TY  - JOUR
A1  - Korhonen, T. K.
A1  - Parkkinen, J.
A1  - Hacker, Jörg
A1  - Finne, J.
A1  - Pere, A.
A1  - Rhen, M.
A1  - Holthöfer, H
T1  - Binding of Escherichia coli S fimbriae to human kidney epithelium
N2  - Purified S fimbriae and an Escherichia coli strain carrying the recombinant plasmid pANN801-4 that encodes S fimbriae were tested for adhesion to frozen sections of human kidney. The fimbrlae and the bacteria bound to the same tissue domains, and in both cases the binding was specifically inhibited by the receptor analog of S fimbria, sialyl(a2-3)1actose. S fimbriae bound specifically to the epithelial elements in the kidneys; to the epithelial cells of proximal and distal tubules as weil as of the collecting ducts and to the visceral and parietal glomerular epithelium. In addition, they bound to the vascular endothelium of glomerull and of the renal Interstitium. No blnding to connective tissue elements was observed. The results suggest that the biological functlon of S fimbriae is to mediate the adheslon of E. coli to human epithelial and vascular endothellal ceUs.
KW  - Infektionsbiologie
Y1  - 1986
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-59415
ER  - 
TY  - JOUR
A1  - Pippias, Maria
A1  - Stel, Vianda S.
A1  - Diez, José Maria Abad
A1  - Afentakis, Nikolaos
A1  - Herrero-Calvo, Jose Antonio
A1  - Arias, Manuel
A1  - Tomilina, Natalia
A1  - Caamaño, Encarnación Bouzas
A1  - Buturovic-Ponikvar, Jadranka
A1  - Čala, Svjetlana
A1  - Caskey, Fergus J.
A1  - de la Nuez, Pablo Castro
A1  - Cernevskis, Harijs
A1  - Collart, Frederic
A1  - de la Torre, Ramón Alonso
A1  - de los Ángeles García Bazaga, Maria
A1  - De Meester, Johan
A1  - Díaz, Joan Manuel
A1  - Djukanovic, Ljubica
A1  - Alamar, Manuel Ferrer
A1  - Finne, Patrik
A1  - Garneata, Liliana
A1  - Golan, Eliezer
A1  - González Fernández, Raquel
A1  - Gutiérrez Avila, Gonzalo
A1  - Heaf, James
A1  - Hoitsma, Andries
A1  - Kantaria, Nino
A1  - Kolesnyk, Mykola
A1  - Kramar, Reinhard
A1  - Kramer, Anneke
A1  - Lassalle, Mathilde
A1  - Leivestad, Torbjørn
A1  - Lopot, Frantisek
A1  - Macário, Fernando
A1  - Magaz, Angela
A1  - Martín-Escobar, Eduardo
A1  - Metcalfe, Wendy
A1  - Noordzij, Marlies
A1  - Palsson, Runolfur
A1  - Pechter, Ülle
A1  - Prütz, Karl G.
A1  - Ratkovic, Marina
A1  - Resić, Halima
A1  - Rutkowski, Boleslaw
A1  - de Pablos, Carmen Santiuste
A1  - Spustová, Viera
A1  - Süleymanlar, Gültekin
A1  - Van Stralen, Karlijn
A1  - Thereska, Nestor
A1  - Wanner, Christoph
A1  - Jager, Kitty J.
T1  - Renal replacement therapy in Europe: a summary of the 2012 ERA-EDTA Registry Annual Report
JF  - Clinical Kidney Journal
N2  - Background
This article summarizes the 2012 European Renal Association—European Dialysis and Transplant Association Registry Annual Report (available at www.era-edta-reg.org) with a specific focus on older patients (defined as ≥65 years).

Methods
Data provided by 45 national or regional renal registries in 30 countries in Europe and bordering the Mediterranean Sea were used. Individual patient level data were received from 31 renal registries, whereas 14 renal registries contributed data in an aggregated form. The incidence, prevalence and survival probabilities of patients with end-stage renal disease (ESRD) receiving renal replacement therapy (RRT) and renal transplantation rates for 2012 are presented.

Results
In 2012, the overall unadjusted incidence rate of patients with ESRD receiving RRT was 109.6 per million population (pmp) (n = 69 035), ranging from 219.9 pmp in Portugal to 24.2 pmp in Montenegro. The proportion of incident patients ≥75 years varied from 15 to 44% between countries. The overall unadjusted prevalence on 31 December 2012 was 716.7 pmp (n = 451 270), ranging from 1670.2 pmp in Portugal to 146.7 pmp in the Ukraine. The proportion of prevalent patients ≥75 years varied from 11 to 32% between countries. The overall renal transplantation rate in 2012 was 28.3 pmp (n = 15 673), with the highest rate seen in the Spanish region of Catalonia. The proportion of patients ≥65 years receiving a transplant ranged from 0 to 35%. Five-year adjusted survival for all RRT patients was 59.7% (95% confidence interval, CI: 59.3–60.0) which fell to 39.3% (95% CI: 38.7–39.9) in patients 65–74 years and 21.3% (95% CI: 20.8–21.9) in patients ≥75 years.
KW  - end-stage renal disease
KW  - incidence
KW  - prevalence
KW  - renal replacement therapy
KW  - survival
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150054
VL  - 8
IS  - 3
ER  -