TY  - JOUR
A1  - Jung‐König, Mona
A1  - Füllenbach, Christoph
A1  - Murphy, Michael F.
A1  - Manzini, Paola
A1  - Laspina, Stefan
A1  - Pendry, Kate
A1  - Mühling, Jörg
A1  - Wikman, Agneta
A1  - Humbrecht, Catherine
A1  - Rigal, Jean‐Christophe
A1  - Lasocki, Sigismond
A1  - Folléa, Gilles
A1  - Seifried, Erhard
A1  - Müller, Markus M.
A1  - Geisen, Christof
A1  - Aranko, Kari
A1  - Zacharowski, Kai
A1  - Meybohm, Patrick
T1  - Programmes for the management of preoperative anaemia: audit in ten European hospitals within the PaBloE (Patient Blood Management in Europe) working group
JF  - Vox Sanguinis
N2  - Background and objectives
Preoperative anaemia is an independent risk factor for a higher morbidity and mortality, a longer hospitalization and increased perioperative transfusion rates. Managing preoperative anaemia is the first of three pillars of Patient Blood Management (PBM), a multidisciplinary concept to improve patient safety. While various studies provide medical information on (successful) anaemia treatment pathways, knowledge of organizational details of diagnosis and management of preoperative anaemia across Europe is scarce.

Materials and methods
To gain information on various aspects of preoperative anaemia management including organization, financing, diagnostics and treatment, we conducted a survey (74 questions) in ten hospitals from seven European nations within the PaBloE (Patient Blood Management in Europe) working group covering the year 2016.

Results
Organization and activity in the field of preoperative anaemia management were heterogeneous in the participating hospitals. Almost all hospitals had pathways for managing preoperative anaemia in place, however, only two nations had national guidelines. In six of the ten participating hospitals, preoperative anaemia management was organized by anaesthetists. Diagnostics and treatment focused on iron deficiency anaemia which, in most hospitals, was corrected with intravenous iron.

Conclusion
Implementation and approaches of preoperative anaemia management vary across Europe with a primary focus on treating iron deficiency anaemia. Findings of this survey motivated the hospitals involved to critically evaluate their practice and may also help other hospitals interested in PBM to develop action plans for diagnosis and management of preoperative anaemia.
KW  - iron deficiency
KW  - patient blood management
KW  - preoperative anaemia management
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-214049
VL  - 115
IS  - 3
SP  - 182
EP  - 191
ER  - 
TY  - JOUR
A1  - Fischer, Dania
A1  - Thies, Fabian
A1  - Awad, Omar
A1  - Brat, Camilla
A1  - Meybohm, Patrick
A1  - Baer, Patrick C.
A1  - Müller, Markus M.
A1  - Urbschat, Anja
A1  - Maier, Thorsten J.
A1  - Zacharowski, Kai
A1  - Roos, Jessica
T1  - Red blood cell-derived microparticles exert no cancer promoting effects on colorectal cancer cells in vitro
JF  - International Journal of Molecular Sciences
N2  - The biomedical consequences of allogeneic blood transfusions and the possible pathomechanisms of transfusion-related morbidity and mortality are still not entirely understood. In retrospective studies, allogeneic transfusion was associated with increased rates of cancer recurrence, metastasis and death in patients with colorectal cancer. However, correlation does not imply causation. The purpose of this study was to elucidate this empirical observation further in order to address insecurity among patients and clinicians. We focused on the in vitro effect of microparticles derived from red blood cell units (RMPs). We incubated different colon carcinoma cells with RMPs and analyzed their effects on growth, invasion, migration and tumor marker expression. Furthermore, effects on Wnt, Akt and ERK signaling were explored. Our results show RMPs do not seem to affect functional and phenotypic characteristics of different colon carcinoma cells and did not induce or inhibit Wnt, Akt or ERK signaling, albeit in cell culture models lacking tumor microenvironment. Allogeneic blood transfusions are associated with poor prognosis, but RMPs do not seem to convey tumor-enhancing effects. Most likely, the circumstances that necessitate the transfusion, such as preoperative anemia, tumor stage, perioperative blood loss and extension of surgery, take center stage.
KW  - transfusion
KW  - red blood cells
KW  - microparticles
KW  - colorectal carcinoma
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-286018
SN  - 1422-0067
VL  - 23
IS  - 16
ER  -