TY  - JOUR
A1  - Vendelova, Emilia
A1  - Ashour, Diyaaeldin
A1  - Blank, Patrick
A1  - Erhard, Florian
A1  - Saliba, Antoine-Emmanuel
A1  - Kalinke, Ulrich
A1  - Lutz, Manfred B.
T1  - Tolerogenic transcriptional signatures of steady-state and pathogen-induced dendritic cells
JF  - Frontiers in Immunology
N2  - Dendritic cells (DCs) are key directors of tolerogenic and immunogenic immune responses. During the steady state, DCs maintain T cell tolerance to self-antigens by multiple mechanisms including inducing anergy, deletion, and Treg activity. All of these mechanisms help to prevent autoimmune diseases or other hyperreactivities. Different DC subsets contribute to pathogen recognition by expression of different subsets of pattern recognition receptors, including Toll-like receptors or C-type lectins. In addition to the triggering of immune responses in infected hosts, most pathogens have evolved mechanisms for evasion of targeted responses. One such strategy is characterized by adopting the host's T cell tolerance mechanisms. Understanding these tolerogenic mechanisms is of utmost importance for therapeutic approaches to treat immune pathologies, tumors and infections. Transcriptional profiling has developed into a potent tool for DC subset identification. Here, we review and compile pathogen-induced tolerogenic transcriptional signatures from mRNA profiling data of currently available bacterial- or helminth-induced transcriptional signatures. We compare them with signatures of tolerogenic steady-state DC subtypes to identify common and divergent strategies of pathogen induced immune evasion. Candidate molecules are discussed in detail. Our analysis provides further insights into tolerogenic DC signatures and their exploitation by different pathogens.
KW  - bacteria
KW  - helminths
KW  - immune evasion
KW  - mycobacteria
KW  - transcriptional profiling
KW  - tolerogenic dendritic cells
KW  - steady-state dendritic cells
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-175636
VL  - 9
IS  - 333
ER  - 
TY  - GEN
A1  - Tort, Jose F.
A1  - Mitreva, Makedonka
A1  - Brehm, Klaus R.
A1  - Rinaldi, Gabriel
T1  - Editorial: Novel Frontiers in Helminth Genomics
T2  - Frontiers in Genetics
N2  - No abstract available.
KW  - flatworm
KW  - nematodes
KW  - genomics
KW  - helminths
KW  - neglected diseases
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-210209
SN  - 1664-8021
VL  - 11
IS  - 791
ER  - 
TY  - JOUR
A1  - Ntoukas, Vasileios
A1  - Tappe, Dennis
A1  - Pfütze, Daniel
A1  - Simon, Michaela
A1  - Holzmann, Thomas
T1  - Cerebellar Cysticercosis Caused by Larval Taenia crassiceps Tapeworm in Immunocompetent Woman, Germany
JF  - Emerging Infectious Diseases
N2  - Human cysticercosis caused by Taenia crassiceps tapeworm larvae involves the muscles and subcutis mostly in immunocompromised patients and the eye in immunocompetent persons. We report a successfully treated cerebellar infection in an immunocompetent woman. We developed serologic tests, and the parasite was identified by histologic examination and 12s rDNA PCR and sequencing.
KW  - helminths
KW  - acquired immunodeficiency-syndrome
KW  - foxes vulpes-vulpes
KW  - invasive cysticerocsis
KW  - infection
KW  - patient
KW  - AIDS
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-131686
N1  - Public Domain
VL  - 19
IS  - 12
ER  -