TY  - JOUR
A1  - Glaser, Rüdiger
A1  - Sponholz, Barbara
T1  - Erste Untersuchungen von Hangrutschungen an der Frankenhöhe
N2  - Der vorliegende Beitrag faßt den derzeitigen Stand der Untersuchungen von Hangrutschungen im Bereich der Frankenhöhe, die im Rahmen des EPOCH-Programmes durchgeführt wurden, zusammen. Nach einer Inventarisierung der regionalen Rutschungsereignisse wird die Rutschung bei Obergailnau in einer geomorphologischen Detailkartierung vorgestellt. Für die Auslösung der Rutschung kommen mehrere Faktoren in Betracht: neben einer erhöhten Rutschungsanfälligkeit aufgrund der geologisch-tektonischen Verhältnisse muß v.a. auch eine Einflußnahme durch die Landnutzung mit berücksichtigt werden. Dazu zählen Steinbrucharbeiten in unmittelbarer Nähe der Rutschung, aber auch Wasserbaumaßnahmen am Schloßberg. In diesem potentielllabilisierten Gebiet kam es nach überdurchschnittlichen Niederschlägen Anfang 1958 zu einer Überschreitung der Belastungsgrenze des Hanges, die sich in einer großflächigen Rutschung äußerte. Die weiteren Untersuchungen sollen zeigen, ob sich die für Obergailnau herausgestellten Faktorenkomplexe im regionalen Rahmen verifizieren lassen.
N2  - The paper summarizes the present status of investigations on landslides at a section of the Frankenhöhe escarpment of northem Bavaria, conducted within the context of an EPOCH program. Following an overview of landslide events in the region a recent landslide near the village of Obergailnau is presented in a detailed geomorphological map. Several factors may have contributed to triggering the landslide: an increased susceptibility to landsliding because of the geological and tectonical setting of the area may have been compounded with the landuse there, such as quarrying in the immediate vicinity and hydraulic engineering works at the Schloß mtn. upslope of the landslide area. Unusually high precipitation at the beginning of 1958 sufficiently lowered the load limit of this potentially unstable area, thus causing a major landslide. Further studies are planned in order to fmd out weiher Ihe complex of faclors identified at Obergailnau is of regional significance.
KW  - Geographie
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-53615
ER  - 
TY  - JOUR
A1  - Recke, Andreas
A1  - Konitzer, Sarah
A1  - Lemcke, Susanne
A1  - Freitag, Miriam
A1  - Sommer, Nele Maxi
A1  - Abdelhady, Mohammad
A1  - Amoli, Mahsa M.
A1  - Benoit, Sandrine
A1  - El-Chennawy, Farha
A1  - Eldarouti, Mohammad
A1  - Eming, Rüdiger
A1  - Gläser, Regine
A1  - Günther, Claudia
A1  - Hadaschik, Eva
A1  - Homey, Bernhard
A1  - Lieb, Wolfgang
A1  - Peitsch, Wiebke K.
A1  - Pföhler, Claudia
A1  - Robati, Reza M.
A1  - Saeedi, Marjan
A1  - Sárdy, Miklós
A1  - Sticherling, Michael
A1  - Uzun, Soner
A1  - Worm, Margitta
A1  - Zillikens, Detlef
A1  - Ibrahim, Saleh
A1  - Vidarsson, Gestur
A1  - Schmidt, Enno
T1  - The p.Arg435His Variation of IgG3 With High Affinity to FcRn Is Associated With Susceptibility for Pemphigus Vulgaris-Analysis of Four Different Ethnic Cohorts
JF  - frontiers in Immunology
N2  - IgG3 is the IgG subclass with the strongest effector functions among all four IgG subclasses and the highest degree of allelic variability among all constant immunoglobulin genes. Due to its genetic position, IgG3 is often the first isotype an antibody switches to before IgG1 or IgG4. Compared with the other IgG subclasses, it has a reduced half-life which is probably connected to a decreased affinity to the neonatal Fc receptor (FcRn). However, a few allelic variants harbor an amino acid replacement of His435 to Arg that reverts the half-life of the resulting IgG3 to the same level as the other IgG subclasses. Because of its functional impact, we hypothesized that the p.Arg435His variation could be associated with susceptibility to autoantibody-mediated diseases like pemphigus vulgaris (PV) and bullous pemphigoid (BP). Using a set of samples from German, Turkish, Egyptian, and Iranian patients and controls, we were able to demonstrate a genetic association of the p.Arg435His variation with PV risk, but not with BP risk. Our results suggest a hitherto unknown role for the function of IgG3 in the pathogenesis of PV.
KW  - immunology
KW  - dermatology
KW  - autoantibodies
KW  - allotype
KW  - pemphigus
KW  - Diagnose
KW  - pemphigoid
KW  - half-life
KW  - functional genetics
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-225073
VL  - 9
ER  -