TY  - JOUR
A1  - Stock, Benjamin
A1  - Möckel, Sigrid
A1  - Zander, Christine
A1  - Heinsen, Helmut
A1  - Bohnert, Simone
A1  - Bohnert, Michael
T1  - „Black esophagus“ – zwei Obduktionsfälle mit infektiöser Beteiligung
JF  - Rechtsmedizin
N2  - „Black esophagus“ oder „akute Ösophagusnekrose“ (AÖN) ist eine seltene Erkrankung, die sich makroskopisch durch eine zirkumferente Schwarzverfärbung der Ösophagusmukosa mit abruptem Ende am gastroösophagealen Übergang auszeichnet. Die genaue Pathogenese ist unbekannt; es werden multifaktorielle Einflüsse wie z. B. Säurereflux, Ischämie und verringerte Schutzmechanismen der Mukosa als mögliche Ursachen diskutiert.

Vorgestellt werden 2 Obduktionsfälle, die typische Befunde einer AÖN aufwiesen. Zusätzlich hatten Fall 1 eine Candida-Infektion und Fall 2 eine Appendizitis, sodass eine infektiöse Genese in beiden Fällen eine Rolle gespielt haben könnte.
N2  - Black esophagus, also known as acute esophageal necrosis, is a rare disease characterized by a circumferential black discoloration of the esophageal mucosa with an abrupt stop at the gastroesophageal junction. The exact pathogenesis is unknown, but multifactorial influences, such as acid reflux, ischemia and reduced protective mechanisms of the mucosa are discussed as possible causes.

Two autopsy cases are presented with typical signs of a black esophagus. The first case showed an infection with Candida albicans, the second one died of appendicitis, so in both cases an infectious genesis might have played a role.
T2  - Black esophagus—Two autopsy cases with infectious involvement
KW  - Histopathologie
KW  - Blinddarmentzündung
KW  - Speiseröhre
KW  - Nekrose
KW  - Schleimhaut
KW  - Candida
KW  - Akute Ösophagusnekrose
KW  - Schleimhaut-Ulzera
KW  - Appendizitis
KW  - acute esophageal necrosis
KW  - histopathology
KW  - mucosal ulcers
KW  - appendicitis
KW  - Candida
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-325022
SN  - 0937-9819
VL  - 33
IS  - 3
ER  - 
TY  - JOUR
A1  - Köhler, Franziska
A1  - Reese, Lena
A1  - Kastner, Carolin
A1  - Hendricks, Anne
A1  - Müller, Sophie
A1  - Lock, Johan F.
A1  - Germer, Christoph-Thomas
A1  - Wiegering, Armin
T1  - Surgical site infection following single-port appendectomy: a systematic review of the literature and meta-analysis
JF  - Frontiers in Surgery
N2  - Introduction
Surgical site infections (SSIs) are one of the most common postoperative complications after appendectomy leading to recurrent surgery, prolonged hospital stay, and the use of antibiotics. Numerous studies and meta-analyses have been published on the effect of open versus conventional laparoscopic appendectomy (CLA) reporting faster postoperative recovery and less postoperative pain for CLA. A development from CLA has been the single-port appendectomy (SPA), associated with a better cosmesis but seemingly having a higher risk of wound infections. The aim of this systematic literature review and meta-analysis is to investigate whether reduced port or SPA alters the ratio of SSIs.

Methods
Pubmed, Embase, and Cochrane databases were screened for suitable articles. All articles published between January 1, 2002, and March 23, 2022, were included. Articles regarding children below the age of 18 were excluded as well as manuscripts that investigated solemnly open appendectomies. Articles were screened for inclusion criteria by two independent authors. Incidence of SSI was the primary outcome. Duration of operation and length of hospital stay were defined as secondary outcomes.

Results
A total of 25 studies were found through a database search describing 5484 patients. A total of 2749 patients received SPA and 2735 received CLA. There was no statistical difference in the rate of SSI (P = 0.98). A total of 22 studies including 4699 patients reported the duration of operation (2223 SPA and 2476 CLA). There was a significantly shorter operation time seen in CLA. The length of hospital stay was reported in 23 studies (4735 patients: 2235 SPA and 2500 CLA). A shorter hospital stay was seen in the SPA group (P < 0.00001). Separately performed analysis of randomized controlled trials could not confirm this effect (P = 0.29).

Discussion
SPA is an equally safe procedure considering SSI compared to CLA and does not lead to an increased risk of SSI. A longer operation time for SPA and a minor difference in the length of stay does lead to the use of SPA in selected patients only.
KW  - appendicitis
KW  - appendectomy
KW  - surgical site infection
KW  - single-port appendectomy
KW  - conventional laparoscopic appendectomy
KW  - wound infection
KW  - SSI
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-276943
SN  - 2296-875X
VL  - 9
ER  -