TY  - JOUR
A1  - Moll, Heidrun
A1  - Emmrich, F.
A1  - Simon, Markus M.
T1  - Recombinant human interleukin 2 directly provides signals for the proliferation and functional maturation of murine B lymphocytes
N2  - In this study the effect of recombinant human interleukin 2 (rec.hIL-2) on the proliferation and maturation of B lymphocytes was investigated. It was found that the presence of rec.hIL 2 results in proliferation of mitogen (LPS)-activated B cell blasts. In addition, it is shown that highly enriched murine B cells can be induced by rec.hIL-2 to proliferate and to develop into antibody-secreting cells (PFC) in the presence of antigen (SRBC). When tested for its effect on B cell preparations enriched for resting (small) or activated (blasted) B lymphocytes, it was found that rec.hIL 2 provides signals for both B cell populations to develop into PFC. In contrast, induction of proliferation by the same lymphokine source was only seen in blasted B cells. The data indicate that IL 2 is involved in the generation of B effector cells by directly acting on their precursors thereby providing differentiation as well as proliferation signals.
Y1  - 1985
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-34090
ER  - 
TY  - JOUR
A1  - Emmrich, F.
A1  - Moll, Heidrun
A1  - Simon, Markus M.
T1  - Recombinant human interleukin 2 acts as a B cell growth and differentiation promoting factor
N2  - Human B cells appropriately activated by a B cell mitogen are rendered susceptible to human Interleukin 2 (IL-2) as demonstrated with recombinant human IL-2 (rec. h IL-2). They show increased proliferation and drastically enhanced immunoglobulin secretion. Susceptibility to IL-2 is accompanied with the expression of the IL-2 receptor (Tac antigen) on B cells. The data suggest that IL-2 is one of the lymphokines directly involved in the activation of B lymphocytes.
Y1  - 1985
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-34132
ER  - 
TY  - JOUR
A1  - Barej, Michael F.
A1  - Schmitz, Andreas
A1  - Penner, Johannes
A1  - Doumbia, Joseph
A1  - Sandberger-Loua, Laura
A1  - Hirschfeld, Mareike
A1  - Brede, Christian
A1  - Emmrich, Mike
A1  - Kouamé, N'Goran Germain
A1  - Hillers, Annika
A1  - Gonwouo, Nono L.
A1  - Nopper, Joachim
A1  - Adeba, Patrick Joël
A1  - Bangoura, Mohamed A.
A1  - Gage, Ceri
A1  - Anderson, Gail
A1  - Rödel, Mark-Oliver
T1  - Life in the spray zone - overlooked diversity in West African torrent-frogs (Anura, Odontobatrachidae, Odontobatrachus)
JF  - Zoosystematics and Evolution
N2  - West African torrent-frogs of the genus Odontobatrachus currently belong to a single species: Odontobatrachus natator (Boulenger, 1905). Recently, molecular results and biogeographic separation led to the recognition of five Operational Taxonomic Units (OTUs) thus identifying a species-complex. Based on these insights, morphological analyses on more than 150 adult specimens, covering the entire distribution of the family and all OTUs, were carried out. Despite strong morphological congruence, combinations of morphological characters made the differentiation of OTUs successful and allowed the recognition of five distinct species: Odontobatrachus natator, and four species new to science: Odontobatrachus arndti sp. n., O. fouta sp. n., O. smithi sp. n. and O. ziama sp. n. All species occur in parapatry: Odontobatrachus natator is known from western Guinea to eastern Liberia, O. ziama sp. n. from eastern Guinea, O. smithi sp. n. and O. fouta sp. n. from western Guinea, O. arndti sp. n. from the border triangle Guinea-Liberia-Cote d'Ivoire. In addition, for the first time the advertisement call of a West African torrent-frog (O. arndti sp. n.) is described.
KW  - Guinean rain forest
KW  - molecular data
KW  - conservation
KW  - Upper Guinea
KW  - new species
KW  - Phrynobatrachus amphibia
KW  - Arthroleptis amphibia
KW  - ivory coast
KW  - genus
KW  - biodiversity
KW  - Ranidae
KW  - Petropedetidae
KW  - biodiversity hotspot
KW  - rainforest
KW  - taxonomy
KW  - Amphibia
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-144254
VL  - 91
IS  - 2
ER  -