Bobineau, Julien and Dembruk, Sofina and Eibensteiner, Lukas and Goldmann, Julius and Hesselbach, Robert and Koch, Christian and Ravasio, Paola},
  isbn      = {978-3-946101-04-8},
  issn      = {2364-6705},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-243951},
  year      = {2020},
  abstract  = {Die Zeitschrift promptus - W{\"u}rzburger Beitr{\"a}ge zur Romanistik erscheint einmal j{\"a}hrlich und wird durch den gemeinn{\"u}tzigen Verein promptus e.V. herausgegeben. Sie richtet sich an alle Nachwuchswissenschaftler im Bereich der romanistischen Sprach- und Literaturwissenschaft sowie der Fachdidaktik und bietet diesen die M{\"o}glichkeit, in einem fr{\"u}hen Stadium ihrer akademischen Laufbahn qualitativ hochwertige Arbeiten zu publizieren. Zudem versteht sich die Zeitschrift als Impulsgeber f{\"u}r junge romanistische Forschung, ohne sich dabei thematisch zu beschr{\"a}nken.},
  language  = {mul}
}
@article{Leschzyk2020,
  author    = {Leschzyk, Dinah},
  title     = {Corona-Kommunikation. Wie Jair Bolsonaro die Wissenschaft diskreditiert und Verschw{\"o}rungstheorien befeuert},
  series = {promptus - W{\"u}rzburger Beitr{\"a}ge zur Romanistik},
  volume    = {6},
  journal   = {promptus - W{\"u}rzburger Beitr{\"a}ge zur Romanistik},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-244271},
  pages     = {107-129},
  year      = {2020},
  abstract  = {This article deals with discursive and argumentative strategies used by Brazilian President Jair Bolsonaro to bring science in discredit during the 2020's COVID-19-pandemic. Based on official statements and Tweets launched over the crisis the Discourse-Historical Approach is applied to make strategies brought into play by Bolsonaro visible. While the President declares scientific advice such as distancing and quarantine as ineffective, he recommends the use of hydroxychloroquine as well as old fashioned prayers for staying safe and healthy. He evokes that there are «fake news» and «partners of paralysis», to which he responds by demasking and bringing the one and only truth towards «the people». The analysis points out that Bolsonaro is downplaying the virus and the risk of transmission and puts the economy ahead of health. His supporters as a consequence tend to ignore the WHO recommendations how to behave during the pandemic.},
  language  = {de}
}
@article{MuellerUlyshenSeiboldetal.2020,
  author    = {M{\"u}ller, J{\"o}rg and Ulyshen, Mike and Seibold, Sebastian and Cadotte, Marc and Chao, Anne and B{\"a}ssler, Claus and Vogel, Sebastian and Hagge, Jonas and Weiß, Ingmar and Baldrian, Petr and Tl{\´a}skal, Vojtěch and Thorn, Simon},
  title     = {Primary determinants of communities in deadwood vary among taxa but are regionally consistent},
  series = {Oikos},
  volume    = {129},
  journal   = {Oikos},
  number    = {10},
  doi       = {10.1111/oik.07335},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-228201},
  pages     = {1579 -- 1588},
  year      = {2020},
  abstract  = {The evolutionary split between gymnosperms and angiosperms has far-reaching implications for the current communities colonizing trees. The inherent characteristics of dead wood include its role as a spatially scattered habitat of plant tissue, transient in time. Thus, local assemblages in deadwood forming a food web in a necrobiome should be affected not only by dispersal ability but also by host tree identity, the decay stage and local abiotic conditions. However, experiments simultaneously manipulating these potential community drivers in deadwood are lacking. To disentangle the importance of spatial distance and microclimate, as well as host identity and decay stage as drivers of local assemblages, we conducted two consecutive experiments, a 2-tree species and 6-tree species experiment with 80 and 72 tree logs, respectively, located in canopy openings and under closed canopies of a montane and a lowland forest. We sampled saproxylic beetles, spiders, fungi and bacterial assemblages from logs. Variation partitioning for community metrics based on a unified framework of Hill numbers showed consistent results for both studies: host identity was most important for sporocarp-detected fungal assemblages, decay stage and host tree for DNA-detected fungal assemblages, microclimate and decay stage for beetles and spiders and decay stage for bacteria. Spatial distance was of minor importance for most taxa but showed the strongest effects for arthropods. The contrasting patterns among the taxa highlight the need for multi-taxon analyses in identifying the importance of abiotic and biotic drivers of community composition. Moreover, the consistent finding of microclimate as the primary driver for saproxylic beetles compared to host identity shows, for the first time that existing evolutionary host adaptions can be outcompeted by local climate conditions in deadwood.},
  language  = {en}
}
@article{JanssenHoffmannKannoetal.2020,
  author    = {Janssen, Jan P. and Hoffmann, Jan V. and Kanno, Takayuki and Nose, Naoko and Grunz, Jan-Peter and Onoguchi, Masahisa and Chen, Xinyu and Lapa, Constantin and Buck, Andreas K. and Higuchi, Takahiro},
  title     = {Capabilities of multi-pinhole SPECT with two stationary detectors for in vivo rat imaging},
  series = {Scientific Reports},
  volume    = {10},
  journal   = {Scientific Reports},
  doi       = {10.1038/s41598-020-75696-0},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-230616},
  year      = {2020},
  abstract  = {We aimed to investigate the image quality of the U-SPECT5/CT E-Class a micro single-photon emission computed tomography (SPECT) system with two large stationary detectors for visualization of rat hearts and bones using clinically available \(^{99m}\)Tc-labelled tracers. Sensitivity, spatial resolution, uniformity and contrast-to-noise ratio (CNR) of the small-animal SPECT scanner were investigated in phantom studies using an ultra-high-resolution rat and mouse multi-pinhole collimator (UHR-RM). Point source, hot-rod, and uniform phantoms with \(^{99m}\)Tc-solution were scanned for high-count performance assessment and count levels equal to animal scans, respectively. Reconstruction was performed using the similarity-regulated ordered-subsets expectation maximization (SROSEM) algorithm with Gaussian smoothing. Rats were injected with similar to 100 MBq [\(^{99m}\)TcTc-MIBI or similar to 150 MBq [\(^{99m}\)Tc]Tc-HMDP and received multi-frame micro-SPECT imaging after tracer distribution. Animal scans were reconstructed for three different acquisition times and post-processed with different sized Gaussian filters. Following reconstruction, CNR was calculated and image quality evaluated by three independent readers on a five-point scale from 1="very poor" to 5="very good". Point source sensitivity was 567 cps/MBq and radioactive rods as small as 1.2 mm were resolved with the UHR-RM collimator. Collimator-dependent uniformity was 55.5\%. Phantom CNR improved with increasing rod size, filter size and activity concentration. Left ventricle and bone structures were successfully visualized in rat experiments. Image quality was strongly affected by the extent of post-filtering, whereas scan time did not have substantial influence on visual assessment. Good image quality was achieved for resolution range greater than 1.8 mm in bone and 2.8 mm in heart. The recently introduced small animal SPECT system with two stationary detectors and UHR-RM collimator is capable to provide excellent image quality in heart and bone scans in a rat using standardized reconstruction parameters and appropriate post-filtering. However, there are still challenges in achieving maximum system resolution in the sub-millimeter range with in vivo settings under limited injection dose and acquisition time.},
  language  = {en}
}
@article{SchaeblerAmatobiHornetal.2020,
  author    = {Sch{\"a}bler, Stefan and Amatobi, Kelechi M. and Horn, Melanie and Rieger, Dirk and Helfrich‑F{\"o}rster, Charlotte and Mueller, Martin J. and Wegener, Christian and Fekete, Agnes},
  title     = {Loss of function in the Drosophila clock gene period results in altered intermediary lipid metabolism and increased susceptibility to starvation},
  series = {Cellular and Molecular Life Sciences},
  volume    = {77},
  journal   = {Cellular and Molecular Life Sciences},
  issn      = {1420-682X},
  doi       = {10.1007/s00018-019-03441-6},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-232432},
  pages     = {4939-4956},
  year      = {2020},
  abstract  = {The fruit fly Drosophila is a prime model in circadian research, but still little is known about its circadian regulation of metabolism. Daily rhythmicity in levels of several metabolites has been found, but knowledge about hydrophobic metabolites is limited. We here compared metabolite levels including lipids between period\(^{01}\) (per\(^{01}\)) clock mutants and Canton-S wildtype (WT\(_{CS}\)) flies in an isogenic and non-isogenic background using LC-MS. In the non-isogenic background, metabo-lites with differing levels comprised essential amino acids, kynurenines, pterinates, glycero(phospho)lipids, and fatty acid esters. Notably, detectable diacylglycerols (DAG) and acylcarnitines (AC), involved in lipid metabolism, showed lower levels in per\(^{01}\) mutants. Most of these differences disappeared in the isogenic background, yet the level differences for AC as well as DAG were consistent for fly bodies. AC levels were dependent on the time of day in WTCS in phase with food consumption under LD conditions, while DAGs showed weak daily oscillations. Two short-chain ACs continued to cycle even in constant darkness. per\(^{01}\) mutants in LD showed no or very weak diel AC oscillations out of phase with feeding activity. The low levels of DAGs and ACs in per\(^{01}\) did not correlate with lower total food consumption, body mass or weight. Clock mutant flies showed higher sensitivity to starvation independent of their background-dependent activity level. Our results suggest that neither feeding, energy storage nor mobilisation is significantly affected in per\(^{01}\) mutants, but point towards impaired mitochondrial activity, supported by upregulation of the mitochondrial stress marker 4EBP in the clock mutants},
  language  = {en}
}
@article{ManukjanWiegeringReindletal.2020,
  author    = {Manukjan, Georgi and Wiegering, Verena and Reindl, Tobias and Strauß, Gabriele and Klopocki, Eva and Schulze, Harald and Andres, Oliver},
  title     = {Novel variants in FERMT3 and RASGRP2 - Genetic linkage in Glanzmann-like bleeding disorders},
  series = {Pediatric Blood \& Cancer},
  volume    = {67},
  journal   = {Pediatric Blood \& Cancer},
  number    = {2},
  doi       = {10.1002/pbc.28078},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-208129},
  pages     = {e28078},
  year      = {2020},
  abstract  = {Defects of platelet intracellular signaling can result in severe platelet dysfunction. Several mutations in each of the linked genes FERMT3 and RASGRP2 on chromosome 11 causing a Glanzmann-like bleeding phenotype have been identified so far. We report on novel variants in two unrelated pediatric patients with severe bleeding diathesis—one with leukocyte adhesion deficiency type III due to a homozygous frameshift in FERMT3 and the other with homozygous variants in both, FERMT3 and RASGRP2 . We focus on the challenging genetic and functional variant assessment and aim to accentuate the risk of obtaining misleading results due to the phenomenon of genetic linkage.},
  language  = {en}
}
@article{SteudingSuriajaya2020,
  author    = {Steuding, J{\"o}rn and Suriajaya, Ade Irma},
  title     = {Value-Distribution of the Riemann Zeta-Function Along Its Julia Lines},
  series = {Computational Methods and Function Theory},
  volume    = {20},
  journal   = {Computational Methods and Function Theory},
  issn      = {1617-9447},
  doi       = {10.1007/s40315-020-00316-x},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-232621},
  pages     = {389-401},
  year      = {2020},
  abstract  = {For an arbitrary complex number a≠0 we consider the distribution of values of the Riemann zeta-function ζ at the a-points of the function Δ which appears in the functional equation ζ(s)=Δ(s)ζ(1-s). These a-points δa are clustered around the critical line 1/2+i\(\mathbb {R}\) which happens to be a Julia line for the essential singularity of ζ at infinity. We observe a remarkable average behaviour for the sequence of values ζ(δ\(_a\)).},
  language  = {en}
}
@article{BischoffRieferWirthensohnetal.2020,
  author    = {Bischoff, Lisa A. and Riefer, Jarno and Wirthensohn, Raphael and Bischof, Tobias and Bertermann, R{\"u}diger and Ignat'ev, Nikolai V. and Finze, Maik},
  title     = {Pentafluoroethylaluminates: A Combined Synthetic, Spectroscopic, and Structural Study},
  series = {Chemistry - A European Journal},
  volume    = {26},
  journal   = {Chemistry - A European Journal},
  number    = {60},
  doi       = {10.1002/chem.202000667},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-214666},
  pages     = {13615 -- 13620},
  year      = {2020},
  abstract  = {Salts of the tetrakis(pentafluoroethyl)aluminate anion [Al(C\(_{2}\)F\(_{5}\))\(_{2}\)]\(^{-}\) were obtained from AlCl\(_{3}\) and LiC\(_{2}\)F\(_{5}\). They were isolated with different counter-cations and characterized by NMR and vibrational spectroscopy and mass spectrometry. Degradation of the [Al(C\(_{2}\)F\(_{5}\))\(_{4}\)]\(^{-}\) ion was found to proceed via 1,2-fluorine shifts and stepwise loss of CF(CF\(_{3}\)) under formation of [(C\(_{2}\)F\(_{5}\))\(_{4-n}\)AlF\(_{n}\)]- (n=1-4) as assessed by NMR spectroscopy and mass spectrometry and supported by results of DFT calculations. In addition, the [(C\(_{2}\)F\(_{5}\))AlF\(_{3}\)]\(^{-}\) ion was structurally characterized.},
  language  = {en}
}
@unpublished{BrychHaendel2020,
  author    = {Brych, Mareike and H{\"a}ndel, Barbara},
  title     = {Disentangling top-down and bottom-up influences on blinks in the visual and auditory domain},
  series = {International Journal of Psychophysiology},
  journal   = {International Journal of Psychophysiology},
  issn      = {1872-7697},
  doi       = {10.1016/j.ijpsycho.2020.11.002},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-246590},
  year      = {2020},
  abstract  = {Sensory input as well as cognitive factors can drive the modulation of blinking. Our aim was to dissociate sensory driven bottom-up from cognitive top-down influences on blinking behavior and compare these influences between the auditory and the visual domain. Using an oddball paradigm, we found a significant pre-stimulus decrease in blink probability for visual input compared to auditory input. Sensory input further led to an early post-stimulus blink increase in both modalities if a task demanded attention to the input. Only visual input caused a pronounced early increase without a task. In case of a target or the omission of a stimulus (as compared to standard input), an additional late increase in blink rate was found in the auditory and visual domain. This suggests that blink modulation must be based on the interpretation of the input, but does not need any sensory input at all to occur. Our results show a complex modulation of blinking based on top-down factors such as prediction and attention in addition to sensory-based influences. The magnitude of the modulation is mainly influenced by general attentional demands, while the latency of this modulation allows to dissociate general from specific top-down influences that are independent of the sensory domain.},
  language  = {en}
}
@article{WasmusDudek2020,
  author    = {Wasmus, Christina and Dudek, Jan},
  title     = {Metabolic Alterations Caused by Defective Cardiolipin Remodeling in Inherited Cardiomyopathies},
  series = {Life},
  volume    = {10},
  journal   = {Life},
  number    = {11},
  issn      = {2075-1729},
  doi       = {10.3390/life10110277},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-219286},
  year      = {2020},
  abstract  = {The heart is the most energy-consuming organ in the human body. In heart failure, the homeostasis of energy supply and demand is endangered by an increase in cardiomyocyte workload, or by an insufficiency in energy-providing processes. Energy metabolism is directly associated with mitochondrial redox homeostasis. The production of toxic reactive oxygen species (ROS) may overwhelm mitochondrial and cellular ROS defense mechanisms in case of heart failure. Mitochondria are essential cell organelles and provide 95\% of the required energy in the heart. Metabolic remodeling, changes in mitochondrial structure or function, and alterations in mitochondrial calcium signaling diminish mitochondrial energy provision in many forms of cardiomyopathy. The mitochondrial respiratory chain creates a proton gradient across the inner mitochondrial membrane, which couples respiration with oxidative phosphorylation and the preservation of energy in the chemical bonds of ATP. Akin to other mitochondrial enzymes, the respiratory chain is integrated into the inner mitochondrial membrane. The tight association with the mitochondrial phospholipid cardiolipin (CL) ensures its structural integrity and coordinates enzymatic activity. This review focuses on how changes in mitochondrial CL may be associated with heart failure. Dysfunctional CL has been found in diabetic cardiomyopathy, ischemia reperfusion injury and the aging heart. Barth syndrome (BTHS) is caused by an inherited defect in the biosynthesis of cardiolipin. Moreover, a dysfunctional CL pool causes other types of rare inherited cardiomyopathies, such as Sengers syndrome and Dilated Cardiomyopathy with Ataxia (DCMA). Here we review the impact of cardiolipin deficiency on mitochondrial functions in cellular and animal models. We describe the molecular mechanisms concerning mitochondrial dysfunction as an incitement of cardiomyopathy and discuss potential therapeutic strategies.},
  language  = {en}
}