TY  - JOUR
A1  - Shityakov, Sergey
A1  - Hayashi, Kentaro
A1  - Störk, Stefan
A1  - Scheper, Verena
A1  - Lenarz, Thomas
A1  - Förster, Carola Y.
T1  - The conspicuous link between ear, brain and heart − Could neurotrophin-treatment of age-related hearing loss help prevent Alzheimer's disease and associated amyloid cardiomyopathy?
JF  - Biomolecules
N2  - Alzheimer's disease (AD), the most common cause of dementia in the elderly, is a neurodegenerative disorder associated with neurovascular dysfunction and cognitive decline. While the deposition of amyloid β peptide (Aβ) and the formation of neurofibrillary tangles (NFTs) are the pathological hallmarks of AD-affected brains, the majority of cases exhibits a combination of comorbidities that ultimately lead to multi-organ failure. Of particular interest, it can be demonstrated that Aβ pathology is present in the hearts of patients with AD, while the formation of NFT in the auditory system can be detected much earlier than the onset of symptoms. Progressive hearing impairment may beget social isolation and accelerate cognitive decline and increase the risk of developing dementia. The current review discusses the concept of a brain–ear–heart axis by which Aβ and NFT inhibition could be achieved through targeted supplementation of neurotrophic factors to the cochlea and the brain. Such amyloid inhibition might also indirectly affect amyloid accumulation in the heart, thus reducing the risk of developing AD-associated amyloid cardiomyopathy and cardiovascular disease.
KW  - Alzheimer's disease
KW  - amyloid cardiomyopathy
KW  - heart failure
KW  - age-related hearing loss
KW  - neurotrophins
KW  - blood–brain barrier
KW  - blood–labyrinth barrier
KW  - spiral ganglion neuron
KW  - BDNF
KW  - GDNF
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-241084
SN  - 2218-273X
VL  - 11
IS  - 6
ER  -