TY  - JOUR
A1  - Bleilevens, Christian
A1  - Soppert, Josefin
A1  - Hoffmann, Adrian
A1  - Breuer, Thomas
A1  - Bernhagen, Jürgen
A1  - Martin, Lukas
A1  - Stiehler, Lara
A1  - Marx, Gernot
A1  - Dreher, Michael
A1  - Stoppe, Christian
A1  - Simon, Tim-Philipp
T1  - Macrophage migration inhibitory factor (MIF) plasma concentration in critically ill COVID-19 patients: a prospective observational study
JF  - Diagnostics
N2  - Mortality in critically ill coronavirus disease 2019 (COVID-19) patients is high and pharmacological treatment strategies remain limited. Early-stage predictive biomarkers are needed to identify patients with a high risk of severe clinical courses and to stratify treatment strategies. Macrophage migration inhibitory factor (MIF) was previously described as a potential predictor for the outcome of critically ill patients and for acute respiratory distress syndrome (ARDS), a hallmark of severe COVID-19 disease. This prospective observational study evaluates the predictive potential of MIF for the clinical outcome after severe COVID-19 infection. Plasma MIF concentrations were measured in 36 mechanically ventilated COVID-19 patients over three days after intensive care unit (ICU) admission. Increased compared to decreased MIF was significantly associated with aggravated organ function and a significantly lower 28-day survival (sequential organ failure assessment (SOFA) score; 8.2 ± 4.5 to 14.3 ± 3, p = 0.009 vs. 8.9 ± 1.9 to 12 ± 2, p = 0.296; survival: 56% vs. 93%; p = 0.003). Arterial hypertension was the predominant comorbidity in 85% of patients with increasing MIF concentrations (vs. decreasing MIF: 39%; p = 0.015). Without reaching significance, more patients with decreasing MIF were able to improve their ARDS status (p = 0.142). The identified association between an early MIF response, aggravation of organ function and 28-day survival may open future perspectives for biomarker-based diagnostic approaches for ICU management of COVID-19 patients.
KW  - Macrophage Migration Inhibitory Factor (MIF)
KW  - COVID-19
KW  - ICU treatment
KW  - acute respiratory distress syndrome (ARDS)
KW  - SOFA Score
KW  - Horowitz Quotient
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-228967
SN  - 2075-4418
VL  - 11
IS  - 2
ER  - 
TY  - JOUR
A1  - Brixner, Tobias
A1  - Pawłowska, Monika
A1  - Goetz, Sebastian
A1  - Dreher, Christian
A1  - Wurdack, Matthias
A1  - Krauss, Enno
A1  - Razinskas, Gary
A1  - Geisler, Peter
A1  - Hecht, Bert
T1  - Shaping and spatiotemporal characterization of sub-10-fs pulses focused by a high-NA objective
N2  - We describe a setup consisting of a 4 f pulse shaper and a microscope with a high-NA objective lens and discuss the spects most relevant for an undistorted spatiotemporal profile of the focused beam. We demonstrate shaper-assisted pulse compression in focus to a sub-10-fs duration using phase-resolved interferometric spectral modulation (PRISM). We introduce a nanostructure-based method for sub-diffraction spatiotemporal characterization of strongly focused pulses. The distortions caused by optical aberrations and space–time coupling from the shaper can be reduced by careful setup design and alignment to about 10 nm in space and 1 fs in time.
KW  - Interference microscopy
KW  - Scanning microscopy
KW  - Subwavelength structures
KW  - nanostructures
KW  - Pulse shaping
KW  - Ultrafast measurements
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-111120
ER  -