TY  - JOUR
A1  - Huang, Bei
A1  - Belharazem, Djeda
A1  - Li, Li
A1  - Kneitz, Susanne
A1  - Schnabel, Philipp A.
A1  - Rieker, Ralf J.
A1  - Körner, Daniel
A1  - Nix, Wilfried
A1  - Schalke, Berthold
A1  - Müller-Hermelink, Hans Konrad
A1  - Ott, German
A1  - Rosenwald, Andreas
A1  - Ströbel, Philipp
A1  - Marx, Alexander
T1  - Anti-apoptotic signature in thymic squamous cell carcinomas – functional relevance of anti-apoptotic BIRC3 expression in the thymic carcinoma cell line 1889c
JF  - Frontiers in Oncology
N2  - The molecular pathogenesis of thymomas and thymic arcinomas (TCs) is poorly understood and results of adjuvant therapy are unsatisfactory in case of metastatic disease and tumor recurrence. For these clinical settings, novel therapeutic strategies are urgently needed. Recently, limited sequencing efforts revealed that a broad spectrum of genes that play key roles in various common cancers are rarely affected in thymomas and TCs, suggesting that other oncogenic principles might be important.This made us re-analyze historic expression data obtained in a spectrumof thymomas and thymic squamous cell carcinomas (TSCCs) with a custom-made cDNA microarray. By cluster analysis, different anti-apoptotic signatures were detected in type B3 thymoma and TSCC, including overexpression of BIRC3 in TSCCs. This was confirmed by qRT-PCR in the original and an independent validation set of tumors. In contrast to several other cancer cell lines, the BIRC3-positive TSCC cell line, 1889c showed spontaneous apoptosis after BIRC3 knock-down. Targeting apoptosis genes is worth testing as therapeutic principle in TSCC.
KW  - gene expression
KW  - MTCH2
KW  - targeted
KW  - myasthenia gravis
KW  - apoptosis
KW  - thymus
KW  - thymoma
KW  - thymic carcinoma
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-132214
VL  - 3
IS  - 316
ER  - 
TY  - JOUR
A1  - Englmeier, Jana
A1  - von Hoermann, Christian
A1  - Rieker, Daniel
A1  - Benbow, Marc Eric
A1  - Benjamin, Caryl
A1  - Fricke, Ute
A1  - Ganuza, Cristina
A1  - Haensel, Maria
A1  - Lackner, Tomáš
A1  - Mitesser, Oliver
A1  - Redlich, Sarah
A1  - Riebl, Rebekka
A1  - Rojas-Botero, Sandra
A1  - Rummler, Thomas
A1  - Salamon, Jörg-Alfred
A1  - Sommer, David
A1  - Steffan-Dewenter, Ingolf
A1  - Tobisch, Cynthia
A1  - Uhler, Johannes
A1  - Uphus, Lars
A1  - Zhang, Jie
A1  - Müller, Jörg
T1  - Dung-visiting beetle diversity is mainly affected by land use, while community specialization is driven by climate
JF  - Ecology and Evolution
N2  - Dung beetles are important actors in the self-regulation of ecosystems by driving nutrient cycling, bioturbation, and pest suppression. Urbanization and the sprawl of agricultural areas, however, destroy natural habitats and may threaten dung beetle diversity. In addition, climate change may cause shifts in geographical distribution and community composition. We used a space-for-time approach to test the effects of land use and climate on α-diversity, local community specialization (H\(_2\)′) on dung resources, and γ-diversity of dung-visiting beetles. For this, we used pitfall traps baited with four different dung types at 115 study sites, distributed over a spatial extent of 300 km × 300 km and 1000 m in elevation. Study sites were established in four local land-use types: forests, grasslands, arable sites, and settlements, embedded in near-natural, agricultural, or urban landscapes. Our results show that abundance and species density of dung-visiting beetles were negatively affected by agricultural land use at both spatial scales, whereas γ-diversity at the local scale was negatively affected by settlements and on a landscape scale equally by agricultural and urban land use. Increasing precipitation diminished dung-visiting beetle abundance, and higher temperatures reduced community specialization on dung types and γ-diversity. These results indicate that intensive land use and high temperatures may cause a loss in dung-visiting beetle diversity and alter community networks. A decrease in dung-visiting beetle diversity may disturb decomposition processes at both local and landscape scales and alter ecosystem functioning, which may lead to drastic ecological and economic damage.
KW  - coleoptera
KW  - coprophagous beetles
KW  - decomposition
KW  - global change
KW  - hill numbers
KW  - network analysis
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-312846
SN  - 2045-7758
VL  - 12
IS  - 10
ER  -