TY  - JOUR
A1  - Winter, Anna
A1  - Schulz, Stefan M.
A1  - Schmitter, Marc
A1  - Brands, Roman C.
A1  - Straub, Anton
A1  - Kübler, Alexander
A1  - Borgmann, Anna
A1  - Hartmann, Stefan
T1  - Oral-health-related quality of life in patients with medication-related osteonecrosis of the jaw: a prospective clinical study
JF  - International Journal of Environmental Research and Public Health
N2  - Medication-related osteonecrosis of the jaw (MRONJ) represents an adverse side effect of antiresorptive and antiangiogenic medications. It is associated with impaired quality of life, oral health, and oral function and can be classified into various stages. The purpose of this prospective clinical study is to evaluate the impact of stages I and II MRONJ on oral-health-related quality of life (OHRQoL) and related parameters. Patients’ OHRQoL, satisfaction with life, oral discomfort, and oral health were assessed using the German version of the Oral Health Impact Profile (OHIP-G49), visual analog scales (VAS), and Satisfaction with Life Scale (SWLS) at baseline (T0), 10 days (T1), and 3 months after treatment (T2) in 36 patients. Data were analyzed using Kolmogorov–Smirnov test, two-way mixed ANOVAs, and follow-up Mann–Whitney U tests. The impact of treatment effects on the original seven OHIP domain structures and the recently introduced four-dimensional OHIP structure were evaluated using linear regression analysis. Thirty-six patients received surgical MRONJ treatment. Before treatment, patients’ perceived OHRQoL, oral discomfort, oral health, and satisfaction with life were negatively affected by MRONJ. Surgical treatment significantly improved OHRQoL and related parameters (all p ≤ 0.012). This improvement was greater in patients with higher impairment at T0. OHRQoL and oral restrictions were still impaired after treatment in patients who needed prosthetic treatment. The four-dimensional structure revealed valuable information beyond the standard seven OHIP domains. Increased awareness of MRONJ risks and an interdisciplinary treatment approach for MRONJ patients are needed.
KW  - oral-health-related quality of life
KW  - satisfaction with life
KW  - oral health
KW  - medication-related osteonecrosis of the jaw
KW  - treatment benefit
KW  - OHIP-49
KW  - SWLS
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-288141
SN  - 1660-4601
VL  - 19
IS  - 18
ER  - 
TY  - JOUR
A1  - Straub, Anton
A1  - Brands, Roman
A1  - Borgmann, Anna
A1  - Vollmer, Andreas
A1  - Hohm, Julian
A1  - Linz, Christian
A1  - Müller-Richter, Urs
A1  - Kübler, Alexander C.
A1  - Hartmann, Stefan
T1  - Free skin grafting to reconstruct donor sites after radial forearm flap harvesting: a prospective study with platelet-rich fibrin (PRF)
JF  - Journal of Clinical Medicine
N2  - Reconstruction of the donor site after radial forearm flap harvesting is a common procedure in maxillofacial plastic surgery. It is normally carried out with split-thickness or full-thickness free skin grafts. Unfortunately, free skin graft transplantation faces wound healing impairments such as necrosis, (partial) graft loss, or tendon exposure. Several studies have investigated methods to reduce these impairments and demonstrated improvements if the wound bed is optimised, for example, through negative-pressure wound therapy or vacuum-assisted closure. However, these methods are device-dependent, expansive, and time-consuming. Therefore, the application of platelet-rich fibrin (PRF) to the wound bed could be a simple, cost-effective, and device-independent method to optimise wound-bed conditions instead. In this study, PRF membranes were applied between the wound bed and skin graft. Results of this study indicate improvements in the PRF versus non-PRF group (93.44% versus 86.96% graft survival, p = 0.0292). PRF applied to the wound bed increases graft survival and reduces impairments. A possible explanation for this is the release of growth factors, which stimulate angiogenesis and fibroblast migration. Furthermore, the solid PRF membranes act as a mechanical barrier (“lubrication” layer) to protect the skin graft from tendon motion. The results of this study support the application of PRF in donor-site reconstruction with free skin grafts.
KW  - platelet-rich fibrin
KW  - free skin grafts
KW  - radial forearm flap
KW  - donor-site morbidity
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-278854
SN  - 2077-0383
VL  - 11
IS  - 12
ER  -