TY - BOOK A1 - Kossatz, Tilman T1 - Johann Philipp Preuss (1605 - ca. 1687) : ein Beitrag zur Genese barocker Bildkunst in Franken N2 - Diese Arbeit beschäftigt sich mit dem Würzburger Bildhauer und Architekten Johann Philipp Preuß (1605 - ca 1687). KW - Preiss, Hans Philipp KW - Franken KW - Plastik KW - Geschichte 1605-1687 KW - Architekt KW - Bildhauer KW - Würzburg Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-203117 ER - TY - JOUR A1 - Lohse, Martin J. A1 - Klotz, Karl-Norbert A1 - Salzer, Manfred J. A1 - Schwabe, Ulrich T1 - Adenosine regulates the \(Ca^{2+} \) sensitivity of mast cell mediator release : (histamine secretion/inositol phosphates/calcium) JF - Proceedings of the National Academy of Sciences of the United States of America N2 - Mast cells release histamine and other mediators of allergy in response to stimulation of their IgE receptors. This release is generally thought to be mediated by an elevation of cytosolic \(Ca^{2+}\). Recent evidence suggests that there might be factors that modulate the coupling between \(Ca^{2+}\) levels and mediator release. The present report identifies adenosine as one such modulator. Adenosine and several of its metabolically stable analogues were shown to enhance histamine release from rat peritoneal mast cells in response to stimuli such as concanavalin A. Metabolizing endogenous adenosine with adenosine deaminase dampened the response to stimuli, whereas trapping endogenous adenosine inside mast cells with nucleoside-transport inhibitors markedly enhanced stimulated histamine release. The metabolically stable adenosine analogue 5' -(N-ethylcarboxamido)adenosine (NECA) did not affect the initial steps in the sequence from IgE-receptor activation to mediator release, which are generation of inositol trisphosphate and increase of cytosolic \(Ca^{2+}\). However, NECA did enhance the release induced in ATP-permeabilized cells by exogenous \(Ca^{2+}\), but it had no effect on the release induced by phorbol esters. These data suggest that adenosine sensitizes mediator release by a mechanism regulating stimulus-secretion coupling at a step distal to receptor activation and second-messenger generation. Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-127883 VL - 85 ER - TY - JOUR A1 - Wilhelm, Gernot T1 - K Churritskoj i urartskoj grammatikje N2 - No Abstract available Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-82984 ER - TY - JOUR A1 - Wilhelm, Gernot T1 - Zu den Wollmaßen in Nuzi N2 - no Abstract available KW - Nuzi Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87792 ER - TY - CHAP A1 - Wilhelm, Gernot T1 - Gedanken zur Frühgeschichte der Hurriter und zum hurritisch-urartäischen Sprachvergleich N2 - No abstract available. KW - Geschichte KW - Churriter Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87728 ER - TY - JOUR A1 - Wilhelm, Gernot T1 - Neue akkadische Gilgameš-Fragmente aus Hattusa N2 - No abstract available. KW - Gilgameschichtung Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87718 ER - TY - CHAP A1 - Wilhelm, Gernot T1 - Zur ersten Zeile des Šunaššura-Vertrages N2 - No abstract available. Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-72337 ER - TY - JOUR A1 - Wehgartner, Irma T1 - Eine neue "pontische" Oinochoe und Überlegungen zur Genese ihrer Form N2 - Das Martin-von-Wagner-Museum besitzt eine seit langem bekannte Sammlung bedeutender 'pontischer' Vasen, die vor kurzem durch die Erwerbung einer Oinochoe dieser Gattung sinnvoll ergänzt werden konnte (Abb. 30-34. 38. 40-45). Denn obwohl in der 'pontischen' Keramik die Oinochoen nach den Amphoren die häufigste Gefäßform sind, war gerade diese Form in der Würzburger Sammlung bisher nur durch zwei kleine, atypische Exemplare vertreten gewesen. Die neu erworbene Oinochoe kann dagegen nach ihrer Größe, ihren Formmerkmalen und ihrer Bemalung als eine typische Vertreterio dieser Form innerhalb der 'pontischen' Gattung gelten. KW - Martin-von-Wagner-Museum / Antikenabteilung KW - Oinochoë Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87561 ER - TY - CHAP A1 - Kreuzer, Hans A1 - Vejnar, Zdenek A1 - Schüssler, Ulrich A1 - Okrusch, Martin A1 - Seidel, Eberhard T1 - K-Ar dating of the last metamorphic events in different tectonic units of the western margin of the Bohemian Massif N2 - K-Ar dating on hornblendes and micas from the TepläDomazlice zone revealed a pattern of dates which significantly deviates from the mid-Carboniferous to early Permian one that is found in the adjacent low-pressure metamorphic Moldanubian and Saxothuringian. Especially for the Mariänske Läzne metabasic complex, confirming early Czech determinations, the dates resemble the early Devonian pattern determined for the Münchberg Gneiss Massif and the Erbendorf-Vohenstrauß zone of northeastern Bavaria. This supports the idea that all three units are remnants of a huge complex which suffered a metamorphic overprint under medium-pressure conditions, probably in the early Devonian. Streng rejuvenation is found in the southern part of the Teplä-Domailice zone by which micas and even two hornblendes were reset to mid-Carboniferous ages. According to the geological setting, part of the apparently preDevonian dates may be explained by inherited argon from earlier metamorphic and magmatic events, e.g. the high-pressure metamorphism documented in eclogitic relics. However, excess argon, caused by the mid-Carboniferous overprint cannot be excluded. KW - Geochemie Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87527 ER - TY - CHAP A1 - Schüssler, Ulrich A1 - Vejnar, Z. A1 - Okrusch, M. A1 - Rose, S. A1 - Seidel, E. T1 - Geochemistry of Metabasites and gabbroic rocks from the Tepla-Domazlice zone N2 - Various amphibolites, metagabbros and eclogitic relics of the Mariänske Läzne complex, and amphibolites from the Cernä Hora Massif exhibit an uniform geochemical character which compares weil with modern mid-ocean ridge basalts. Geochemically these metabasites are similar to the amphibolites of the Myto area and to schistose, partly striped amphibolites of the neighbouring Tirschenreuth-Mähring Zone and the Erbendorf-Vohenstrauss Zone (Bavaria). Greenschists and amphibolites from the Domazlice metamorphic complex show an alkaline-basaltic tendency conforming to modern within-plate basalts or basalts from anomalaus midocean ridge segments. In their chemical character, these metabasites compare weil with the flaseramphibolites of the Erbendorf-Vohenstrauss Zone. Fine-grained amphibolites in the Warzenrieth area and (gabbro-) amphibolites in the Blätterberg-Hoher Bogen area show normal MORB character. The metamorphosed gabbroic rocks in the southern part of the Neukirchen-Kdyne (meta-) igneous complex are subalkaline - tholeiitic and exhibit a magmatic differentiation trend. They differ from the neighbouring amphibolites by generally lower contents of incompatible elements. KW - Geochemie Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87511 ER - TY - JOUR A1 - Kurtz, Beth E. A1 - Schneider, Wolfgang T1 - The effects of age, study time, and importance of text units on strategy use and memory for texts N2 - This study investigated study behavior and recall of a narrative text as a function of the reader's age, study time, and importance level of text units. Fifth graders, seventh graders, young- and older adults were asked to read a fairy tale, and do anything they liked to prepare for verbatim recall. Half of the subjects in each age group were assigned to an immediate recall condition; half were given additional study time. Examination of recall data showed that all subjects showed higher recall of important units in the text than unimportant units. This effect was independent of age and study time condition. Study behaviors varied significantly across age groups and study conditions: while adults underlined or took notes with equal frequency, children preferred note-taking as a study strategy. With additional study time, fifth graders, seventh graders, and older adults increased their strategic behavior; young adults did not. KW - Studienzeit KW - Lebensalter KW - Gedächtnis Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87408 ER - TY - JOUR A1 - Schneider, Wolfgang T1 - Zur Rolle des Wissens bei kognitiven Höchstleistungen T1 - The Impact of the Knowledge Base on Exceptional Cognitive Performance N2 - Neuere Ansätze der Hochbegabtenforschung haben demonstriert, daß herausragende intellektuelle Fähigkeiten alleine noch keine kognitiven Höchstleistungen in späteren Lebensabschnitten garantieren. Insbesondere retrospektive Analysen der Daten genialer bzw. kognitiv hochproduktiver Persönlichkeiten lassen darauf schließen, daß neben Intelligenzmerkmalen auch Wissensaspekte und nichtkognitive Persönlichkeitsmerkmale entscheidend dafür verantwortlich sind, daß Höchstleistungen erzielt werden können. Im vorliegenden Beitrag wird ein Überblick über Studien gegeben, die den Einfluß bereichsspezifiscben Wissens auf kognitive Höchstleistungen darstellt, daß jedoch ab einem bestimmten Grenzwert intellektueller Fähigkeit allein das Ausmaß bereichsspezifischen Wissens in Kombination mit extremen Ausprägungen in nichtkognitiven Merkmalen wie Konzentrationsfähigkeit, Ausdauer und Erfolgsmotivation darüber entscheidet, ob intellektuelle Höchstleistungen erbracht werden können. KW - Hochbegabung KW - Intelligenzleistung KW - Vorwissen KW - Hochbegabung KW - bereichsspezifisches Vorwissen KW - kognitive Höchstleistung KW - giftedness KW - the knowledge base KW - exceptional cognitive performance Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87383 ER - TY - CHAP A1 - Weinert, Franz E. A1 - Schneider, Wolfgang A1 - Asendorpf, Jens A1 - Helmke, Andreas A1 - Knopf, Monika A1 - Kuhl, Julius A1 - Nunner-Winkler, Gertrud A1 - Strube, Gerhard T1 - Entwicklung im Vorschulalter: Bericht über eine Längsschnittstudie N2 - Dargestellt werden die theoretischen Ziele, das methodische Vorgehen und die ersten Ergebnisse einer Longitudinalstudie zur Genese individueller Kompetenzen (LOGIK) im Vorschulalter. Dabei geht es vor allem um generelle Merkmale und differentielle Verläufe bei der Entwicklung kognitiver, sozialer und motivationaler Kompetenzen. KW - Vorschulkind KW - Entwicklung Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86699 ER - TY - JOUR A1 - Schneider, Wolfgang A1 - Hasselhorn, Marcus T1 - Metakognitionen bei der Lösung mathematischer Probleme: Gestaltungsperspektiven für den Mathematikunterricht N2 - In neueren Untersuchungen zur Mathematikerziehung im Elementarbereich wird verstärkt auf die Bedeutung kognitiver Prozesse (Strategien) für die erfolgreiche Bewältigung von Problemlöseaufgaben hingewiesen. Im vorliegenden Beitrag wird insbesondere auf das Wissen um kognitive Prozesse und deren Steuerung, also auf Metakognitionen eingegangen. Es wird zunächst eine Einführung in traditionelle Kategorien von Metakognition gegeben und dann auf eine Weiterentwicklung eingegangen, die als "Modell des kompetenten Strategie-Anwenders" bekanntgeworden ist. Dieses Modell wird dann als Grundlage für Empfehlungen benutzt, die darauf abzielen, den Mathematikunterricht effizienter zu gestalten. N2 - Recent studies into math instruction in elementary schools have emphasized the importance of cognitive processes ( strategies) for successful problem solving. This paper focuses on the impact of metacognition, that is, knowledge about cognitive processes and their conscious regulation, on performance in mathematics. In a first step, traditional categories of metacognition are described. Next, a recent elaboration of more traditional approaches, namely the "good strategy user model", is presented in more detail. Recommendations concerning a more efficient construction of math instruction based on this model are given in the last section of this paper. KW - Mathematikunterricht Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86477 ER - TY - CHAP A1 - Maurer, B. A1 - Bannert, H. A1 - Rethwilm, Axel A1 - Darai, B. A1 - Flügel, R. M. T1 - Characterization of the env gene and of two novel coding regions of the human spumaretrovirus N2 - Recombinant clones harboring retroviral DNA were established. The nucleotide sequence of the central and 3' region of the genome of the human spumaretrovirus was determined. The 5' end of the deduced protein sequence was homologaus to the endonuclease domain of retroviral reverse transcriptases. A small intergenic region is followed by a lang open reading frame of 985 aminoacid residues that according to its genomic location and structural features is a typical retroviral env gene. Surprisingly, the postenv region contains two open reading frames that encodes two novel retroviral genes, termed bel-l and bel-2. The 3' LTR is 963 nucleotides lang and contains the signal sequences characteristic for transcriptional regulation of retrovirus genomes. KW - Spumaviren Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86334 ER - TY - CHAP A1 - Lohse, M. J. A1 - Klotz, K.-N. A1 - Schwabe, U. A1 - Christalli, G. A1 - Vittori, S. A1 - Grifantini, M. T1 - Pharmacology and Biochemistry of Adenosine Receptors N2 - Adenosine modulates a variety of physiological functions via membrane-bound receptors. These receptors couple via G proteins to adenylate cyclase and K+channels. The A1 subtype mediates an inhibition of adenylate cyclase and an opening of K+-channels, and the A2 subtype a Stimulation of adenylate cyclase. Both subtypes have been characterized by radioligand binding. This has facilitated the development of agonists and antagonists with more than 1000-fold A1 selectivity. A1-selective photoaffinity labels have been used for the biochemical characterization of A1 receptors and the study of their coupling to adenylate cyclase. Such selective ligands allow the analysis of the involvement of adenosine receptors in physiological functions. Selective interference with adenosine receptors provides new pharmacological tools and eventually new therapeutic approaches to a number of pathophysiological states. KW - Adenosinrezeptor KW - Pharmakologie KW - Toxikologie Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86251 ER - TY - JOUR A1 - Maueler, W. A1 - Barnekow, A. A1 - Eigenbrodt, E. A1 - Raulf, F. A1 - Falk, H. F. A1 - Telling, A. A1 - Schartl, Manfred T1 - Different regulation of oncogene expression in tumor and embryonal cells of Xiphophorus N2 - Melanoma formation in the poeciliid fish Xiphophorus is mediated primarily by a cellular oncogene, designated Tu. Elimination of Tu-specific genes releases the transforming function of Tu and leads to melanoma formation. Southern blot analyses revealed a tight linkage of a v-erb B related gene to the Tu-locus and Northern blot analyses of RNA of solid melanomas indicated a coordinated deregulation and for mutational activation of several oncogenes. In order to get a better insight into the regulation of oncogene expression in normal and transformed cells of Xiphophorus, we studied the expression of Xsrc, Xras, Xmyc, Xerb A, Xsis, and the v-erb B related gene in a melanoma derived cell line (PSM) and an embryonic cell line (A2) under conditions of low growth factor supply. Both celllines express the Xsrc, Xmyc, and Xras genes, while PSM cells in addition express the v-erb B related gene and A2 cells the Xsis gene. In PSM cells serum deprivation leads to an accumulation of most of the oncogene mRNAs analysed. This is most apparent for a 5.0 kb transcript of the v-erb B related gene, probably due to an increase in transcript stability. The levels of these mRNAs returned to normal within 2h after stimulation with 10% fetal calf serum. At the protein level we observed an initial decrease followed by an increase of the n-p60c-src kinase (the protein product of tbe Xsrc gene) activity in cells deprived of serum. Serum stimulation restored a normal pp60"-src kinase activity. In contrast serum deprivation of A2 cells reduced the transcript amounts of each of the oncogenes analysed. The same holds true for one beta-tubulin transcript, while the level of a second beta-tubulin transcript was unaffected. Serum stimulation led to a reactivation of Xras and Xsrc after a delay of approximately 48b. The pp60(c-src) kinase activity was found to be 6-10 times lower as compared to the PSM cells and did not differ between serum deprived and serum stimulated cells. Enzyme activities and isoenzyme patterns of several glycolytic enzymes were found to be not affected by serum deprivation and stimulation in both celllines. KW - Schwertkärpfling KW - Tumorzelle Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86240 ER - TY - JOUR A1 - Mäueler, Winfried A1 - Raulf, Friedrich A1 - Schartl, Manfred T1 - Expression of proto-oncogenes in embryonic, adult, and transformed tissue of Xiphophorus (Teleostei: Poeciliidae) N2 - In Xiphophorus the causative, primary cellular oncogene for melanoma formation has been assigned by classical genetics to a sex-chromosomal locus, designated Tu. Activation of Tu was proposed to be the result of the elimination of Tu-specific regulatory genes which normally suppress the transforming function in the nontumorous state. In order to understand the role which known proto-oncogenes migbt play in this process, we have analysed the expression of src, erb A, erb B, ras, abl, sis and mil related genes from Xiphophorus during embryogenesis, in non-tumorous organs and in melanoma cells. For src, ras, erb B and sis a differential expression during embryogenesis and/or in normal organs was detected, with preferential expression of src in neural tissues, a high abundance of sis transcripts in an embryonal epitheloid cellline and of erbB transcripts in the head nephros. In melanoma cells ras, src and a v-erb B related gene were found to be expressed. The src gene most likely is more involved in secondary processes during tumor progression, while the expression of the v-erb B related gene might be transformation-specific because recently such a sequence was found to map to the close vicinity of the Tu-locus. KW - Schwertkärpfling KW - Protoonkogen KW - Gewebe Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86233 ER - TY - CHAP A1 - Weinert, Franz E. A1 - Schneider, Wolfgang A1 - Knopf, Monika T1 - Individual differences in memory development across the life-span N2 - Experimental research on memory development has typically focused on the description of universal development trends across the life span and the identification of major sources of development within this domain. However, there is a lack of studies investigating the preconditions and effects of interindividual variability within age groups across different memory tasks. Similarly, our knowledge about the stability of interindividual differences across the life span as well as the sources and the amount of intraindividual variability across memory tasks is scarce. In the present chapter, we concentrate on these neglected issues. First, theoretical assumptions concerning the interindividual and intraindividual variability of memory development are discussed. Next, empirical evidence is presented that seems suited to document the importance of these neglected issues. While we try to give a representative account of the literature, the emphasis is on more recent studies of memory development in children and elderly adults conducted in our laboratory. The results demonstrate that age-related changes and individual differences in the knowledge base are particularly important for describing and explaining individual differences in memory develoment. In comparison, the rote of stable individual differences in basic memory capacities in explaining variations in memory development is less clear given tbe conflicting empirical evidence. In the final section of the chapter consequences for future research are discussed. KW - Gedächtnisbildung KW - Lebensalter Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-70666 ER - TY - CHAP A1 - Schartl, Manfred A1 - Mäueler, Winfried A1 - Raulf, Friedrich A1 - Robertson, Scott M. T1 - Molecular aspects of melanoma formation in Xiphophorus N2 - No abstract available. KW - Schwertkärpfling KW - Krebs Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-72689 ER -