TY  - JOUR
A1  - Goméz-H, Laura
A1  - Felipe-Medina, Natalia
A1  - Sánchez-Martín, Manuel
A1  - Davies, Owen R.
A1  - Ramos, Isabel
A1  - García-Tuñón, Ignacio
A1  - de Rooij, Dirk G.
A1  - Dereli, Ihsan
A1  - Tóth, Attila
A1  - Barbero, José Luis
A1  - Benavente, Ricardo
A1  - Llano, Elena
A1  - Pendas, Alberto M.
T1  - C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility
JF  - Nature Communications
N2  - Meiotic recombination generates crossovers between homologous chromosomes that are essential for genome haploidization. The synaptonemal complex is a ‘zipper’-like protein assembly that synapses homologue pairs together and provides the structural framework for processing recombination sites into crossovers. Humans show individual differences in the number of crossovers generated across the genome. Recently, an anonymous gene variant in C14ORF39/SIX6OS1 was identified that influences the recombination rate in humans. Here we show that C14ORF39/SIX6OS1 encodes a component of the central element of the synaptonemal complex. Yeast two-hybrid analysis reveals that SIX6OS1 interacts with the well-established protein synaptonemal complex central element 1 (SYCE1). Mice lacking SIX6OS1 are defective in chromosome synapsis at meiotic prophase I, which provokes an arrest at the pachytene-like stage and results in infertility. In accordance with its role as a modifier of the human recombination rate, SIX6OS1 is essential for the appropriate processing of intermediate recombination nodules before crossover formation.
KW  - Chromosomes
KW  - Meiosis
KW  - Spermatogenesis
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-165907
VL  - 7
ER  - 
TY  - JOUR
A1  - Trafimow, David
A1  - Amrhein, Valentin
A1  - Areshenkoff, Corson N.
A1  - Barrera-Causil, Carlos J.
A1  - Beh, Eric J.
A1  - Bilgiç, Yusuf K.
A1  - Bono, Roser
A1  - Bradley, Michael T.
A1  - Briggs, William M.
A1  - Cepeda-Freyre, Héctor A.
A1  - Chaigneau, Sergio E.
A1  - Ciocca, Daniel R.
A1  - Correa, Juan C.
A1  - Cousineau, Denis
A1  - de Boer, Michiel R.
A1  - Dhar, Subhra S.
A1  - Dolgov, Igor
A1  - Gómez-Benito, Juana
A1  - Grendar, Marian
A1  - Grice, James W.
A1  - Guerrero-Gimenez, Martin E.
A1  - Gutiérrez, Andrés
A1  - Huedo-Medina, Tania B.
A1  - Jaffe, Klaus
A1  - Janyan, Armina
A1  - Karimnezhad, Ali
A1  - Korner-Nievergelt, Fränzi
A1  - Kosugi, Koji
A1  - Lachmair, Martin
A1  - Ledesma, Rubén D.
A1  - Limongi, Roberto
A1  - Liuzza, Marco T.
A1  - Lombardo, Rosaria
A1  - Marks, Michael J.
A1  - Meinlschmidt, Gunther
A1  - Nalborczyk, Ladislas
A1  - Nguyen, Hung T.
A1  - Ospina, Raydonal
A1  - Perezgonzalez, Jose D.
A1  - Pfister, Roland
A1  - Rahona, Juan J.
A1  - Rodríguez-Medina, David A.
A1  - Romão, Xavier
A1  - Ruiz-Fernández, Susana
A1  - Suarez, Isabel
A1  - Tegethoff, Marion
A1  - Tejo, Mauricio
A1  - van de Schoot, Rens
A1  - Vankov, Ivan I.
A1  - Velasco-Forero, Santiago
A1  - Wang, Tonghui
A1  - Yamada, Yuki
A1  - Zoppino, Felipe C. M.
A1  - Marmolejo-Ramos, Fernando
T1  - Manipulating the Alpha Level Cannot Cure Significance Testing
JF  - Frontiers in Psychology
N2  - We argue that making accept/reject decisions on scientific hypotheses, including a recent call for changing the canonical alpha level from p = 0.05 to p = 0.005, is deleterious for the finding of new discoveries and the progress of science. Given that blanket and variable alpha levels both are problematic, it is sensible to dispense with significance testing altogether. There are alternatives that address study design and sample size much more directly than significance testing does; but none of the statistical tools should be taken as the new magic method giving clear-cut mechanical answers. Inference should not be based on single studies at all, but on cumulative evidence from multiple independent studies. When evaluating the strength of the evidence, we should consider, for example, auxiliary assumptions, the strength of the experimental design, and implications for applications. To boil all this down to a binary decision based on a p-value threshold of 0.05, 0.01, 0.005, or anything else, is not acceptable.
KW  - statistical significance
KW  - null hypothesis testing
KW  - p-value
KW  - significance testing
KW  - decision making
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-189973
SN  - 1664-1078
VL  - 9
IS  - 699
ER  - 
TY  - JOUR
A1  - Ruiz-Heredia, Yanira
A1  - Sánchez-Vega, Beatriz
A1  - Onecha, Esther
A1  - Barrio, Santiago
A1  - Alonso, Rafael
A1  - Carlos Martínez-Avila, Jose
A1  - Cuenca, Isabel
A1  - Agirre, Xabier
A1  - Braggio, Esteban
A1  - Hernández, Miguel-T.
A1  - Martínez, Rafael
A1  - Rosiñol, Laura
A1  - Gutierrez, Norma
A1  - Martin-Ramos, Marisa
A1  - Ocio, Enrique M.
A1  - Echeveste, María-Asunción
A1  - Pérez de Oteyza, Jaime
A1  - Oriol, Albert
A1  - Bargay, Joan
A1  - Gironella, Mercedes
A1  - Ayala, Rosa
A1  - Bladé, Joan
A1  - Mateos, María-Victoria
A1  - Kortum, Klaus M.
A1  - Stewart, Keith
A1  - García-Sanz, Ramón
A1  - San Miguel, Jesús
A1  - José Lahuerta, Juan
A1  - Martinez-Lopez, Joaquín
T1  - Mutational screening of newly diagnosed multiple myeloma patients by deep targeted sequencing
JF  - Haematologica
N2  - no abstract available
KW  - Copy number changes
KW  - Survival
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-227151
VL  - 103
IS  - 11
ER  -