Dokument-ID Dokumenttyp Verfasser/Autoren Herausgeber Haupttitel Abstract Auflage Verlagsort Verlag Erscheinungsjahr Seitenzahl Schriftenreihe Titel Schriftenreihe Bandzahl ISBN Quelle der Hochschulschrift Konferenzname Quelle:Titel Quelle:Jahrgang Quelle:Heftnummer Quelle:Erste Seite Quelle:Letzte Seite URN DOI Abteilungen OPUS4-4991 Wissenschaftlicher Artikel Christl, Manfred; Herbert, R. Unusual Carbon Shielding Effects of Cyclopropanes and Double Bonds in Strained Bicyclo[3.1.0]hexanes and Cyclopentenes Carbon-13 shieldings and one-bond \(^{13}\)C-H coupling constants of bicydo[2.1.1]hexane, bicydo[2.l.l]hex- 2-ene, tricydo[3.1.1.0\(^{2.4}\)]heptane and benzvalene are presented and compared. to the data of related. compounds. H a bicydo[3.1.0]hexane system is part of a rigid skeleton, the cydopropane ring exerts spedfk: 'Y substituent eflects of two ldnds. In the case of the bicyclobexane boat form an upfield shift of the C-3 signal is observed and in tbe esse of the chair form a downfield shift of 15-20 ppm. Compared to the corresponding cydopentanes the double bond in strained cydopentenes causes downfield shifts of the C-4 absorption. 1bis eftect increases witb increasing strain, reaching 8 45.9 ppm maximum in benzvalene. Hence it is tbe only known bicydo[l.l.O]butane baving 8 reversed order of carbon shieldings. The downfield shifts are e:xplained by means of simple orbital interaction schemes. 1979 urn:nbn:de:bvb:20-opus-58038 Institut für Organische Chemie OPUS4-5822 Wissenschaftlicher Artikel Sebald, Walter; Wachter, E.; Tzagoloff, A. Identification of amino acid substitutions in the dicyclohexylcarbodiimide-binding subunit of the mitochondrial ATPase complex from oligomycin-resistant mutants of Saccharomyces cerevisiae No abstract available 1979 urn:nbn:de:bvb:20-opus-62770 Theodor-Boveri-Institut für Biowissenschaften OPUS4-5827 Wissenschaftlicher Artikel Michel, R.; Wachter, E.; Sebald, Walter Synthesis of a larger precursor for the proteolipid subunit of the mitochondrial ATPase complex of Neurospora crassa in a cell-free wheat germ system No abstract available 1979 urn:nbn:de:bvb:20-opus-62789 Theodor-Boveri-Institut für Biowissenschaften OPUS4-5828 Wissenschaftlicher Artikel Sebald, Walter; Graf, T.; Lukins, H. B. The dicyclohexylcarbodiimide-binding protein of the mitochondrial ATPase complex from Neurospora crassa and Saccharomyces cerevisiae. Identification and isolation Incubation of mitochondria from Neuraspara crassa and Saccharomyces cerevisiae with the radioactive ATPase inhibitor [14C]dicyclohexylcarbodiimide results in the irreversible and rather specific labelling of a low-molecular-weight polypeptide. This dicyclohexylcarbodiimide-binding protein is identical with the smallest subunit (Mr 8000) of the mitochondrial ATPase complex, and it occurs as oligomer, probably as hexamer, in the enzyme protein. The dicyclohexylcarbodiimide-binding protein is extracted from whole mitochondria with neutral chloroformjmethanol both in the free and in the inhibitor-modified form. In Neuraspara and yeast, this extraction is highly selective and the protein is obtained in homogeneaus form when the mitochondria have been prewashed with certain organic solvents. The bound dicyclohexylcarbodiimide Iabel is enriched in the purified protein up to 50-fold compared to whole mitochondria. Based on the amino acid analysis, the dicyclohexylcarbodiimide-binding protein from Neurospora and yeast consists of at least 81 and 76 residues, respectively. The content of hydrophobic residues is extremely high. Histidine and tryptophan are absent. The N-terminal ~mino acid is tyrosine in Neuraspara and formylmethionine in yeast. 1979 urn:nbn:de:bvb:20-opus-62792 Theodor-Boveri-Institut für Biowissenschaften OPUS4-4591 Wissenschaftlicher Artikel Karppanen, H.; Sirén, Anna-Leena; Eskeli-Kaivosoja, Alice Central cardiovascular and thermal effects of Prostaglandin F2α in rats Administration of PGF 2IX (0.2-6.4 J.lg) into the lateral cerebral ventricle (i.c.v.) induced dosedependent increases in blood pressure , heart rate and body temperature in urethane-anaesthetised rats, but had no effect on these parameters when the same dose range was administered intravenously. Peripheral pretreatment with sodium meclofenamate (50 mg/kg s.c.) sltifted all the dose-response curves for PGF 2IX (i.c.v.) to the left, but indomethacin (50 mg/kg s.c.) did not significantly affect those changes. Central pretreatment with sodiurn meclofenamate or indomethacin (1.25 mg per rat i.c.v.) failed to modify significantly the effects of centrally administered PGF 2IX' The results support previous suggestions that PGF 2IX may participate in the central control of the cardiovascular and thermoregulatory systems, and also suggest that there may be differences in the sites and/or modes of action between sodiurn meclofenamate and indomethacin. 1979 urn:nbn:de:bvb:20-opus-47955 Neurochirurgische Klinik und Poliklinik OPUS4-4109 Wissenschaftlicher Artikel Burschka, Christian Na\(_3\)Cu\(_4\)S\(_4\) - ein Thiocuprat mit verknüpften \(^1 _\infty\)[Cu\(_4\)S\(_4\)]-Ketten No abstract available 1979 urn:nbn:de:bvb:20-opus-46828 Institut für Anorganische Chemie OPUS4-4110 Wissenschaftlicher Artikel Burschka, Christian Zur Kristallstruktur der Thiocuprate K\(_3\)Cu\(_8\)S\(_6\) und Rb\(_3\)Cu\(_8\)S\(_6\) No abstract available 1979 urn:nbn:de:bvb:20-opus-46819 Institut für Anorganische Chemie OPUS4-4062 Wissenschaftlicher Artikel Schmidt, M.; Bender, R.; Burschka, Christian Additionsverbindungen zwischen Antimon(III)-Halogeniden und 1,4-Dithiacycloheptan No abstract available 1979 urn:nbn:de:bvb:20-opus-46570 Institut für Anorganische Chemie OPUS4-4082 Wissenschaftlicher Artikel Kutateladze, T. V.; Axelrod, V. D.; Gorboulev, Valentin G.; Belzhelarskaya, S. N.; Vartikyan, R. V. New procedure of high-voltage electrophoresis in polyacrylamide gel and its application to the sequencing of nucleic acids Fractionation of nucleic acids and their fragments with polyacrylamide gel has been widely applied in sequencing of nucleic acids. Although the conditions of electrophoresis for this purpose have previously been suggested. we have found that polyacrylamide gel electrophoresis at 5000 V (100 V/cm) is possible and effective. An apparatus consisting of a horizontal thermostated plate is used to remove the heat which was formed during the electrophoretic process. The techniques for loading samples on the horizontal thin gel and the procedure for high-voltage gel electrophoresis are described and illustrated by the fractionation of the spleen phosphodiesterase partial digest of tRNA¥~1 as well as by the RNA synthesis by RNA polymerase from E. coli with poly[d(A- T)j as template in the presence of "terminator," 3'-O-methyluridine 5'-triphosphate. This same technique was used for electrophoresis of oligonucleotides on acetylcellulose and was incorporated into a two-dimensional system which was demonstrated by fingerprinting of the guanylo-RNase digest of tRNAT'P from baker's yeast. In the third part of the article a simple technique for the electric trapping of nucleic acids or their fragments from a slab gel on a DEAE-paper sheet is presented. 1979 urn:nbn:de:bvb:20-opus-46927 Institut für Anatomie und Zellbiologie OPUS4-4407 Wissenschaftlicher Artikel Burschka, Christian; Wieber, Markus Eine pentagonal pyramidale Koordination des Bismuts. Kristallstruktur von Methylbismutbis(dietyldithiocarbonat) The crystal structure of the title compound, recrystallized from ethanol, was solved by means of X-ray diffraction methods and could be refined to an R-value of 0.050 with 2126 reflections observed. In contrast to its behaviour in benzene solution, where the compound is monomerie, in the crystalline state dimerie units are formed by intermoleeular Bi-S-interactions. The bismuth atoms are coordinated in form of a slightly distorted pentagonal pyramid with the free electron pair presumably directed opposite the apical C-atom. 1979 urn:nbn:de:bvb:20-opus-46750 Institut für Anorganische Chemie OPUS4-4461 Wissenschaftlicher Artikel Wilhelm, Gernot Die Hurriter : Archäologen suchen ihr verschollenes Reich No abstract available 1979 urn:nbn:de:bvb:20-opus-51130 Institut für Altertumswissenschaften (bis Sept. 2007) OPUS4-4462 Wissenschaftlicher Artikel Wilhelm, Gernot; Boese, Johannes Aššur-dān I., Ninurta-apil-Ekur und die mittelassyrische Chronologie No abstract available 1979 urn:nbn:de:bvb:20-opus-51147 Institut für Altertumswissenschaften (bis Sept. 2007) OPUS4-4249 Wissenschaftlicher Artikel Ulrichs, Karin; Kuhlencordt, KM; Müller-Ruchholtz, W. Plating inhibition assay (PIA): a new test for cell mediated cytotoxicity No abstract available 1979 urn:nbn:de:bvb:20-opus-45443 Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) OPUS4-5498 Wissenschaftlicher Artikel Lutz, Werner K. In vivo covalent binding of organic chemicals to DNA as a quantitative indicator in the process of chemical carcinogenesis The covalent binding of chemical carcinogens to DNA of mammalian organs is expressed per unit dose, and a 'Covalent-Binding Index', CBI, is defined. CBI for various carcinogens span over 6 orders of magnitude. A similar range is observed for the carcinogenic potency in long-term bioassays on carcinogenicity. For the assessment of a risk from exposure to a carcinogen, the total DN A darnage can be estimated if the actual dose is also accounted for. A detailed description is given for planning and performing a DNA-binding assay. A complete literature survey on DNA binding in vivo (83 compounds) is given with a calculation of CBI, where possible, 153 compounds are listed where a covalent binding to any biological macromolecule has been shown in vivo or in vitro. Recent, so far unpublished findings with aflatoxin Mh macromolecule- bound aflatoxin Bh ·diethylstilbestrol, and 1,2-epithiobutyronitrile are included. A comparison of CBI for rat-liver DNA with hepatocarcinogenic potency reveals a surprisingly good quantitative correlation. Refinements for a DN A-binding assay are proposed. Possibilities and Iimitations in the use of D NA binding in chemical carcinogenesis are discussed extensively. 1979 urn:nbn:de:bvb:20-opus-61122 Institut für Pharmakologie und Toxikologie OPUS4-5499 Wissenschaftlicher Artikel Jaggi, W.; Lutz, Werner K.; Schlatter, C. Comparative studies on the covalent binding of the carcinogen benzo(a)pyrene to DNA in various model systems The covalent binding of tritiated benzo(a)pyrene (BP) to DNA has been determined in rat liver in vivo, in rat liver perfused in situ, after incubation of BP with liver single cells, with liver homogenate, with liver microsomes and DNA, with fibroblasts from a rat granulorna pouch, and with · 2 cell lines. Li ver single cells were found to be a valuable compromise between the rnost sensitive system (microsomal incubation of BP with DNA) and the biologically most relevant system (in vivo ). 1979 urn:nbn:de:bvb:20-opus-61131 Institut für Pharmakologie und Toxikologie OPUS4-5534 Wissenschaftlicher Artikel Steiling, L.; Tacke, Reinhold; Wannagat, U. Diphenyl(3-piperidinopropyl)silanol, ein Sila-Analogon des Difenidols Diphenyl(3-piperidinopropyl)silanol (6b), ein Sila-Analogon des Arzneimittels Difenidol (6a), und dessen Methoiodid 7 wurden erstmals gemäß Schema 1 synthetisiert. - Die pharmakologischen und toxikologischen Eigenschaften der Analoga 6a und 6b wurden vergleichend untersucht. 1979 urn:nbn:de:bvb:20-opus-63618 Institut für Anorganische Chemie OPUS4-5535 Wissenschaftlicher Artikel Ackermann, J.; Tacke, Reinhold; Wannagat, U.; Koke, U.; Meyer, F. Derivate des 1-(4-Chlorphenyl)silacyclohexans mit 3-(Diethylamino)propyl- und 2-(Diethylamino)ethyl-Gruppierungen Die Darstellung der Verbindungen 3a (sowie 3b) und 10, die sich vom 1-(4-Chlorphenyl)-1-(2~ diethylaminoethoxy)silacyclohexan (Sila-Chlorphencyclan, II a) ableiten, wird beschrieben. Die Verbindung 3 b wurde pharmakologisch und toxikologisch untersucht. Die biologischen Eigen· schaften von 3b wurden mit denen von Ila (sowie Chlorphencyclan) und seinem Hydrochiarid Ilb verglichen. 1979 urn:nbn:de:bvb:20-opus-63621 Institut für Anorganische Chemie OPUS4-5529 Wissenschaftlicher Artikel Tacke, Reinhold; Zimonyi-Hegedüs, E.; Wannagat, U. Si-C-Spaltung in 2-Thienylsilanen durch sekundäre Amine Die Umsetzung von Diphenyl-vinylsilan mit zyklischen sekundären Aminen (z.B. Morpholin) in Gegenwart der entsprechenden Lithium-amide führt zu einer Substitution des an Silicium gebundenen H-Atoms durch eine Aminogruppe und zu einer Addition des Amins an die Vinylgruppe. 2-Thienylphenyl- vinylsilan reagiert jedoch zusätzlich unter Spaltung der Si-e-Bindung und Aminosubstitution der 2-Thienylgruppe. 1979 urn:nbn:de:bvb:20-opus-63608 Institut für Anorganische Chemie OPUS4-5005 Wissenschaftlicher Artikel Herbert, R.; Christl, Manfred Bicyclo[2.1.1]hexane aus Tricyclo[3.1.0.0\(^{2,6}\)]hexanen No abstract available 1979 urn:nbn:de:bvb:20-opus-58042 Institut für Organische Chemie OPUS4-5006 Wissenschaftlicher Artikel Christl, Manfred; Herbert, R. Der Einfluß anellierter Ringe auf die \(^{13}\)C-NMR-chemischen Verschiebungen von Tricyclo[3.1.0.0\(^{2,6}\)]hexan- und Bicyclo[2.1.1]hexan-Derivaten No abstract available 1979 urn:nbn:de:bvb:20-opus-58058 Institut für Organische Chemie OPUS4-4957 Wissenschaftlicher Artikel Heinsen, Helmut Lipofuscin in the cerebellar cortex of albino rats: an electron microscopic study The ultrastructure of autofluorescent, PAS-positive lipofuscin in Purkinje, granule, Golgi epithelial, basket and stellate, microglial and perivascular cells in the cerebellar cortex of senescent rats is described. The membrane- bounded pigment is composed ofthree elements: 1) electron-lucent homogeneaus droplets, 2) a granular matrix and 3) intensely osmiophilic patches. The proportians ofthese three components vary between cell types and one can grossly differentiate a neuronal and a gliallipofuscin. The lipofuscin granules of stellate and perivscular cells are different from lipofuscin of other cerebellar neurons and glia. lt can be concluded from these morphological observations that each cerebellar cell type has its distinct lipofuscin. 1979 urn:nbn:de:bvb:20-opus-59891 Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie OPUS4-3476 misc Jahresbericht 1978 Die Entwicklung der Universitätsbibliothek Würzburg im Jahr 1978. 1979 urn:nbn:de:bvb:20-opus-42216 Universitätsbibliothek OPUS4-3815 Wissenschaftlicher Artikel Hommers, Wilfried; Trempler, V. Zur Problematik sozialpsychologischer Interpretation des Verhaltens von Kindern in Zwei-Personen-Spielen No abstract available 1979 urn:nbn:de:bvb:20-opus-43860 Institut für Psychologie (bis Sept. 2007) OPUS4-12839 Wissenschaftlicher Artikel Tacke, R.; Strecker, M.; Sheldrick, W. S.; Heeg, E.; Berndt, B.; Knapstein, K. M. Sila-Pharmaka, 14. Mitt. Darstellung und Eigenschaften sowie Kristall-und Molekülstruktur von Sila-Difenidol Sila-difenidol (6b), a sila-analogue of the drug difenidol (6a), was synthesized according to Scheme 1. 6b and its new precursors 3 and 5 were characterized by their physical and chemical properties, and their structures confirmed by elementary analyses, 1H NMR and mass spectroscopy. 6 b crystallizes orthorhombic \(P2_12_12_1\) with a = 11.523(1), b = 14.366(4), c = 11.450(1) Å, Z = 4, \(D_{ber} = 1.14 gcm^{-3}\). The structure was refined to R = 0.050 for 1897 reflexions. A strong nearly linear intramolecular O-H···N hydrogen bond of 2.685 Å is observed. The anticholinergic, histaminolytic and musculotropic spasmolytic activities of 6 a and 6 b are reported. 1979 1279–1285 Zeitschrift für Naturforschung B 34 9 urn:nbn:de:bvb:20-opus-128391 Institut für Anorganische Chemie OPUS4-3345 Wissenschaftlicher Artikel Linsenmair, Karl Eduard Untersuchungen zur Soziobiologie der Wüstenassel Hemilepistus reaumuri und verwandter Isopodenarten (Isopoda, Oniscoidea): Paarbildung und Evolution der Monogamie The desert isopod, Hemilepistus reaumuri, extremely common in the arid regions of North Africa and Asia Minor, depends upon the burrows it itself digs for survival during the hotter parts of the year. The dig-ging of new burrows is limited by chmatic conditions to a short period during the spring. Burrows must be constantly defendet - especially against roving eonspecifics. The decisive problem of a connnuous burrow defense is solved through cooperative behavior: the adult woodlice form monogamous pairs whose partners recognize one another individually. Here, questions on the binding of partners, especially the problem of the binding of male to female will be treated upon, along with questions on the evolution of monogamy, wherein the purely maternal families of Porcellio species will be taken as models for intermediäre stages. At first, males olHemilepistus are not permitted to copulate at all; later, for a relatively long period, they are only permitted incomplete copulations, the females alone have control over the partunal ecdysis; they alone determine the moment of final copulations. Under the thermal conditions prevalent during the season of pair formation, a female irreversibly induces a parturial ecdysis only when it has spent a minimum of sev-eral days in her own burrow with a specific male. At higher average temperatures, the number of females which undergo parturial ecdyses without these preconditions increases sharply. Males cannot greatly lnrlu-ence the willingness of females to reproduce with the investment they make in the digging of burrows; the factors deciding this are the male's presence and its role as guard. The first condition necessary for the genesis of monogamy might have been the evolution of a stncüy lo-cation-dependent copulatory behavior, which guaranteed the male exclusive mating pnveliges with the female whose location - the burrow - he acheived control of. A male must, under these conditions, serve guard duty in his own interest, and defend the burrow against competitors (Cf or 2) seeking an already-dug burrow. The decisive advantage for the female in the beginning of the development was probably that she could leave the burrow for extended feeding excursions, whereas alone it would have to either completely forego nourishment or, as is the case with the Porcellio species mentioned, must greatly restrict the spectrum of food that it can use (to that which is to be found only a short distance from the burrow and which can eas-ily be carried inside the burrow). This could be a disadvantage, especially during egg production. Necessary to the male's successful defense of the burrow is that he recognises his female. Studies of the Canary Island Porcellio species have shown over which pathways and under what selection pressures the recopinon of individuals, as is realized mHemilepistus, could have evolved. Females can bind males longer, the longer the period of their attraction is extended: Females olHemilepistus reaumuri have been proven to be al·ready att-ractive before they are ready to copulate and still remain attractive after they have copulated. The conse-quences of the last fact will be discussed. The question of why the males remain with the females after the parturial ecdysis will also be discussed: The great danger to the male's investment resulting from a tooi early abandoning, and the low probability of successfully finding another partner after a later abandomng should prevent a positive balance in the males' cost-effecriveness calculations. 1979 urn:nbn:de:bvb:20-opus-30854 Theodor-Boveri-Institut für Biowissenschaften OPUS4-3375 Teil eines Buches Franke, Werner W.; Scheer, Ulrich; Spring, Herbert; Trendelenburg, Michael F.; Zentgraf, Hanswalter Organization of nucleolar chromatin No abstract available 1979 urn:nbn:de:bvb:20-opus-39410 Theodor-Boveri-Institut für Biowissenschaften OPUS4-3380 Teil eines Buches Scheer, Ulrich; Spring, Herbert; Trendelenburg, Michael F. Organization of transcriptionally active chromatin in lampbrush chromosome loops No abstract available 1979 urn:nbn:de:bvb:20-opus-39293 Theodor-Boveri-Institut für Biowissenschaften OPUS4-2585 Wissenschaftlicher Artikel Christl, Manfred; Leininger, Hartmut 7-Azatetracyclo[4.1.0.02,4.03,5]heptan - ein neues Valenzisomeres des Azepins No abstract available 1979 urn:nbn:de:bvb:20-opus-30034 Institut für Organische Chemie OPUS4-3087 Wissenschaftlicher Artikel Zentgraf, Hanswalter; Trendelenburg, Michael F.; Spring, Herbert; Scheer, Ulrich; Franke, Werner W.; Müller, Ulrike; Drury, Kenneth C.; Rungger, Duri Mitochondrial DNA arranged into chromatin-like structures after injection into amphibian oocyte nuclei Purified mitochondrial DNA (mitDNA) from ovaries ofXenopus lae vis was injected into the nuclei (germinal vesicles) of large viteUogenic oocytes of the same organism and examined by electron microscopy ofthe spread nuclear contents. Normally located nuclei of untreated oocytes as weil as peripherally translocated nuclei of centrifuged oocytes were used. In addition, oocyte nuclei isolated and incubated under liquid paraffin oil were injected with DNA. The integrity oftranscriptional structures of endogenous chromosomal (Iampbrush chromosomes) and extrachromosomal (nucleoli) genes of the injected nuclei was demonstrated. Microinjected mitDN A was identified as circles of chromatin exhibiting polynucleosome-like organization and a me an contour length of 2.6 J.Lm, corresponding to a compaction ratio of the mitDN A of about 2 : I. This DNA packing ratio is similar to that observed after preparation of various kinds of native chromatin in low salt buffers. The chromatin circles formed from injected mitDNA only very rarely exhibited lateral fibrils suggestive of transcriptional activity. These results suggest that purified mitDNA can be transformed to normally structured chromatin when exposed to oocyte nuclear contents but is rarely , if at all , transcribed in this form and in this environment. 1979 urn:nbn:de:bvb:20-opus-33174 Theodor-Boveri-Institut für Biowissenschaften OPUS4-3134 Wissenschaftlicher Artikel Scheer, Ulrich; Sommerville, John; Bustin, M. Injected histone antibodies interfere with transcription of lampbrush chromosome loops in oocytes of Pleurodeles Antibodies to calf thymus histone H2B were purified by chromatography on DEAE-cellulose and injected into oocyte nuclei of Pleurodeles waltlii. As shown by indirect immunofluorescence these antibodies cross-reacted strongly with corresponding histones associated with lampbrush chromosomes. Shortly after injection the lateral loops of the chromosomes retracted into the chromomeres and by 3 h postinjection the 'lampbrush' appearance was completely lost and the chromosomes appeared in light-microscopic preparations as rod-like structures consisting of 10ngitudina11y coalesced chromomeres. In control oocytes injected with non-immune immunoglobulins or antibodies against a ubiquitous transcript-associated protein no morphological alterations of the lampbrush chromosomes could be observed. Electron microscopic spreads of chromosomes prepared at various times after injection of anti-H2B revealed a progressive loss of transcriptional complexes from the loop axes. Finally, higher-order chromatin configurations, like supranuc1eosomal globules (' superbeads ') or cable-like chromatin strands 50- 60 nm thick predominated, indicating complete transcriptional inactivation of a11 chromosomal regions. The results indicate that H2B antibodies react specifically with his tones associated with the transcribed DNA of lateral loops in their native state. The resulting antigenantibody complexes seem to inhibit progression of the R A polymerases along the template, thus causing the premature release of transcripts, a process analogous to the stripping effect of actinomycin D. The demonstration of histones associated with heavily transcribed regions, which are not compacted into nucleosomes but largely extended, supports the current concept that unfolding of nucleosomes to a110w transcription of the DNA does not involve dissociation of histones. In contrast, amplified ribosomal RNA genes are unaffected by injected HzB antibodies. This does not necessarily indicate absence of his tones from nucleolar chromatin, since we do not know whether it is accessible in vivo to antibodies or whether the histone antigenie determinants are masked by the presence of other proteins. The technique of injecting specific antibodies should be widely applicable when analysing the in vivo distribution of chromosomal components at the electron-microscopic level and when studying complex metabolie processes, like the cleavage and modification of RNA, by selective inhibition of defined enzymic steps. 1979 urn:nbn:de:bvb:20-opus-33166 Theodor-Boveri-Institut für Biowissenschaften OPUS4-6973 Wissenschaftlicher Artikel Meyer, Manfred K.; Schartl, Manfred Eine neue Xiphophorus-Art aus Vera Cruz, Mexiko : (Pisces: Poeciliidae) Xiphophorus andersi n. sp. from the Rio Atoyac, Vera Cruz, Mexico is described: lang head, moderately slender body, large dark black spar at the basis of the anal fin; adult male with short sword-like caudal appendage; rip of ray 5a of gonopodium without a developed claw. Xiphophorus andersi n. sp. differs by the combination of distinct characters from all the other species of the genus known so far. The new species shows features of both the so-called platyfish species group and the so-called swordtail species group. 1979 urn:nbn:de:bvb:20-opus-87124 Theodor-Boveri-Institut für Biowissenschaften OPUS4-4525 Wissenschaftlicher Artikel Tzagoloff, A.; Macino, G.; Sebald, Walter Mitochondrial genes and translation products No abstract available 1979 urn:nbn:de:bvb:20-opus-47408 Theodor-Boveri-Institut für Biowissenschaften OPUS4-6814 Wissenschaftlicher Artikel Lutz, Werner K.; Schlatter, C. In vivo covalent binding of chemicals to DNA as a short-term test for carcinogenicity The determination of a covalent binding of radioactive chemieals to DNA in intact mammalian organisms is proposedas a short-term test for carcinogenicity. The effectiveness of covalent binding to rat liver DNA correlates well with the hepatocarcinogenicity known from long-term bioassays. The binding indices range over more than five orders of rriagnitude between the strongest hepatocarcinogen aflatoxin B 1 and the limit of detection of a binding with 100 f-LCi 14C-labelled chemical. The order of magnitude of binding is therefore a surprisingly good quantitative measure for carcinogenicity. The pattern of DNA binding sites is important especially for small alkylating agents where the determination of total binding might indicate a higher carcinogenic potency than is actually observed. 1979 urn:nbn:de:bvb:20-opus-80127 Institut für Pharmakologie und Toxikologie OPUS4-6818 Konferenzveröffentlichung Viviani, A.; Lutz, Werner K. Modulation of the in vivo covalent binding of the carcinogen benzo(a)pyrene to rat liver DNA by selective induction of microsomal and nuclear aryl hydrocarbon hydroxylase activity The influence of microsomal (mAHH) and nuclear (nAHH) aryl hydrocarbon hydroxylase activity on the covalent binding of t:titiated benzo(a)pyrene to rat liver DNA was evaluated in vivo. Induction ofmAHH was obtained after phenobarbitone treatment (180% of control), which increased DNA binding to 210%, but left the nAHH unchanged. mAHH and nAHH were slightly indilced with dieldrin (130% and 120%), but the binding remairred unchanged. The increasing effect of mAHlt as weil as the possibly decreasing effect of nAHH induction on the binding became obvious when the data of 11 individual rats were used to solve the equation Binding = aX(mAHH) + bX(nAHH) + c. Multiple linear regression analysis resulted in positive values for a and c, a negative value for b, and a multiple correlation coefficient R = 0.82. An influence of other enzymes involved in the metabolism of benzo(a)pyrene cannot be excluded. The Study shows clearly that the binding of a foreign compound to DNA in vivo is not only dependent on microsomal enzyme activities but also on nuclear activities even if the latter are considerably lower than those of mic'rosomes. 1979 urn:nbn:de:bvb:20-opus-80132 Institut für Anatomie und Zellbiologie OPUS4-6884 Wissenschaftlicher Artikel Sebald, Walter; Werner, S; Weiss, H Biogenesis of mitochondrial membrane proteins in Neurospora crassa no abstract available 1979 urn:nbn:de:bvb:20-opus-82055 Theodor-Boveri-Institut für Biowissenschaften OPUS4-6895 Wissenschaftlicher Artikel Sebald, Walter; Wild, G. Mitochondrial ATPase complex from Neurospora crassa The A TPase eomplex has been isolated from mitoehondria of N eurospora crassa by immunologieal teehniques. The protein ean be obtained rapidly and qua ntitatively in high purity by miero- or large-seale immunopreeipitation. Immunopreeipitation has been applied to labeled and doubly labeled mitoehondrial proteins in order to investigate the number and moleeular weights of subunit polypeptides , the site of synthesis of subunit polypeptides, and the dieycIohexyIcarbodiimide-binding protein . The A TPase complex obtained by large-seale immunopreeipitation has been used as starting ma terial for the isolation of hydrophobie polypeptides. 1979 urn:nbn:de:bvb:20-opus-82065 Theodor-Boveri-Institut für Biowissenschaften OPUS4-6896 Wissenschaftlicher Artikel Sebald, Walter; Neupert, W.; Weiss, H. Preparation of Neurospora crassa mitochondria The fungus Neurospora crassa represents a eukaryotic cell with high biosynthetic activities. Cell mass doubles in 2-4 hr during expone ntial growth , even in simple salt media with sucrose as the sole carbon source. The microorgani sm forms a mycelium of long hyphae durlng vegetative growth . The mitochondria can be isolated under relatively gentle condi tions since a few breaks in the threadlike hyphae are sufficient to cause the outflow of the organelles. This article describes two methods for the physical disruption of the hyphae : (I) The cell s are opened in a grind mill between two rotating corundum di sks. This is a continuous and fast procedure and allows large- and small-scale preparations of mitochondria. (2) Hyphae are ground with sand in a mortar and pestle. This procedure can be applied to microscale preparations of mitochondria starting with minute amounts of cells. Other procedures for the isolation of Neurospora mitochondria after the physical di sruption or the enzymatic degradation of the cell wall have been described elsewhere 1979 urn:nbn:de:bvb:20-opus-82070 Theodor-Boveri-Institut für Biowissenschaften OPUS4-7309 Wissenschaftlicher Artikel Tacke, Reinhold; Haller, Ingo; Zeiler, Hans-Joachim Sila-Analoga der Antiseptica Octafoniumchlorid und p-tert-Butylphenol No abstract available. 1979 urn:nbn:de:bvb:20-opus-86893 Institut für Anorganische Chemie OPUS4-7275 Teil eines Buches Anders, F.; Scholl, E.; Schartl, Manfred Xiphophorus als Modell in der Krebsforschung No abstract available. 1979 urn:nbn:de:bvb:20-opus-72752 Theodor-Boveri-Institut für Biowissenschaften OPUS4-4630 misc Schneider, Wolfgang Materialien zur deutschen Rechtschreibung : Textsammlung von Probearbeiten, Diktaten und Schulbüchern, alphabetische Indices, Frequenzranglisten, Konkordanzen Textsammlung von Probearbeiten, Diktaten und Schulbüchern, alphabetische Indices, Frequenzranglisten, Konkordanzen 1979 urn:nbn:de:bvb:20-opus-50571 Institut für Psychologie (bis Sept. 2007) OPUS4-3848 Wissenschaftlicher Artikel Krüger, Hans-Peter Zur Anwendungsindikation von nonparametrischen Prädiktionsverfahren No abstract available 1979 urn:nbn:de:bvb:20-opus-40925 Institut für Psychologie (bis Sept. 2007) OPUS4-3838 Wissenschaftlicher Artikel Krüger, Hans-Peter; Lienert, Gustav A.; Eye, Alexander von; Gebert, Alfred Eine inferentielle nonparametrische Clusteranalyse mit Alternativdaten Am Konzept der Axialsymmetrie multivariater Daten wird eine Methode entwickelt, mit der statistisch Cluster aus gleich interkorrelierenden Variablen gebildet werden können. Es wird eine heuristische Vorgehensweise empfohlen, die nicht wie die übliche deskriptive Clusteranalyse willkürliche Entscheidungen über Abbruchkriterien u.ä. verlangt. Die vorgeschlagene Methode ist insbesondere zur mediandichotomierte kontinuierliche Variablen geeignet. Werden echte Alternativdaten verwendet, resultieren Cluster, die zusätzlich zur gleichen Interkorrelation Variablen mit gleicher Schwierigkeit aufweisen. Das Vorgehen wird an einem Beispiel illustriert. 1979 urn:nbn:de:bvb:20-opus-41606 Institut für Psychologie (bis Sept. 2007) OPUS4-6951 Wissenschaftlicher Artikel Weinert, Franz E.; Treiber, Bernhard; Schneider, Wolfgang Educational psychology This is a report on the more recent developments and the present state of research into educational psychology in German speaking countries. Particular emphasis is given to research on: parental upbringing and its effects on child development; the examination of socialization effects within and across different scbool systems; studies on teaching-leaming processes and on social interaction in the classroom; the systematic promotion of the development of cognitive abilities and motives in students; and, finally, the design of improved instruments in methods of describing, explaining and predicting school success. Subsequently, the report will look into problems in tbe practical application of research findings in educational psychology. Finally, there follows a sbort discussion of various metatheoretical positions in educational psycbology in German speaking countries and their possible effects on the future development of the field. 1979 urn:nbn:de:bvb:20-opus-87234 Institut für Psychologie (bis Sept. 2007) OPUS4-6979 Konferenzveröffentlichung Krüger, Hans-Peter Die Selbst- und Fremdbeurteilung als Resultante sozialer Erfahrung No abstract available 1979 urn:nbn:de:bvb:20-opus-86039 Institut für Psychologie (bis Sept. 2007) OPUS4-6758 Wissenschaftlicher Artikel Krüger, Hans-Peter Zum Problem der Bestimmung zweiseitiger Überschreitungswahrscheinlichkeiten beim exakten Vierfeldertest Drei Methoden zur Bestimmung zweiseitiger Überschreitungswahrscheinlichkeiten bei der exakten Prüfung von Vierfeldertafeln nach FISCHER-YATES werden diskutiert. An einem Beispiel wird aufgezeigt, daß diese Methoden zu verschiedenen Signifikanzentscheidungen führen können. Es werden Möglichkeiten aufgezeigt, wie diese Schwierigkeiten in der Praxis umgangen werden können. 1979 urn:nbn:de:bvb:20-opus-79816 Institut für Psychologie (bis Sept. 2007) OPUS4-10352 Wissenschaftlicher Artikel Wilhelm, Gernot Ein neues Lamaštu-Amulett no Abstract available 1979 urn:nbn:de:bvb:20-opus-103520 Institut für Altertumswissenschaften (bis Sept. 2007) OPUS4-2848 Konferenzveröffentlichung Ruhe, Ernstpeter Repetition und Integration: Strukturprobleme des 'Roman de Tristan en prose' No abstract available 1979 urn:nbn:de:bvb:20-opus-33610 Neuphilologisches Institut - Moderne Fremdsprachen (bis 2007) OPUS4-2847 Konferenzveröffentlichung Ruhe, Ernstpeter Thesen zum Ende der Gattungsgeschichte des höfischen Romans No abstract available 1979 urn:nbn:de:bvb:20-opus-33626 Neuphilologisches Institut - Moderne Fremdsprachen (bis 2007)