TY  - THES
A1  - Wolfschmidt, Franziska
T1  - Radio- und/oder Chemotherapie-induzierte Ototoxizität bei Kindern mit Medulloblastom im Alter von 4 bis 21 Jahren, die im Rahmen der Studie HIT 2000 - AB 4 mit postoperativer normofraktionierter bzw. hyperfraktionierter Bestrahlung und anschließender Erhaltungschemotherapie behandelt wurden
T1  - Radiation and/or Chemotherapy induced Ototoxicity in Children with Medulloblastoma
N2  - Radio- und/oder Chemotherapie-induzierte Ototoxizität bei Kindern mit Medulloblastom im Alter von 4 bis 21 Jahren, die im Rahmen der Studie HIT 2000 – AB 4 mit postoperativer normofraktionierter bzw. hyperfraktionierter Bestrahlung und anschließender Erhaltungschemotherapie behandelt wurden.
N2  - Radiation and/or chemotherapy induced ototoxicity in children with medulloblastoma aged 4 to 21 years treated within the study HIT 2000 - AB 4 with postoperative normofractionated or hyperfractionated radiation and following maintenance chemotherapy.
KW  - Ototoxizität
KW  - Cisplatin
KW  - Ototoxizität
KW  - Cisplatin
KW  - Medulloblastom
KW  - HIT
KW  - Hörverlust
KW  - Radiotherapie
KW  - Ototoxicity
KW  - Medulloblastoma
KW  - Radiotherapy
KW  - HIT
KW  - Hearing Impairment
KW  - Cisplatin
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-73144
ER  - 
TY  - JOUR
A1  - Augustin, Anne Marie
A1  - Wolfschmidt, Franziska
A1  - Elsässer, Thilo
A1  - Sauer, Alexander
A1  - Dierks, Alexander
A1  - Bley, Thorsten Alexander
A1  - Kickuth, Ralph
T1  - Color-coded summation images for the evaluation of blood flow in endovascular aortic dissection fenestration
JF  - BMC Medical Imaging
N2  - Background
To analyze the benefit of color-coded summation images in the assessment of target lumen perfusion in patients with aortic dissection and malperfusion syndrome before and after fluoroscopy-guided aortic fenestration.

Methods
Between December 2011 and April 2020 25 patients with Stanford type A (n = 13) or type B dissection (n = 12) and malperfusion syndromes were treated with fluoroscopy-guided fenestration of the dissection flap using a re-entry catheter. The procedure was technically successful in 100% of the cases and included additional iliofemoral stent implantation in four patients. Intraprocedural systolic blood pressure measurements for gradient evaluation were performed in 19 cases. Post-processed color-coded DSA images were obtained from all DSA series before and following fenestration. Differences in time to peak (dTTP) values in the compromised aortic lumen and transluminal systolic blood pressure gradients were analyzed retrospectively. Correlation analysis between dTTP and changes in blood pressure gradients was performed.

Results
Mean TTP prior to dissection flap fenestration was 6.85 ± 1.35 s. After fenestration, mean TTP decreased significantly to 4.96 ± 0.94 s (p < 0.001). Available systolic blood pressure gradients between the true and the false lumen were reduced by a median of 4.0 mmHg following fenestration (p = 0.031), with significant reductions in Stanford type B dissections (p = 0.013) and minor reductions in type A dissections (p = 0.530). A moderate correlation with no statistical significance was found between dTTP and the difference in systolic blood pressure (r = 0.226; p = 0.351).

Conclusions
Hemodynamic parameters obtained from color-coded DSA confirmed a significant reduction of TTP values in the aortic target lumen in terms of an improved perfusion in the compromised aortic region. Color-coded DSA might thus be a suitable complementary tool in the assessment of complex vascular patterns prevailing in aortic dissections, especially when blood pressure measurements are not conclusive or feasible.
KW  - angiography
KW  - fenestration
KW  - color-coding
KW  - aortic dissection
KW  - DSA
KW  - endovascular
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-301107
VL  - 22
IS  - 1
ER  -