TY  - JOUR
A1  - Mitchell, Jonathan S.
A1  - Li, Ni
A1  - Weinhold, Niels
A1  - Försti, Asta
A1  - Ali, Mina
A1  - van Duin, Mark
A1  - Thorleifsson, Gudmar
A1  - Johnson, David C.
A1  - Chen, Bowang
A1  - Halvarsson, Britt-Marie
A1  - Gudbjartsson, Daniel F.
A1  - Kuiper, Rowan
A1  - Stephens, Owen W.
A1  - Bertsch, Uta
A1  - Broderick, Peter
A1  - Campo, Chiara
A1  - Einsele, Hermann
A1  - Gregory, Walter A.
A1  - Gullberg, Urban
A1  - Henrion, Marc
A1  - Hillengass, Jens
A1  - Hoffmann, Per
A1  - Jackson, Graham H.
A1  - Johnsson, Ellinor
A1  - Jöud, Magnus
A1  - Kristinsson, Sigurdur Y.
A1  - Lenhoff, Stig
A1  - Lenive, Oleg
A1  - Mellqvist, Ulf-Henrik
A1  - Migliorini, Gabriele
A1  - Nahi, Hareth
A1  - Nelander, Sven
A1  - Nickel, Jolanta
A1  - Nöthen, Markus M.
A1  - Rafnar, Thorunn
A1  - Ross, Fiona M.
A1  - da Silva Filho, Miguel Inacio
A1  - Swaminathan, Bhairavi
A1  - Thomsen, Hauke
A1  - Turesson, Ingemar
A1  - Vangsted, Annette
A1  - Vogel, Ulla
A1  - Waage, Anders
A1  - Walker, Brian A.
A1  - Wihlborg, Anna-Karin
A1  - Broyl, Annemiek
A1  - Davies, Faith E.
A1  - Thorsteinsdottir, Unnur
A1  - Langer, Christian
A1  - Hansson, Markus
A1  - Kaiser, Martin
A1  - Sonneveld, Pieter
A1  - Stefansson, Kari
A1  - Morgan, Gareth J.
A1  - Goldschmidt, Hartmut
A1  - Hemminki, Kari
A1  - Nilsson, Björn
A1  - Houlston, Richard S.
T1  - Genome-wide association study identifies multiple susceptibility loci for multiple myeloma
JF  - Nature Communications
N2  - Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P=1.31 × 10−8), 6q21 (rs9372120, P=9.09 × 10−15), 7q36.1 (rs7781265, P=9.71 × 10−9), 8q24.21 (rs1948915, P=4.20 × 10−11), 9p21.3 (rs2811710, P=1.72 × 10−13), 10p12.1 (rs2790457, P=1.77 × 10−8), 16q23.1 (rs7193541, P=5.00 × 10−12) and 20q13.13 (rs6066835, P=1.36 × 10−13), which localize in or near to JARID2, ATG5, SMARCD3, CCAT1, CDKN2A, WAC, RFWD3 and PREX1. These findings provide additional support for a polygenic model of MM and insight into the biological basis of tumour development.
KW  - Cancer genetics
KW  - Genome-wide association studies
KW  - Myeloma
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-165983
VL  - 7
ER  - 
TY  - JOUR
A1  - Johnson, Michael D.
A1  - Akiyama, Kazunori
A1  - Blackburn, Lindy
A1  - Bouman, Katherine L.
A1  - Broderick, Avery E.
A1  - Cardoso, Vitor
A1  - Fender, Rob P.
A1  - Fromm, Christian M.
A1  - Galison, Peter
A1  - Gómez, José L.
A1  - Haggard, Daryl
A1  - Lister, Matthew L.
A1  - Lobanov, Andrei P.
A1  - Markoff, Sera
A1  - Narayan, Ramesh
A1  - Natarajan, Priyamvada
A1  - Nichols, Tiffany
A1  - Pesce, Dominic W.
A1  - Younsi, Ziri
A1  - Chael, Andrew
A1  - Chatterjee, Koushik
A1  - Chaves, Ryan
A1  - Doboszewski, Juliusz
A1  - Dodson, Richard
A1  - Doeleman, Sheperd S.
A1  - Elder, Jamee
A1  - Fitzpatrick, Garret
A1  - Haworth, Kari
A1  - Houston, Janice
A1  - Issaoun, Sara
A1  - Kovalev, Yuri Y.
A1  - Levis, Aviad
A1  - Lico, Rocco
A1  - Marcoci, Alexandru
A1  - Martens, Niels C. M.
A1  - Nagar, Neil M.
A1  - Oppenheimer, Aaron
A1  - Palumbo, Daniel C. M.
A1  - Ricarte, Angelo
A1  - Rioja, María  J.
A1  - Roelofs, Freek
A1  - Thresher, Ann C.
A1  - Tiede, Paul
A1  - Weintroub, Jonathan
A1  - Wielgus, Maciek
T1  - Key science goals for the next-generation Event Horizon Telescope
JF  - Galaxies
N2  - The Event Horizon Telescope (EHT) has led to the first images of a supermassive black hole, revealing the central compact objects in the elliptical galaxy M87 and the Milky Way. Proposed upgrades to this array through the next-generation EHT (ngEHT) program would sharply improve the angular resolution, dynamic range, and temporal coverage of the existing EHT observations. These improvements will uniquely enable a wealth of transformative new discoveries related to black hole science, extending from event-horizon-scale studies of strong gravity to studies of explosive transients to the cosmological growth and influence of supermassive black holes. Here, we present the key science goals for the ngEHT and their associated instrument requirements, both of which have been formulated through a multi-year international effort involving hundreds of scientists worldwide.
KW  - black holes
KW  - general relativity
KW  - interferometry
KW  - accretion
KW  - relativistic jets
KW  - very-long-baseline interferometry
KW  - EHT
KW  - ngEHT
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-313525
SN  - 2075-4434
VL  - 11
IS  - 3
ER  -