TY  - THES
A1  - Kreczy, Dorothea
T1  - Untersuchung des in vivo Einwachsverhaltens von Zementgranulaten und -pasten aus resorbierbaren Calcium-dotierten Magnesiumphosphat-Phasen
T1  - Investigating the in vivo ingrowth behavior of cement granules and pastes from resorbable calcium-doped magnesium phosphate phases
N2  - In der vorliegenden Arbeit wurden unterschiedliche zementbasierte Knochenersatzmaterialien hinsichtlich ihres Potentials zur Behandlung knöcherner Defekte in vivo untersucht. Zwei verschiedene Calcium-dotierten Magnesiumphosphat Zementformulierungen (CMPC) wurden mit einem Referenzmaterial aus Calciumphosphat Zement (CPC) verglichen. Dazu wurden auf Basis von CMPC präfabrizierte, injizierbare Pasten bzw. sphärische Granulate hergestellt und anhand von orthotopen, potenziell kraftbelasteten Defekten in Kaninchenfemora getestet. Zentrales Ziel hierbei war es, herauszufinden, wie sich die Materialien in Defektsituationen mit Hartgewebekontakt biologisch verhalten und degradieren bzw. in Knochen umbauen. Nach einer Liegedauer von 6 bzw. 12 Wochen wurden die Knochenneubildung und die Degradation der Materialien mittels Histomorphometrie analysiert. 
Alle Materialien waren biokompatibel und führten zur Bildung von neuem Knochen. Der CMPC-Zement zeigte im Vergleich zu CPC einen beschleunigten Abbau, während sich am Referenzmaterial mehr mineralisierter Knochen bildete. Die untersuchten Calcium-dotierten Struvit-bildenden Magnesiumphosphatzemente erwiesen sich als biokompatibel, gut resorbierbar und stellen mit ihrer Fähigkeit zur Knochenbildung ein vielversprechendes Knochenersatzmaterial dar.
N2  - Two different bone replacement materials where tested for their in vivo bone regeneration capacity. Two different calcium-magnesia-phosphate cement (CMPC) formulations in form of premixed, injectable oil-based cement paste and granulates and a reference calcium-phosphate cement (CPC) cement were implanted into semi-load bearing femoral drill hole in rabbits.
After 6 or 12 weeks the implants were retrieved, and cement degradation and new bone formation was analyzed by histomorphometry. The result showed that all cements where biocompatible, triggered the formation of and were surrounded by new bone. The CMPC cement showed an accelerated degradation compared to CPC, while more new bone was built on the CPC materials. The calcium-doped magnesium phosphate cement materials exhibited regeneration of the host bone and demonstrated enhanced degradability in vivo, which makes them a promising bone replacement material.
KW  - Knochenzement
KW  - Knochenersatzmaterial
KW  - Magnesiumphosphate
KW  - Granulat
KW  - Paste
KW  - injizierbare Paste
KW  - präfabrizierte Paste
KW  - injectable paste
KW  - premixed paste
KW  - spherical granules
KW  - sphärische Granulate
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-205510
ER  - 
TY  - JOUR
A1  - Fuchs, Andreas
A1  - Kreczy, Dorothea
A1  - Brückner, Theresa
A1  - Gbureck, Uwe
A1  - Stahlhut, Philipp
A1  - Bengel, Melanie
A1  - Hoess, Andreas
A1  - Nies, Berthold
A1  - Bator, Julia
A1  - Klammert, Uwe
A1  - Linz, Christian
A1  - Ewald, Andrea
T1  - Bone regeneration capacity of newly developed spherical magnesium phosphate cement granules
JF  - Clinical Oral Investigations
N2  - Objectives
Magnesium phosphate-based cements begin to catch more attention as bone substitute materials and especially as alternatives for the more commonly used calcium phosphates. In bone substitutes for augmentation purposes, atraumatic materials with good biocompatibility and resorbability are favorable. In the current study, we describe the in vivo testing of novel bone augmentation materials in form of spherical granules based on a calcium-doped magnesium phosphate (CaMgP) cement.
Materials and Methods
Granules with diameters between 500 and 710 μm were fabricated via the emulsification of CaMgP cement pastes in a lipophilic liquid. As basic material, two different CaMgP formulations were used. The obtained granules were implanted into drill hole defects at the distal femoral condyle of 27 New Zealand white rabbits for 6 and 12 weeks. After explantation, the femora were examined via X-ray diffraction analysis, histological staining, radiological examination, and EDX measurement.
Results
Both granule types display excellent biocompatibility without any signs of inflammation and allow for proper bone healing without the interposition of connective tissue. CaMgP granules show a fast and continuous degradation and enable fully adequate bone regeneration.
Conclusions
Due to their biocompatibility, their degradation behavior, and their completely spherical morphology, these CaMgP granules present a promising bone substitute material for bone augmentation procedures, especially in sensitive areas.
Clinical Relevance
The mostly insufficient local bone supply after tooth extractions complicates prosthetic dental restoration or makes it even impossible. Therefore, bone augmentation procedures are oftentimes inevitable. Spherical CaMgP granules may represent a valuable bone replacement material in many situations.
KW  - implantation
KW  - calcium-magnesium phosphate cement
KW  - cement pastes
KW  - prefabricated granules
KW  - bone replacement material
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-268872
SN  - 1436-3771
VL  - 26
IS  - 3
ER  -