22771
2019
eng
1-35
12
1
article
1
2021-02-26
--
--
Holographic subregion complexity from kinematic space
We consider the computation of volumes contained in a spatial slice of AdS(3) in terms of observables in a dual CFT. Our main tool is kinematic space, defined either from the bulk perspective as the space of oriented bulk geodesics, or from the CFT perspective as the space of entangling intervals. We give an explicit formula for the volume of a general region in a spatial slice of AdS(3) as an integral over kinematic space. For the region lying below a geodesic, we show how to write this volume purely in terms of entangling entropies in the dual CFT. This expression is perhaps most interesting in light of the complexity = volume proposal, which posits that complexity of holographic quantum states is computed by bulk volumes. An extension of this idea proposes that the holographic subregion complexity of an interval, defined as the volume under its Ryu-Takayanagi surface, is a measure of the complexity of the corresponding reduced density matrix. If this is true, our results give an explicit relationship between entanglement and subregion complexity in CFT, at least in the vacuum. We further extend many of our results to conical defect and BTZ black hole geometries.
Journal of High Energy Physics
10.1007/JHEP01(2019)012
urn:nbn:de:bvb:20-opus-227711
publish
J. High Energ. Phys. 01, 2019, 12. doi:10.1007/JHEP01(2019)012
true
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Raimond Abt
Johanna Erdmenger
Marius Gerbershagen
Charles M. Melby-Thompson
Christian Northe
eng
uncontrolled
AdS-CFT Correspondence
eng
uncontrolled
Gauge-gravity correspondence
eng
uncontrolled
Black Holes in String Theory
eng
uncontrolled
Black-hole
eng
uncontrolled
Entanglement
Physik
open_access
Institut für Theoretische Physik und Astrophysik
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/opus4-wuerzburg/files/22771/holographic_subregion.pdf
22696
2019
eng
326-336
3
37
article
1
2021-02-24
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Clonal Clusters and Virulence Factors of Methicillin-Resistant \(Staphylococcus\) \(Aureus\): Evidence for Community-Acquired Methicillin-Resistant \(Staphylococcus\) \(Aureus\) Infiltration into Hospital Settings in Chennai, South India
Background and Objective: Staphylococcus aureus is one of the major pathogens of nosocomial infections as wells as community-acquired (CA) infections worldwide. So far, large-scale comprehensive molecular and epidemiological characterisation of S. aureus from very diverse settings has not been carried out in India. The objective of this study is to evaluate the molecular, epidemiological and virulence characteristics of S. aureus in both community and hospital settings in Chennai, southern India. Methods: S. aureus isolates were obtained from four different groups (a) healthy individuals from closed community settings, (b) inpatients from hospitals, (c) outpatients from hospitals, representing isolates of hospital-community interface and (d) HIV-infected patients to define isolates associated with the immunocompromised. Antibiotic susceptibility testing, multiplex polymerase chain reactions for detection of virulence and resistance determinants, molecular typing including Staphylococcal cassette chromosome mec (SCCmec) and agr typing, were carried out. Sequencing-based typing was done using spa and multilocus sequence typing (MLST) methods. Clonal complexes (CC) of hospital and CA methicillin-resistant S. aureus (MRSA) were identified and compared for virulence and resistance.
Results and Conclusion: A total of 769 isolates of S. aureus isolates were studied. The prevalence of MRSA was found to be 7.17%, 81.67%, 58.33% and 22.85% for groups a, b, c and d, respectively. Of the four SCCmec types (I, III, IV and V) detected, SCCmec V was found to be predominant. Panton-Valentine leucocidin toxin genes were detected among MRSA isolates harbouring SCCmec IV and V. A total of 78 spa types were detected, t657 being the most prevalent. 13 MLST types belonging to 9 CC were detected. CC1 (ST-772, ST-1) and CC8 (ST238, ST368 and ST1208) were found to be predominant among MRSA. CA-MRSA isolates with SCCmec IV and V were isolated from all study groups including hospitalised patients and were found to be similar by molecular tools. This shows that CA MRSA has probably infiltrated into the hospital settings.
Indian Journal of Medical Microbiology
10.4103/ijmm.IJMM_18_271
urn:nbn:de:bvb:20-opus-226963
publish
Indian Journal of Medical Microbiology, Volume 37, Issue 3, 2019, Pages 326-336. doi:10.4103/ijmm.IJMM_18_271
CC BY-NC-ND: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell, Keine Bearbeitungen 4.0 International
Nagarajan Abimannan
G. Sumathi
O. R. Krishnarajasekhar
Bhanu Sinha
Padma Krishnan
eng
uncontrolled
Community-acquired methicillin-resistant Staphylococcus aureus
eng
uncontrolled
HIV
eng
uncontrolled
hospital-acquired methicillin-resistant Staphylococcus aureus
eng
uncontrolled
innate immune evasions
eng
uncontrolled
MLST
eng
uncontrolled
microbial surface component recognising adhesive matrix molecules
eng
uncontrolled
spa typing
eng
uncontrolled
ST 772
eng
uncontrolled
Inducible Clindamycin Resistance
eng
uncontrolled
Valentine Leukocidin Genes
eng
uncontrolled
Multiplex PCR
eng
uncontrolled
Nasal Carriage
eng
uncontrolled
Colonization
eng
uncontrolled
Prevalence
eng
uncontrolled
Emergence
eng
uncontrolled
Skin
Medizin und Gesundheit
open_access
Institut für Hygiene und Mikrobiologie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/opus4-wuerzburg/files/22696/clonal_clusters_and_virulence.pdf
22316
2019
eng
84
7
article
1
2021-02-05
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NG-meta-profiler: fast processing of metagenomes using NGLess, a domain-specific language
Background
Shotgun metagenomes contain a sample of all the genomic material in an environment, allowing for the characterization of a microbial community. In order to understand these communities, bioinformatics methods are crucial. A common first step in processing metagenomes is to compute abundance estimates of different taxonomic or functional groups from the raw sequencing data.
Given the breadth of the field, computational solutions need to be flexible and extensible, enabling the combination of different tools into a larger pipeline.
Results
We present NGLess and NG-meta-profiler. NGLess is a domain specific language for describing next-generation sequence processing pipelines. It was developed with the goal of enabling user-friendly computational reproducibility. It provides built-in support for many common operations on sequencing data and is extensible with external tools with configuration files.
Using this framework, we developed NG-meta-profiler, a fast profiler for metagenomes which performs sequence preprocessing, mapping to bundled databases, filtering of the mapping results, and profiling (taxonomic and functional). It is significantly faster than either MOCAT2 or htseq-count and (as it builds on NGLess) its results are perfectly reproducible.
Conclusions
NG-meta-profiler is a high-performance solution for metagenomics processing built on NGLess. It can be used as-is to execute standard analyses or serve as the starting point for customization in a perfectly reproducible fashion.
NGLess and NG-meta-profiler are open source software (under the liberal MIT license) and can be downloaded from https://ngless.embl.de or installed through bioconda.
Microbiome
10.1186/s40168-019-0684-8
urn:nbn:de:bvb:20-opus-223161
publish
Microbiome (2019) 7:84. https://doi.org/10.1186/s40168-019-0684-8
686070
669830
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Luis Pedro Coelho
Renato Alves
Paulo Monteiro
Jaime Huerta-Cepas
Ana Teresa Freitas
Peer Bork
eng
uncontrolled
metagenomics
eng
uncontrolled
next-generation sequencing
eng
uncontrolled
domain-specific language
Biowissenschaften; Biologie
open_access
Theodor-Boveri-Institut für Biowissenschaften
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/opus4-wuerzburg/files/22316/s40168-019-0684-8.pdf
22363
2019
eng
11
article
1
2021-02-10
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DNA methyltransferase isoforms expression in the temporal lobe of epilepsy patients with a history of febrile seizures
Background
Temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS) is a common pharmaco-resistant epilepsy referred for adult epilepsy surgery. Though associated with prolonged febrile seizures (FS) in childhood, the neurobiological basis for this relationship is not fully understood and currently no preventive or curative therapies are available. DNA methylation, an epigenetic mechanism catalyzed by DNA methyltransferases (DNMTs), potentially plays a pivotal role in epileptogenesis associated with FS. In an attempt to start exploring this notion, the present cross-sectional pilot study investigated whether global DNA methylation levels (5-mC and 5-hmC markers) and DNMT isoforms (DNMT1, DNMT3a1, and DNMT3a2) expression would be different in hippocampal and neocortical tissues between controls and TLE patients with or without a history of FS.
Results
We found that global DNA methylation levels and DNMT3a2 isoform expression were lower in the hippocampus for all TLE groups when compared to control patients, with a more significant decrease amongst the TLE groups with a history of FS. Interestingly, we showed that DNMT3a1 expression was severely diminished in the hippocampus of TLE patients with a history of FS in comparison with control and other TLE groups. In the neocortex, we found a higher expression of DNMT1 and DNMT3a1 as well as increased levels of global DNA methylation for all TLE patients compared to controls.
Conclusion
Together, the findings of this descriptive cross-sectional pilot study demonstrated brain region-specific changes in DNMT1 and DNMT3a isoform expression as well as global DNA methylation levels in human TLE with or without a history of FS. They highlighted a specific implication of DNMT3a isoforms in TLE after FS. Therefore, longitudinal studies that aim at targeting DNMT3a isoforms to evaluate the potential causal relationship between FS and TLE or treatment of FS-induced epileptogenesis seem warranted.
Clinical Epigenetics
10.1186/s13148-019-0721-2
urn:nbn:de:bvb:20-opus-223636
publish
Clinical Epigenetics (2019) 11:118. https://doi.org/10.1186/s13148-019-0721-2
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Laurence de Nijs
Kyonghwan Choe
Hellen Steinbusch
Olaf E. M. G. Schijns
Jim Dings
Daniel L. A. van den Hove
Bart P. F. Rutten
Govert Hoogland
eng
uncontrolled
febrile seizures
eng
uncontrolled
temporal lobe epilepsy
eng
uncontrolled
epigenetics
eng
uncontrolled
DNA methylation
eng
uncontrolled
DNA methyltransferases
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/opus4-wuerzburg/files/22363/s13148-019-0721-2.pdf
32586
2019
eng
13
article
1
2023-08-22
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Does refugee status matter? Medical needs of newly arrived asylum seekers and resettlement refugees - a retrospective observational study of diagnoses in a primary care setting
Background
Providing adequate healthcare to newly arrived refugees is considered one of the significant challenges for the German healthcare system. These refugees can be classified mainly into two groups: asylum seekers (who have applied for asylum after arrival in Germany and are waiting for the refugee-status decision) and resettlement refugees (who have already been granted asylum status before arriving in Germany). Whereas earlier studies have explored the health status of asylum seekers especially in terms of mental and behavioural disorders and infectious diseases without distinguishing between these two groups, our study aims to evaluate possible relationships of asylum status and medical needs of these two groups with a special focus on mental and behavioural disorders and infectious diseases.
Methods
In this retrospective observational study, collected data on all asylum-seeker and resettlement-refugee patients (N = 2252) of a German reception centre (August 2017 to August 2018) is analysed by absolute and relative frequencies and medians. Patient data, collected by chart review, include age, gender, country of origin, asylum status, and diagnoses (ICD-10). To describe the relationship between sociodemographic factors (including asylum status) and diagnoses, we used tests of significance and bivariate correlations with Spearman correlation coefficients. All collected data are pseudonymised.
Results
Of all 2252 patients, 43% were resettlement refugees. In almost all ICD-10 categories, asylum seekers received significantly more diagnoses than resettlement refugees. According to our data, asylum seekers presented with mental and behavioural disorders nine times more often (9%) than resettlement refugees (1%). In the case of infectious diseases, the results are mixed: asylum seekers were twice as frequently (11%) diagnosed with certain infectious and parasitic diseases than resettlement refugees (5%), but resettlement refugees were treated twice as often (22% of the asylum seekers and 41% of the resettlement refugees) for diseases of the respiratory system, of which 84% were acute respiratory infections (in both groups).
Conclusion
This study indicates that patients with unregulated migration more frequently present symptoms of psychiatric diseases and somatoform symptoms than resettlement refugees. A health policy approach within migration policy should aim to enable persecuted persons to migrate under regulated and safe conditions.
Trial registration
German Clinical Trials Register: DRKS00013076, retrospectively registered on 29.09.2017.
Conflict and Health
10.1186/s13031-019-0223-z
urn:nbn:de:bvb:20-opus-325869
publish
Conflict and Health (2019) 13:39. https://doi.org/10.1186/s13031-019-0223-z
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Evelyn Kleinert
Frank Müller
Ghefar Furaijat
Nele Hillermann
Alexandra Jablonka
Christine Happle
Anne Simmenroth
eng
uncontrolled
primary healthcare
eng
uncontrolled
resettlement refugees
eng
uncontrolled
asylum seekers
eng
uncontrolled
asylum status
eng
uncontrolled
common diseases
eng
uncontrolled
migrant
eng
uncontrolled
infections
eng
uncontrolled
mental health
Medizin und Gesundheit
open_access
Institut für Allgemeinmedizin
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/opus4-wuerzburg/files/32586/s13031-019-0223-z.pdf
32266
2019
eng
14
article
1
2023-07-27
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Panniculitis-like T-cell-lymphoma in the mesentery associated with hemophagocytic syndrome: autopsy case report
Background
Panniculitis-like T-cell lymphoma is an uncommon type of non-Hodgkin lymphoma, occurring usually in the form of nodules within the subcutaneous fat tissue of the extremities or trunk. In the literature, subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is described as a distinct type of T-cell lymphoma with a variable clinical behavior, depending on molecular phenotype of T-cell receptor (TCR) and on the presence or absence of hemophagocytic syndrome.
Case presentation
We present a bioptic and autoptic case of a 65-years old Caucasian man with panniculitic T-cell lymphoma with morphological and immunohistochemical features of SPTCL, limited to the retroperitoneal and mesenteric mass, i.e. without any cutaneous involvement, and associated with severe hemophagocytic lymphohistiocytosis.
Conclusion
A panniculitic T-cell lymphoma with morphological and molecular features of SPTCL, which is limited to mesentery, i.e. does not involve subcutaneous fat, seems to be exceedingly rare.
Diagnostic Pathology
10.1186/s13000-019-0854-9
urn:nbn:de:bvb:20-opus-322665
publish
Diagnostic Pathology (2019) 14:80. https://doi.org/10.1186/s13000-019-0854-9
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Jan Hrudka
Václav Eis
Josef Heřman
Zuzana Prouzová
Andreas Rosenwald
Duška František
eng
uncontrolled
panniculitis
eng
uncontrolled
T-cell lymphoma
eng
uncontrolled
mesentery
eng
uncontrolled
hemophagocytosis
eng
uncontrolled
lymphohistiocytosis
Medizin und Gesundheit
open_access
Pathologisches Institut
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/opus4-wuerzburg/files/32266/s13000-019-0854-9.pdf
32371
2019
eng
17
article
1
2023-08-11
--
--
Physical activity and health-related quality of life in chronic non-bacterial osteomyelitis
Background
Chronic non-bacterial osteomyelitis (CNO) is an autoinflammatory disorder of the skeletal system of yet unknown etiology. Patients present with local bone pain and inflammation and - to our experience - often suffer from functional impairment with significant disabilities of daily life. The objective of this study was to assess physical activity, fitness and health-related quality of life (HRQOL) in adolescents with established diagnosis of CNO versus healthy controls (HC).
Methods
15 patients with CNO and 15 age and gender matched HC aged 13–18 years, completed questionnaires, performed an incremental exercise test with gas exchange measures up to voluntary fatigue and wore an accelerometer over 7 days at home to assess physical activity behavior.
Results
At the time of assessment, 5 CNO patients were in clinical, one in radiological and 5 in clinical and radiological remission. 7 did not receive any therapy at the time of assessment. The results of the exercise test and of the accelerometry did not show any significant difference between CNO and HC. However, reported sports participation was lower in patients with CNO and PedsQL3.0 and 4.0 showed significant lower values in most of the scores indicating reduced HRQOL.
Conclusion
Although most CNO patients showed a favorable course of disease without any relevant differences in objective measurements of physical activity and fitness versus HC at the time of assessment, questionnaires revealed perceived limitations. Further studies are needed to measure HRQOL and to validate questionnaires in patients with CNO against objective measures including more participants with a higher level of disease activity.
Pediatric Rheumatology
10.1186/s12969-019-0351-4
urn:nbn:de:bvb:20-opus-323710
publish
Pediatric Rheumatology (2019) 17:45. https://doi.org/10.1186/s12969-019-0351-4
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Julia Nentwich
Katharina Ruf
Hermann Girschick
Annette Holl-Wieden
Henner Morbach
Helge Hebestreit
Christine Hofmann
eng
uncontrolled
chronic non-bacterial osteomyelitis
eng
uncontrolled
CRMO
eng
uncontrolled
HRQOL
eng
uncontrolled
physical activity
Medizin und Gesundheit
open_access
Kinderklinik und Poliklinik
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/opus4-wuerzburg/files/32371/s12969-019-0351-4.pdf
32120
2019
eng
20
article
1
2023-07-07
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--
Clinical outcome and concomitant injuries in operatively treated fractures of the lateral process of the talus
Background
The aim of this study was to review the patient rated outcome (PROM) of surgically treated fractures to the lateral process of the talus (LPTF) and identify factors influencing the outcome.
Methods
Retrospective study with a current follow-up. Eligible were all patients treated surgically for a LPTF (n = 23) with a minimum follow-up of one year. Demographics, medical history, trauma mechanism, fracture characteristics, concomitant injuries, treatment details, complications, return to work and sports were assessed retrospectively. The current follow-up included the VAS FA, Karlsson Score, and SF-12. The primary outcome was the VAS FA. Secondary aim was the identification of parameters influencing the PROMs.
Results
22 patients (96% follow-up) with a mean age of 32 ± 9 (18 to 49) years were included. 73% suffered a Hawkins Type 1, 23% a Type 2, and one patient a Type 3 fracture. 82% suffered concomitant injuries. 9% suffered minor surgical side infections, 50% developed symptomatic subtalar osteoarthritis. At final follow-up (44 ± 2 (12 to 97) months), the mean VAS FA Overall was 77 ± 21 (20 to 100), the Karlsson Score 72 ± 21 (34 to 97), and for the SF 12 the PCS 53 ± 8 (36 to 64) and the MCS 53 ± 7 (32 to 63). 50% of patients returned to their previous level of sports. Hawkins Type 1 fractures resulted in better VAS FA Overall score than Type 2 fractures. Posttraumatic subtalar osteoarthritis was the independent factor associated to a poor patient rated outcome (VAS FA, Karlsson Score).
Conclusion
After a follow-up of over 3.5 years, surgically treated LPTF resulted in only moderate results. 50% suffered posttraumatic symptomatic subtalar osteoarthritis, which was the primary independent parameter for a poor outcome following LPTF.
Level of evidence
Level III.
BMC Musculoskeletal Disorders
10.1186/s12891-019-2603-3
urn:nbn:de:bvb:20-opus-321207
publish
BMC Musculoskeletal Disorders (2019) 20:219. https://doi.org/10.1186/s12891-019-2603-3
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Hubert Hörterer
Sebastian Felix Baumbach
Stefan Lemperle
Sebastian Altenberger
Oliver Gottschalk
Alexander Tobias Mehlhorn
Anke Röser
Markus Walther
eng
uncontrolled
fracture
eng
uncontrolled
snowboarder's ankle
eng
uncontrolled
snowboarder's fracture
eng
uncontrolled
lateral process of the talus
Medizin und Gesundheit
open_access
Lehrstuhl für Orthopädie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/opus4-wuerzburg/files/32120/s12891-019-2603-3.pdf
32576
2019
eng
19
article
1
2023-08-18
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miR-221-5p regulates proliferation and migration in human prostate cancer cells and reduces tumor growth in vivo
Background
Despite latest advances in prostate cancer (PCa) therapy, PCa remains the third-leading cause of cancer-related death in European men. Dysregulation of microRNAs (miRNAs), small non-coding RNA molecules with gene expression regulatory function, has been reported in all types of epithelial and haematological cancers. In particular, miR-221-5p alterations have been reported in PCa.
Methods
miRNA expression data was retrieved from a comprehensive publicly available dataset of 218 PCa patients (GSE21036) and miR-221-5p expression levels were analysed. The functional role of miR-221-5p was characterised in androgen- dependent and androgen- independent PCa cell line models (C4–2 and PC-3M-Pro4 cells) by miR-221-5p overexpression and knock-down experiments. The metastatic potential of highly aggressive PC-3M-Pro4 cells overexpressing miR-221-5p was determined by studying extravasation in a zebrafish model. Finally, the effect of miR-221-5p overexpression on the growth of PC-3M-Pro4luc2 cells in vivo was studied by orthotopic implantation in male Balb/cByJ nude mice and assessment of tumor growth.
Results
Analysis of microRNA expression dataset for human primary and metastatic PCa samples and control normal adjacent benign prostate revealed miR-221-5p to be significantly downregulated in PCa compared to normal prostate tissue and in metastasis compared to primary PCa. Our in vitro data suggest that miR-221-5p overexpression reduced PCa cell proliferation and colony formation. Furthermore, miR-221-5p overexpression dramatically reduced migration of PCa cells, which was associated with differential expression of selected EMT markers. The functional changes of miR-221-5p overexpression were reversible by the loss of miR-221-5p levels, indicating that the tumor suppressive effects were specific to miR-221-5p. Additionally, miR-221-5p overexpression significantly reduced PC-3M-Pro4 cell extravasation and metastasis formation in a zebrafish model and decreased tumor burden in an orthotopic mouse model of PCa.
Conclusions
Together these data strongly support a tumor suppressive role of miR-221-5p in the context of PCa and its potential as therapeutic target.
BMC Cancer
10.1186/s12885-019-5819-6
urn:nbn:de:bvb:20-opus-325762
publish
BMC Cancer (2019) 19:627. https://doi.org/10.1186/s12885-019-5819-6
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Mirjam Kiener
Lanpeng Chen
Markus Krebs
Joȅl Grosjean
Irena Klima
Charis Kalogirou
Hubertus Riedmiller
Burkhard Kneitz
George N. Thalmann
Ewa Snaar-Jagalska
Martin Spahn
Marianna Kruithof-de Julio
Eugenio Zoni
eng
uncontrolled
prostate cancer
eng
uncontrolled
miR-221-5p
eng
uncontrolled
proliferation
eng
uncontrolled
migration
eng
uncontrolled
tumor suppressor miRNA
Medizin und Gesundheit
open_access
Urologische Klinik und Poliklinik
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/opus4-wuerzburg/files/32576/s12885-019-5819-6.pdf
32587
2019
eng
19
article
1
2023-08-22
--
--
The impact of local control on overall survival after stereotactic body radiotherapy for liver and lung metastases from colorectal cancer: a combined analysis of 388 patients with 500 metastases
Background
The aim of this analysis was to model the effect of local control (LC) on overall survival (OS) in patients treated with stereotactic body radiotherapy (SBRT) for liver or lung metastases from colorectal cancer.
Methods
The analysis is based on pooled data from two retrospective SBRT databases for pulmonary and hepatic metastases from 27 centers from Germany and Switzerland. Only patients with metastases from colorectal cancer were considered to avoid histology as a confounding factor. An illness-death model was employed to model the relationship between LC and OS.
Results
Three hundred eighty-eight patients with 500 metastatic lesions (lung n = 209, liver n = 291) were included and analyzed. Median follow-up time for local recurrence assessment was 12.1 months. Ninety-nine patients with 112 lesions experienced local failure. Seventy-one of these patients died after local failure. Median survival time was 27.9 months in all patients and 25.4 months versus 30.6 months in patients with and without local failure after SBRT. The baseline risk of death after local failure exceeds the baseline risk of death without local failure at 10 months indicating better survival with LC.
Conclusion
In CRC patients with lung or liver metastases, our findings suggest improved long-term OS by achieving metastatic disease control using SBRT in patients with a projected OS estimate of > 12 months.
BMC Cancer
10.1186/s12885-019-5362-5
urn:nbn:de:bvb:20-opus-325877
publish
BMC Cancer (2019) 19:173. https://doi.org/10.1186/s12885-019-5362-5
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Rainer J. Klement
N. Abbasi-Senger
S. Adebahr
H. Alheid
M. Allgaeuer
G. Becker
O. Blanck
J. Boda-Heggemann
T. Brunner
M. Duma
M. J. Eble
I. Ernst
S. Gerum
D. Habermehl
P. Hass
C. Henkenberens
G. Hildebrandt
D. Imhoff
H. Kahl
N. D. Klass
R. Krempien
V. Lewitzki
F. Lohaus
C. Ostheimer
A. Papachristofilou
C. Petersen
J. Rieber
T. Schneider
E. Schrade
R. Semrau
S. Wachter
A. Wittig
M. Guckenberger
N. Andratschke
eng
uncontrolled
colorectal cancer
eng
uncontrolled
illness-death model
eng
uncontrolled
liver metastases
eng
uncontrolled
lung metastases
eng
uncontrolled
tumor control probability
eng
uncontrolled
stereotactic body radiation therapy
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Strahlentherapie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/opus4-wuerzburg/files/32587/s12885-019-5362-5.pdf