TY  - JOUR
A1  - Esmaeilpour, Donya
A1  - Broscheit, Jens Albert
A1  - Shityakov, Sergey
T1  - Cyclodextrin-based polymeric materials bound to corona protein for theranostic applications
JF  - International Journal of Molecular Sciences
N2  - Cyclodextrins (CDs) are cyclic oligosaccharide structures that could be used for theranostic applications in personalized medicine. These compounds have been widely utilized not only for enhancing drug solubility, stability, and bioavailability but also for controlled and targeted delivery of small molecules. These compounds can be complexed with various biomolecules, such as peptides or proteins, via host-guest interactions. CDs are amphiphilic compounds with water-hating holes and water-absorbing surfaces. Architectures of CDs allow the drawing and preparation of CD-based polymers (CDbPs) with optimal pharmacokinetic and pharmacodynamic properties. These polymers can be cloaked with protein corona consisting of adsorbed plasma or extracellular proteins to improve nanoparticle biodistribution and half-life. Besides, CDs have become famous in applications ranging from biomedicine to environmental sciences. In this review, we emphasize ongoing research in biomedical fields using CD-based centered, pendant, and terminated polymers and their interactions with protein corona for theranostic applications. Overall, a perusal of information concerning this novel approach in biomedicine will help to implement this methodology based on host-guest interaction to improve therapeutic and diagnostic strategies.
KW  - cyclodextrin
KW  - theranostics
KW  - protein corona
KW  - nanomedicine
KW  - therapy
KW  - polymers
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-297399
SN  - 1422-0067
VL  - 23
IS  - 21
ER  - 
TY  - JOUR
A1  - Tessmer, Ingrid
A1  - Kaur, Parminder
A1  - Lin, Jiangguo
A1  - Wang, Hong
T1  - Investigating bioconjugation by atomic force microscopy
JF  - Journal of Nanobiotechnology
N2  - Nanotechnological applications increasingly exploit the selectivity and processivity of biological molecules. Integration of biomolecules such as proteins or DNA into nano-systems typically requires their conjugation to surfaces, for example of carbon-nanotubes or fluorescent quantum dots. The bioconjugated nanostructures exploit the unique strengths of both their biological and nanoparticle components and are used in diverse, future oriented research areas ranging from nanoelectronics to biosensing and nanomedicine. Atomic force microscopy imaging provides valuable, direct insight for the evaluation of different conjugation approaches at the level of the individual molecules. Recent technical advances have enabled high speed imaging by AFM supporting time resolutions sufficient to follow conformational changes of intricately assembled nanostructures in solution. In addition, integration of AFM with different spectroscopic and imaging approaches provides an enhanced level of information on the investigated sample. Furthermore, the AFM itself can serve as an active tool for the assembly of nanostructures based on bioconjugation. AFM is hence a major workhorse in nanotechnology; it is a powerful tool for the structural investigation of bioconjugation and bioconjugation-induced effects as well as the simultaneous active assembly and analysis of bioconjugation-based nanostructures.
KW  - nanorobot
KW  - biosensors
KW  - nanomedicine
KW  - nanolithography
KW  - nanoelectronics
KW  - bioconjugation
KW  - nanotechnology
KW  - atomic force microscopy (AFM)
KW  - DNA origami
KW  - single molecule
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-129477
VL  - 11
IS  - 25
ER  -