TY  - JOUR
A1  - Miralles, Felip
A1  - Vargiu, Eloisa
A1  - Dauwalder, Stefan
A1  - Solà, Marc
A1  - Müller-Putz, Gernot
A1  - Wriessnegger, Selina C.
A1  - Pinegger, Andreas
A1  - Kübler, Andrea
A1  - Halder, Sebastian
A1  - Käthner, Ivo
A1  - Martin, Suzanne
A1  - Daly, Jean
A1  - Armstrong, Elaine
A1  - Guger, Christoph
A1  - Hintermüller, Christoph
A1  - Lowish, Hannah
T1  - Brain computer interface on track to home.
JF  - The Scientific World Journal
N2  - The novel BackHome system offers individuals with disabilities a range of useful services available via brain-computer interfaces (BCIs), to help restore their independence. This is the time such technology is ready to be deployed in the real world, that is, at the target end users’ home. This has been achieved by the development of practical electrodes, easy to use software, and delivering telemonitoring and home support capabilities which have been conceived, implemented, and tested within a user-centred design approach. The final BackHome system is the result of a 3-year long process involving extensive user engagement to maximize effectiveness, reliability, robustness, and ease of use of a home based BCI system. The system is comprised of ergonomic and hassle-free BCI equipment; one-click software services for Smart Home control, cognitive stimulation, and web browsing; and remote telemonitoring and home support tools to enable independent home use for nonexpert caregivers and users. BackHome aims to successfully bring BCIs to the home of people with limited mobility to restore their independence and ultimately improve their quality of life.
KW  - brain computer interface
KW  - disability
KW  - limited mobility
KW  - independence
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-149575
VL  - 2015
IS  - 623896
ER  - 
TY  - JOUR
A1  - Rovituso, Damiano M.
A1  - Duffy, Catharina E.
A1  - Schroeter, Michael
A1  - Kaiser, Claudia C.
A1  - Kleinschnitz, Christoph
A1  - Bayas, Antonios
A1  - Elsner, Rebecca
A1  - Kuerten, Stefanie
T1  - The brain antigen-specific B cell response correlates with glatiramer acetate responsiveness in relapsing-remitting multiple sclerosis patients
JF  - Scientific Reports
N2  - B cells have only recently begun to attract attention in the immunopathology of multiple sclerosis (MS). Suitable markers for the prediction of treatment success with immunomodulatory drugs are still missing. Here we evaluated the B cell response to brain antigens in n = 34 relapsing-remitting MS (RRMS) patients treated with glatiramer acetate (GA) using the enzyme-linked immunospot technique (ELISPOT). Our data demonstrate that patients can be subdivided into responders that show brain-specific B cell reactivity in the blood and patients without this reactivity. Only in patients that classified as B cell responders, there was a significant positive correlation between treatment duration and the time since last relapse in our study. This correlation was GA-specific because it was absent in a control group that consisted of interferon-\(\beta\) (IFN-\(\beta\))-treated RRMS patients (n = 23). These data suggest that GA has an effect on brain-reactive B cells in a subset of patients and that only this subset benefits from treatment. The detection of brain-reactive B cells is likely to be a suitable tool to identify drug responders.
KW  - cortical pathology
KW  - natural history
KW  - disability
KW  - expression
KW  - antibodies
KW  - disease
KW  - lesions
KW  - trial
KW  - multiple sclerosis
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-148172
VL  - 5
IS  - 14265
ER  -