TY  - CHAP
A1  - Toepfer, Regina
T1  - Antike Historiographie im deutschen Südwesten: Das Übersetzungswerk Hieronymus Boners
T2  - Humanismus im deutschen Südwesten: Akten des gemeinsam mit dem Verein für Kunst und Altertum in Ulm und Oberschwaben und dem Stadtarchiv-Haus der Stadtgeschichte Ulm am 25./26. Oktober 2013 veranstalteten Symposions im Schwörhaus Ulm
N2  - Die Druckerstädte im deutschen Südwesten, allen voran Augsburg und Straßburg, leisteten einen entscheidenden Beitrag bei der Erschließung antiker Literatur für lateinunkundige Leser. Einer der produktivsten Autoren war Hieronymus Boner, der zahlreiche historiographische Werke des Altertums übersetzte. Der Beitrag untersucht Boners Geschichtsverständnis und seinen Übersetzungsstil, um daraus grundlegende Schlussfolgerungen für das Verhältnis von Volkssprache und Humanismus abzuleiten. Das Beispiel einer übersetzten Episode aus dem ersten Buch von Herodots ‚Historien‘ zeigt, wie die Beschäftigung mit antiken Klassikern zur Ausbildung einer frühneuhochdeutschen Literatur und Literatursprache beitrug. Weil Boners Übersetzungswerk sich sowohl von freieren mittelalterlichen Adaptationen als auch von modernen philologischen Editionen unterscheidet, wird sein Verfahren als erzählendes Übersetzen charakterisiert.
KW  - Übersetzung
KW  - Volkssprache
KW  - Poetologie
KW  - Antikenrezeption
KW  - Südwestdeutschland
KW  - Humanismus
KW  - Boner, Hieronymus
KW  - Geschichtsschreibung
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-303261
SN  - 978-3-447-10344-2
PB  - Harrassowitz Verlag
CY  - Wiesbaden
ER  - 
TY  - CHAP
A1  - Toepfer, Regina
T1  - ‚So voll Zorns / daß alle vernunfft vom ihm schied.’: Handlungsmotivation und Tragikkonzept in der ‚Melusine’ des Thüring von Ringoltingen.
T2  - Tragik vor der Moderne: Literaturwissenschaftliche Analyse.
N2  - Mittels der basalen narratologischen Kategorie der Handlungsmotivierung wird gezeigt, inwiefern sich antike Tragödientheorien und das moderne Tragikverständnis unterscheiden. Während Aristoteles und Seneca den Sturz ins Unglück kausal begründen und dem Helden selbst die Verantwortung zuschreiben, ist die Katastrophe bei Hegel, aber auch schon bei Boethius final motiviert und kann nicht verhindert werden. Wie verschiedene Erklärungsansätze innerhalb eines frühneuhochdeutschen Prosaromans miteinander konkurrieren, beleuchtet die Autorin an der ‘Melusine’ des Thüring von Ringoltingen. Wird das Unglück der Protagonisten auf das Strukturschema der gestörten Mahrtenehe oder einen Plan Gottes zurückgeführt, erscheint die Handlung final motiviert. Die reuevollen Klagen des Ehemanns, der einen Tabubruch begangen hat und sich selbst eines Fehlverhaltens bezichtigt, weisen jedoch in eine andere Richtung. Vor allem die paradigmatischen Bezüge zu anderen Normverstößen belegen, dass Thüring von Ringoltingen das Unglück hauptsächlich kausal erklärt und wie Seneca auf den Affekt des Zorns zurückführt.
KW  - Prosaroman
KW  - Affekt
KW  - Tabu
KW  - Narratologie
KW  - Tragik
KW  - Zorn <Motiv>
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-299188
SN  - 978-3-8253-6309-3
PB  - Universitätsverlag Winter
CY  - Heidelberg
ER  - 
TY  - JOUR
A1  - Toepfer, Regina
T1  - Mediävistik für das 21. Jahrhundert: Die App ‚Frankfurt im Mittelalter. Auf den Spuren des Passionsspiels von 1492‘ aus fachwissenschaftlicher Perspektive
JF  - Zeitschrift für deutsches Altertum und deutsche Literatur
N2  - Der Beitrag stellt das didaktische Konzept und das digitale Produkt eines mediävistischen Lehrprojekts der Goethe-Universität Frankfurt vor. In einem auf zwei Semester angelegten ‚Schreibforschungsseminar‘ setzten sich Studierende wissenschaftlich mit der lokalen Spieltradition im späten Mittelalter auseinander und entwickelten einen Stadtrundgang in zwölf Stationen für eine App, die Geschichten rund um das ‚Frankfurter Passionsspiels‘ von 1493 erzählt. Was bei der Vermittlung fachspezifischer Inhalte an ein fachfremdes Publikum zu beachten ist, wird thematisiert und an der Hörstation zur Frankfurter Nikolaikirche ‚Die Ratsherren und das Letzte Abendmahl‘ exemplarisch vorgeführt.
KW  - Frankfurter Passionsspiel
KW  - Lehrprojekt
KW  - Mittelalterdidaktik
KW  - Schreibdidaktik
KW  - Mediävistik
KW  - App
KW  - Didaktik
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-298447
UR  - https://www.hirzel.de/brand/ZfdA
SN  - 0044-2518
VL  - 144
IS  - 2
PB  - S. Hirzel
CY  - Stuttgart
ER  - 
TY  - CHAP
A1  - Kraft, Stephan
T1  - Auswege aus der Gewissensfalle? : zu August von Kotzebues "Menschenhaß und Reue" und seinem Folgestück "Die edle Lüge"
T2  - Gewissen
N2  - Kein Abstract verfügbar.
KW  - Kotzebue, August von / Menschenhaß und Reue
KW  - Kotzebue, August von / Die edle Lüge
KW  - Gewissen <Motiv>
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-282543
PB  - Könighausen&Neumann
CY  - Würzburg
ER  - 
TY  - JOUR
A1  - Bauer, Boris
A1  - Goebeler, Matthias
A1  - Weissbrich, Benedikt
A1  - Kerstan, Andreas
T1  - Kerinokeratosis papulosa of childhood
JF  - Dermatology
N2  - Background: Kerinokeratosis papulosa (KP) is considered an extremely rare genodermatosis presenting usually as waxy papules on the trunk in childhood. 
Objective: To describe and analyze the clinical, histological and potential etiopathological aspects of KP. 
Methods: The dermatoscopic features of a new case of KP of childhood are investigated. The presence of human papillomavirus (HPV) DNA in lesional skin was studied by polymerase chain reaction. Furthermore, all cases of KP of childhood reported so far were reviewed. 
Results: As a diagnostic tool, we describe for the first time a dermatoscopic feature, namely a cribriform pattern of KP, in an 11-year-old boy. In addition, we detected HPV (type 57) in his KP lesions. 
Conclusions: Dermatoscopic examination might be a useful tool to distinguish KP from other skin lesions, e.g. common warts. The detection of HPV type 57 might hint to an etiological role of HPV for KP.
KW  - Waxy papulosis of childhood
KW  - Human papillomavirus
KW  - EVER1
KW  - EVER2
KW  - Kerinokeratosis papulosa
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-198997
SN  - 1018-8665
SN  - 1421-9832
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 231
IS  - 1
SP  - 1
EP  - 4
ER  - 
TY  - CHAP
A1  - Kraft, Stephan
T1  - Ein Fürst, ein Philosoph und ein Roman. Herzog Anton Ulrich und Gottfried Wilhelm Leibniz im Gespräch über »Die Römische Octavia«
T2  - ossa leibnitii. 10. und 11. Leibniz-Festtage 2013/2014
N2  - Kein Abstract verfügbar.
KW  - Anton Ulrich, Braunschweig-Lüneburg, Herzog
KW  - Leibniz, Gottfried Wilhelm
KW  - Anton Ulrich, Braunschweig-Lüneburg, Herzog / Octavia
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-257910
ER  - 
TY  - CHAP
A1  - Kraft, Stephan
T1  - "So ahm den Griechen nach. Der Griech‘ erfand!". Reflexionen über eine Nachfolge Arno Schmidts bei Uwe Timm und Georg Klein
T2  - Arno Schmidt und der Kanon
N2  - Kein Abstract verfügbar.
KW  - Timm, Uwe / Freitisch
KW  - Klein, Georg / Chicago / Baracken
KW  - Klein, Georg / Arbeit am Blasator
KW  - Rezeption
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-257739
PB  - text + kritik
CY  - München
ER  - 
TY  - JOUR
A1  - Hochleitner, Gernot
A1  - Jüngst, Tomasz
A1  - Brown, Toby D
A1  - Hahn, Kathrin
A1  - Moseke, Claus
A1  - Jakob, Franz
A1  - Dalton, Paul D
A1  - Groll, Jürgen
T1  - Additive manufacturing of scaffolds with sub-micron filaments via melt electrospinning writing
JF  - Biofabrication
N2  - The aim of this study was to explore the lower resolution limits of an electrohydrodynamic process combined with direct writing technology of polymer melts. Termed melt electrospinning writing, filaments are deposited layer-by-layer to produce discrete three-dimensional scaffolds for in vitro research. Through optimization of the parameters (flow rate, spinneret diameter, voltage, collector distance) for poly-ϵ-caprolactone, we could direct-write coherent scaffolds with ultrafine filaments, the smallest being 817 ± 165 nm. These low diameter filaments were deposited to form box-structures with a periodicity of 100.6 ± 5.1 μm and a height of 80 μm (50 stacked filaments; 100 overlap at intersections). We also observed oriented crystalline regions within such ultrafine filaments after annealing at 55 °C. The scaffolds were printed upon NCO-sP(EO-stat-PO)-coated glass slide surfaces and withstood frequent liquid exchanges with negligible scaffold detachment for at least 10 days in vitro.
KW  - additive manufacturing
KW  - 3D printing
KW  - biodegradable polymers
KW  - microstructures
KW  - nanostructures
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-254053
VL  - 7
IS  - 3
ER  - 
TY  - JOUR
A1  - Hinderer, Svenja
A1  - Shen, Nian
A1  - Ringuette, Léa-Jeanne
A1  - Hansmann, Jan
A1  - Reinhardt, Dieter P
A1  - Brucker, Sara Y
A1  - Davis, Elaine C
A1  - Schenke-Layland, Katja
T1  - In vitro elastogenesis: instructing human vascular smooth muscle cells to generate an elastic fiber-containing extracellular matrix scaffold
JF  - Biomedical Materials
N2  - Elastic fibers are essential for the proper function of organs including cardiovascular tissues such as heart valves and blood vessels. Although (tropo)elastin production in a tissue-engineered construct has previously been described, the assembly to functional elastic fibers in vitro using human cells has been highly challenging. In the present study, we seeded primary isolated human vascular smooth muscle cells (VSMCs) onto 3D electrospun scaffolds and exposed them to defined laminar shear stress using a customized bioreactor system. Increased elastin expression followed by elastin deposition onto the electrospun scaffolds, as well as on newly formed fibers, was observed after six days. Most interestingly, we identified the successful deposition of elastogenesis-associated proteins, including fibrillin-1 and -2, fibulin-4 and -5, fibronectin, elastin microfibril interface located protein 1 (EMILIN-1) and lysyl oxidase (LOX) within our engineered constructs. Ultrastructural analyses revealed a developing extracellular matrix (ECM) similar to native human fetal tissue, which is composed of collagens, microfibrils and elastin. To conclude, the combination of a novel dynamic flow bioreactor and an electrospun hybrid polymer scaffold allowed the production and assembly of an elastic fiber-containing ECM.
KW  - elastin
KW  - elastic fibers
KW  - electrospinning
KW  - tissue engineering
KW  - regenerative medicine
KW  - heart valve
KW  - cardiovascular
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-254074
VL  - 10
IS  - 3
ER  - 
TY  - CHAP
A1  - Kraft, Stephan
T1  - Benn, Oelze und das Dritte Reich : zum Oelzebriefwechsel im Nationalsozialismus
T2  - Benn-Forum. Beiträge zur literarischen Moderne
N2  - Kein Abstract verfügbar.
KW  - Benn, Gottfried
KW  - Oelze, Friedrich Wilhelm
KW  - Briefwechsel
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-252887
VL  - 4 (2014/2015)
ER  - 
TY  - JOUR
A1  - Staffeldt, Sven
T1  - Rezension: Rolf, Eckard. 2013. Inferentielle Pragmatik. Zur Theorie der Sprecher-Bedeutung. Berlin: Erich Schmidt Verlag. 209 S., 29,80 €, ISBN 978-3-503-13754-1
JF  - Zeitschrift für Angewandte Linguistik
N2  - No abstract available.
KW  - Rezension
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-193340
SN  - 2190-0191
SN  - 1433-9889
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 62
IS  - 1
ER  - 
TY  - JOUR
A1  - Altenburger, Roland
T1  - Cao, Juan: In der Sackgasse oder auf dem Weg zu einem neuen Paradigma? Die Erforschung des Romans Der Traum der roten Kammer (Rotologie) im 21. Jahrhundert (Lun Wen: Studien zur Geistesgeschichte und Literatur in China; 17). Wiesbaden: Harrassowitz Verlag, 2013. XII, 256 S. ISBN 978-3-447-06992-2
JF  - Asiatische Studien - Études Asiatiques
N2  - No abstract available.
KW  - Rezension
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-193941
SN  - 0004-4717
SN  - 2235-5871
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 69
IS  - 1
ER  - 
TY  - JOUR
A1  - Matsuda, Yoichi
A1  - Uno, Yoshinobu
A1  - Kondo, Mariko
A1  - Gilchrist, Michael J.
A1  - Zorn, Aaron M.
A1  - Rokhsar, Daniel S.
A1  - Schmid, Michael
A1  - Taira, Masanori
T1  - A New Nomenclature of Xenopus laevis Chromosomes Based on the Phylogenetic Relationship to Silurana/Xenopus tropicalis
JF  - Cytogenetic and Genome Research
N2  - Xenopus laevis (XLA) is an allotetraploid species which appears to have undergone whole-genome duplication after the interspecific hybridization of 2 diploid species closely related to Silurana/Xenopus tropicalis (XTR). Previous cDNA fluorescence in situ hybridization (FISH) experiments have identified 9 sets of homoeologous chromosomes in X. laevis, in which 8 sets correspond to chromosomes 1-8 of X. tropicalis (XTR1-XTR8), and the last set corresponds to a fusion of XTR9 and XTR10. In addition, recent X. laevis genome sequencing and BAC-FISH experiments support this physiological relationship and show no gross chromosome translocation in the X. laevis karyotype. Therefore, for the benefit of both comparative cytogenetics and genome research, we here propose a new chromosome nomenclature for X. laevis based on the phylogenetic relationship and chromosome length, i.e. XLA1L, XLA1S, XLA2L, XLA2S, and so on, in which the numbering of XLA chromosomes corresponds to that in X. tropicalis and the postfixes ‘L' and ‘S' stand for ‘long' and ‘short' chromosomes in the homoeologous pairs, which can be distinguished cytologically by their relative size. The last chromosome set is named XLA9L and XLA9S, in which XLA9 corresponds to both XTR9 and XTR10, and hence, to emphasize the phylogenetic relationship to X. tropicalis, XLA9_10L and XLA9_10S are also used as synonyms.
KW  - BrdU replication banding pattern
KW  - homoeologous chromosomes
KW  - nomenclature
KW  - Xenopus laevis
KW  - Xenopus tropicalis
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196748
SN  - 1424-8581
SN  - 1424-859X
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 145
IS  - 3-4
ER  - 
TY  - JOUR
A1  - Schmid, Michael
A1  - Evans, Ben J.
A1  - Bogart, James P.
T1  - Polyploidy in Amphibia
JF  - Cytogenetic and Genome Research
N2  - This review summarizes the current status of the known extant genuine polyploid anuran and urodelan species, as well as spontaneously originated and/or experimentally produced amphibian polyploids. The mechanisms by which polyploids can originate, the meiotic pairing configurations, the diploidization processes operating in polyploid genomes, the phenomenon of hybridogenesis, and the relationship between polyploidization and sex chromosome evolution are discussed. The polyploid systems in some important amphibian taxa are described in more detail.
KW  - allopolyploidy
KW  - Anura
KW  - autopolyploidy
KW  - diploidization
KW  - hybridogenesis
KW  - polyploidization
KW  - sex chromosome evolution
KW  - Urodela
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196730
SN  - 1424-8581
SN  - 1424-859X
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 145
IS  - 3-4
ER  - 
TY  - JOUR
A1  - Schmid, Michael
A1  - Steinlein, Claus
T1  - Chromosome Banding in Amphibia. XXXII. The Genus Xenopus (Anura, Pipidae)
JF  - Cytogenetic and Genome Research
N2  - Mitotic chromosomes of 16 species of the frog genus Xenopus were prepared from kidney and lung cell cultures. In the chromosomes of 7 species, high-resolution replication banding patterns could be induced by treating the cultures with 5-bromodeoxyuridine (BrdU) and deoxythymidine (dT) in succession, and in 6 of these species the BrdU/dT-banded chromosomes could be arranged into karyotypes. In the 3 species of the clade with 2n = 20 and 4n = 40 chromosomes (X. tropicalis, X. epitropicalis, X. new tetraploid 1), as well as in the 3 species with 4n = 36 chromosomes (X. laevis, X. borealis, X. muelleri), the BrdU/dT-banded karyotypes show a high degree of homoeology, though differences were detected between these groups. Translocations, inversions, insertions or sex-specific replication bands were not observed. Minor replication asynchronies found between chromosomes probably involve heterochromatic regions. BrdU/dT replication banding of Xenopus chromosomes provides the landmarks necessary for the exact physical mapping of genes and repetitive sequences. FISH with an X. laevis 5S rDNA probe detected multiple hybridization sites at or near the long-arm telomeric regions in most chromosomes of X. laevis and X. borealis, whereas in X. muelleri, the 5S rDNA sequences are located exclusively at the long-arm telomeres of a single chromosome pair. Staining with the AT base pair-specific fluorochrome quinacrine mustard revealed brightly fluorescing heterochromatic regions in the majority of X. borealis chromosomes which are absent in other Xenopus species.
KW  - X. laevis-type karyotype
KW  - X. tropicalis-type karyotype
KW  - BrdU/dT replication banding
KW  - chromosome staining
KW  - FISH
KW  - polyploidy
KW  - Xenopus
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196727
SN  - 1424-8581
SN  - 1424-859X
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 145
IS  - 3-4
ER  - 
TY  - JOUR
A1  - Poot, Martin
A1  - Haaf, Thomas
T1  - Mechanisms of Origin, Phenotypic Effects and Diagnostic Implications of Complex Chromosome Rearrangements
JF  - Molecular Syndromology
N2  - Complex chromosome rearrangements (CCRs) are currently defined as structural genome variations that involve more than 2 chromosome breaks and result in exchanges of chromosomal segments. They are thought to be extremely rare, but their detection rate is rising because of improvements in molecular cytogenetic technology. Their population frequency is also underestimated, since many CCRs may not elicit a phenotypic effect. CCRs may be the result of fork stalling and template switching, microhomology-mediated break-induced repair, breakage-fusion-bridge cycles, or chromothripsis. Patients with chromosomal instability syndromes show elevated rates of CCRs due to impaired DNA double-strand break responses during meiosis. Therefore, the putative functions of the proteins encoded by ATM, BLM, WRN, ATR, MRE11, NBS1, and RAD51 in preventing CCRs are discussed. CCRs may exert a pathogenic effect by either (1) gene dosage-dependent mechanisms, e.g. haploinsufficiency, (2) mechanisms based on disruption of the genomic architecture, such that genes, parts of genes or regulatory elements are truncated, fused or relocated and thus their interactions disturbed - these mechanisms will predominantly affect gene expression - or (3) mixed mutation mechanisms in which a CCR on one chromosome is combined with a different type of mutation on the other chromosome. Such inferred mechanisms of pathogenicity need corroboration by mRNA sequencing. Also, future studies with in vitro models, such as inducible pluripotent stem cells from patients with CCRs, and transgenic model organisms should substantiate current inferences regarding putative pathogenic effects of CCRs. The ramifications of the growing body of information on CCRs for clinical and experimental genetics and future treatment modalities are briefly illustrated with 2 cases, one of which suggests KDM4C(JMJD2C) as a novel candidate gene for mental retardation.
KW  - triplosufficiency
KW  - complex chromosome rearrangements
KW  - DNA double-strand break
KW  - haploinsufficiency
KW  - mixed mutation mechanisms
KW  - structural genome variations
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196524
SN  - 1661-8769
SN  - 1661-8777
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 6
IS  - 3
ER  - 
TY  - JOUR
A1  - Schneider, Eberhard
A1  - El Hajj, Nady
A1  - Müller, Fabian
A1  - Navarro, Bianca
A1  - Haaf, Thomas
T1  - Epigenetic Dysregulation in the Prefrontal Cortex of Suicide Completers
JF  - Cytogenetic and Genome Research
N2  - The epigenome is thought to mediate between genes and the environment, particularly in response to adverse life experiences. Similar to other psychiatric diseases, the suicide liability of an individual appears to be influenced by many genetic factors of small effect size as well as by environmental stressors. To identify epigenetic marks associated with suicide, which is considered the endpoint of complex gene-environment interactions, we compared the cortex DNA methylation patterns of 6 suicide completers versus 6 non-psychiatric sudden-death controls, using Illumina 450K methylation arrays. Consistent with a multifactorial disease model, we found DNA methylation changes in a large number of genes, but no changes with large effects reaching genome-wide significance. Global methylation of all analyzed CpG sites was significantly (0.25 percentage point) lower in suicide than in control brains, whereas the vast majority (97%) of the top 1,000 differentially methylated regions (DMRs) were higher methylated (0.6 percentage point) in suicide brains. Annotation analysis of the top 1,000 DMRs revealed an enrichment of differentially methylated promoters in functional categories associated with transcription and expression in the brain. In addition, we performed a comprehensive literature research to identify suicide genes that have been replicated in independent genetic association, brain methylation and/or expression studies. Although, in general, there was no significant overlap between different published data sets or between our top 1,000 DMRs and published data sets, our methylation screen strengthens a number of candidate genes (APLP2, BDNF, HTR1A, NUAK1, PHACTR3, MSMP, SLC6A4, SYN2, and SYNE2) and supports a role for epigenetics in the pathophysiology of suicide.
KW  - Cortex
KW  - DNA methylation
KW  - Suicidal behavior
KW  - Transcription regulation
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-199032
SN  - 1424-8581
SN  - 1424-859X
VL  - 146
IS  - 1
ER  - 
TY  - JOUR
A1  - Kolominsky-Rabas, Peter L.
A1  - Wiedmann, Silke
A1  - Weingärtner, Michael
A1  - Liman, Thomas G.
A1  - Endres, Matthias
A1  - Schwab, Stefan
A1  - Buchfelder, Michael
A1  - Heuschmann, Peter U.
T1  - Time Trends in Incidence of Pathological and Etiological Stroke Subtypes during 16 Years: The Erlangen Stroke Project
JF  - Neuroepidemiology
N2  - Background: Population-based data, which continuously monitors time trends in stroke epidemiology are limited. We investigated the incidence of pathological and etiological stroke subtypes over a 16 year time period. Methods: Data were collected within the Erlangen Stroke Project (ESPro), a prospective, population-based stroke register in Germany covering a total study population of 105,164 inhabitants (2010). Etiology of ischemic stroke was classified according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria. Results: Between January 1995 and December 2010, 3,243 patients with first-ever stroke were documented. The median age was 75 and 55% were females. The total stroke incidence decreased over the 16 year study period in men (Incidence Rate Ratio 1995-1996 vs. 2009-2010 (IRR) 0.78; 95% CI 0.58-0.90) but not in women. Among stroke subtypes, a decrease in ischemic stroke incidence (IRR 0.73; 95% CI 0.57-0.93) and of large artery atherosclerotic stroke (IRR 0.27; 95% CI 0.12-0.59) was found in men and an increase of stroke due to small artery occlusion in women (IRR 2.33; 95% CI 1.39-3.90). Conclusions: Variations in time trends of pathological and etiological stroke subtypes were found between men and women that might be linked to gender differences in the development of major vascular risk factors in the study population.
KW  - stroke
KW  - epidemiology
KW  - incidence
KW  - time trends
KW  - register
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196503
SN  - 0251-5350
SN  - 1423-0208
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 44
IS  - 1
ER  - 
TY  - JOUR
A1  - Osmers, Maria
T1  - Zwischen Vergemeinschaftung und Anarchie. Zur Konzeption und Wahrnehmung polisübergreifender Beziehungen in klassischer Zeit
JF  - Klio
N2  - Der Artikel fragt zunächst nach Konzepten, die in klassischer Zeit von Außenpolitik existierten. Überlegungen zu diesem Thema sind in den antiken philosophischen Schriften greifbar, wobei Vorstellungen von der Funktionsweise des Oikos und der Polis auf den griechischen Raum übertragen wurden. Ähnliche Kategorien, um polisübergreifende Beziehungen zu beschreiben, griff die politische Rhetorik auf. Bezogen sich antike Autoren jedoch in allgemeinen Abhandlungen auf die Außenpolitik, wurde der Krieg als bestimmendes Element identifiziert. Das theoretische Konzept von Außenpolitik konnte demnach für die Zeitgenossen in der Praxis wenig Wirkung entfalten. Ursachen hierfür waren sowohl die unsteten Verhältnisse des 4. Jahrhunderts als auch die konkrete Konzeption der Außenpolitik, da die Interaktion im griechischen Raum anders funktionierte als in kleineren sozialen Einheiten. Zudem wurden real existierende Mechanismen zur Befriedung von Hellas nur unzureichend in die Konzeption integriert.
N2  - This paper explores Classical Greek concepts of what today is understood as foreign policy. In philosophical treatises, the matter is mainly conceived by transferring the idea of how oikos and polis functioned onto the field of inter-state relations. Similar notions were employed by political rhetoric to describe interaction between poleis. Yet, whenever literature makes reference to foreign policy in more general considerations, warfare is identified as the decisive element. In practice, the theoretical concept of foreign policy therefore could not be brought to any considerable effect. The causes for this lay in the unsteady conditions of the 4th century as well as in the very concept itself, because the interaction in the Greek world in its  entirety worked differently from the interaction in smaller social units. Further, the existing modes of pacifying Hellas only played an insuffient part in the concept.
KW  - griechische Antike
KW  - klassische Zeit
KW  - polisübergreifende Beziehungen
KW  - antike Wahrnehmungsmuster
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-193997
SN  - 2192-7669
SN  - 0075-6334
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 97
IS  - 1
SP  - 32-58
ER  - 
TY  - JOUR
A1  - Knoll, Johannes
A1  - Schramm, Holger
T1  - Advertising in social network sites – Investigating the social influence of user-generated content on online advertising effects
JF  - Communications
N2  - In today’s social online world there is a variety of interaction and participatory possibilities which enable web users to actively produce content themselves. 
This user-generated content is omnipresent in the web and there is growing evidence that it is used to select or evaluate professionally created online information. 
The present study investigated how this surrounding content affects online advertising by drawing from social influence theory. Specifically, it was assumed that 
web users sharing an interpersonal relationship (interpersonal influence) and/or a group membership (collective influence) with authors of user-generated content 
which appears next to advertising on the web page are more strongly influenced in their response to the advertising than unrelated users. These assumptions were 
tested in a 2 × 2 between-subject experiment with 118 students who were exposed to four different Facebook profiles that differed in terms of interpersonal 
connection to the source (existent/non-existent) and collective connection to the source (existent/non-existent). The results show a significant impact in the case 
of collective influence, but not in the case of interpersonal influence. The underlying mechanisms of this effect and implications of the results for online advertising 
are discussed.
KW  - online advertising
KW  - social network sites
KW  - social influence
KW  - user-generated content
KW  - advertising effects
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-194192
SN  - 1613-4087
SN  - 0341-2059
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 40
IS  - 3
ER  - 
TY  - JOUR
A1  - Berenike Herrmann, J.
A1  - van Dalen-Oskam, Karina
A1  - Schöch, Christof
T1  - Revisiting Style, a Key Concept in Literary Studies
JF  - Journal of Literary Theory
N2  - Language and literary studies have studied style for centuries, and even since the advent of ›stylistics‹ as a discipline at the beginning of the twentieth century, definitions of ›style‹ have varied heavily across time, space and fields. Today, with increasingly large collections of literary texts being made available in digital form, computational approaches to literary style are proliferating. New methods from disciplines such as corpus linguistics and computer science are being adopted and adapted in interrelated fields such as computational stylistics and corpus stylistics, and are facilitating new approaches to literary style.
The relation between definitions of style in established linguistic or literary stylistics, and definitions of style in computational or corpus stylistics has not, however, been systematically assessed. This contribution aims to respond to the need to redefine style in the light of this new situation and to establish a clearer perception of both the overlap and the boundaries between ›mainstream‹ and ›computational‹ and/or ›empirical‹ literary stylistics. While stylistic studies of non-literary texts are currently flourishing, our contribution deliberately centers on those approaches relevant to ›literary stylistics‹. It concludes by proposing an operational definition of style that we hope can act as a common ground for diverse approaches to literary style, fostering transdisciplinary research.
The focus of this contribution is on literary style in linguistics and literary studies (rather than in art history, musicology or fashion), on textual aspects of style (rather than production- or reception-oriented theories of style), and on a descriptive perspective (rather than a prescriptive or didactic one). Even within these limits, however, it appears necessary to build on a broad understanding of the various perspectives on style that have been adopted at different times and in different traditions. For this reason, the contribution first traces the development of the notion of style in three different traditions, those of German, Dutch and French language and literary studies. Despite the numerous links between each other, and between each of them to the British and American traditions, these three traditions each have their proper dynamics, especially with regard to the convergence and/or confrontation between mainstream and computational stylistics. For reasons of space and coherence, the contribution is limited to theoretical developments occurring since 1945.
The contribution begins by briefly outlining the range of definitions of style that can be encountered across traditions today: style as revealing a higher-order aesthetic value, as the holistic ›gestalt‹ of single texts, as an expression of the individuality of an author, as an artifact presupposing choice among alternatives, as a deviation from a norm or reference, or as any formal property of a text. The contribution then traces the development of definitions of style in each of the three traditions mentioned, with the aim of giving a concise account of how, in each tradition, definitions of style have evolved over time, with special regard to the way such definitions relate to empirical, quantitative or otherwise computational approaches to style in literary texts. It will become apparent how, in each of the three traditions, foundational texts continue to influence current discussions on literary style, but also how stylistics has continuously reacted to broader developments in cultural and literary theory, and how empirical, quantitative or computational approaches have long ­existed, usually in parallel to or at the margins of mainstream stylistics. The review will also reflect the lines of discussion around style as a property of literary texts – or of any textual entity in general.
The perspective on three stylistic traditions is accompanied by a more systematic perspective. The rationale is to work towards a common ground for literary scholars and linguists when talking about (literary) style, across traditions of stylistics, with respect for established definitions of style, but also in light of the digital paradigm. Here, we first show to what extent, at similar or different moments in time, the three traditions have developed comparable positions on style, and which definitions out of the range of possible definitions have been proposed or promoted by which authors in each of the three traditions.
On the basis of this synthesis, we then conclude by proposing an operational definition of style that is an attempt to provide a common ground for both mainstream and computational literary stylistics. This definition is discussed in some detail in order to explain not only what is meant by each term in the definition, but also how it relates to computational analyses of style – and how this definition aims to avoid some of the pitfalls that can be perceived in earlier definitions of style. Our definition, we hope, will be put to use by a new generation of computational, quantitative, and empirical studies of style in literary texts.
KW  - literary studies
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-194349
SN  - 1862-8990
SN  - 1862-5290
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 9
IS  - 1
ER  - 
TY  - JOUR
A1  - Hoeres, Peter
T1  - Patrick Bernhard / Holger Nehring (Hrsg.), Den Kalten Krieg denken. Beiträge zur sozialen Ideengeschichte. (Frieden und Krieg, Bd. 19.) Essen, Klartext 2014
JF  - Historische Zeitschrift
N2  - Kein Abstract verfügbar.
KW  - Rezension
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-194373
SN  - 2196-680X
SN  - 0018-2613
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 300
IS  - 3
ER  - 
TY  - JOUR
A1  - Hoeres, Peter
T1  - Gefangen in der analytisch-normativen Westernisierung der Zeitgeschichte
JF  - Vierteljahrshefte für Zeitgeschichte
N2  - Der Tübinger Historiker Anselm Doering-Manteuffel hat in den Vierteljahrsheften für Zeitgeschichte vor kurzem sein Konzept der Zeitbögen vorgestellt. Er bietet damit ein politische Zäsuren übergreifendes, an handlungssteuernden Ideen orientiertes Deutungsmuster an, um die deutsche Geschichte im 20. Jahrhundert zu verorten. Peter Hoeres nimmt das Konzept der Zeitbögen kritisch unter die Lupe, hinterfragt seine normativen Implikationen, wägt analytisches Potenzial und inhaltlich- methodische Blindstellen gegeneinander ab und zeigt Perspektiven für alternative Interpretationen auf.
KW  - Kritik an Doering-Manteuffels Zeitbögen
KW  - Das Konzept der Westernisierung
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-194499
SN  - 2196-7121
SN  - 0042-5702
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 63
IS  - 3
ER  - 
TY  - JOUR
A1  - Brinktrine, Ralf
T1  - Konkurrentenstreitverfahren im Beamtenrecht
JF  - JURA - Juristische Ausbildung
N2  - Kein Abstract verfügbar.
KW  - Konkurrentenstreitverfahren
KW  - Beamtenrecht
KW  - Klausur
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-194866
SN  - 1612-7021
SN  - 0170-1452
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 37
IS  - 11
ER  - 
TY  - JOUR
A1  - Teichmann, Christoph
T1  - Corporate Groups within the Legal Framework of the European Union: The Group-Related Aspects of the SUP Proposal and the EU Freedom of Establishment
JF  - European Company and Financial Law Review
N2  - No abstract available.
KW  - EU
KW  - corporate groups
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-194513
SN  - 1613-2556
SN  - 1613-2548
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 12
IS  - 2
SP  - 202
EP  - 229
ER  - 
TY  - JOUR
A1  - Beck, Lukas
T1  - Kein König von Mallorca mehr
JF  - JURA - Juristische Ausbildung
N2  - Kein Abstract verfügbar.
KW  - Klausur
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-194158
SN  - 1612-7021
SN  - 0170-1452
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 37
IS  - 4
SP  - 383
EP  - 395
ER  - 
TY  - JOUR
A1  - Stickler, Matthias
T1  - Habsburgermonarchie, Die Habsburgermonarchie 1848–1918. Im Auftrag des Instituts für Neuzeit- und Zeitgeschichtsforschung, Forschungsbereich Geschichte der Habsburgermonarchie hrsg. v. Helmut Rumpler. Bd. 11: Die Habsburgermonarchie und der Erste Weltkrieg. Teilbd. 2: Weltkriegsstatistik Österreich-Ungarn 1914–1918. Bevölkerungsbewegung, Kriegstote, Kriegswirtschaft. Bearb. v. Helmut Rumpler u. Anatol Schmied-Kowarzik. Wien, Verlag der Österreichischen Akademie der Wissenschaften 2014
JF  - Historische Zeitschrift
N2  - Rezension zu Habsburgermonarchie, Die Habsburgermonarchie 1848–1918. Im Auftrag des Instituts für Neuzeit- und Zeitgeschichtsforschung, Forschungsbereich Geschichte der Habsburgermonarchie hrsg. v. Helmut Rumpler. Bd. 11: Die Habsburgermonarchie und der Erste Weltkrieg. Teilbd. 2: Weltkriegsstatistik Österreich-Ungarn 1914–1918. Bevölkerungsbewegung, Kriegstote, Kriegswirtschaft. Bearb. v. Helmut Rumpler u. Anatol Schmied-Kowarzik. Wien, Verlag der Österreichischen Akademie der Wissenschaften 2014
KW  - Rezension
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-194383
SN  - 2196-680X
SN  - 0018-2613
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 300
IS  - 3
SP  - 830
EP  - 832
ER  - 
TY  - JOUR
A1  - Tischer, Anuschka
T1  - Diplomatische Korrespondenz, Die Diplomatische Korrespondenz Kurbayerns zum Westfälischen Friedenskongress. Bd. 2: Die diplomatische Korrespondenz Kurfürst Maximilians I. von Bayern mit seinen Gesandten in Münster und Osnabrück. Teilbd. 2: August – November 1645. Bearb. v. Gabriele Greindl u. Gerhard Immler. (Quellen zur Neueren Geschichte Bayerns, I, Bd. 2/2.) München, Kommission für bayerische Landesgeschichte 2013
JF  - Historische Zeitschrift
N2  - Rezension zu Diplomatische Korrespondenz, Die Diplomatische Korrespondenz Kurbayerns zum Westfälischen Friedenskongress. Bd. 2: Die diplomatische Korrespondenz Kurfürst Maximilians I. von Bayern mit seinen Gesandten in Münster und Osnabrück. Teilbd. 2: August – November 1645. Bearb. v. Gabriele Greindl u. Gerhard Immler. (Quellen zur Neueren Geschichte Bayerns, I, Bd. 2/2.) München, Kommission für bayerische Landesgeschichte 2013
KW  - Rezension
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-194390
SN  - 2196-680X
SN  - 0018-2613
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 300
IS  - 3
SP  - 794
EP  - 795
ER  - 
TY  - JOUR
A1  - Ellena, Sandra
T1  - Maria Selig / Gerald Bernhard (edd.), Sprachliche Dynamiken. Das Italienische in Geschichte und Gegenwart (Studia Romanica et Linguistica, 34), Frankfurt am Main et al., Lang, 2011, 253 p.
JF  - Zeitschrift für romanische Philologie
N2  - Rezension zu Maria Selig / Gerald Bernhard (edd.), Sprachliche Dynamiken. Das Italienische in Geschichte und Gegenwart (Studia Romanica et Linguistica, 34), Frankfurt am Main et al., Lang, 2011, 253 p.
KW  - Rezension
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-195058
SN  - 1865-9063
SN  - 0049-8661
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 131
IS  - 4
PB  - De Gruyter Mouton
ER  - 
TY  - JOUR
A1  - Essler, Holger
A1  - Hermes-Wladarsch, Maria
T1  - Zur Erwerbung der Bremer Papyrussammlung und des Apollonios-Archivs
JF  - Archiv für Papyrusforschung und verwandte Gebiete
N2  - Abstract
In the past, there have been contradictory statements about the acquisition of the Bremer Papyri, particularly in respect of their relationship to the “Deutsches Papyruskartell”. The article reconstructs in detail the history of the Bremen collection and the beginning of the Gießen collection by publishing the relevant documents held by Deutsches Archäologisches Insitut in Cairo and the state and university library Bremen.
KW  - Deutsches Papyruskartell
KW  - acquisition
KW  - papyrus collection Bremen
KW  - papyrus collection Gießen
KW  - Ludwig Borchardt
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-195071
SN  - 1867-1551
SN  - 0066-6459
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 61
IS  - 2
SP  - 431
EP  - 481
PB  - De Gruyter
ER  - 
TY  - JOUR
A1  - Schulze, Daniel
T1  - The Passive Gaze and Hyper-Immunised Spectators: The Politics of Theatrical Live-Broadcasting
JF  - Journal of Contemporary Drama in English
N2  - No abstract available.
KW  - theatre
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-195091
SN  - 2195-0164
SN  - 2195-0156
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 3
IS  - 2
ER  - 
TY  - JOUR
A1  - Borgards, Roland
T1  - Introduction: Cultural and Literary Animal Studies
JF  - Journal of Literary Theory
N2  - No abstract available.
KW  - Cultural studies
KW  - Animal studies
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-195123
SN  - 1862-8990
SN  - 1862-5290
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 9
IS  - 2
ER  - 
TY  - JOUR
A1  - Ludwigs, Markus
A1  - Schmidt, Valeria
T1  - Auflösung eines Skinheadkonzerts
JF  - JURA - Juristische Ausbildung
N2  - Kein Abstract verfügbar.
KW  - Klausur
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-195261
SN  - 1612-7021
SN  - 0170-1452
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 37
IS  - 5
ER  - 
TY  - JOUR
A1  - Dannecker, Christoph
T1  - Der nemo tenetur-Grundsatz – prozessuale Fundierung und Geltung für juristische Personen
JF  - Zeitschrift für die gesamte Strafrechtswissenschaft
N2  - Kein Abstract verfügbar.
KW  - nemo tenetur-Grundsatz
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-195368
SN  - 1612-703X
SN  - 0084-5310
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 127
IS  - 2
ER  - 
TY  - JOUR
A1  - Tornau, Christian
T1  - Tobias Uhle, Augustin und die Dialektik. Eine Untersuchung der Argumentationsstruktur in den Cassiciacum-Dialogen, Studien und Texte zu Antike und Christentum 67, Tübingen (Mohr Siebeck) 2012, XIV + 293 S., ISBN 978-3-16-151985-7
JF  - Zeitschrift für Antikes Christentum / Journal of Ancient Christianity
N2  - Rezension zu Tobias Uhle, Augustin und die Dialektik. Eine Untersuchung der Argumentationsstruktur in den Cassiciacum-Dialogen, Studien und Texte zu Antike und Christentum 67, Tübingen (Mohr Siebeck) 2012, XIV + 293 S., ISBN 978-3-16-151985-7
KW  - Rezension
KW  - Augustin
KW  - Dialektik
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-195571
SN  - 1612-961X
SN  - 0949-9571
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 18
IS  - 3
SP  - 509
EP  - 559
ER  - 
TY  - JOUR
A1  - Dandekar, Thomas
A1  - Eisenreich, Wolfgang
T1  - Host-adapted metabolism and its regulation in bacterial pathogens
JF  - Frontiers in Cellular and Infection Microbiology
N2  - No abstract available.
KW  - bacterial pathogens
KW  - enteric pathogens
KW  - metabolism
KW  - host-pathogen adaption
KW  - isotopolog profiling
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196876
SN  - 2235-2988
VL  - 5
IS  - 28
ER  - 
TY  - GEN
A1  - Rodríguez-Martín, Boris C.
A1  - Meule, Adrian
T1  - Food craving: new contributions on its assessment, moderators, and consequences
T2  - Frontiers in Psychology
N2  - No abstract available.
KW  - food
KW  - cravings
KW  - emotional eating
KW  - obesity
KW  - pregnancy
KW  - binge eating
KW  - food addiction
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-190299
SN  - 1664-1078
VL  - 6
IS  - 21
ER  - 
TY  - JOUR
A1  - Hopp, Sarah
A1  - Albert-Weissenberger, Christiane
T1  - The kallikrein-kinin system: a promising therapeutic target for traumatic brain injury
JF  - Neural Regeneration Research
N2  - No abstract available.
KW  - kallikrein-kinin system
KW  - traumatic brain injury
KW  - therapy
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-149416
VL  - 10
IS  - 6
ER  - 
TY  - JOUR
A1  - Zinner, Christoph
A1  - Sperlich, Billy
A1  - Krueger, Malte
A1  - Focke, Tim
A1  - Reed, Jennifer
A1  - Mester, Joachim
T1  - Strength, Endurance, Throwing Velocity and in-Water Jump Performance of Elite German Water Polo Players
JF  - Journal of Human Kinetics
N2  - The purpose of this study was threefold: 1) to assess the eggbeater kick and throwing performance using a number of water polo specific tests, 2) to explore the relation between the eggbeater kick and throwing performance, and 3) to investigate the relation between the eggbeater kick in the water and strength tests performed in a controlled laboratory setting in elite water polo players. Fifteen male water polo players of the German National Team completed dynamic and isometric strength tests for muscle groups (adductor, abductor, abdominal, pectoralis) frequently used during water polo. After these laboratory strength tests, six water polo specific in-water tests were conducted. The eggbeater kick assessed leg endurance and agility, maximal throwing velocity and jump height. A 400 m test and a sprint test examined aerobic and anaerobic performance. The strongest correlation was found between jump height and arm length (p < 0.001, r = 0.89). The laboratory diagnostics of important muscles showed positive correlations with the results of the in-water tests (p < 0.05, r = 0.52-0.70). Muscular strength of the adductor, abdominal and pectoralis muscles was positively related to in-water endurance agility as assessed by the eggbeater kick (p < 0.05; r = 0.53-0.66). Findings from the current study emphasize the need to assess indices of water polo performance both in and out of the water as well as the relation among these parameters to best assess the complex profile of water polo players.
KW  - physiological characteristics
KW  - cinematographic analysis
KW  - penalty throw
KW  - strength
KW  - jump height
KW  - team sports
KW  - diagnostics
KW  - anaerobic and aerobic testing
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-148812
VL  - 45
ER  - 
TY  - JOUR
A1  - Sperlich, Paula F.
A1  - Holmberg, Hans-Christer
A1  - Reed, Jennifer L.
A1  - Zinner, Christoph
A1  - Mester, Joachim
A1  - Sperlich, Billy
T1  - Individual versus standardized running protocols in the determination of VO\(_{2max}\)
JF  - Journal of Sports Science and Medicine
N2  - The purpose of this study was to determine whether an individually designed incremental exercise protocol results in greater rates of oxygen uptake VO\(_{2max}\) than standardized testing. Fourteen well-trained, male runners performed five incremental protocols in randomized order to measure their VO\(_{2max}\): i) an incremental test (INC\(_{S+I}\)) with pre-defined increases in speed (2 min at 8.64 km.h\(^{-1}\), then a rise of 1.44 km.h\(^{-1}\) every 30 s up to 14.4 km.h\(^{-1}\)) and thereafter inclination (0.5.every 30 s); ii) an incremental test (INC\(_{I}\)) at constant speed (14.4 km.h\(^{-1}\)) and increasing inclination (2 degrees every 2 min from the initial 0 degrees); iii) an incremental test (INC\(_{S}\)) at constant inclination (0 degrees) and increasing speed (0.5 km.h\(^{-1}\) every 30 s from the initial 12.0 km.h\(^{-1}\)); iv) a graded exercise protocol (GXP) at a 1 degrees incline with increasing speed (initially 8.64 km.h\(^{-1}\) + 1.44 km.h\(^{-1}\) every 5 min); v) an individual exercise protocol (INDXP) in which the runner chose the inclination and speed. VO\(_{2max}\) was lowest (-4.2%) during the GXP (p = 0.01; d = 0.06 - 0.61) compared to all other tests. The highest rating of perceived exertion, heart rate, ventilation and end-exercise blood lactate concentration were similar between the different protocols (p < 0.05). The time to exhaustion ranged from 7 min 18 sec (INC\(_{S}\)) to 25 min 30 sec (GXP) (p = 0.01). The VO\(_{2max}\) attained by employing an individual treadmill protocol does not differ from the values derived from various standardized incremental protocols.
KW  - maximum oxygen uptake
KW  - aerobic power
KW  - treadmill running
KW  - ramp test
KW  - treadmill protocol
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-151890
VL  - 14
ER  - 
TY  - JOUR
A1  - Ayanu, Yohannes
A1  - Conrad, Christopher
A1  - Jentsch, Anke
A1  - Koellner, Thomas
T1  - Unveiling undercover cropland inside forests using landscape variables: a supplement to remote sensing image classification
JF  - PLoS ONE
N2  - The worldwide demand for food has been increasing due to the rapidly growing global population, and agricultural lands have increased in extent to produce more food crops. The pattern of cropland varies among different regions depending on the traditional knowledge of farmers and availability of uncultivated land. Satellite images can be used to map cropland in open areas but have limitations for detecting undergrowth inside forests. Classification results are often biased and need to be supplemented with field observations. Undercover cropland inside forests in the Bale Mountains of Ethiopia was assessed using field observed percentage cover of land use/land cover classes, and topographic and location parameters. The most influential factors were identified using Boosted Regression Trees and used to map undercover cropland area. Elevation, slope, easterly aspect, distance to settlements, and distance to national park were found to be the most influential factors determining undercover cropland area. When there is very high demand for growing food crops, constrained under restricted rights for clearing forest, cultivation could take place within forests as an undercover. Further research on the impact of undercover cropland on ecosystem services and challenges in sustainable management is thus essential.
KW  - climate change
KW  - land-cover classification
KW  - bale mountains national park
KW  - sub-saharan africa
KW  - agroforestry systems
KW  - biodiversity conservation
KW  - ecosystem services
KW  - topographic aspect
KW  - wheat-varieties
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-151686
VL  - 10
IS  - 6
ER  - 
TY  - BOOK
A1  - Wieland, Thomas
T1  - Räumliches Einkaufsverhalten und Standortpolitik im Einzelhandel unter Berücksichtigung von Agglomerationseffekten - Theoretische Erklärungsansätze, modellanalytische Zugänge und eine empirisch-ökonometrische Marktgebietsanalyse anhand eines Fallbeispiels aus dem ländlichen Raum Ostwestfalens/Südniedersachsens
N2  - Die steigende Relevanz von Einzelhandelsagglomerationen zählt zu den zentralen raumbezogenen Elementen des Strukturwandels im Einzelhandel. Sowohl geplante Einkaufszentren als auch Standortkooperationen von eigentlich in interformalem Wettbewerb stehenden Betriebsformen prägen immer mehr die Standortstrukturen des Einzelhandels. Die vorliegende Untersuchung beschäftigt sich mit dem räumlichen Einkaufsverhalten der Konsumenten im Zusammenhang mit derartigen Erscheinungen. Zunächst werden aus verschiedenen theoretischen Perspektiven (Mikroökonomie, Raumwirtschaftstheorie, verhaltenswissenschaftliche Marketing-Forschung) jene positiven Agglomerationseffekte im Einzelhandel hergeleitet, die auf dem Kundenverhalten basieren; hierbei lassen sich verschiedene Typen von Kopplungs- und Vergleichskäufen als relevante Einkaufsstrategien identifizieren. Die angenommene (positive) Wirkung von Einzelhandelsagglomerationen wird mithilfe eines ökonometrischen Marktgebietsmodells – dem Multiplicative Competitive Interaction (MCI) Model – auf der Grundlage primärempirisch erhobener Marktgebiete überprüft. Die Analyseergebnisse zeigen überwiegend positive Einflüsse des Potenzials für Kopplungs- und Vergleichskäufe auf die Kundenzuflüsse einzelner Anbieter, wenngleich sich diese in ihrer Intensität und Ausgestaltung unterscheiden. Die Untersuchung zeigt die Relevanz von Agglomerationseffekten im Einzelhandel auf, wobei ein quantitatives Modell auf der Basis des häufig verwendeten Huff-Modells formuliert wird, mit dem es möglich ist, diese Effekte zu analysieren. Konkrete Anwendungen hierfür finden sich in der betrieblichen Standortanalyse und der Verträglichkeitsbeurteilung von Einzelhandelsansiedlungen.
T3  - Geographische Handelsforschung - 23 
KW  - Einzelhandel
KW  - Kaufverhalten
KW  - Marktgebiet
KW  - Konsumentenverhalten
KW  - Raumwirtschaftstheorien
KW  - Standorttheorien
KW  - Marktgebietsmodelle
KW  - Analyse
KW  - Verbraucherverhalten
KW  - Höxter
KW  - Holzminden
KW  - Beverungen
KW  - Ländlicher Raum
KW  - Agglomerationseffekt
KW  - Niedersachsen <Süd>
KW  - Westfalen <Südost>
KW  - Verbraucherverhalten
KW  - Standortpolitik
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-180753
SN  - 978-3-936438-73-4
N1  - Die gedruckte Version dieses Bandes ist im Buchhandel lieferbar. Nähere Informationen unter:
http://www.metagis.de/MetaGIS-Fachbuch/Schriftenreihen/Reihe-GHF/reihe-ghf.html
PB  - Verlag MetaGIS Infosysteme
CY  - Mannheim
ER  - 
TY  - JOUR
A1  - Iyengar, Sudha K.
A1  - Sedor, John R.
A1  - Freedman, Barry I.
A1  - Kao, W. H. Linda
A1  - Kretzler, Matthias
A1  - Keller, Benjamin J.
A1  - Abboud, Hanna E.
A1  - Adler, Sharon G.
A1  - Best, Lyle G.
A1  - Bowden, Donald W.
A1  - Burlock, Allison
A1  - Chen, Yii-Der Ida
A1  - Cole, Shelley A.
A1  - Comeau, Mary E.
A1  - Curtis, Jeffrey M.
A1  - Divers, Jasmin
A1  - Drechsler, Christiane
A1  - Duggirala, Ravi
A1  - Elston, Robert C.
A1  - Guo, Xiuqing
A1  - Huang, Huateng
A1  - Hoffmann, Michael Marcus
A1  - Howard, Barbara V.
A1  - Ipp, Eli
A1  - Kimmel, Paul L.
A1  - Klag, Michael J.
A1  - Knowler, William C.
A1  - Kohn, Orly F.
A1  - Leak, Tennille S.
A1  - Leehey, David J.
A1  - Li, Man
A1  - Malhotra, Alka
A1  - März, Winfried
A1  - Nair, Viji
A1  - Nelson, Robert G.
A1  - Nicholas, Susanne B.
A1  - O’Brien, Stephen J.
A1  - Pahl, Madeleine V.
A1  - Parekh, Rulan S.
A1  - Pezzolesi, Marcus G.
A1  - Rasooly, Rebekah S.
A1  - Rotimi, Charles N.
A1  - Rotter, Jerome I.
A1  - Schelling, Jeffrey R.
A1  - Seldin, Michael F.
A1  - Shah, Vallabh O.
A1  - Smiles, Adam M.
A1  - Smith, Michael W.
A1  - Taylor, Kent D.
A1  - Thameem, Farook
A1  - Thornley-Brown, Denyse P.
A1  - Truitt, Barbara J.
A1  - Wanner, Christoph
A1  - Weil, E. Jennifer
A1  - Winkler, Cheryl A.
A1  - Zager, Philip G.
A1  - Igo, Jr, Robert P.
A1  - Hanson, Robert L.
A1  - Langefeld, Carl D.
T1  - Genome-wide association and trans-ethnic meta-analysis for advanced diabetic kidney disease: Family Investigation of Nephropathy and Diabetes (FIND)
JF  - PLoS Genetics
N2  - Diabetic kidney disease (DKD) is the most common etiology of chronic kidney disease (CKD) in the industrialized world and accounts for much of the excess mortality in patients with diabetes mellitus. Approximately 45% of U.S. patients with incident end-stage kidney disease (ESKD) have DKD. Independent of glycemic control, DKD aggregates in families and has higher incidence rates in African, Mexican, and American Indian ancestral groups relative to European populations. The Family Investigation of Nephropathy and Diabetes (FIND) performed a genome-wide association study (GWAS) contrasting 6,197 unrelated individuals with advanced DKD with healthy and diabetic individuals lacking nephropathy of European American, African American, Mexican American, or American Indian ancestry. A large-scale replication and trans-ethnic meta-analysis included 7,539 additional European American, African American and American Indian DKD cases and non-nephropathy controls. Within ethnic group meta-analysis of discovery GWAS and replication set results identified genome-wide significant evidence for association between DKD and rs12523822 on chromosome 6q25.2 in American Indians (P = 5.74x10\(^{−9}\)). The strongest signal of association in the trans-ethnic meta-analysis was with a SNP in strong linkage disequilibrium with rs12523822 (rs955333; P = 1.31x10\(^{−8}\)), with directionally consistent results across ethnic groups. These 6q25.2 SNPs are located between the SCAF8 and CNKSR3 genes, a region with DKD relevant changes in gene expression and an eQTL with IPCEF1, a gene co-translated with CNKSR3. Several other SNPs demonstrated suggestive evidence of association with DKD, within and across populations. These data identify a novel DKD susceptibility locus with consistent directions of effect across diverse ancestral groups and provide insight into the genetic architecture of DKD.
KW  - diabetic kidney disease
KW  - genome-wide association study
KW  - Family Investigation of Nephropathy and Diabetes
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-180545
VL  - 11
IS  - 8
ER  - 
TY  - THES
A1  - von Rottkay, Eberhard
T1  - Aktivität und Funktionalität nach Hüfttotalendoprothese über einen direkten anterioren Zugang verglichen mit einem gesunden Bevölkerungskollektiv
T1  - Activity and functionality after total hip arthroplasty via direct anterior approach compared to a healthy population
N2  - Die Möglichkeiten der operativen Rekonstruktion degenerativ veränderter Hüftgelenke sind komplex und vielfältig. Bei den derzeit zur Verfügung stehenden operativen Behandlungsmassnahmen führen die Vor- und Nachteile immer wieder zur Diskussionen und Abwägung der Operationsverfahren. Hierbei stehen sich die rasche postoperative Mobilisierung sowie eine verminderte Rekonvaleszenzzeit mit den diskutierten Nachteilen einer schlechteren Übersichtlichkeit und damit verbundenen Fehlimplantationen gegenüber. Dies und die damit verbundene volkswirtschaftliche Bedeutung sind ein ständiger Ausgangspunkt für das Bemühen den optimalen Zugangsweg zu etablieren. Daher stellte das von Smith-Peterson 1949 publizierte Verfahren einen Meilenstein in der operativen Therapie dar. Hierdurch konnten zum einen die operationstechnischen Vorteile wie auch das volkswirtschaftliche Begehren nach kürzeren postoperativen Verweildauern vereint werden. Die Modifizierung dieses Zugangsweges hat sich bereits in einer großen Anzahl prospektiver Studien als zuverlässiges Rekonstruktionsverfahren etabliert und erfüllt zudem auch die Anforderungen der heutigen Medizin nach ästhetisch schönen Ergebnissen. In der vorliegenden Arbeit wurde eine prospektive Fallstudie des direkten anterioren Zugangs mit einem gesunden Vergleichskollektiv durchgeführt. Mit dem Ziel, die Aktivität ein Jahr postoperativ nach Implantation einer HTEP mit gesunden Probanden zu vergleichen. Von Januar 2009 bis Mai 2011 wurden insgesamt 77 Patienten und 59 Probanden in die Studie aufgenommen. Als Vergleichswerte wurde zum einen die klinische wie auch die radiologische Untersuchung herangezogen. In der klinischen Untersuchung zeigte sich insgesamt ein signifikanter Anstieg der untersuchten Scores im Vergleich mit den präoperativen Ergebnissen bei den Operierten. Im Vergleich zu den Probanden erzielen die Patienten ein Jahr nach HTEP teilweise noch schlechtere Werte in dem Bewegungsumfang und den Aktivitätsniveaus welche mittels der Auswertung des Stepwatches, des TWB und des Arzt-Patienten-Fragebogens erhoben wurden. Die radiologische Bewertung diente zur Feststellung der Positionierung der HTEP. Mit guten Positionierungen durch den direkten anterioren Zugang. Die Bewertung der Funktionalität zwischen den beiden Gruppen erfolgte durch den HHS, XSFMA- D und den Arzt-Patientenfragenbogen. Hierbei konnten ähnliche Ergebnisse, wie bereits oben beschrieben, verzeichnet werden mit guten Werten in der Gruppe der untersuchten Patienten, jedoch einer geringeren Funktionalität im Vergleich zu den Probanden. Die vorliegende Arbeit zeigt, dass der direkte anteriore Zugang die Wiederherstellung eines guten postoperativen Gesundheitszustandes mit erreichen eines hohen postoperativen Aktivitätslevels der Patienten ermöglicht. Ebenso erfüllt dieser Zugangsweg die Anforderungen der heutigen Medizin im Sinne einer schnellen postoperativen Mobilisation. Im Vergleich zu anderen minimal-invasiven Verfahren zeigen sich eine gute Implantierbarkeit, eine gute Positionierung und ein niedriges Komplikationsniveau. Prinzipiell hat der minimal-invasive anteriore Zugang das Potenzial sich als ein Standardverfahren in der operativen Rekonstruktion bei Hüftgelenksersatz zu etablieren, jedoch wäre ein direkter Vergleich mit dem lateralen Zugang erstrebenswert und sollte in weiteren Studien verglichen werden.
N2  - Background: The aim of this prospectve study was to evaluate the clinical results one year after total hip arthroplasty performed through a minimally invasive direct anterior approach versus a healthy volunteer group. 
Methods: 77 patients and 59 probands have been evaltuated applying the Stepwatch activity monitor (SAM), the Harris hip score (HHS), the SF 36, a daliy activity questionnaire (DAQ) and the XSFMA. 
Results: The average SAM showed significant differences of 5658 steps (patients) compared to 6417 steps (proband) (p=0,011). The same routcome can be seen in the DAQ with 4226 (patients) and 4686 (proband) cycles (p=0,327) respectively. No significant difference occured by using the average HHS reflecting an equal outcome of 90,7 points in the patient group compared to 90.8 points in the proband group (p=0,022). In contrast tot he afore-mentioned HHS, was a significant increase of the XSFMA reported with 10,9 (patients) and 5.0 (proband) (p=0,001). The SF -36 physical component scores were 45.8 (patients) and 50.6 (proband) while the psychometric properties added up to 56.6 (patients) and 55.9 (proband). While the physical component scores (p=0,001) showed a significant difference this couldnt be observed for the psychometric properties (p=0,511). Conclusion: In our study, good results have been obtained after the first year of the total hip arthroplasty, however these are not as beneficial as the outcomes in the healthy volunteer group.
KW  - AMIS
KW  - Direct anterior approach
KW  - hip arthroplasty
KW  - stepwatch
KW  - comparison
KW  - AMIS
KW  - Direct anterior approach
KW  - hip arthroplasty
KW  - stepwatch
KW  - comparison
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-178206
N1  - Dieses Dokument wurde aus Urheberrechtsschutzgründen erneut veröffentlicht.

Die ursprüngliche Veröffentlichung war am 18.01.2016.
ER  - 
TY  - JOUR
A1  - Wiedmann, Silke
A1  - Heuschmann, Peter U.
A1  - Hermanek, Peter
T1  - In reply: The quality of acute stroke treatment-an analysis of evidence-based indicators in 260 000 patients
JF  - Deutsches Aerzteblatt International
N2  - No abstract available.
KW  - acute stroke
KW  - treatment
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-148666
VL  - 112
ER  - 
TY  - JOUR
T1  - Two-particle Bose-Einstein correlations in pp collisions at \(\sqrt {s}\) = 0.9 and 7 TeV measured with the ATLAS detector
JF  - European Physical Journal C: Particles and Fields
N2  - The paper presents studies of Bose–Einstein Correlations (BEC) for pairs of like-sign charged particles measured in the kinematic range p\(_{T}\) > 100 MeV and |η| <  2.5 in proton collisions at centre-of-mass energies of 0.9 and 7 TeV with the ATLAS detector at the CERN Large Hadron Collider. The integrated luminosities are approximately 7 μb\(^{−1}\), 190 μb\(^{−1}\) and 12.4 nb\(^{−1}\) for 0.9 TeV, 7 TeV minimum-bias and 7 TeV high-multiplicity data samples, respectively. The multiplicity dependence of the BEC parameters characterizing the correlation strength and the correlation source size are investigated for charged-particle multiplicities of up to 240. A saturation effect in the multiplicity dependence of the correlation source size parameter is observed using the high-multiplicity 7 TeV data sample. The dependence of the BEC parameters on the average transverse momentum of the particle pair is also investigated.
KW  - ATLAS detector
KW  - proton-proton collision
KW  - Bose-Einstein Correlations
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150222
VL  - 75
IS  - 10
ER  - 
TY  - JOUR
T1  - Search for the Standard Model Higgs boson produced in association with top quarks and decaying into b\(\overline{b}\) in pp collisions at \(\sqrt {s}\) = 8 TeV with the ATLAS detector
JF  - European Physical Journal C: Particles and Fields
N2  - A search for the Standard Model Higgs boson produced in association with a top-quark pair, t\(\overline{t}\)H, is presented. The analysis uses 20.3 fb\(^{−1}\) of pp collision data at \(\sqrt {s}\) = 8 TeV, collected with the ATLAS detector at the Large Hadron Collider during 2012. The search is designed for the H→b\(\overline{b}\) decay mode and uses events containing one or two electrons or muons. In order to improve the sensitivity of the search, events are categorised according to their jet and b-tagged jet multiplicities. A neural network is used to discriminate between signal and background events, the latter being dominated by t\(\overline{t}\)+jets production. In the single-lepton channel, variables calculated using a matrix element method are included as inputs to the neural network to improve discrimination of the irreducible t\(\overline{t}\)+b\(\overline{b}\) background. No significant excess of events above the background expectation is found and an observed (expected) limit of 3.4 (2.2) times the Standard Model cross section is obtained at 95 % confidence level. The ratio of the measured t\(\overline{t}\)H signal cross section to the Standard Model expectation is found to be μ = 1.5 ± 1.1 assuming a Higgs boson mass of 125 GeV.
KW  - Higgs boson
KW  - ATLAS detector
KW  - top quarks
KW  - proton-proton collision
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150197
VL  - 75
IS  - 7
ER  - 
TY  - JOUR
T1  - Search for supersymmetry in events containing a same-flavour opposite-sign dilepton pair, jets, and large missing transverse momentum in \(\sqrt {s}\) = 8 TeV pp collisions with the ATLAS detector
JF  - European Physical Journal C: Particles and Fields
N2  - Two searches for supersymmetric particles in final states containing a same-flavour opposite-sign lepton pair, jets and large missing transverse momentum are presented. The proton–proton collision data used in these searches were collected at a centre-of-mass energy \(\sqrt {s}\) = 8 TeV by the ATLAS detector at the Large Hadron Collider and corresponds to an integrated luminosity of 20.3 fb\(^{−1}\). Two leptonic production mechanisms are considered: decays of squarks and gluinos with Z bosons in the final state, resulting in a peak in the dilepton invariant mass distribution around the Z-boson mass; and decays of neutralinos (e.g. \(\tilde{χ}\)\(^{0}_{2}\) → ℓ\(^{+}\)ℓ\(^{−}\)\(\tilde{χ}\)\(^{0}_{1}\)), resulting in a kinematic endpoint in the dilepton invariant mass distribution. For the former, an excess of events above the expected Standard Model background is observed, with a significance of three standard deviations. In the latter case, the data are well-described by the expected Standard Model background. The results from each channel are interpreted in the context of several supersymmetric models involving the production of squarks and gluinos.
KW  - ATLAS detector
KW  - supersymmetry
KW  - proton-proton collision
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150184
VL  - 75
IS  - 7
ER  - 
TY  - JOUR
T1  - Search for resonant diboson production in the ℓℓq\(\overline{q}\) final state in pp collisions at \(\sqrt {s}\) = 8 TeV with the ATLAS detector
JF  - European Physical Journal C: Particles and Fields
N2  - This paper reports on a search for narrow resonances in diboson production in the ℓℓq\(\overline{q}\) final state using pp collision data corresponding to an integrated luminosity of 20 fb\(^{−1}\) collected at \(\sqrt {s}\) = 8 TeV with the ATLAS detector at the Large Hadron Collider. No significant excess of data events over the Standard Model expectation is observed. Upper limits at the 95 % confidence level are set on the production cross section times branching ratio for Kaluza–Klein gravitons predicted by the Randall–Sundrum model and for Extended Gauge Model W′ bosons. These results lead to the exclusion of mass values below 740 and 1590 GeV for the graviton and W′ boson respectively.
KW  - ATLAS detector
KW  - proton-proton collision
KW  - diboson production
KW  - resonances
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150171
VL  - 75
IS  - 2
ER  - 
TY  - JOUR
T1  - Search for production of WW/WZ resonances decaying to a lepton, neutrino and jets in pp collisions at \(\sqrt {s}\)= 8 TeV with the ATLAS detector
JF  - European Physical Journal C: Particles and Fields
N2  - A search is presented for narrow diboson resonances decaying to WW or WZ in the final state where one W boson decays leptonically (to an electron or a muon plus a neutrino) and the other W/Z boson decays hadronically. The analysis is performed using an integrated luminosity of 20.3 fb\(^{−1}\) of pp collisions at \(\sqrt {s}\) = 8 TeV collected by the ATLAS detector at the large hadron collider. No evidence for resonant diboson production is observed, and resonance masses below 700 and 1490 GeV are excluded at 95 % confidence level for the spin-2 Randall–Sundrum bulk graviton G\(^{*}\) with coupling constant of 1.0 and the extended gauge model W′ boson respectively.
KW  - ATLAS detector
KW  - W boson
KW  - Z boson
KW  - proton-proton collision
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150164
VL  - 75
IS  - 5
ER  - 
TY  - JOUR
T1  - Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at \(\sqrt {s}\) = 8 TeV with the ATLAS detector
JF  - European Physical Journal C: Particles and Fields
N2  - Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb\(^{−1}\) of \(\sqrt {s}\) = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between E\(^{miss}_{T}\) > 150 GeV and E\(^{miss}_{T}\) > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presented.
KW  - ATLAS detector
KW  - energetic jet
KW  - proton-proton collision
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150152
VL  - 75
IS  - 7
ER  - 
TY  - JOUR
T1  - Search for metastable heavy charged particles with large ionisation energy loss in pp collisions at \(\sqrt {s}\) = 8 TeV using the ATLAS experiment
JF  - European Physical Journal C: Particles and Fields
N2  - Many extensions of the Standard Model predict the existence of charged heavy long-lived particles, such as R-hadrons or charginos. These particles, if produced at the Large Hadron Collider, should be moving non-relativistically and are therefore identifiable through the measurement of an anomalously large specific energy loss in the ATLAS pixel detector. Measuring heavy long-lived particles through their track parameters in the vicinity of the interaction vertex provides sensitivity to metastable particles with lifetimes from 0.6 ns to 30 ns. A search for such particles with the ATLAS detector at the Large Hadron Collider is presented, based on a data sample corresponding to an integrated luminosity of 18.4 fb\(^{−1}\) of pp collisions at \(\sqrt {s}\) = 8 TeV. No significant deviation from the Standard Model background expectation is observed, and lifetime-dependent upper limits on R-hadrons and chargino production are set. Gluino R-hadrons with 10 ns lifetime and masses up to 1185 GeV are excluded at 95 % confidence level, and so are charginos with 15 ns lifetime and masses up to 482 GeV.
KW  - ATLAS detector
KW  - charged heavy long-lived particles
KW  - proton-proton collision
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150149
VL  - 75
IS  - 9
ER  - 
TY  - JOUR
T1  - Search for invisible particles produced in association with single-top-quarks in proton-proton collisions at \(\sqrt {s}\) = 8 TeV with the ATLAS detector
JF  - European Physical Journal C: Particles and Fields
N2  - A search for the production of single-top-quarks in association with missing energy is performed in proton–proton collisions at a centre-of-mass energy of \(\sqrt {s}\) =8 TeV with the ATLAS experiment at the large hadron collider using data collected in 2012, corresponding to an integrated luminosity of 20.3 fb\(^{−1}\). In this search, the W boson from the top quark is required to decay into an electron or a muon and a neutrino. No deviation from the standard model prediction is observed, and upper limits are set on the production cross-section for resonant and non-resonant production of an invisible exotic state in association with a right-handed top quark. In the case of resonant production, for a spin-0 resonance with a mass of 500 GeV, an effective coupling strength above 0.15 is excluded at 95 % confidence level for the top quark and an invisible spin-1/2 state with mass between 0 and 100 GeV. In the case of non-resonant production, an effective coupling strength above 0.2 is excluded at 95 % confidence level for the top quark and an invisible spin-1 state with mass between 0 and 657 GeV.
KW  - single-top-quarks
KW  - proton-proton collision
KW  - ATLAS detector
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150134
VL  - 75
IS  - 2
ER  - 
TY  - JOUR
T1  - Search for invisible decays of the Higgs boson produced in association with a hadronically decaying vector boson in pp collisions at \(\sqrt {s}\) = TeV with the ATLAS detector
JF  - European Physical Journal C: Particles and Fields
N2  - A search for Higgs boson decays to invisible particles is performed using 20.3 fb\(^{−1}\) of pp collision data at a centre-of-mass energy of 8 TeV recorded by the ATLAS detector at the Large Hadron Collider. The process considered is Higgs boson production in association with a vector boson (V = W or Z) that decays hadronically, resulting in events with two or more jets and large missing transverse momentum. No excess of candidates is observed in the data over the background expectation. The results are used to constrain VH production followed by H decaying to invisible particles for the Higgs boson mass range 115 < m\(_{H}\) < 300 GeV. The 95 % confidence-level observed upper limit on σ\(_{VH}\) × BR(H → inv.) varies from 1.6 pb at 115 GeV to 0.13 pb at 300 GeV. Assuming Standard Model production and including the gg → H contribution as signal, the results also lead to an observed upper limit of 78 % at 95 % confidence level on the branching ratio of Higgs bosons decays to invisible particles at a mass of 125 GeV.
KW  - Higgs boson
KW  - ATLAS detector
KW  - decays
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150126
VL  - 75
IS  - 7
ER  - 
TY  - JOUR
T1  - Search for Higgs boson pair production in the b\(\overline{b}\)b\(\overline{b}\) final state from pp collisions at \(\sqrt {s}\) = 8 TeV with the ATLAS detector
JF  - European Physical Journal C: Particles and Fields
N2  - A search for Higgs boson pair production pp → hh is performed with 19.5 fb\(^{−1}\) of proton–proton collision data at \(\sqrt {s}\) = 8 TeV, which were recorded by the ATLAS detector at the Large Hadron Collider in 2012. The decay products of each Higgs boson are reconstructed as a high-momentum b\(\overline{b}\) system with either a pair of small-radius jets or a single large-radius jet, the latter exploiting jet substructure techniques and associated b-tagged track-jets. No evidence for resonant or non-resonant Higgs boson pair production is observed. The data are interpreted in the context of the Randall–Sundrum model with a warped extra dimension as well as the two-Higgs-doublet model. An upper limit on the cross-section for pp → G\(^{*}_{KK}\) → hh → b\(\overline{b}\)b\(\overline{b}\) of 3.2(2.3) fb is set for a Kaluza–Klein graviton G\(^{*}_{KK}\) mass of 1.0(1.5) TeV, at the 95 % confidence level. The search for non-resonant Standard Model hh production sets an observed 95 % confidence level upper limit on the production cross-section σ(pp → hh → b\(\overline{b}\)b\(\overline{b}\)) of 202 fb, compared to a Standard Model prediction of σ(pp → hh → b\(\overline{b}\)b\(\overline{b}\)) = 3.6±0.5 fb.
KW  - Higgs boson
KW  - proton-proton collision
KW  - ATLAS detector
KW  - pair production
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150119
VL  - 75
IS  - 9
ER  - 
TY  - JOUR
T1  - Search for heavy long-lived multi-charged particles in pp collisions at \(\sqrt {s}\) = 8 TeV using the ATLAS detector
JF  - European Physical Journal C: Particles and Fields
N2  - A search for heavy long-lived multi-charged particles is performed using the ATLAS detector at the LHC. Data collected in 2012 at \(\sqrt {s}\) = 8 TeV from pp collisions corresponding to an integrated luminosity of 20.3 fb\(^{−1}\) are examined. Particles producing anomalously high ionisation, consistent with long-lived massive particles with electric charges from |q| = 2e to |q| = 6e are searched for. No signal candidate events are observed, and 95 % confidence level cross-section upper limits are interpreted as lower mass limits for a Drell–Yan production model. The mass limits range between 660 and 785 GeV.
KW  - ATLAS detector
KW  - proton-proton collision
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150100
VL  - 75
IS  - 8
ER  - 
TY  - JOUR
T1  - Search for direct pair production of a chargino and a neutralino decaying to the 125 GeV Higgs boson in \(\sqrt {s}\) = 8 TeV pp collisions with the ATLAS detector
JF  - European Physical Journal C: Particles and Fields
N2  - A search is presented for the direct pair production of a chargino and a neutralino pp → \(\tilde{χ}\)\(^{±}_{1}\)\(\tilde{χ}\)\(^{0}_{2}\), where the chargino decays to the lightest neutralino and the W boson, \(\tilde{χ}\)\(^{±}_{1}\)→\(\tilde{χ}\)\(^{0}_{1}\)(W\(^{±}\)→ℓ\(^{±}\)ν), while the neutralino decays to the lightest neutralino and the 125 GeV Higgs boson, \(\tilde{χ}\)\(^{0}_{2}\)→\(\tilde{χ}\)\(^{0}_{1}\)(h→bb/γγ/ℓ\(^{±}\)νqq). The final states considered for the search have large missing transverse momentum, an isolated electron or muon, and one of the following: either two jets identified as originating from bottom quarks, or two photons, or a second electron or muon with the same electric charge. The analysis is based on 20.3 fb\(^{-1}\) of \(\sqrt {s}\) = 8 TeV proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with the Standard Model expectations, and limits are set in the context of a simplified supersymmetric model.
KW  - neutralino
KW  - chargino
KW  - proton-proton collision
KW  - Higgs boson
KW  - ATLAS detector
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150099
VL  - 75
IS  - 5
ER  - 
TY  - JOUR
T1  - Search for dark matter in events with heavy quarks and missing transverse momentum in pp collisions with the ATLAS detector
JF  - European Physical Journal C: Particles and Fields
N2  - This article reports on a search for dark matter pair production in association with bottom or top quarks in 20.3 fb\(^{−1}\) of pp collisions collected at \(\sqrt {s}\) = 8 TeV by the ATLAS detector at the LHC. Events with large missing transverse momentum are selected when produced in association with high-momentum jets of which one or more are identified as jets containing b-quarks. Final states with top quarks are selected by requiring a high jet multiplicity and in some cases a single lepton. The data are found to be consistent with the Standard Model expectations and limits are set on the mass scale of effective field theories that describe scalar and tensor interactions between dark matter and Standard Model particles. Limits on the dark-matter–nucleon cross-section for spin-independent and spin-dependent interactions are also provided. These limits are particularly strong for low-mass dark matter. Using a simplified model, constraints are set on the mass of dark matter and of a coloured mediator suitable to explain a possible signal of annihilating dark matter.
KW  - dark matter
KW  - proton-proton collision
KW  - ATLAS detector
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150089
VL  - 75
IS  - 2
ER  - 
TY  - JOUR
T1  - Search for a new resonance decaying to a W or Z boson and a Higgs boson in the ℓℓ/ℓν/νν+b\(\overline{b}\) final states with the ATLAS detector
JF  - European Physical Journal C: Particles and Fields
N2  - A search for a new resonance decaying to a W or Z boson and a Higgs boson in the ℓℓ/ℓν/νν+b\(\overline{b}\) final states is performed using 20.3 fb\(^{−1}\) of pp collision data recorded at \(\sqrt {s}\) = 8 TeV with the ATLAS detector at the Large Hadron Collider. The search is conducted by examining the WH / ZH invariant mass distribution for a localized excess. No significant deviation from the Standard Model background prediction is observed. The results are interpreted in terms of constraints on the Minimal Walking Technicolor model and on a simplified approach based on a phenomenological Lagrangian of Heavy Vector Triplets.
KW  - Higgs boson
KW  - W boson
KW  - Z boson
KW  - ATLAS detector
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150075
VL  - 75
IS  - 6
ER  - 
TY  - JOUR
T1  - Search for W' → tb → qqbb decays in pp collisions at \(\sqrt {s}\) = 8 TeV with the ATLAS detector
JF  - European Physical Journal C: Particles and Fields
N2  - A search for a massive W′ gauge boson decaying to a top quark and a bottom quark is performed with the ATLAS detector in pp collisions at the LHC. The dataset was taken at a centre-of-mass energy of \(\sqrt {s}\) = 8 TeV and corresponds to 20.3 fb\(^{−1}\) of integrated luminosity. This analysis is done in the hadronic decay mode of the top quark, where novel jet substructure techniques are used to identify jets from high-momentum top quarks. This allows for a search for high-mass W′ bosons in the range 1.5–3.0  TeV. b-tagging is used to identify jets originating from b-quarks. The data are consistent with Standard Model background-only expectations, and upper limits at 95 % confidence level are set on the W′ → tb cross section times branching ratio ranging from 0.16 pb to 0.33 pb for left-handed W′ bosons, and ranging from 0.10 pb to 0.21 pb for W′ bosons with purely right-handed couplings. Upper limits at 95 % confidence level are set on the W′-boson coupling to tb as a function of the W′ mass using an effective field theory approach, which is independent of details of particular models predicting a W′ boson.
KW  - ATLAS detector
KW  - proton-proton collision
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150068
VL  - 75
IS  - 4
ER  - 
TY  - JOUR
T1  - Performance of the ATLAS muon trigger in pp collisions at \(\sqrt {s}\)= 8 TeV
JF  - European Physical Journal C: Particles and Fields
N2  - The performance of the ATLAS muon trigger system is evaluated with proton–proton collision data collected in 2012 at the Large Hadron Collider at a centre-of-mass energy of 8 TeV. It is primarily evaluated using events containing a pair of muons from the decay of Z bosons. The efficiency of the single-muon trigger is measured for muons with transverse momentum 25 < p\(_{T}\) < 100GeV, with a statistical uncertainty of less than 0.01 % and a systematic uncertainty of 0.6 %. The pT range for efficiency determination is extended by using muons from decays of J/ψ mesons, W bosons, and top quarks. The muon trigger shows highly uniform and stable performance. The performance is compared to the prediction of a detailed simulation.
KW  - LHC
KW  - proton-proton-collistion
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150032
VL  - 75
IS  - 3
ER  - 
TY  - JOUR
T1  - Observation and measurements of the production of prompt and non-prompt J/ψ mesons in association with a Z boson in pp collisions at \(\sqrt {s}\)=8 TeV with the ATLAS detector
JF  - European Physical Journal C: Particles and Fields
N2  - The production of a Z boson in association with a J/ψ meson in proton–proton collisions probes the production mechanisms of quarkonium and heavy flavour in association with vector bosons, and allows studies of multiple parton scattering. Using 20.3fb\(^{−1}\) of data collected with the ATLAS experiment at the LHC in pp collisions at \(\sqrt {s}\) = 8 TeV, the first measurement of associated Z+J/ψ production is presented for both prompt and non-prompt J/ψ production, with both signatures having a significance in excess of 5σ. The inclusive production cross-sections for Z boson production (analysed in μ\(^{+}\)μ\(^{−}\) or e\(^{+}\)e\(^{−}\) decay modes) in association with prompt and non-prompt J/ψ(→μ\(^{+}\)μ\(^{−}\)) are measured relative to the inclusive production rate of Z bosons in the same fiducial volume to be (36.8±6.7±2.5)×10\(^{−7}\) and (65.8±9.2±4.2)×10\(^{−7}\) respectively. Normalised differential production cross-section ratios are also determined as a function of the J/ψ transverse momentum. The fraction of signal events arising from single and double parton scattering is estimated, and a lower limit of 5.3 (3.7)mb at 68 (95)% confidence level is placed on the effective cross-section regulating double parton interactions.
KW  - ATLAS detector
KW  - Z boson
KW  - proton-proton-collision
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-149970
VL  - 75
IS  - 5
ER  - 
TY  - JOUR
T1  - Measurements of the W production cross sections in association with jets with the ATLAS detector
JF  - European Physical Journal C: Particles and Fields
N2  - This paper presents cross sections for the production of a W boson in association with jets, measured in proton–proton collisions at \(\sqrt {s}\) = 7 TeV with the ATLAS experiment at the large hadron collider. With an integrated luminosity of 4.6 fb\(^{−1}\), this data set allows for an exploration of a large kinematic range, including jet production up to a transverse momentum of 1 TeV and multiplicities up to seven associated jets. The production cross sections for W bosons are measured in both the electron and muon decay channels. Differential cross sections for many observables are also presented including measurements of the jet observables such as the rapidities and the transverse momenta as well as measurements of event observables such as the scalar sums of the transverse momenta of the jets. The measurements are compared to numerous QCD predictions including next-to-leading-order perturbative calculations, resummation calculations and Monte Carlo generators.
KW  - ATLAS detector
KW  - W boson
KW  - proton-prton-collision
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-149925
VL  - 75
IS  - 2
ER  - 
TY  - JOUR
T1  - Measurement of three-jet production cross-sections in pp collisions at 7 TeV centre-of-mass energy using the ATLAS detector
JF  - European Physical Journal C: Particles and Fields
N2  - Double-differential three-jet production cross-sections are measured in proton–proton collisions at a centre-of-mass energy of \(\sqrt {s}\) = 7 TeV using the ATLAS detector at the large hadron collider. The measurements are presented as a function of the three-jet mass (m\(_{jjj}\)), in bins of the sum of the absolute rapidity separations between the three leading jets (|Y\(^{*}\)|). Invariant masses extending up to 5 TeV are reached for 8 < |Y\(^{*}\)| < 10. These measurements use a sample of data recorded using the ATLAS detector in 2011, which corresponds to an integrated luminosity of 4.51 fb\(^{-1}\). Jets are identified using the anti-k\(_{t}\) algorithm with two different jet radius parameters, R = 0.4 and R = 0.6. The dominant uncertainty in these measurements comes from the jet energy scale. Next-to-leading-order QCD calculations corrected to account for non-perturbative effects are compared to the measurements. Good agreement is found between the data and the theoretical predictions based on most of the available sets of parton distribution functions, over the full kinematic range, covering almost seven orders of magnitude in the measured cross-section values.
KW  - proton-proton-collisions
KW  - ATLAS detector
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-149918
VL  - 75
IS  - 5
ER  - 
TY  - JOUR
T1  - Measurement of the top-quark mass in the fully hadronic decay channel from ATLAS data at \(\sqrt {s}\)=7TeV
JF  - European Physical Journal C: Particles and Fields
N2  - The mass of the top quark is measured in a data set corresponding to 4.6  fb\(^{-1}\) of proton–proton collisions with centre-of-mass energy \(\sqrt {s}\)=7 TeV collected by the ATLAS detector at the LHC. Events consistent with hadronic decays of top–antitop quark pairs with at least six jets in the final state are selected. The substantial background from multijet production is modelled with data-driven methods that utilise the number of identified b-quark jets and the transverse momentum of the sixth leading jet, which have minimal correlation. The top-quark mass is obtained from template fits to the ratio of three-jet to dijet mass. The three-jet mass is calculated from the three jets produced in a top-quark decay. Using these three jets the dijet mass is obtained from the two jets produced in the W boson decay. The top-quark mass obtained from this fit is thus less sensitive to the uncertainty in the energy measurement of the jets. A binned likelihood fit yields a top-quark mass of m\(_{t}\)= 175.1 ± 1.4 (stat.) ± 1.2 (syst.) GeV.
KW  - ATLAS
KW  - proton–proton collisions
KW  - top-quark mass
KW  - fully hadronic
KW  - LHC
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-149905
VL  - 75
IS  - 4
ER  - 
TY  - JOUR
T1  - Measurement of the top quark mass in the t\(\overline{t}\)→ lepton+jets and t\(\overline{t}\)→ dilepton channels using \(\sqrt {s}\)=7 TeV ATLAS data
JF  - European Physical Journal C: Particles and Fields
N2  - The top quark mass was measured in the channels t\(\overline{t}\) → lepton+jets and t\(\overline{t}\) → dilepton (lepton = e,μ) based on ATLAS data recorded in 2011. The data were taken at the LHC with a proton–proton centre-of-mass energy of \(\sqrt {s}\) = 7 TeV and correspond to an integrated luminosity of 4.6 fb\(^{-1}\). The t\(\overline{t}\) → lepton+jets analysis uses a three-dimensional template technique which determines the top quark mass together with a global jet energy scale factor (JSF), and a relative b-to-light-jet energy scale factor(bJSF), where the terms b-jets and light-jets refer to jets originating from b-quarks and u, d, c, s-quarks or gluons, respectively. The analysis of the t\(\overline{t}\) → dilepton channel exploits a one-dimensional template method using the m\(_{lb}\) observable, defined as the average invariant mass of the two lepton+b-jet pairs in each event. The top quark
mass is measured to be 172.33±0.75(stat + JSF + bJSF)±1.02(syst) GeV, and 173.79 ± 0.54(stat) ± 1.30(syst) GeV in the t\(\overline{t}\) → lepton+jets and t\(\overline{t}\) → dilepton channels, respectively. The combination of the two results yields m\(_{top}\) =172.99 ± 0.48(stat) ± 0.78(syst) GeV, with a total uncertainty of 0.91 GeV.
KW  - top quark mass
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-149890
VL  - 75
IS  - 7
ER  - 
TY  - JOUR
T1  - Measurement of the production and lepton charge asymmetry of bosons in Pb+Pb collisions at \(\sqrt {^{S}NN}\) with the ATLAS detector
JF  - European Physical Journal C: Particles and Fields
N2  - A measurement of W boson production in lead-lead collisions at \(\sqrt {^{S}NN}\)=2.76 TeV is presented. It is based on the analysis of data collected with the ATLAS detector at the LHC in 2011 corresponding to an integrated luminosity of 0.14 nb\(^{-1}\) and 0.15 nb\(^{-1}\) in the muon and electron decay channels, respectively. The differential production yields and lepton charge asymmetry are each measured as a function of the average number of participating nucleons ⟨N\(_{part}\)⟩ and absolute pseudorapidity of the charged lepton. The results are compared to predictions based on next-to-leading-order QCD calculations. These measurements are, in principle, sensitive to possible nuclear modifications to the parton distribution functions and also provide information on scaling of W boson production in multi-nucleon systems.
KW  - Higgs boson
KW  - lead-lead collision
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-149889
VL  - 75
IS  - 1
ER  - 
TY  - JOUR
T1  - Jet energy measurement and its systematic uncertainty in proton-proton collisions at \(\sqrt {s}\)=7  TeV with the ATLAS detector
JF  - European Physical Journal C: Particles and Fields
N2  - The jet energy scale (JES) and its systematic uncertainty are determined for jets measured with the ATLAS detector using proton–proton collision data with a centre-of-mass energy of \(\sqrt {s}\)=7 TeV corresponding to an integrated luminosity of 4.7  fb\(^{-1}\). Jets are reconstructed from energy deposits forming topological clusters of calorimeter cells using the anti-k\(_t\) algorithm with distance parameters R=0.4 or R=0.6, and are calibrated using MC simulations. A residual JES correction is applied to account for differences between data and MC simulations. This correction and its systematic uncertainty are estimated using a combination of in situ techniques exploiting the transverse momentum balance between a jet and a reference object such as a photon or a Z boson, for 20≤p\(^{jet}_{T}\)<1000 GeV and pseudorapidities |η|<4.5. The effect of multiple proton–proton interactions is corrected for, and an uncertainty is evaluated using in situ techniques. The smallest JES uncertainty of less than 1 % is found in the central calorimeter region (|η|<1.2) for jets with 55≤p\(^{jet}_{T}\)<500 GeV. For central jets at lower p\(_{T}\), the uncertainty is about 3 %. A consistent JES estimate is found using measurements of the calorimeter response of single hadrons in proton–proton collisions and test-beam data, which also provide the estimate for p\(^{jet}_{T}\)>1 TeV. The calibration of forward jets is derived from dijet p\(_{T}\) balance measurements. The resulting uncertainty reaches its largest value of 6 % for low-p\(_{T}\) jets at |η|=4.5. Additional JES uncertainties due to specific event topologies, such as close-by jets or selections of event samples with an enhanced content of jets originating from light quarks or gluons, are also discussed. The magnitude of these uncertainties depends on the event sample used in a given physics analysis, but typically amounts to 0.5–3 %.
KW  - jet energy scale
KW  - proton-proton-collision
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-149854
VL  - 75
IS  - 1
ER  - 
TY  - JOUR
T1  - Identification and energy calibration of hadronically decaying tau leptons with the ATLAS experiment in pp collisions at \(\sqrt {s}\)=8 TeV
JF  - European Physical Journal C: Particles and Fields
N2  - This paper describes the trigger and offline reconstruction, identification and energy calibration algorithms for hadronic decays of tau leptons employed for the data collected from pp collisions in 2012 with the ATLAS detector at the LHC center-of-mass energy \(\sqrt {s}\)=8 TeV. The performance of these algorithms is measured in most cases with Z decays to tau leptons using the full 2012 dataset, corresponding to an integrated luminosity of 20.3 fb\(^{-1}\). An uncertainty on the offline reconstructed tau energy scale of 2–4 %, depending on transverse energy and pseudorapidity, is achieved using two independent methods. The offline tau identification efficiency is measured with a precision of 2.5 % for hadronically decaying tau leptons with one associated track, and of 4 % for the case of three associated tracks, inclusive in pseudorapidity and for a visible transverse energy greater than 20 GeV. For hadronic tau lepton decays selected by offline algorithms, the tau trigger identification efficiency is measured with a precision of 2–8 %, depending on the transverse energy. The performance of the tau algorithms, both offline and at the trigger level, is found to be stable with respect to the number of concurrent proton–proton interactions and has supported a variety of physics results using hadronically decaying tau leptons at ATLAS.
KW  - tau leptons
KW  - hadronic decays
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-149829
VL  - 75
IS  - 7
ER  - 
TY  - JOUR
T1  - Determination of spin and parity of the Higgs boson in the WW\(^{*}\)→eνμν decay channel with the ATLAS detector
JF  - European Physical Journal C: Particles and Fields
N2  - Studies of the spin and parity quantum numbers of the Higgs boson in the WW\(^{*}\)→eνμν final state are presented, based on proton–proton collision data collected by the ATLAS detector at the Large Hadron Collider, corresponding to an integrated luminosity of 20.3 fb\(^{-1}\) at a centre-of-mass energy of \(\sqrt {s}\)=8 TeV. The Standard Model spin-parity J\(^{CP}\)=0\(^{++}\) hypothesis is compared with alternative hypotheses for both spin and CP. The case where the observed resonance is a mixture of the Standard-Model-like Higgs boson and CP-even (J\(^{CP}\)=0\(^{++}\)) or CP-odd (J\(^{CP}\)=0\(^{+-}\)) Higgs boson in scenarios beyond the Standard Model is also studied. The data are found to be consistent with the Standard Model prediction and limits are placed on alternative spin and CP hypotheses, including CP mixing in different scenarios.
KW  - Higgs boson
KW  - spin
KW  - parity
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-149632
VL  - 75
IS  - 5
ER  - 
TY  - JOUR
T1  - Constraints on the off-shell Higgs boson signal strength in the high-mass ZZ and WW final states with the ATLAS detector
JF  - European Physical Journal C: Particles and Fields
N2  - Measurements of the ZZ and WW final states in the mass range above the 2m\(_Z\) and 2m\(_W\) thresholds provide a unique opportunity to measure the off-shell coupling strength of the Higgs boson. This paper presents constraints on the off-shell Higgs boson event yields normalised to the Standard Model prediction (signal strength) in the ZZ→4ℓ, ZZ→2ℓ2ν and WW→eνμν final states. The result is based on pp collision data collected by the ATLAS experiment at the LHC, corresponding to an integrated luminosity of 20.3 fb\(^{-1}\) at a collision energy of \(\sqrt {s}\)=8 TeV. Using the CL\(_S\) method, the observed 95 % confidence level (CL) upper limit on the off-shell signal strength is in the range 5.1–8.6, with an expected range of 6.7–11.0. In each case the range is determined by varying the unknown gg→ZZ and gg→WW background K-factor from higher-order quantum chromodynamics corrections between half and twice the value of the known signal K-factor. Assuming the relevant Higgs boson couplings are independent of the energy scale of the Higgs boson production, a combination with the on-shell measurements yields an observed (expected) 95 % CL upper limit on Γ\(_H\)/Γ\(^{SM}_{H}\) in the range 4.5–7.5 (6.5–11.2) using the same variations of the background K-factor. Assuming that the unknown gg→VV background K-factor is equal to the signal K-factor, this translates into an observed (expected) 95 % CL upper limit on the Higgs boson total width of 22.7 (33.0) MeV.
KW  - Higgs boson
KW  - coupling strength
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-149615
VL  - 75
IS  - 7
ER  - 
TY  - JOUR
A1  - Lewitzki, Victor
A1  - Andratschke, Nicolaus
A1  - Kuhnt, Thomas
A1  - Hildebrandt, Guido
T1  - Radiation myelitis after hypofractionated radiotherapy with concomitant gefitinib
JF  - Radiation Oncology
N2  - We describe the case of a 71-year-old Caucasian female with primary disseminated non-small cell cancer of the lung, presented for palliative radiotherapy of metastatic spread to the 9th and 11th thoracic vertebrae without intramedullary growth. Palliative radiotherapy with daily fractions of 3 Gy and a cumulative dose of 36 Gy to thoracic vertebrae 8-12 was performed. The patient received concomitantly 250 mg gefitinib daily. After a latent period of 16 months, the patient developed symptoms of myelitis. Magnetic resonance imaging (MRI) did not reveal any bony or intraspinal tumor progression, but spinal cord signal alteration. No response to steroids was achieved. The neurological symptoms were progressive in August 2013 with the right leg being completely plegic. The left leg was incompletely paralyzed. Deep and superficial sensitivity was also diminished bilaterally. The patient was completely urinary and anally incontinent. Contrary to the clinical findings, a follow-up MRI (July 2013) showed amelioration of the former signal alterations in the spinal cord. The diagnosis of paraneoplastic myelopathy was refuted by a negative test for autologous antibodies. At the last clinical visit in May 2014, the neurological symptoms were stable. The last tumor-specific treatment the patient is receiving is erlotinib 125 mg/d.

We reviewed the literature and found no reported cases of radiation myelopathy after the treatment in such a setting. The calculated probability of such complication after radiotherapy alone is statistically measurable at the level of 0.02%. We suppose that gefitinib could also play a role in the development of this rare complication.
KW  - radiation myelitis
KW  - concomitant radiotherapy
KW  - gefitinib
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-175443
VL  - 10
IS  - 29
ER  - 
TY  - JOUR
A1  - Thibaudeau, Laure
A1  - Taubenberger, Anna V.
A1  - Theodoropoulos, Christina
A1  - Holzapfel, Boris M.
A1  - Ramuz, Olivier
A1  - Straub, Melanie
A1  - Hutmacher, Dietmar W.
T1  - New mechanistic insights of integrin β1 in breast cancer bone colonization
JF  - Oncotarget
N2  - Bone metastasis is a frequent and life-threatening complication of breast cancer. The molecular mechanisms supporting the establishment of breast cancer cells in the skeleton are still not fully understood, which may be attributed to the lack of suitable models that interrogate interactions between human breast cancer cells and the bone microenvironment. Although it is well-known that integrins mediate adhesion of malignant cells to bone extracellular matrix, their role during bone colonization remains unclear. Here, the role of β1 integrins in bone colonization was investigated using tissue-engineered humanized in vitro and in vivo bone models. In vitro, bone-metastatic breast cancer cells with suppressed integrin β1 expression showed reduced attachment, spreading, and migration within human bone matrix compared to control cells. Cell proliferation in vitro was not affected by β1 integrin knockdown, yet tumor growth in vivo within humanized bone microenvironments was significantly inhibited upon β1 integrin suppression, as revealed by quantitative in/ex vivo fluorescence imaging and histological analysis. Tumor cells invaded bone marrow spaces in the humanized bone and formed osteolytic lesions; osteoclastic bone resorption was, however, not reduced by β1 integrin knockdown. Taken together, we demonstrate that β1 integrins have a pivotal role in bone colonization using unique tissue-engineered humanized bone models.
KW  - tissue engineering
KW  - bone colonization
KW  - breast cancer
KW  - β1 integrin
KW  - humanized bone models
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-175432
VL  - 6
IS  - 1
ER  - 
TY  - JOUR
A1  - Orth, Martin F.
A1  - Cazes, Alex
A1  - Butt, Elke
A1  - Grunewald, Thomas G. P.
T1  - An update on the LIM and SH3 domain protein 1 (LASP1): a versatile structural, signaling, and biomarker protein
JF  - Oncotarget
N2  - The gene encoding the LIM and SH3 domain protein (LASP1) was cloned two decades ago from a cDNA library of breast cancer metastases. As the first protein of a class comprising one N-terminal LIM and one C-terminal SH3 domain, LASP1 founded a new LIM-protein subfamily of the nebulin group. Since its discovery LASP1 proved to be an extremely versatile protein because of its exceptional structure allowing interaction with various binding partners, its ubiquitous expression in normal tissues, albeit with distinct expression patterns, and its ability to transmit signals from the cytoplasm into the nucleus. As a result, LASP1 plays key roles in cell structure, physiological processes, and cell signaling. Furthermore, LASP1 overexpression contributes to cancer aggressiveness hinting to a potential value of LASP1 as a cancer biomarker. In this review we summarize published data on structure, regulation, function, and expression pattern of LASP1, with a focus on its role in human cancer and as a biomarker protein. In addition, we provide a comprehensive transcriptome analysis of published microarrays (n=2,780) that illustrates the expression profile of LASP1 in normal tissues and its overexpression in a broad range of human cancer entities.
KW  - LASP1
KW  - cancer
KW  - biomarker
KW  - microRNA
KW  - nucleo-cytoplasmic
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-144546
VL  - 6
IS  - 1
ER  - 
TY  - JOUR
A1  - Luger, Sebastian
A1  - Hohmann, Carina
A1  - Niemann, Daniela
A1  - Kraft, Peter
A1  - Gunreben, Ignaz
A1  - Neumann-Haefelin, Tobias
A1  - Kleinschnitz, Christoph
A1  - Steinmetz, Helmuth
A1  - Foerch, Christian
A1  - Pfeilschifter, Waltraud
T1  - Adherence to oral anticoagulant therapy in secondary stroke prevention - impact of the novel oral anticoagulants
JF  - Patient Preference and Adherence
N2  - Background: 
Oral anticoagulant therapy (OAT) potently prevents strokes in patients with atrial fibrillation. Vitamin K antagonists (VKA) have been the standard of care for long-term OAT for decades, but non-VKA oral anticoagulants (NOAC) have recently been approved for this indication, and raised many questions, among them their influence on medication adherence. We assessed adherence to VKA and NOAC in secondary stroke prevention. 

Methods: 
All patients treated from October 2011 to September 2012 for ischemic stroke or transient ischemic attack with a subsequent indication for OAT, at three academic hospitals were entered into a prospective registry, and baseline data and antithrombotic treatment at discharge were recorded. At the 1-year follow-up, we assessed the adherence to different OAT strategies and patients' adherence to their respective OAT. We noted OAT changes, reasons to change treatment, and factors that influence persistence to the prescribed OAT. 

Results: 
In patients discharged on OAT, we achieved a fatality corrected response rate of 73.3% (n=209). A total of 92% of these patients received OAT at the 1-year follow-up. We observed good adherence to both VKA and NOAC (VKA, 80.9%; NOAC, 74.8%; P=0.243) with a statistically nonsignificant tendency toward a weaker adherence to dabigatran. Disability at 1-year follow-up was an independent predictor of lower adherence to any OAT after multivariate analysis, whereas the choice of OAT did not have a relevant influence. 

Conclusion: 
One-year adherence to OAT after stroke is strong (>90%) and patients who switch therapy most commonly switch toward another OAT. The 1-year adherence rates to VKA and NOAC in secondary stroke prevention do not differ significantly between both therapeutic strategies.
KW  - transient ischemic attack
KW  - adherence
KW  - non-VKA oral anticoagulants
KW  - vitamin K antagonists
KW  - prevention
KW  - stroke
KW  - atrial fibrillation
KW  - warfarin
KW  - guidelines
KW  - scale
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-144477
VL  - 9
ER  - 
TY  - JOUR
A1  - Gordon, Sarah
A1  - Daneshian, Mardas
A1  - Bouwstra, Joke
A1  - Caloni, Francesca
A1  - Constant, Samuel
A1  - Davies, Donna E.
A1  - Dandekar, Gudrun
A1  - Guzman, Carlos A.
A1  - Fabian, Eric
A1  - Haltner, Eleonore
A1  - Hartung, Thomas
A1  - Hasiwa, Nina
A1  - Hayden, Patrick
A1  - Kandarova, Helena
A1  - Khare, Sangeeta
A1  - Krug, Harald F.
A1  - Kneuer, Carsten
A1  - Leist, Marcel
A1  - Lian, Guoping
A1  - Marx, Uwe
A1  - Metzger, Marco
A1  - Ott, Katharina
A1  - Prieto, Pilar
A1  - Roberts, Michael S.
A1  - Roggen, Erwin L.
A1  - Tralau, Tewes
A1  - van den Braak, Claudia
A1  - Walles, Heike
A1  - Lehr, Claus-Michael
T1  - Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology
JF  - ALTEX: Alternatives to Animal Experimentation
N2  - Models of the outer epithelia of the human body namely the skin, the intestine and the lung have found valid applications in both research and industrial settings as attractive alternatives to animal testing. A variety of approaches to model these barriers are currently employed in such fields, ranging from the utilization of ex vivo tissue to reconstructed in vitro models, and further to chip-based technologies, synthetic membrane systems and, of increasing current interest, in silico modeling approaches. An international group of experts in the field of epithelial barriers was convened from academia, industry and regulatory bodies to present both the current state of the art of non-animal models of the skin, intestinal and pulmonary barriers in their various fields of application, and to discuss research-based, industry-driven and regulatory-relevant future directions for both the development of new models and the refinement of existing test methods. Issues of model relevance and preference, validation and standardization, acceptance, and the need for simplicity versus complexity were focal themes of the discussions. The outcomes of workshop presentations and discussions, in relation to both current status and future directions in the utilization and development of epithelial barrier models, are presented by the attending experts in the current report.
KW  - on-a-chip
KW  - asthmatic bronchial epithelium
KW  - vesicle-based barrier
KW  - pulmonary drug-delivery
KW  - epithelial cell culture
KW  - cytotoxicity
KW  - transport studies
KW  - permeability
KW  - in vitro models
KW  - air-liquid interface
KW  - respiratory syncytial virus
KW  - reconstructed human epidermis
KW  - artificial membrane-permeability
KW  - embryonic stem cells
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-144275
VL  - 32
IS  - 4
ER  - 
TY  - JOUR
A1  - Kumar, Praveen
A1  - Naumann, Ulrike
A1  - Aigner, Ludwig
A1  - Wischhusen, Joerg
A1  - Beier, Christoph P
A1  - Beier, Dagmar
T1  - Impaired TGF-β induced growth inhibition contributes to the increased proliferation rate of neural stem cells harboring mutant p53
JF  - American Journal of Cancer Research
N2  - Gliomas have been classified according to their histological properties. However, their respective cells of origin are still unknown. Neural progenitor cells (NPC) from the subventricular zone (SVZ) can initiate tumors in murine models of glioma and are likely cells of origin in the human disease. In both, p53 signaling is often functionally impaired which may contribute to tumor formation. Also, TGF-beta, which under physiological conditions exerts a strong control on the proliferation of NPCs in the SVZ, is a potent mitogen on glioma cells. Here, we approach on the crosstalk between p53 and TGF-beta by loss of function experiments using NPCs derived from p53 mutant mice, as well as pharmacological inhibition of TGF-beta signaling using TGF-beta receptor inhibitors. NPC derived from p53 mutant mice showed increased clonogenicity and more rapid proliferation than their wildtype counterparts. Further, NPC derived from p53\(^{mut/mut}\) mice were insensitive to TGF-beta induced growth arrest. Still, the canonical TGF-beta signaling pathway remained functional in the absence of p53 signaling and expression of key proteins as well as phosphorylation and nuclear translocation of SMAD2 were unaltered. TGF-beta-induced p21 expression could, in contrast, only be detected in p53\(^{wt/wt}\) but not in p53\(^{mut/mut}\) NPC. Conversely, inhibition of TGF-beta signaling using SB431542 increased proliferation of p53\(^{wt/wt}\) but not of p53\(^{mut/mut}\) NPC. In conclusion, our data suggest that the TGF-beta induced growth arrest in NPC depends on functional p53. Mutational inactivation of p53 hence contributes to increased proliferation of NPC and likely to the formation of hyperplasia of the SVZ observed in p53 deficient mice in vivo.
KW  - mouse brain
KW  - tumors
KW  - cancer
KW  - TGF-beta
KW  - glioblastoma stem cell
KW  - pathways
KW  - expression
KW  - astrocytoma
KW  - glioblastoma
KW  - transforming growth factor-beta-1
KW  - neurogenesis
KW  - gliomas
KW  - neural stem cell
KW  - p53
KW  - subventricular zone
KW  - premalignant lesion
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-144262
VL  - 5
IS  - 11
ER  - 
TY  - JOUR
T1  - Measurement of exclusive γγ→ℓ\(^{+}\)ℓ\(^{−}\) production in proton–proton collisions at \(\sqrt {s}\)=7 TeV with the ATLAS detector
JF  - Physics Letters B
N2  - This Letter reports a measurement of the exclusive γγ→ℓ\(^{+}\)ℓ\(^{−}\) (ℓ=e, μℓ=e, μ) cross-section in proton–proton collisions at a centre-of-mass energy of 7 TeV by the ATLAS experiment at the LHC, based on an integrated luminosity of 4.6 fb\(^{−1}\). For the electron or muon pairs satisfying exclusive selection criteria, a fit to the dilepton acoplanarity distribution is used to extract the fiducial cross-sections. The cross-section in the electron channel is determined to be \(^{excl.}_{γγ→e^{+}e^{-}}\)=0.428 ± 0.035 (stat.) ± 0.018 (syst.) pb for a phase–space region with invariant mass of the electron pairs greater than 24 GeV, in which both electrons have transverse momentum p\(_{T}\)>12 GeV and pseudorapidity |η|<2.4. For muon pairs with invariant mass greater than 20 GeV, muon transverse momentum p\(_{T}\)>10 GeV and pseudorapidity |η|<2.4, the cross-section is determined to be \(^{excl.}_{γγ→μ^{+}μ^{-}}\) =0.628 ± 0.032 (stat.) ± 0.021 (syst.) pb. When proton absorptive effects due to the finite size of the proton are taken into account in the theory calculation, the measured cross-sections are found to be consistent with the theory prediction.
KW  - physics
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-144247
VL  - 749
ER  - 
TY  - JOUR
T1  - Search for the associated production of the Higgs boson with a top quark pair in multilepton final states with the ATLAS detector
JF  - Physics Letters B
N2  - A search for the associated production of the Higgs boson with a top quark pair is performed in multilepton final states using 20.3 fb\(^{−1}\) of proton–proton collision data recorded by the ATLAS experiment at \(\sqrt {s}\)=8 TeV at the Large Hadron Collider. Five final states, targeting the decays H→WW\(^{*}\), ττ, and ZZ\(^{*}\), are examined for the presence of the Standard Model (SM) Higgs boson: two same-charge light leptons (e or μ) without a hadronically decaying τ lepton; three light leptons; two same-charge light leptons with a hadronically decaying τ lepton; four light leptons; and one light lepton and two hadronically decaying τ leptons. No significant excess of events is observed above the background expectation. The best fit for the t\(\overline{t}\)H production cross section, assuming a Higgs boson mass of 125 GeV, is 2.1\(^{+1.4}_{-1.2}\) times the SM expectation, and the observed (expected) upper limit at the 95% confidence level is 4.7 (2.4) times the SM rate. The p-value for compatibility with the background-only hypothesis is 1.8σ; the expectation in the presence of a Standard Model signal is 0.9σ.
KW  - physics
KW  - associated production
KW  - Higgs boson
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-144231
VL  - 749
ER  - 
TY  - JOUR
T1  - Measurement of colour flow with the jet pull angle in t\(\overline{t}\) events using the ATLAS detector at \(\sqrt {s}\)=8 TeV
JF  - Physics Letters B
N2  - The distribution and orientation of energy inside jets is predicted to be an experimental handle on colour connections between the hard-scatter quarks and gluons initiating the jets. This Letter presents a measurement of the distribution of one such variable, the jet pull angle. The pull angle is measured for jets produced in t\(\overline{t}\) events with one W boson decaying leptonically and the other decaying to jets using 20.3 fb\(^{−1}\) of data recorded with the ATLAS detector at a centre-of-mass energy of \(\sqrt {s}\)=8 TeV at the LHC. The jet pull angle distribution is corrected for detector resolution and acceptance effects and is compared to various models.
KW  - physics
KW  - colour flow
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-144229
VL  - 750
ER  - 
TY  - JOUR
A1  - Stijnis, Kees
A1  - Dijkmans, Anneke C.
A1  - Bart, Aldert
A1  - Brosens, Lodewijk A. A.
A1  - Muntau, Birgit
A1  - Schoen, Christoph
A1  - Barth, Thomas F.
A1  - van Gulik, Thomas
A1  - van Gool, Tom
A1  - Grobusch, Martin P.
A1  - Tappe, Dennis
T1  - Echinococcus vogeli in Immigrant from Suriname to the Netherlands
JF  - Emerging Infectious Diseases
KW  - alveolar echinococcosis
KW  - monoclonal antibody
KW  - multilocularis
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-143953
VL  - 21
IS  - 3
ER  - 
TY  - JOUR
A1  - Drube, Sebastian
A1  - Weber, Franziska
A1  - Loschinski, Romy
A1  - Beyer, Mandy
A1  - Rothe, Mandy
A1  - Rabenhorst, Anja
A1  - Göpfert, Christiane
A1  - Meininger, Isabel
A1  - Diamanti, Michaela A.
A1  - Stegner, David
A1  - Häfner, Norman
A1  - Böttcher, Martin
A1  - Reinecke, Kirstin
A1  - Herdegen, Thomas
A1  - Greten, Florian R.
A1  - Nieswandt, Bernhard
A1  - Hartmann, Karin
A1  - Krämer, Oliver H.
A1  - Kamradt, Thomas
T1  - Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells
JF  - Oncotarget
N2  - Mast cell differentiation and proliferation depends on IL-3. IL-3 induces the activation of MAP-kinases and STATs and consequently induces proliferation and survival. Dysregulation of IL-3 signaling pathways also contribute to inflammation and tumorigenesis. We show here that IL-3 induces a SFK- and Ca2\(^{+}\)-dependent activation of the inhibitor of κB kinases 2 (IKK2) which results in mast cell proliferation and survival but does not induce IκBα-degradation and NFκB activation. Therefore we propose the term "subthreshold IKK activation". This subthreshold IKK activation also primes mast cells for enhanced responsiveness to IL-33R signaling. Consequently, co-stimulation with IL-3 and IL-33 increases IKK activation and massively enhances cytokine production induced by IL-33. We further reveal that in neoplastic mast cells expressing constitutively active Ras, subthreshold IKK activation is associated with uncontrolled proliferation. Consequently, pharmacological IKK inhibition reduces tumor growth selectively by inducing apoptosis in vivo. Together, subthreshold IKK activation is crucial to mediate the full IL-33-induced effector functions in primary mast cells and to mediate uncontrolled proliferation of neoplastic mast cells. Thus, IKK2 is a new molecularly defined target structure.
KW  - mast cells
KW  - subthreshold IKK activation
KW  - mitogenic signaling
KW  - NFκB-activation
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-143681
VL  - 6
IS  - 7
ER  - 
TY  - JOUR
A1  - Biegstraaten, Marieke
A1  - Arngrímsson, Reynir
A1  - Barbey, Frederic
A1  - Boks, Lut
A1  - Cecchi, Franco
A1  - Deegan, Patrick B
A1  - Feldt-Rasmussen, Ulla
A1  - Geberhiwot, Tarekegn
A1  - Germain, Dominique P
A1  - Hendriksz, Chris
A1  - Hughes, Derralynn A
A1  - Kantola, Ilkka
A1  - Karabul, Nesrin
A1  - Lavery, Christine
A1  - Linthorst, Gabor E
A1  - Mehta, Atul
A1  - van de Mheen, Erica
A1  - Oliveira, João P
A1  - Parini, Rossella
A1  - Ramaswami, Uma
A1  - Rudnicki, Michael
A1  - Serra, Andreas
A1  - Sommer, Claudia
A1  - Sunder-Plassmann, Gere
A1  - Svarstad, Einar
A1  - Sweeb, Annelies
A1  - Terryn, Wim
A1  - Tylki-Szymanska, Anna
A1  - Tøndel, Camilla
A1  - Vujkovac, Bojan
A1  - Weidemann, Frank
A1  - Wijburg, Frits A
A1  - Woolfson, Peter
A1  - Hollak, Carla EM
T1  - Recommendations for initiation and cessation of enzyme replacement therapy in patients with Fabry disease: the European Fabry Working Group consensus document
JF  - Orphanet Journal of Rare Diseases
N2  - Introduction:
Fabry disease (FD) is a lysosomal storage disorder resulting in progressive nervous system, kidney and heart disease. Enzyme replacement therapy (ERT) may halt or attenuate disease progression. Since administration is burdensome and expensive, appropriate use is mandatory. We aimed to define European consensus recommendations for the initiation and cessation of ERT in patients with FD.

Methods:
A Delphi procedure was conducted with an online survey (n = 28) and a meeting (n = 15). Patient organization representatives were present at the meeting to give their views. Recommendations were accepted with ≥75% agreement and no disagreement.

Results:
For classically affected males, consensus was achieved that ERT is recommended as soon as there are early clinical signs of kidney, heart or brain involvement, but may be considered in patients of ≥16 years in the absence of clinical signs or symptoms of organ involvement. Classically affected females and males with non-classical FD should be treated as soon as there are early clinical signs of kidney, heart or brain involvement, while treatment may be considered in females with non-classical FD with early clinical signs that are considered to be due to FD. Consensus was achieved that treatment should not be withheld from patients with severe renal insufficiency (GFR < 45 ml/min/1.73 m\(^{2}\)) and from those on dialysis or with cognitive decline, but carefully considered on an individual basis. Stopping ERT may be considered in patients with end stage FD or other co-morbidities, leading to a life expectancy of <1 year. In those with cognitive decline of any cause, or lack of response for 1 year when the sole indication for ERT is neuropathic pain, stopping ERT may be considered. Also, in patients with end stage renal disease, without an option for renal transplantation, in combination with advanced heart failure (NYHA class IV), cessation of ERT should be considered. ERT in patients who are non-compliant or fail to attend regularly at visits should be stopped.

Conclusion:
The recommendations can be used as a benchmark for initiation and cessation of ERT, although final decisions should be made on an individual basis. Future collaborative efforts are needed for optimization of these recommendations.
KW  - Fabry disease
KW  - enzyme replacement therapy
KW  - recommendations
KW  - Delphi procedure
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-175374
VL  - 10
IS  - 36
ER  - 
TY  - JOUR
T1  - Measurement of transverse energy–energy correlations in multi-jet events in pp collisions at \(\sqrt {s}\)=7 TeV using the ATLAS detector and determination of the strong coupling constant αs(m\(_{Z}\))
JF  - Physics Letters B
N2  - High transverse momentum jets produced in pp collisions at a centre of mass energy of 7 TeV are used to measure the transverse energy–energy correlation function and its associated azimuthal asymmetry. The data were recorded with the ATLAS detector at the LHC in the year 2011 and correspond to an integrated luminosity of 158 pb\(^{-1}\). The selection criteria demand the average transverse momentum of the two leading jets in an event to be larger than 250 GeV. The data at detector level are well described by Monte Carlo event generators. They are unfolded to the particle level and compared with theoretical calculations at next-to-leading-order accuracy. The agreement between data and theory is good and provides a precision test of perturbative Quantum Chromodynamics at large momentum transfers. From this comparison, the strong coupling constant given at the Z   boson mass is determined to be αs(m\(_{Z}\))=0.1173±0.0010 (exp.) \(^{+0.0065}_{−0.0026}\) (theo.).
KW  - physics
KW  - high transverse momentum jets
KW  - transverse energy–energy correlation function
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-143398
VL  - 750
ER  - 
TY  - JOUR
T1  - Measurement of the branching ratio Γ(Λ\(^0_b\)→ψ(2S)Λ\(^0\))/Γ(Λ\(^0_b\)→J/ψΛ\(^0\)) with the ATLAS detector
JF  - Physics Letters B
N2  - An observation of the View the Λ\(^0_b\)→ψ(2S)Λ\(^0\) decay and a comparison of its branching fraction with that of the Λ\(^0_b\)→J/ψΛ\(^0\) decay has been made with the ATLAS detector in proton–proton collisions at \(\sqrt {s}\)=8 TeV at the LHC using an integrated luminosity of 20.6 fb\(^{-1}\). The J/ψJ/ψ and ψ(2S) mesons are reconstructed in their decays to a muon pair, while the Λ\(^0\)→pπ\(^-\) decay is exploited for the Λ\(^0\) baryon reconstruction. The Λ\(^0_b\) baryons are reconstructed with transverse momentum p\(_T\)>10 GeV pT>10 GeV and pseudorapidity |η|<2.1. The measured branching ratio of the Λ\(^0_b\)→ψ(2S)Λ\(^0\) and Λ\(^0_b\)→J/ψΛ\(^0\) decays is Γ(Λ\(^0_b\)→ψ(2S)Λ\(^0\))/Γ(Λ\(^0_b\)→J/ψΛ\(^0\))=0.501±0.033(stat)±0.019(syst), lower than the expectation from the covariant quark model.
KW  - physics
KW  - proton–proton collisions
KW  - Large Hadron Collider
KW  - decay
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-143375
VL  - 751
ER  - 
TY  - JOUR
A1  - Elkon, Ran
A1  - Loayza-Puch, Fabricio
A1  - Korkmaz, Gozde
A1  - Lopes, Rui
A1  - van Breugel, Pieter C
A1  - Bleijerveld, Onno B
A1  - Altelaar, AF Maarten
A1  - Wolf, Elmar
A1  - Lorenzin, Francesca
A1  - Eilers, Martin
A1  - Agami, Reuven
T1  - Myc coordinates transcription and translation to enhance transformation and suppress invasiveness
JF  - EMBO reports
N2  - c‐Myc is one of the major human proto‐oncogenes and is often associated with tumor aggression and poor clinical outcome. Paradoxically, Myc was also reported as a suppressor of cell motility, invasiveness, and metastasis. Among the direct targets of Myc are many components of the protein synthesis machinery whose induction results in an overall increase in protein synthesis that empowers tumor cell growth. At present, it is largely unknown whether beyond the global enhancement of protein synthesis, Myc activation results in translation modulation of specific genes. Here, we measured Myc‐induced global changes in gene expression at the transcription, translation, and protein levels and uncovered extensive transcript‐specific regulation of protein translation. Particularly, we detected a broad coordination between regulation of transcription and translation upon modulation of Myc activity and showed the connection of these responses to mTOR signaling to enhance oncogenic transformation and to the TGFβ pathway to modulate cell migration and invasiveness. Our results elucidate novel facets of Myc‐induced cellular responses and provide a more comprehensive view of the consequences of its activation in cancer cells.
KW  - c‐Myc
KW  - transcriptional responses
KW  - translational regulation
KW  - transcription
KW  - transformation
KW  - metastasis
KW  - cancer
KW  - protein biosynthesis & quality control
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150373
VL  - 16
IS  - 12
ER  - 
TY  - JOUR
A1  - Wunsch, Marie
A1  - Caspell, Richard
A1  - Kuerten, Stefanie
A1  - Lehmann, Paul V.
A1  - Sundararaman, Srividya
T1  - Serial measurements of apoptotic cell numbers provide better acceptance criterion for PBMC quality than a single measurement prior to the T cell assay
JF  - Cells
N2  - As soon as Peripheral Blood Mononuclear Cells (PBMC) are isolated from whole blood, some cells begin dying. The rate of apoptotic cell death is increased when PBMC are shipped, cryopreserved, or stored under suboptimal conditions. Apoptotic cells secrete cytokines that suppress inflammation while promoting phagocytosis. Increased numbers of apoptotic cells in PBMC may modulate T cell functions in antigen-triggered T cell assays. We assessed the effect of apoptotic bystander cells on a T cell ELISPOT assay by selectively inducing B cell apoptosis using α-CD20 mAbs. The presence of large numbers of apoptotic B cells did not affect T cell functionality. In contrast, when PBMC were stored under unfavorable conditions, leading to damage and apoptosis in the T cells as well as bystander cells, T cell functionality was greatly impaired. We observed that measuring the number of apoptotic cells before plating the PBMC into an ELISPOT assay did not reflect the extent of PBMC injury, but measuring apoptotic cell frequencies at the end of the assay did. Our data suggest that measuring the numbers of apoptotic cells prior to and post T cell assays may provide more stringent PBMC quality acceptance criteria than measurements done only prior to the start of the assay.
KW  - T cell assay
KW  - apoptosis
KW  - acceptance
KW  - viability
KW  - ELISPOT
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150213
VL  - 4
IS  - 1
ER  - 
TY  - JOUR
A1  - Barteit, Sandra
A1  - Hoepffner, Philip
A1  - Huwendiek, Sören
A1  - Karamagi, Angela
A1  - Munthali, Charles
A1  - Theurer, Antje
A1  - Neuhann, Florian
T1  - Self-directed e-learning at a tertiary hospital in Malawi - a qualitative evaluation and lessons learnt
JF  - GMS Journal for Medical Education
N2  - Background: 
Malawi faces a severe lack of health workers. Despite initiatives to address this problem, a critical shortage of health care staff remains. This lack challenges the education and training of junior medical staff, especially medical interns in their final and crucial training year before they independently work as medical doctors.

Project description: 
We have introduced an e-learning platform in the medical department of the Kamuzu Central Hospital (KCH) in Malawi. With the support of computer-assisted instruction, we aimed to improve the quality of medical training and education, as well as access to current medical materials, in particular for interns.

Method: 
From March to April 2012, we conducted a qualitative evaluation to assess relevance and appropriateness of the e-learning platform. Data was collected via face-to-face interviews, a guided group discussion and a checklist based observation log. Evaluation data was recorded and coded using content analysis, interviewees were chosen via purposive sampling.

Results: 
E-learning proved to be technically feasible in this setting. Users considered the e-learning platform to be relevant and appropriate. Concerns were raised about sustainability, accessibility and technical infrastructure, as well as limited involvement and responsibilities of Malawian partners. Interest in e-learning was high, yet, awareness of and knowledge about the e-learning platform among potential users was low. Evaluation results indicated that further adaptions to local needs are necessary to increase usage and accessibility.

Conclusions: 
Interview results and our project experiences showed that, in the given setting, e-learning requires commitment from local stakeholders, adequate technical infrastructure, identification and assignation of responsibilities, as well as specific adaption to local needs.
T2  - Selbstgesteuertes medizinisches Lernen via E-Learning an einem Lehrkrankenhaus in Malawi: Aufbau,Erkenntnisse und Erfahrungen
KW  - computer-assisted instruction
KW  - capacity
KW  - multimedia,
KW  - ICT
KW  - virtual patients
KW  - medical Education
KW  - understaffed
KW  - teaching hospital
KW  - Sub-saharan Africa
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150208
N1  - Deutschsprachige Version des Artikels ab Seite 8 des Dokuments.
VL  - 32
IS  - 1
ER  - 
TY  - JOUR
A1  - Pippias, Maria
A1  - Stel, Vianda S.
A1  - Diez, José Maria Abad
A1  - Afentakis, Nikolaos
A1  - Herrero-Calvo, Jose Antonio
A1  - Arias, Manuel
A1  - Tomilina, Natalia
A1  - Caamaño, Encarnación Bouzas
A1  - Buturovic-Ponikvar, Jadranka
A1  - Čala, Svjetlana
A1  - Caskey, Fergus J.
A1  - de la Nuez, Pablo Castro
A1  - Cernevskis, Harijs
A1  - Collart, Frederic
A1  - de la Torre, Ramón Alonso
A1  - de los Ángeles García Bazaga, Maria
A1  - De Meester, Johan
A1  - Díaz, Joan Manuel
A1  - Djukanovic, Ljubica
A1  - Alamar, Manuel Ferrer
A1  - Finne, Patrik
A1  - Garneata, Liliana
A1  - Golan, Eliezer
A1  - González Fernández, Raquel
A1  - Gutiérrez Avila, Gonzalo
A1  - Heaf, James
A1  - Hoitsma, Andries
A1  - Kantaria, Nino
A1  - Kolesnyk, Mykola
A1  - Kramar, Reinhard
A1  - Kramer, Anneke
A1  - Lassalle, Mathilde
A1  - Leivestad, Torbjørn
A1  - Lopot, Frantisek
A1  - Macário, Fernando
A1  - Magaz, Angela
A1  - Martín-Escobar, Eduardo
A1  - Metcalfe, Wendy
A1  - Noordzij, Marlies
A1  - Palsson, Runolfur
A1  - Pechter, Ülle
A1  - Prütz, Karl G.
A1  - Ratkovic, Marina
A1  - Resić, Halima
A1  - Rutkowski, Boleslaw
A1  - de Pablos, Carmen Santiuste
A1  - Spustová, Viera
A1  - Süleymanlar, Gültekin
A1  - Van Stralen, Karlijn
A1  - Thereska, Nestor
A1  - Wanner, Christoph
A1  - Jager, Kitty J.
T1  - Renal replacement therapy in Europe: a summary of the 2012 ERA-EDTA Registry Annual Report
JF  - Clinical Kidney Journal
N2  - Background
This article summarizes the 2012 European Renal Association—European Dialysis and Transplant Association Registry Annual Report (available at www.era-edta-reg.org) with a specific focus on older patients (defined as ≥65 years).

Methods
Data provided by 45 national or regional renal registries in 30 countries in Europe and bordering the Mediterranean Sea were used. Individual patient level data were received from 31 renal registries, whereas 14 renal registries contributed data in an aggregated form. The incidence, prevalence and survival probabilities of patients with end-stage renal disease (ESRD) receiving renal replacement therapy (RRT) and renal transplantation rates for 2012 are presented.

Results
In 2012, the overall unadjusted incidence rate of patients with ESRD receiving RRT was 109.6 per million population (pmp) (n = 69 035), ranging from 219.9 pmp in Portugal to 24.2 pmp in Montenegro. The proportion of incident patients ≥75 years varied from 15 to 44% between countries. The overall unadjusted prevalence on 31 December 2012 was 716.7 pmp (n = 451 270), ranging from 1670.2 pmp in Portugal to 146.7 pmp in the Ukraine. The proportion of prevalent patients ≥75 years varied from 11 to 32% between countries. The overall renal transplantation rate in 2012 was 28.3 pmp (n = 15 673), with the highest rate seen in the Spanish region of Catalonia. The proportion of patients ≥65 years receiving a transplant ranged from 0 to 35%. Five-year adjusted survival for all RRT patients was 59.7% (95% confidence interval, CI: 59.3–60.0) which fell to 39.3% (95% CI: 38.7–39.9) in patients 65–74 years and 21.3% (95% CI: 20.8–21.9) in patients ≥75 years.
KW  - end-stage renal disease
KW  - incidence
KW  - prevalence
KW  - renal replacement therapy
KW  - survival
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150054
VL  - 8
IS  - 3
ER  - 
TY  - JOUR
A1  - Gulberti, A.
A1  - Moll, C.K.E.
A1  - Hamel, W.
A1  - Buhmann, C.
A1  - Koeppen, J.A.
A1  - Boelmans, K.
A1  - Zittel, S.
A1  - Gerloff, C.
A1  - Westphal, M.
A1  - Schneider, T.R.
A1  - Engel, A.K.
T1  - Predictive timing functions of cortical beta oscillations are impaired in Parkinson's disease and influenced by L-DOPA and deep brain stimulation of the subthalamic nucleus Impaired beta-band timing functions in PD
JF  - NeuroImage: Clinical
N2  - Cortex-basal ganglia circuits participate in motor timing and temporal perception, and are important for the dynamic configuration of sensorimotor networks in response to exogenous demands. In Parkinson's disease (PD) patients, rhythmic auditory stimulation (RAS) induces motor performance benefits. Hitherto, little is known concerning contributions of the basal ganglia to sensory facilitation and cortical responses to RAS in PD. Therefore, we conducted an EEG study in 12 PD patients before and after surgery for subthalamic nucleus deep brain stimulation (STN-DBS) and in 12 age-matched controls. Here we investigated the effects of levodopa and STN-DBS on resting-state EEG and on the cortical-response profile to slow and fast RAS in a passive-listening paradigm focusing on beta-band oscillations, which are important for auditory–motor coupling. The beta-modulation profile to RAS in healthy participants was characterized by local peaks preceding and following auditory stimuli. In PD patients RAS failed to induce pre-stimulus beta increases. The absence of pre-stimulus beta-band modulation may contribute to impaired rhythm perception in PD. Moreover, post-stimulus beta-band responses were highly abnormal during fast RAS in PD patients. Treatment with levodopa and STN-DBS reinstated a post-stimulus beta-modulation profile similar to controls, while STN-DBS reduced beta-band power in the resting-state. The treatment-sensitivity of beta oscillations suggests that STN-DBS may specifically improve timekeeping functions of cortical beta oscillations during fast auditory pacing.
KW  - Parkinson's disease
KW  - interval timing
KW  - beta oscillations
KW  - subthalamic nucleus
KW  - deep brain stimulation
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150049
VL  - 9
ER  - 
TY  - JOUR
A1  - Chapdelaine, Isabelle
A1  - de Roij van Zuijdewijn, Camiel L.M.
A1  - Mostovaya, Ira M.
A1  - Lévesque, Renée
A1  - Davenport, Andrew
A1  - Blankestijn, Peter J.
A1  - Wanner, Christoph
A1  - Nubé, Menso J.
A1  - Grooteman, Muriel P.C.
T1  - Optimization of the convection volume in online post-dilution haemodiafiltration: practical and technical issues
JF  - Clinical Kidney Journal
N2  - In post-dilution online haemodiafiltration (ol-HDF), a relationship has been demonstrated between the magnitude of the convection volume and survival. However, to achieve high convection volumes (>22 L per session) detailed notion of its determining factors is highly desirable. This manuscript summarizes practical problems and pitfalls that were encountered during the quest for high convection volumes. Specifically, it addresses issues such as type of vascular access, needles, blood flow rate, recirculation, filtration fraction, anticoagulation and dialysers. Finally, five of the main HDF systems in Europe are briefly described as far as HDF prescription and optimization of the convection volume is concerned.
KW  - convection volume
KW  - haemodiafiltration
KW  - dialysis
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150020
VL  - 8
IS  - 2
ER  - 
TY  - JOUR
A1  - Karulin, Alexey Y.
A1  - Caspell, Richard
A1  - Dittrich, Marcus
A1  - Lehmann, Paul V.
T1  - Normal distribution of CD8+ T-cell-derived ELISPOT counts within replicates justifies the reliance on parametric statistics for identifying positive responses
JF  - Cells
N2  - Accurate assessment of positive ELISPOT responses for low frequencies of antigen-specific T-cells is controversial. In particular, it is still unknown whether ELISPOT counts within replicate wells follow a theoretical distribution function, and thus whether high power parametric statistics can be used to discriminate between positive and negative wells. We studied experimental distributions of spot counts for up to 120 replicate wells of IFN-γ production by CD8+ T-cell responding to EBV LMP2A (426 – 434) peptide in human PBMC. The cells were tested in serial dilutions covering a wide range of average spot counts per condition, from just a few to hundreds of spots per well. Statistical analysis of the data using diagnostic Q-Q plots and the Shapiro-Wilk normality test showed that in the entire dynamic range of ELISPOT spot counts within replicate wells followed a normal distribution. This result implies that the Student t-Test and ANOVA are suited to identify positive responses. We also show experimentally that borderline responses can be reliably detected by involving more replicate wells, plating higher numbers of PBMC, addition of IL-7, or a combination of these. Furthermore, we have experimentally verified that the number of replicates needed for detection of weak responses can be calculated using parametric statistics.
KW  - ELISPOT
KW  - statistics
KW  - t-Test
KW  - ANOVA
KW  - T-cells
KW  - normal distribution
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-149968
VL  - 4
IS  - 1
ER  - 
TY  - JOUR
A1  - Seegers, Joachim
A1  - Zabel, Markus
A1  - Grüter, Timo
A1  - Ammermann, Antje
A1  - Weber-Krüger, Mark
A1  - Edelmann, Frank
A1  - Gelbrich, Götz
A1  - Binder, Lutz
A1  - Herrmann-Lingen, Christoph
A1  - Gröschel, Klaus
A1  - Hasenfuß, Gerd
A1  - Feltgen, Nicolas
A1  - Pieske, Burkert
A1  - Wachter, Rolf
T1  - Natriuretic peptides for the detection of paroxysmal atrial fibrillation
JF  - Open Heart
N2  - Background and purpose: 
Silent atrial fibrillation (AF) and tachycardia (AT) are considered precursors of ischaemic stroke. Therefore, detection of paroxysmal atrial rhythm disorders is highly relevant, but is clinically challenging. We aimed to evaluate the diagnostic value of natriuretic peptide levels in the detection of paroxysmal AT/AF in a pilot study.

Methods:
Natriuretic peptide levels were analysed in two independent patient cohorts (162 patients with arterial hypertension or other cardiovascular risk factors and 82 patients with retinal vessel disease). N-terminal-pro-brain natriuretic peptide (NT-proBNP) and BNP were measured before the start of a 7-day Holter monitoring period carefully screened for AT/AF.

Results: 
244 patients were included; 16 had paroxysmal AT/AF. After excluding patients with a history of AT/AF (n=5), 14 patients had newly diagnosed AT/AF (5.8%) NT-proBNP and BNP levels were higher in patients with paroxysmal AT/AF in both cohorts: (1) 154.4 (IQR 41.7; 303.6) versus 52.8 (30.4; 178.0) pg/mL and 70.0 (31.9; 142.4) versus 43.9 (16.3; 95.2) and (2) 216.9 (201.4; 277.1) versus 90.8 (42.3–141.7) and 96.0 (54.7; 108.2) versus 29.1 (12.0; 58.1). For the detection of AT/AF episodes, NT-proBNP and BNP had an area under the curve in receiver operating characteristic analysis of 0.76 (95% CI, 0.64 to 0.88; p=0.002) and 0.75 (0.61 to 0.89; p=0.004), respectively.

Conclusions:
NT-proBNP and BNP levels are elevated in patients with silent AT/AF as compared with sinus rhythm. Thus, screening for undiagnosed paroxysmal AF using natriuretic peptide level initiated Holter monitoring may be a useful strategy in prevention of stroke or systemic embolism.
KW  - paroxysmal atrial fibrillation
KW  - ischaemic stroke
KW  - natriuretic peptide levels
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-149939
VL  - 2
IS  - e000182
ER  - 
TY  - JOUR
A1  - Zannas, Anthony S.
A1  - Arloth, Janine
A1  - Carrillo-Roa, Tania
A1  - Iurato, Stella
A1  - Röh, Simone
A1  - Ressler, Kerry J.
A1  - Nemeroff, Charles B.
A1  - Smith, Alicia K.
A1  - Bradley, Bekh
A1  - Heim, Christine
A1  - Menke, Andreas
A1  - Lange, Jennifer F.
A1  - Brückl, Tanja
A1  - Ising, Marcus
A1  - Wray, Naomi R.
A1  - Erhardt, Angelika
A1  - Binder, Elisabeth B.
A1  - Mehta, Divya
T1  - Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling
JF  - Genome Biology
N2  - Background
Chronic psychological stress is associated with accelerated aging and increased risk for aging-related diseases, but the underlying molecular mechanisms are unclear.

Results
We examined the effect of lifetime stressors on a DNA methylation-based age predictor, epigenetic clock. After controlling for blood cell-type composition and lifestyle parameters, cumulative lifetime stress, but not childhood maltreatment or current stress alone, predicted accelerated epigenetic aging in an urban, African American cohort (n = 392). This effect was primarily driven by personal life stressors, was more pronounced with advancing age, and was blunted in individuals with higher childhood abuse exposure. Hypothesizing that these epigenetic effects could be mediated by glucocorticoid signaling, we found that a high number (n = 85) of epigenetic clock CpG sites were located within glucocorticoid response elements. We further examined the functional effects of glucocorticoids on epigenetic clock CpGs in an independent sample with genome-wide DNA methylation (n = 124) and gene expression data (n = 297) before and after exposure to the glucocorticoid receptor agonist dexamethasone. Dexamethasone induced dynamic changes in methylation in 31.2 % (110/353) of these CpGs and transcription in 81.7 % (139/170) of genes neighboring epigenetic clock CpGs. Disease enrichment analysis of these dexamethasone-regulated genes showed enriched association for aging-related diseases, including coronary artery disease, arteriosclerosis, and leukemias.

Conclusions
Cumulative lifetime stress may accelerate epigenetic aging, an effect that could be driven by glucocorticoid-induced epigenetic changes. These findings contribute to our understanding of mechanisms linking chronic stress with accelerated aging and heightened disease risk.
KW  - aging
KW  - DNA methylation
KW  - gene expression
KW  - glucocorticoids
KW  - psychological stress
KW  - aging-related disease
KW  - epigenetics
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-149865
VL  - 16
IS  - 266
ER  - 
TY  - JOUR
A1  - Torkzad, Michael R.
A1  - Masselli, Gabriele
A1  - Halligan, Steve
A1  - Oto, Aytek
A1  - Neubauer, Henning
A1  - Taylor, Stuart
A1  - Gupta, Arun
A1  - Frøkjær, Jens Brøndum
A1  - Lawrance, Ian C.
A1  - Welman, Christopher J.
A1  - Negård, Anne
A1  - Ekberg, Olle
A1  - Patak, Michael
A1  - Lauenstein, Thomas
T1  - Indications and selection of MR enterography vs. MR enteroclysis with emphasis on patients who need small bowel MRI and general anaesthesia: results of a survey
JF  - Insights into Imaging
N2  - Aims
To survey the perceived indications for magnetic resonance imaging of the small bowel (MRE) by experts, when MR enteroclysis (MREc) or MR enterography (MREg) may be chosen, and to determine how the approach to MRE is modified when general anaesthesia (GA) is required.

Materials and methods
Selected opinion leaders in MRE completed a questionnaire that included clinical indications (MREg or MREc), specifics regarding administration of enteral contrast, and how the technique is altered to accommodate GA.

Results
Fourteen responded. Only the diagnosis and follow-up of Crohn’s disease were considered by over 80 % as a valid MRE indication. The remaining indications ranged between 35.7 % for diagnosis of caeliac disease and unknown sources of gastrointestinal bleeding to 78.6 % for motility disorders. The majority chose MREg over MREc for all indications (from 100 % for follow-up of caeliac disease to 57.7 % for tumour diagnosis). Fifty per cent of responders had needed to consider MRE under GA. The most commonly recommended procedural change was MRI without enteral distention. Three had experience with intubation under GA (MREc modification).

Conclusion
Views were variable. Requests for MRE under GA are not uncommon. Presently most opinion leaders suggest standard abdominal MRI when GA is required.
KW  - small bowel MRI
KW  - Crohn’s disease
KW  - general anaesthesia
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-149847
VL  - 6
IS  - 3
ER  - 
TY  - JOUR
A1  - Karastaneva, Anna
A1  - Lanz, Sofia
A1  - Wawer, Angela
A1  - Behrends, Uta
A1  - Schindler, Detlev
A1  - Dietrich, Ralf
A1  - Burdach, Stefan
A1  - Urban, Christian
A1  - Benesch, Martin
A1  - Seidel, Markus G.
T1  - Immune thrombocytopenia in two unrelated Fanconi anemia patients - a mere coincidence?
JF  - Frontiers in Pediatrics
N2  - Thrombocytopenia and pancytopenia, occurring in patients with Fanconi anemia (FA), are interpreted either as progression to bone marrow failure or as developing myelodysplasia. On the other hand, immune thrombocytopenia (ITP) represents an acquired and often self-limiting benign hematologic disorder, associated with peripheral, immune-mediated, platelet destruction requiring different management modalities than those used in congenital bone marrow failure syndromes, including FA. Here, we describe the clinical course of two independent FA patients with atypical – namely immune – thrombocytopenia. While in one patient belonging to complementation group FA-A, the ITP started at 17 months of age and showed a chronically persisting course with severe purpura, responding well to intravenous immunoglobulins (IVIG) and later also danazol, a synthetic androgen, the other patient (of complementation group FA-D2) had a self-limiting course that resolved after one administration of IVIG. No cytogenetic aberrations or bone marrow abnormalities other than FA-typical mild dysplasia were detected. Our data show that acute and chronic ITP may occur in FA patients and impose individual diagnostic and therapeutic challenges in this rare congenital bone marrow failure/tumor predisposition syndrome. The management and a potential context of immune pathogenesis with the underlying marrow disorder are discussed.
KW  - immune thrombocytopenia
KW  - bone marrow failure syndrome
KW  - Evans syndrome
KW  - danazol
KW  - FANCA
KW  - FANCD2
KW  - Fanconi anemia
KW  - DNA repair defect
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-149837
VL  - 3
IS  - 50
ER  - 
TY  - JOUR
A1  - Mostovaya, Ira M.
A1  - Grooteman, Muriel P.C.
A1  - Basile, Carlo
A1  - Davenport, Andrew
A1  - de Roij van Zuijdewijn, Camiel L.M.
A1  - Wanner, Christoph
A1  - Nubé, Menso J.
A1  - Blankestijn, Peter J.
T1  - High convection volume in online post-dilution haemodiafiltration: relevance, safety and costs
JF  - Clinical Kidney Journal
N2  - Increasing evidence suggests that treatment with online post-dilution haemodiafiltration (HDF) improves clinical outcome in patients with end-stage kidney disease, if compared with haemodialysis (HD). Although the primary analyses of three large randomized controlled trials (RCTs) showed inconclusive results, post hoc analyses of these and previous observational studies comparing online post-dilution HDF with HD showed that the risk of overall and cardiovascular mortality is lowest in patients who are treated with high-volume HDF. As such, the magnitude of the convection volume seems crucial and can be considered as the ‘dose’ of HDF. In this narrative review, the relevance of high convection volume in online post-dilution HDF is discussed. In addition, we briefly touch upon some safety and cost issues.
KW  - convection volume
KW  - costs
KW  - hemodiafiltration
KW  - mortality
KW  - safety
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-149814
VL  - 8
IS  - 4
ER  - 
TY  - JOUR
A1  - Karulin, Alexey Y.
A1  - Karacsony, Kinga
A1  - Zhang, Wenji
A1  - Targoni, Oleg S.
A1  - Moldova, Ioana
A1  - Dittrich, Marcus
A1  - Sundararaman, Srividya
A1  - Lehmann, Paul V.
T1  - ELISPOTs produced by CD8 and CD4 cells follow Log Normal size distribution permitting objective counting
JF  - Cells
N2  - Each positive well in ELISPOT assays contains spots of variable sizes that can range from tens of micrometers up to a millimeter in diameter. Therefore, when it comes to counting these spots the decision on setting the lower and the upper spot size thresholds to discriminate between non-specific background noise, spots produced by individual T cells, and spots formed by T cell clusters is critical. If the spot sizes follow a known statistical distribution, precise predictions on minimal and maximal spot sizes, belonging to a given T cell population, can be made. We studied the size distributional properties of IFN-γ, IL-2, IL-4, IL-5 and IL-17 spots elicited in ELISPOT assays with PBMC from 172 healthy donors, upon stimulation with 32 individual viral peptides representing defined HLA Class I-restricted epitopes for CD8 cells, and with protein antigens of CMV and EBV activating CD4 cells. A total of 334 CD8 and 80 CD4 positive T cell responses were analyzed. In 99.7% of the test cases, spot size distributions followed Log Normal function. These data formally demonstrate that it is possible to establish objective, statistically validated parameters for counting T cell ELISPOTs.
KW  - ELISPOT
KW  - software
KW  - IFN-γ
KW  - IL-17
KW  - T cells
KW  - Normal Distribution
KW  - spot size
KW  - gating
KW  - cytokines
KW  - IL-2
KW  - IL-4
KW  - IL-5
KW  - CD8
KW  - CD4
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-149648
VL  - 4
IS  - 1
ER  - 
TY  - JOUR
A1  - Riad, Noura M.
A1  - Zlotos, Darius P.
A1  - Holzgrabe, Ulrike
T1  - Crystal structure of 5,11-dihydropyrido[2,3-b][1,4]benzodiazepin-6-one.
JF  - Acta Crystallographica Section E Crystallographic Communications
N2  - The title compound, C\(_{12}\)H\(_{9}\)N\(_{3}\)O, is an inter­mediate in the synthesis of the muscarinic M2 receptor antagonist AFDX-384. The seven-membered ring adopts a boat conformation and the dihedral angle between the planes of the aromatic rings is 41.51 (9)°. In the crystal, mol­ecules are linked into [001] chains of alternating inversion dimers formed by pairs of N-H・・・O hydrogen bonds and pairs of N-H・・・N hydrogen bonds. In both cases, R\(_{2}\)\(^{2}\)(8) loops are generated.
KW  - crystal structure
KW  - pyridobenzodiazepine
KW  - boat conformation
KW  - hydrogen bonding
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-149627
VL  - E71
ER  - 
TY  - JOUR
A1  - Grünblatt, Edna
A1  - Bartl, Jasmin
A1  - Iuhos, Diana-Iulia
A1  - Knezovic, Ana
A1  - Trkulja, Vladimir
A1  - Riederer, Peter
A1  - Walitza, Susanne
A1  - Salkovic-Petrisic, Melita
T1  - Characterization of cognitive deficits in spontaneously hypertensive rats, accompanied by brain insulin receptor dysfunction
JF  - Journal of Molecular Psychiatry
N2  - Background
The spontaneously hypertensive rat (SHR) has been used to model changes in the central nervous system associated with cognitive-related disorders. Recent human and animal studies indicate a possible relationship between cognitive deficits, insulin resistance and hypertension. We aimed to investigate whether cognitively impaired SHRs develop central and/or peripheral insulin resistance and how their cognitive performance is influenced by the animal’s sex and age as well as strains used for comparison (Wistar and Wistar-Kyoto/WKY).

Methods
Three and seven-month-old SHR, Wistar, and WKY rats were studied for their cognitive performance using Morris Water Maze (MWM) and Passive Avoidance tests (PAT). Plasma glucose and insulin were obtained after oral glucose tolerance tests. Cerebral cortex, hippocampus, and striatum status of insulin-receptor (IR) β-subunit and glycogen synthase kinase-3β (GSK3β) and their phosphorylated forms were obtained via ELISA.

Results
SHRs performed poorly in MWM and PAT in comparison to both control strains but more pronouncedly compared to WKY. Females performed poorer than males and 7-month-old SHRs had poorer MWM performance than 3-month-old ones. Although plasma glucose levels remained unchanged, plasma insulin levels were significantly increased in the glucose tolerance test in 7-month-old SHRs. SHRs demonstrated reduced expression and increased activity of IRβ-subunit in cerebral cortex, hippocampus, and striatum with different regional changes in phospho/total GSK3β ratio, as compared to WKYs.

Conclusion
Results indicate that cognitive deficits in SHRs are accompanied by both central and peripheral insulin dysfunction, thus allowing for the speculation that SHRs might additionally be considered as a model of insulin resistance-induced type of dementia.
KW  - spontaneously hypertensive rat
KW  - age
KW  - control strain
KW  - gender
KW  - glycogen synthase kinase-3β
KW  - insulin resistance
KW  - learning and memory
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-149593
VL  - 3
IS  - 6
ER  -