TY  - JOUR
A1  - Koenig, Sebastian
A1  - Wolf, Reinhard
A1  - Heisenberg, Martin
T1  - Visual Attention in Flies-Dopamine in the Mushroom Bodies Mediates the After-Effect of Cueing
JF  - PLoS ONE
N2  - Visual environments may simultaneously comprise stimuli of different significance. Often such stimuli require incompatible responses. Selective visual attention allows an animal to respond exclusively to the stimuli at a certain location in the visual field. In the process of establishing its focus of attention the animal can be influenced by external cues. Here we characterize the behavioral properties and neural mechanism of cueing in the fly Drosophila melanogaster. A cue can be attractive, repulsive or ineffective depending upon (e.g.) its visual properties and location in the visual field. Dopamine signaling in the brain is required to maintain the effect of cueing once the cue has disappeared. Raising or lowering dopamine at the synapse abolishes this after-effect. Specifically, dopamine is necessary and sufficient in the αβ-lobes of the mushroom bodies. Evidence is provided for an involvement of the αβ\(_{posterior}\) Kenyon cells.
KW  - dopamine transporters
KW  - Drosophila melanogaster
KW  - synapses
KW  - dopaminergics
KW  - dopamine
KW  - sensory cues
KW  - RNA interference
KW  - vision
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-179564
VL  - 11
IS  - 8
ER  -