TY - JOUR A1 - Zvirblis, G. S. A1 - Gorboulev, Valentin G. A1 - Rubtsov, P. M. A1 - Chernov, B. K. A1 - Golova, Yu. B. A1 - Pozmogova, G. E. A1 - Skryabin, K. G. A1 - Bayev, A. A. T1 - Genetic engineering of peptide hormones : III. Cloning of cDNA of porcine growth hormone and construction of gene for expression of hormone in bacteria N2 - Results are presented of cloning cDNA of procine growth hormone, analysis of its primary structure, and creation of a construction capable of expression of this cDNA in Esqheriahia coti cells. It is shown that in the population of mRNA coding porcine growth hormone, heterogeneity is noted which is manifested not only at the level of the nucleotide sequence, but also is reflected in the amino acid sequence of the mature hormone. Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-46958 ER - TY - JOUR A1 - Wirbelauer, J. A1 - Hof, H. A1 - Hacker, Jörg T1 - Die Wirkung von Desacetylcefotaxin, einem Metaboliten von Cefotaxim, in vitro und auf die experimentelle Infektion mit Escherichia coli T1 - Activity of Desacetylcefotaxime, a Metabolite of Cefotaxime, In Vitro and in a Model of Experimental Infection with Escherichia coli N2 - Die MHK-Werte von Desacetylcefotaxim gegen verschiedene, z. T. ampicillinresistente Stämme von Escherichia coH, die mit Hilfe einer Agardilutionsmethode erhoben wurden, waren höher als die von Cefotaxim und Ceftriaxon, jedoch niedriger als die von Cefoxitin. In einem Modell der systemischen Infektion der Maus mit einem plasmidtragenden, betalactamaseproduzierenden Stamm von E. coli führte die Therapie mit Desacetylcefotaxim zu einer starken Reduktion der Keime pro Leber. Im Vergleich zur Therapie mit Cefotaxim trat die protektive Wirkung aber verlangsamt ein. Desacetylcefotaxim ist also kein unnützes Abbauprodukt von Cefotaxim. N2 - The MIC values of desacetylcefotaxime, as determined by an agar dilution method, for several strains of Escherichia coli largely resistant to ampicillin were considerably higher than those of cefotaxime or ceftriaxone respectively. The values were, however, definitely lower than those of cefoxitin. In a mouse model of a systemic infection with a plasmid-bearing, j3-lactamase producing strain of E. coli the therapeutic potency of ampicillin, cefotaxime and desacetylcefotaxime was determined by counting the bacterial numbers per liver at days 1,3 and 7 after subcutaneous infection with about 103 viable bacteria. Desacety1cefotaxime was able to redure thc bacterial load considerably, though with a delay in comparison to cefotaxime. Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-40348 ER - TY - JOUR A1 - Winoto-Morbach, S. A1 - Leyhausen, G. A1 - Müller-Ruchholtz, W. A1 - Ulrichs, Karin T1 - The Electromagnetic Separation Principle: A Basis for Human Pancreatic Islet Transplantation N2 - No abstract available KW - Allergie Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-82520 ER - TY - JOUR A1 - Wilhelm, Gernot T1 - K Churritskoj i urartskoj grammatikje N2 - No Abstract available Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-82984 ER - TY - CHAP A1 - Wilhelm, Gernot T1 - Zur ersten Zeile des Šunaššura-Vertrages N2 - No abstract available. Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-72337 ER - TY - JOUR A1 - Wilhelm, Gernot T1 - Neue akkadische Gilgameš-Fragmente aus Hattusa N2 - No abstract available. KW - Gilgameschichtung Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87718 ER - TY - JOUR A1 - Wilhelm, Gernot T1 - Zu den Wollmaßen in Nuzi N2 - no Abstract available KW - Nuzi Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87792 ER - TY - CHAP A1 - Wilhelm, Gernot T1 - Gedanken zur Frühgeschichte der Hurriter und zum hurritisch-urartäischen Sprachvergleich N2 - No abstract available. KW - Geschichte KW - Churriter Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87728 ER - TY - CHAP A1 - Weinert, Franz E. A1 - Schneider, Wolfgang A1 - Knopf, Monika T1 - Individual differences in memory development across the life-span N2 - Experimental research on memory development has typically focused on the description of universal development trends across the life span and the identification of major sources of development within this domain. However, there is a lack of studies investigating the preconditions and effects of interindividual variability within age groups across different memory tasks. Similarly, our knowledge about the stability of interindividual differences across the life span as well as the sources and the amount of intraindividual variability across memory tasks is scarce. In the present chapter, we concentrate on these neglected issues. First, theoretical assumptions concerning the interindividual and intraindividual variability of memory development are discussed. Next, empirical evidence is presented that seems suited to document the importance of these neglected issues. While we try to give a representative account of the literature, the emphasis is on more recent studies of memory development in children and elderly adults conducted in our laboratory. The results demonstrate that age-related changes and individual differences in the knowledge base are particularly important for describing and explaining individual differences in memory develoment. In comparison, the rote of stable individual differences in basic memory capacities in explaining variations in memory development is less clear given tbe conflicting empirical evidence. In the final section of the chapter consequences for future research are discussed. KW - Gedächtnisbildung KW - Lebensalter Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-70666 ER - TY - CHAP A1 - Weinert, Franz E. A1 - Schneider, Wolfgang A1 - Asendorpf, Jens A1 - Helmke, Andreas A1 - Knopf, Monika A1 - Kuhl, Julius A1 - Nunner-Winkler, Gertrud A1 - Strube, Gerhard T1 - Entwicklung im Vorschulalter: Bericht über eine Längsschnittstudie N2 - Dargestellt werden die theoretischen Ziele, das methodische Vorgehen und die ersten Ergebnisse einer Longitudinalstudie zur Genese individueller Kompetenzen (LOGIK) im Vorschulalter. Dabei geht es vor allem um generelle Merkmale und differentielle Verläufe bei der Entwicklung kognitiver, sozialer und motivationaler Kompetenzen. KW - Vorschulkind KW - Entwicklung Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86699 ER -