TY  - JOUR
A1  - Esmaeilpour, Donya
A1  - Broscheit, Jens Albert
A1  - Shityakov, Sergey
T1  - Cyclodextrin-based polymeric materials bound to corona protein for theranostic applications
JF  - International Journal of Molecular Sciences
N2  - Cyclodextrins (CDs) are cyclic oligosaccharide structures that could be used for theranostic applications in personalized medicine. These compounds have been widely utilized not only for enhancing drug solubility, stability, and bioavailability but also for controlled and targeted delivery of small molecules. These compounds can be complexed with various biomolecules, such as peptides or proteins, via host-guest interactions. CDs are amphiphilic compounds with water-hating holes and water-absorbing surfaces. Architectures of CDs allow the drawing and preparation of CD-based polymers (CDbPs) with optimal pharmacokinetic and pharmacodynamic properties. These polymers can be cloaked with protein corona consisting of adsorbed plasma or extracellular proteins to improve nanoparticle biodistribution and half-life. Besides, CDs have become famous in applications ranging from biomedicine to environmental sciences. In this review, we emphasize ongoing research in biomedical fields using CD-based centered, pendant, and terminated polymers and their interactions with protein corona for theranostic applications. Overall, a perusal of information concerning this novel approach in biomedicine will help to implement this methodology based on host-guest interaction to improve therapeutic and diagnostic strategies.
KW  - cyclodextrin
KW  - theranostics
KW  - protein corona
KW  - nanomedicine
KW  - therapy
KW  - polymers
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-297399
SN  - 1422-0067
VL  - 23
IS  - 21
ER  - 
TY  - JOUR
A1  - Markenstein, Lisa
A1  - Appelt-Menzel, Antje
A1  - Metzger, Marco
A1  - Wenz, Gerhard
T1  - Conjugates of methylated cyclodextrin derivatives and hydroxyethyl starch (HES): Synthesis, cytotoxicity and inclusion of anaesthetic actives
JF  - Beilstein Journal of Organic Chemistry
N2  - The mono-6-deoxy-6-azides of 2,6-di-O-methyl-beta-cyclodextrin (DIMEB) and randomly methylated-beta-cyclodextrin (RAMEB) were conjugated to propargylated hydroxyethyl starch (HES) by Cu+-catalysed [2 + 3] cycloaddition. The resulting water soluble polymers showed lower critical solution temperatures (LCST) at 52.5 degrees C (DIMEB-HES) and 84.5 degrees C (RAMEB-HES), respectively. LCST phase separations could be completely avoided by the introduction of a small amount of carboxylate groups at the HES backbone. The methylated CDs conjugated to the HES backbone exhibited significantly lower cytotoxicities than the corresponding monomeric CD derivatives. Since the binding potentials of these CD conjugates were very high, they are promising candidates for new oral dosage forms of anaesthetic actives.
KW  - midazolam
KW  - supermolecular carrier systems
KW  - beta-cyclodextrin
KW  - pharmaceutical applications
KW  - gamma-cyclodextrin
KW  - anaesthetics
KW  - complexation
KW  - cyclodextrin
KW  - LCST
KW  - lower critical solution temperature
KW  - acid dissociation
KW  - drug
KW  - rat
KW  - cycloaddition
KW  - occupancy
KW  - polymer
KW  - sevoflurane
KW  - solubility
KW  - starch
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-114280
SN  - 1860-5397
VL  - 10
ER  -