TY - JOUR A1 - Schlagenhauf, Ulrich A1 - Rehder, Juliane A1 - Gelbrich, Götz A1 - Jockel‐Schneider, Yvonne T1 - Consumption of Lactobacillus reuteri‐containing lozenges improves periodontal health in navy sailors at sea: A randomized controlled trial JF - Journal of Periodontology N2 - Background The objective of this trial was to evaluate whether the regular consumption of probiotics may improve the known deterioration of periodontal health in navy sailors during deployments at sea. Methods 72 healthy sailors of a naval ship on a practicing mission at sea were recruited and randomly provided with a blinded supply of lozenges to be consumed twice daily for the following 42 days containing either the probiotic strains Lactobacillus reuteri (DSM 17938 and L. reuteri (ATTC PTA 5289) (test n = 36) or no probiotics (placebo n = 36). At baseline, at day 14 and day 42 bleeding on probing (primary outcome), gingival index, plaque control record, probing attachment level, and probing pocket depth were assessed at the Ramfjord teeth. Results At baseline there were no significant differences between the groups. At day 14 and day 42 test group scores of all assessed parameters were significantly improved (P < 0.001) compared to baseline and to the placebo group which by contrast showed a significant (P < 0.001) deterioration of all parameters at the end of the study. Conclusions The consumption of probiotic L. reuteri‐lozenges is an efficacious measure to improve and maintain periodontal health in situations with waning efficacy of personal oral hygiene. KW - gingivitis KW - oral hygiene KW - probiotics Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-215577 VL - 91 IS - 10 SP - 1328 EP - 1338 ER - TY - JOUR A1 - Matern, Johannes A1 - Koch, Raphael A1 - Petersmann, Astrid A1 - Kocher, Thomas A1 - Eickholz, Peter A1 - Lorenz, Katrin A1 - Kim, Ti‐Sun A1 - Meyle, Jörg A1 - Kaner, Doğan A1 - Schlagenhauf, Ulrich A1 - Gravemeier, Martina A1 - Harks, Inga A1 - Ehmke, Benjamin T1 - Effect of periodontal therapy on adipokine biomarkers in overweight JF - Journal of Clinical Periodontology N2 - Aim The aim of this study was to evaluate the effect of non‐surgical periodontal therapy on circulating levels of the systemic inflammation‐associated biomarkers orosomucoid (ORM), high‐sensitivity C‐reactive protein (hsCRP), chemerin, and retinol‐binding protein 4 (RBP4) in overweight or normal‐weight patients with periodontitis at 27.5 months after therapy. Materials and methods This exploratory subanalysis includes patients from the ABPARO‐trial (ClinicalTrials.gov NCT00707369). The per‐protocol collective provided untreated periodontitis patients with high (≥28 kg/m\(^{2}\)) or moderate (21–24 kg/m\(^{2}\)) BMI. Out of the per‐protocol collective, 80 patients were randomly selected and stratified for BMI group, sex, and treatment group (antibiotics/placebo), resulting in 40 overweight and normal‐weight patients. Patients received non‐surgical periodontal therapy and maintenance at 3‐month intervals. Plasma samples from baseline and 27.5 months following initial treatment were used to measure the concentrations of ORM, hsCRP, chemerin, and RBP4. Results At the 27.5‐month examination, ORM and hsCRP decreased noticeably in the overweight group (ORM: p = .001, hsCRP: p = .004) and normal‐weight patients (ORM: p = .007, hsCRP: p < .001). Chemerin decreased in the overweight group (p = .048), and RBP4 concentrations remained stable. Conclusion Non‐surgical periodontal therapy reduced systemically elevated inflammation‐associated biomarkers in periodontitis patients. These improvements were more pronounced in overweight patients than in normal‐weight patients. KW - chemerin KW - orosomucoid KW - overweight KW - periodontitis KW - retinol‐binding protein 4 Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-215546 VL - 47 IS - 7 SP - 842 EP - 850 ER - TY - JOUR A1 - Dannewitz, Bettina A1 - Sommerer, Claudia A1 - Stölzel, Peggy A1 - Baid‐Agrawal, Seema A1 - Nadal, Jennifer A1 - Bärthlein, Barbara A1 - Wanner, Christoph A1 - Eckardt, Kai‐Uwe A1 - Zeier, Martin A1 - Schlagenhauf, Ulrich A1 - Krane, Vera A1 - Jockel‐Schneider, Yvonne T1 - Status of periodontal health in German patients suffering from chronic kidney disease—Data from the GCKD study JF - Journal of Clinical Periodontology N2 - Aim To assess the prevalence and severity of periodontitis in patients with moderate chronic kidney disease (CKD) and comparing the results with the self‐reported periodontitis awareness of the study subjects. Material and methods The periodontal status of 270 patients with moderate CKD randomly selected from a cohort of 5,217 subjects participating in the prospective observational German Chronic Kidney Disease (GCKD) project was analysed by recording bleeding on probing (BOP), probing pocket depth (PPD) and clinical attachment level (CAL). Furthermore, the awareness of the study subjects of their periodontal conditions was evaluated by a self‐reported questionnaire. Results 24.4% of the CKD study patients showed no or only mild signs of periodontal disease, 47.6% displayed moderate and 27% severe periodontitis. Questionnaire data revealed that 62.3% of the study subjects with severe periodontitis were not aware of the presence of the disease, 44.4% denied having received any systematic periodontal therapy so far, although 50% of them indicated to visit their dentist regularly for professional tooth cleanings. Conclusion While the clinical study data confirm an increased prevalence of periodontitis in CKD patients, their self‐reported awareness of periodontitis was low. KW - chronic kidney disease KW - observational cohort study KW - periodontitis KW - risk factors Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-217821 VL - 47 IS - 1 SP - 19 EP - 29 ER -