TY  - JOUR
A1  - Heinemann, Anna Sophie
A1  - Stalp, Jan Lennart
A1  - Bonifacio, João Pedro Pereira
A1  - Silva, Filo
A1  - Willers, Maike
A1  - Heckmann, Julia
A1  - Fehlhaber, Beate
A1  - Völlger, Lena
A1  - Raafat, Dina
A1  - Normann, Nicole
A1  - Klos, Andreas
A1  - Hansen, Gesine
A1  - Schmolke, Mirco
A1  - Viemann, Dorothee
T1  - Silent neonatal influenza A virus infection primes systemic antimicrobial immunity
JF  - Frontiers in Immunology
N2  - Infections with influenza A viruses (IAV) cause seasonal epidemics and global pandemics. The majority of these infections remain asymptomatic, especially among children below five years of age. Importantly, this is a time, when immunological imprinting takes place. Whether early-life infections with IAV affect the development of antimicrobial immunity is unknown. Using a preclinical mouse model, we demonstrate here that silent neonatal influenza infections have a remote beneficial impact on the later control of systemic juvenile-onset and adult-onset infections with an unrelated pathogen, Staphylococcus aureus, due to improved pathogen clearance and clinical resolution. Strategic vaccination with a live attenuated IAV vaccine elicited a similar protection phenotype. Mechanistically, the IAV priming effect primarily targets antimicrobial functions of the developing innate immune system including increased antimicrobial plasma activity and enhanced phagocyte functions and antigen-presenting properties at mucosal sites. Our results suggest a long-term benefit from an exposure to IAV during the neonatal phase, which might be exploited by strategic vaccination against influenza early in life to enforce the host’s resistance to later bacterial infections.
KW  - neonate
KW  - influenza A virus
KW  - influenza vaccination
KW  - innate immunity training
KW  - antimicrobial immunity
KW  - Staphylococcus aureus
KW  - sepsis
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-304782
VL  - 14
ER  -